Article
Ecology
Md Saiful Islam, Md Abdus Sobur, Saifur Rahman, Fatimah Mohammed Ballah, Samina Ievy, Mahbubul Pratik Siddique, Marzia Rahman, Md Abdul Kafi, Md Tanvir Rahman
Summary: Migratory birds may carry ESBL-producing E. coli and other antibiotic resistance genes, posing potential threats to human health.
Article
Immunology
Tam Tran, Sylvia Checkley, Niamh Caffrey, Chunu Mainali, Sheryl Gow, Agnes Agunos, Karen Liljebjelke
Summary: This study identified potential horizontal gene transfer events of antimicrobial resistance genes between E. coli and Salmonella in broiler chicken production, revealing various resistant genes in the process.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Cheng-Hsun Chiu, Jen-Jain Lee, Mei-Hui Wang, Chishih Chu
Summary: This study investigated the role of plasmid-mediated ISEcp-1 tnpA-bla(CMY-2)-blc-sugE in regulating ceftriaxone susceptibility in different hosts. The results showed a correlation between these genes and different hosts, affecting the susceptibility to the antibiotic ceftriaxone.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Matheus Silva Sanches, Luana Carvalho Silva, Caroline Rodrigues da Silva, Victor Hugo Montini, Bruno Henrique Dias de Oliva, Gustavo Henrique Migliorini Guidone, Mara Correa Lelles Nogueira, Maisa Fabiana Menck-Costa, Renata Katsuko Takayama Kobayashi, Eliana Carolina Vespero, Sergio Paulo Dejato Rocha
Summary: The study aimed to evaluate the prevalence of antimicrobial resistance and clonal relationships in Proteus mirabilis isolated from different sources. Results showed that chicken meat had the highest multidrug resistance, followed by pork and community-acquired urinary tract infections (UTI-CA), while beef had relatively few multidrug-resistant strains. Various antimicrobial resistance genes were detected, especially in chicken meat and UTI-CA isolates. Molecular typing revealed genetic similarity between chicken meat and UTI-CA isolates, indicating that chicken could be a source of P. mirabilis causing UTI-CA. It was concluded that meat, especially chicken, can be an important source of multidrug-resistant P. mirabilis dissemination in the community.
Article
Microbiology
Live L. Nesse, Solveig S. Mo, Silje N. Ramstad, Ingun L. Witso, Camilla Sekse, Anna Eline E. Bruvoll, Anne Margrete Urdahl, Lene K. Vestby
Summary: Norwegian monitoring program detected Extended-spectrum cephalosporin-resistant Escherichia coli (ESCR E. coli) with plasmids carrying the bla(CMY-2) resistance gene in the Norwegian broiler production chain, which displayed relatively low biofilm forming abilities. The study found that these plasmids may cause the observed reduction in biofilm formation through changes in flagellar expression or function.
Article
Food Science & Technology
Mohammad M. Obaidat, Wasan A. Gharaibeh
Summary: Limited data is available on the prevalence and antimicrobial resistance of ESBL and AmpC beta-lactamases E. coli in sheep and goats in Jordan. This study found a high prevalence of ESBL and AmpC beta-lactamases E. coli in milk samples from sheep and goats, with a significant resistance to multiple antimicrobial drugs. Therefore, good hygiene practices and judicious antimicrobial use are crucial in small ruminant farming.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Microbiology
Junxin Zhou, Weiping Wang, Min Liang, Qian Yu, Shiqi Cai, Tailong Lei, Yan Jiang, Xiaoxing Du, Zhihui Zhou, Yunsong Yu
Summary: The study aimed to investigate the molecular mechanism underlying ceftazidime-avibactam resistance caused by a novel CMY-178 variant. The results showed that CMY-178 increased the resistance to multiple cephalosporins and ceftazidime-avibactam compared with CMY-172. Structural modeling and molecular docking revealed that CMY-178 had a narrower ligand-binding pocket and a stronger positive charge at the pocket entrance than CMY-172. The bla(CMY-178) gene was located in a transferable plasmid with high transfer frequency and no fitness costs.
MICROBIOLOGY SPECTRUM
(2023)
Article
Food Science & Technology
Mikaela dos Anjos Adur, Pierre Chatre, Veronique Metayer, Antoine Drapeau, Marcelo Pillonetto, Margareth Leonor Penkal, Jessica Kayamori Lopes, Breno Castello Branco Beira, Jean -Yves Madec, Renata Ernlund Freitas de Macedo, Marisa Haenni
Summary: This study investigated the prevalence, diversity, and genomic characteristics of ESBL/AmpC Enterobacterales in poultry flocks in different farms and cities in the state of Paraná, Brazil. The results showed that these resistant bacteria are highly transmissible and have similar clones between different farms. This highlights the potential role of centralized and vertically integrated poultry industry in the spread of these resistant bacteria.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Microbiology
Jiacui Lai, Hao Mu, Bingqian Zhou, Jiawei He, Xiangning Cheng, Yujie Gan, Meiyuan Zhao, Mengqi Xie, Yang Zhang, Ying He, Yujiao Yang, Jian Wang, Haoju Wang, Honglei Ding
Summary: This study aimed to investigate the epidemiological characteristics and antimicrobial resistance of Salmonella from livestock and poultry in Chongqing municipality, China. The results showed that Salmonella strains from different animal sources exhibited high resistance to multiple antibiotics and showed multidrug resistance phenotypes. Many isolates also carried beta-lactamase genes and plasmid-mediated quinolone resistance genes. To ensure public health, rational use and strict control strategies for antimicrobials in animal husbandry and treatment are necessary.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Johannetsy J. Avillan, Parvaneh Ahmadvand, Shao-Yeh Lu, Jennifer Horton, Jinxin Liu, Eric Lofgren, Margaret A. Davis, ChulHee Kang, Douglas R. Call
Summary: Understanding the mechanisms responsible for the emergence of new antibiotic resistance genes can provide insights into the persistence and dissemination of antibiotic-resistant organisms. This study found that Escherichia coli strains harboring a certain gene were replacing strains with another gene in dairy cattle. The results showed that E. coli strains carrying one gene had a selective advantage when exposed to antibiotics in the absence of competing genes.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Zoi Athanasakopoulou, Celia Diezel, Sascha D. Braun, Marina Sofia, Alexios Giannakopoulos, Stefan Monecke, Dominik Gary, Domenique Kraehmer, Dimitris C. Chatzopoulos, Antonia Touloudi, Periklis Birtsas, Matina Palli, Giorgos Georgakopoulos, Vassiliki Spyrou, Efthymia Petinaki, Ralf Ehricht, Charalambos Billinis
Summary: This study evaluated the antimicrobial resistance of Escherichia coli in wild birds from Greece and found strains producing ESBL and carbapenemase. The results highlight the importance of including wild birds in the assessment of antimicrobial resistance circulation in non-clinical settings.
Article
Agriculture, Dairy & Animal Science
Bo-Ram Kwon, Bai Wei, Se-Yeoun Cha, Ke Shang, Jun-Feng Zhang, Hyung-Kwan Jang, Min Kang
Summary: The study found that there are ESC-resistant Salmonella strains with the same resistance genes in both chickens and humans, highlighting the potential risk of gene transfer between different pathogens. Specifically, the bla(CMY-2) gene was shown to be easily transferred between Salmonella and E. coli in the intestines of mice, even in the absence of antimicrobial pressure, indicating an increased risk of multidrug resistance in potentially virulent E. coli isolates.
Article
Biotechnology & Applied Microbiology
Mashkoor Mohsin, Brekhna Hassan, Ali Usman Khan, Arslan Ali, Gote Swedberg, Badrul Hasan
Summary: The presence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales in urinary tract infection cases in Pakistan was investigated. The study revealed the presence of ESBL-producing Escherichia coli and Enterobacter hormaechei strains, some of which were multidrug-resistant and carried resistance genes. Screening of these strains may be effective in controlling the spread of multidrug-resistant bacteria.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Xenia Vazquez, Vanesa Garcia, Javier Fernandez, Margarita Bances, Maria de Toro, Victor Ladero, Rosaura Rodicio, M. Rosario Rodicio
Summary: This study assessed the prevalence of colistin resistance in food-borne Salmonella enterica isolates in Asturias, Spain, and identified the genetic basis and transferability of this resistance. The study found that meat products serve as reservoirs of highly successful clones and transferable plasmids carrying colistin resistance and other clinically important antibiotic resistance.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Melek Ben Aissa, Sana Ferjani, Mohamed Salah Abassi, Nada Al-Suwailem, Ilhem Boutiba
Summary: In this study, an antibiotic resistance mechanism was identified in the eastern region of Saudi Arabia. The clonal relatedness within Gram-negative bacteria was also investigated. The presence of various resistance genes, including bla genes and plasmid-mediated quinolone resistance genes, was detected. The study also revealed the occurrence of previously unreported genes and the prevalence of certain clones in the region.
APPLIED SCIENCES-BASEL
(2022)
Article
Infectious Diseases
Shizhen Ma, Chengtao Sun, Anette Hulth, Jiyun Li, Lennart E. Nilsson, Yuqing Zhou, Stefan Borjesson, Zhenwang Bi, Zhenqiang Bi, Qiang Sun, Yang Wang
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Letter
Infectious Diseases
Jiyun Li, Anette Hulth, Lennart E. Nilsson, Stefan Borjesson, Baoli Chen, Zhenwang Bi, Yang Wang, Stefan Schwarz, Congming Wu
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Article
Infectious Diseases
Agnese Lupo, Marisa Haenni, Estelle Saras, Joanna Gradin, Jean-Yves Madec, Stefan Borjesson
MICROBIAL DRUG RESISTANCE
(2018)
Letter
Microbiology
G. Strom Hallenberg, S. Borjesson, S. Sokerya, T. Sothyra, U. Magnusson
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Agriculture, Dairy & Animal Science
Bui Phan Thu Hang, Ewa Wredle, Stefan Borjesson, Kerstin Svennersten Sjaunja, Johan Dicksved, Anna Duse
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2019)
Article
Microbiology
Xiaohui Chi, Bjorn Berglund, Huiyun Zou, Beiwen Zheng, Stefan Borjesson, Xiang Ji, Jakob Ottoson, Cecilia Stalsby Lundborg, Xuewen Li, Lennart E. Nilsson
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Infectious Diseases
Chengtao Sun, Baoli Chen, Anette Hulth, Stefan Schwarz, Xing Ji, Lennart E. Nilsson, Shizhen Ma, Qiang Sun, Zhenwang Bi, Yang Wang, Zhenqiang Bi, Congming Wu, Stefan Borjesson
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2019)
Article
Public, Environmental & Occupational Health
Clara Atterby, Kristina Osbjer, Viktoria Tepper, Elisabeth Rajala, Jorge Hernandez, Sokerya Seng, Davun Holl, Jonas Bonnedahl, Stefan Borjesson, Ulf Magnusson, Josef D. Jarhult
ZOONOSES AND PUBLIC HEALTH
(2019)
Article
Infectious Diseases
Stefan Borjesson, Christina Greko, Mattias Myrenas, Annica Landen, Oskar Nilsson, Karl Pedersen
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2020)
Article
Environmental Sciences
Jiyun Li, Zhenwang Bi, Shizhen Ma, Baoli Chen, Chang Cai, Junjia He, Stefan Schwarz, Chengtao Sun, Yuqing Zhou, Jia Yin, Anette Hulth, Yongqiang Wang, Zhangqi Shen, Shaolin Wang, Congming Wu, Lennart E. Nilsson, Timothy R. Walsh, Stefan Borjesson, Jianzhong Shen, Qiang Sun, Yang Wang
ENVIRONMENTAL HEALTH PERSPECTIVES
(2019)
Review
Microbiology
Muna F. Anjum, Heike Schmitt, Stefan Boerjesson, Thomas U. Berendonk, Eliana Guedes Stehling, Patrick Boerlin, Edward Topp, Claire Jardine, Xuewen Li, Bing Li, Monika Dolejska, Jean-Yves Madec, Christophe Dagot, Sebastian Guenther, Fiona Walsh, Laura Villa, Kees Veldman, Marianne Sunde, Pawel Krzeminski, Dariusz Wasyl, Magdalena Popowska, Josef Jaerhult, Stefan Oern, Olfa Mahjoub, Wejdene Mansour, Dinh Nho Thai, Josefine Elving, Karl Pedersen
Summary: The dynamics of antimicrobial resistance (AMR) are better understood through a One-Health perspective with surveillance playing a crucial role. Establishing environmental monitoring programs for AMR is urgently needed to complement existing systems in different sectors and to identify transmissions between human, animal, and environmental populations. Using antimicrobial resistant Escherichia coli as indicators for monitoring can help in assessing the occurrence and levels of AMR in the environment, including wildlife.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Cameron J. Reid, Max L. Cummins, Stefan Borjesson, Michael S. M. Brouwer, Henrik Hasman, Anette M. Hammerum, Louise Roer, Stefanie Hess, Thomas Berendonk, Kristina Nesporova, Marisa Haenni, Jean-Yves Madec, Astrid Bethe, Geovana B. Michael, Anne-Kathrin Schink, Stefan Schwarz, Monika Dolejska, Steven P. Djordjevic
Summary: This study presents a pan-genomic analysis of Escherichia coli ST58 isolates from animal and human sources. The analysis reveals a major sub-lineage of ST58 that is characterized by the presence of ColV plasmids carrying virulence genes, and a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage has a broad host range, with poultry and swine being the predominant sources.
NATURE COMMUNICATIONS
(2022)
Article
Infectious Diseases
Baoli Chen, Bjorn Berglund, Shuang Wang, Stefan Borjesson, Zhenqiang Bi, Maud Nilsson, Hong Yin, Beiwen Zheng, Yonghong Xiao, Zhenwang Bi, Lennart E. Nilsson
Summary: This study investigated the occurrence and characteristics of carbapenem-resistant Enterobacteriaceae (CRE) in fecal samples from healthy individuals in 12 villages in Shandong Province, China. The results showed a rapid increase in CRE carriage from 2.4% to 13.4% from 2015 to 2017, with the majority of isolates being Escherichia coli carrying NDM-type carbapenemases. The worsening epidemiological situation highlights the need for further monitoring and interventions in the region.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Agriculture, Dairy & Animal Science
K. Persson Waller, M. Myrenas, S. Borjesson, H. Kim, M. Widerstrom, T. Monsen, A. K. Sigurdarson Sandholt, E. Ostlund, W. Cha
Summary: This study investigated the genotypic variation and relatedness of Staphylococcus chromogenes and Staphylococcus simulans, commonly found in bovine subclinical mastitis. Whole-genome sequencing was used to characterize the isolates and analyze antimicrobial resistance and potential virulence factors. The study found substantial variation in genotypes and clusters among cows and herds, with some genotypes being spread between herds. The results also showed differences in inflammatory response and persistent intramammary infection at the udder quarter level for S. chromogenes subtypes. The findings provide new insights into the epidemiology of these infections and can inform future prevention and treatment strategies.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Veterinary Sciences
Oskar Nilsson, Stefan Borjesson, Annica Landen, Christina Greko, Bjorn Bengtsson
ACTA VETERINARIA SCANDINAVICA
(2020)