Article
Engineering, Biomedical
Yuanyuan Zhu, Huan Liu, Sumei Qin, Cheng Yang, Qiying Lv, Zheng Wang, Lin Wang
Summary: This study developed a cryogel SMC@Ag with high water/blood absorption, outstanding hemostatic and antibacterial performance, which showed much better hemostatic performance than the commercial gelatin sponge. The excellent hemostatic activity of SMC@Ag is due to facilitating the coagulation pathway activation and enhancing the platelets adhesion during coagulation process.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Medicinal
Francisco Jose Palacios-Can, Jesus Silva-Sanchez, Ismael Leon-Rivera, Hugo Tlahuext, Nina Pastor, Rodrigo Said Razo-Hernandez
Summary: As the rate of discovery of new antibacterial compounds for multidrug-resistant bacteria is declining, there is an urge for the search for molecules that could revert this tendency. In this study, a quantitative structure-property relationship (QSPR) model was developed to identify structural parameters related to antibacterial activity against Acinetobacter baumannii. The QSPR model was validated and used for virtual screening of the BIOFACQUIM natural product database, leading to the discovery of potential antibacterials against A. baumannii. Biological assays confirmed the antibacterial activity of some of the identified molecules, highlighting their potential as lead compounds for further development. The QSPR model proved to be a useful tool for the investigation and search for new antibacterial compounds against A. baumannii.
Review
Engineering, Biomedical
Huifeng Shao, Tao Zhang, Youping Gong, Yong He
Summary: Bacterial infection caused by biomaterials is a serious problem in implant clinical treatment. The emergence of antibiotic resistance has led to the exploration of alternative antibacterial agents, with silver being a promising candidate due to its high antibacterial properties and low susceptibility to resistance. However, the cytotoxicity of silver poses challenges for its application in biomaterials.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Youzi Zhao, Honglei Kang, Yuhao Xia, Lingshun Sun, Feng Li, Honglian Dai
Summary: The study combines photothermal therapy and copper ion release to construct a multifunctional scaffold for treating infected bone defects. It uses programmed temperature control to kill bacteria and promote bone tissue growth, while gradually releasing copper ions to enhance the antibacterial effect and promote angiogenesis. This approach reduces damage to healthy cells and tissues.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Yu Qiu, Jun Tian, Siyi Kong, Yanping Feng, Yangyu Lu, Lefeng Su, Yanling Cai, Mengjie Li, Jiang Chang, Chen Yang, Xi Wei
Summary: A SrCuSi4O10/gelatin methacrylate (SC/Gel) composite hydrogel has been proposed for infected dental pulp treatment, which efficiently eliminates bacteria and promotes pulp and dentine repair. It has shown potential as a pulp-capping material with improved effects on dentine-pulp complex repair in infected pulp.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Medicinal
Ilaria D'Agostino, Claudia Ardino, Giulio Poli, Filomena Sannio, Massimiliano Lucidi, Federica Poggialini, Daniela Visaggio, Enrico Rango, Silvia Filippi, Elena Petricci, Paolo Visca, Lorenzo Botta, Jean-Denis Docquier, Elena Dreassi
Summary: The ever-faster rise of antimicrobial resistance poses a major challenge to global public health. Researchers have developed a novel class of broad-spectrum bactericidal agents called AlkylGuanidino Ureas (AGU) that likely target bacterial membranes. By synthesizing a library of AGU derivatives and conducting specific assays, they have provided evidence that AGUs disrupt bacterial membranes without hemolytic behavior.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Engineering, Biomedical
Baoxuan Huang, Mingjiao Chen, Jia Tian, Yuanhao Zhang, Zhaobo Dai, Jin Li, Weian Zhang
Summary: A versatile fluorine-incorporating hydrogel is designed to supply oxygen and prevent bacterial infections in tissue engineering. In vitro and in vivo experiments show that the hydrogel improves cell survival and promotes bone tissue generation under hypoxic conditions, while also inhibiting bacterial growth. This suggests that the rational design of fluorinated hydrogel has significant clinical application prospects for bone regeneration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Medicinal
Tatu Rimpilainen, Alexandra Nunes, Rita Calado, Ana S. Fernandes, Joana Andrade, Epole Ntungwe, Gabriella Spengler, Nikoletta Szemeredi, Joao Rodrigues, Joao Paulo Gomes, Patricia Rijo, Nuno R. Candeias
Summary: The study identified two promising aminoalkylphenols with potential antibacterial activity against reference strain and clinical isolates. Despite exhibiting high cytotoxicity in vitro, these compounds may have potential as antibacterial agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Daniel Teitelbaum, Marion Elligsen, Kevin Katz, Philip W. Lam, Jennifer Lo, Derek MacFadden, Christie Vermeiren, Nick Daneman
Summary: The concept of an escalation antibiogram was introduced for gram-negative bacteremia, calculating the likelihood of susceptibility to different antibiotics for resistant organisms. Results showed significant differences in coverage rates among antibiotics for different pathogens, highlighting the importance of escalation antibiograms in guiding treatment decisions and avoiding common therapeutic errors.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Daniel Teitelbaum, Marion Elligsen, Kevin Katz, Philip W. Lam, Jennifer Lo, Derek MacFadden, Christie Vermeiren, Nick Daneman
Summary: The study introduces the concept of an escalation antibiogram to provide guidance for the escalation of treatment in nonresponding patients. The results show significant shifts in likelihood of coverage among different antibiotics for gram-negative bacteria. These tools can yield important insights, such as avoiding the common maneuver of escalating from ceftriaxone to piperacillin-tazobactam.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Despina Vougiouklaki, Theofania Tsironi, Joseph Papaparaskevas, Panagiotis Halvatsiotis, Dimitra Houhoula
Summary: The variety of metabolites produced by lactic acid bacteria (LAB) is not well characterized. This study used HPLC-UV/DAD to determine the specific metabolites produced by Lacticaseibacillus rhamnosus, Levilactobacillus brevis, and Lactiplantibacillus plantarum, and investigated their antimicrobial activity against specific food pathogens. The results identified several metabolites with potential antimicrobial properties, which could be used as natural antimicrobial ingredients in the food industry.
APPLIED SCIENCES-BASEL
(2022)
Review
Chemistry, Inorganic & Nuclear
Xudong Zhao, Meiqi Zheng, Xinli Gao, Jing Zhang, Erbing Wang, Zhuqing Gao
Summary: This article discusses the application of metal-organic frameworks (MOFs) in the removal of antibacterials from pharmaceutical wastewater, exploring adsorption behaviors and structure-performance relationships, and proposing strategies to enhance adsorption performance.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
James W. Southwell, Reyme Herman, Daniel J. Raines, Justin E. Clarke, Isabelle Boeswald, Thorsten Dreher, Sophie M. Gutenthaler, Nicole Schubert, Jana Seefeldt, Nils Metzler-Nolte, Gavin H. Thomas, Keith S. Wilson, Anne-Kathrin Duhme-Klair
Summary: This study investigates the use of siderophore-linked ruthenium catalysts for the activation of antibacterial prodrugs within cells. It demonstrates that moxifloxacin-based prodrugs can be activated under anaerobic, biologically relevant conditions with the help of these catalysts. Conjugates containing siderophore units based on catechol and azotochelin are found to be the most promising for intracellular prodrug activation.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Engineering, Biomedical
Yuyu Cui, Wei Zhang, Jie Shan, Jia He, Qiang Niu, Can Zhu, Wenqi Wang, Xu-Lin Chen, Xianwen Wang
Summary: Nanozyme technology has potential applications in wound treatment, and Cu ND/CG hydrogels offer a promising solution for controlling bacterial infection, reducing inflammation, and promoting vascular regeneration in acute and infected wounds.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Medicinal
Luka Posa, Petr Tomek, Saurabh Lamba, Vijayalekshmi Sarojini, David Barker
Summary: Octapeptin B5 peptides containing a novel fatty acid have been found to have enhanced antibacterial activity against Staphylococcus aureus and excellent safety profile in haemolytic and cytotoxicity assays.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Letter
Infectious Diseases
Jan Hendrik Grothe, Oliver A. Comely, Jon Salmanton-Garcia
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Infectious Diseases
Jannik Stemler, Jon Salmanton-Garcia, Ben Weise, Christina Toebben, Carolin Joisten, Julian Fleig, Oliver A. Cornely
Summary: A prevalence investigation using rapid antigen testing found a more than twofold higher prevalence of SARS-CoV-2 infection compared to governmental reports in Germany. Out of 419 valid test results, 7 (1.67%) were positive, and three positive individuals were not included in the governmental statistics as they did not have a PCR test.
Review
Infectious Diseases
Molly Murton, Emma Drane, James Jarrett, Oliver A. Cornely, Alex Soriano
Summary: This study conducted a systematic literature review to summarize economic evaluations, and cost and resource use evidence related to remdesivir during the COVID-19 pandemic. The results showed an increase in the prescription rate of remdesivir and a decrease in bed occupancy with its use. The cost estimates for remdesivir varied widely, and most economic evaluations considered it cost-effective.
Article
Dermatology
Maria Ilaria Del Principe, Danila Seidel, Marianna Criscuolo, Michelina Dargenio, Zdenek Racil, Monica Piedimonte, Francesco Marchesi, Gianpaolo Nadali, Philipp Koehler, Nicola Fracchiolla, Chiara Cattaneo, Nikolai Klimko, Angelica Spolzino, Deniz Yilmaz Karapinar, Hayati Demiraslan, Rafael F. Duarte, Judit Demeter, Marta Stanzani, Lorella Maria Antonia Melillo, Claudia Maria Basilico, Simone Cesaro, Giovangiacinto Paterno, Catello Califano, Mario Delia, Elisa Buzzatti, Alessandro Busca, Oliver A. Cornely, Livio Pagano, Nael Alakel, Valentina Arsi'c Arsenijevi'c, Vincent Camus, Iker Falces-Romero, Levy Itzhak, Michal Kouba, Rodrigo Martino, Petr Sedlacek, Barbora Weinbergerova
Summary: Our study aims to identify and provide therapeutic guidance for Magnusiomyces-associated infections, an emerging threat in patients with haematological malignancies. Neutrophil recovery appears to play a crucial role in the favorable outcome of these infections.
Article
Immunology
Joachim Doua, Jeroen Geurtsen, Jesus Rodriguez-Bano, Oliver A. Cornely, Oscar Go, Aina Gomila-Grange, Andrew Kirby, Peter Hermans, Andrea Gori, Valentina Zuccaro, Stefan Gravenstein, Marc Bonten, Jan Poolman, Michal Sarnecki
Summary: This multinational study describes the clinical profile of patients with invasive Escherichia coli disease (IED) in tertiary care hospitals. Most patients with IED were adults aged >= 60 years, and the urinary tract was the most common source of infection. Systemic inflammatory response syndrome (SIRS) was identified in 77.4% of patients, and the case-fatality rate was 20.0%. A proposed clinical case definition showed a 96.1% agreement with physician's diagnoses.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
L. Haensel, J. Schumacher, B. Denis, S. Hamane, O. A. Cornely, P. Koehler
Summary: The incidence of Pneumocystis jirovecii pneumonia (PCP) is increasing in patients without HIV infection. Unlike PCP in HIV-infected patients, diagnosis is often delayed in non-HIV-infected patients and is associated with higher mortality. This comprehensive review provides information on clinical presentation, risk factors, diagnostic strategies, and treatment options for PCP in non-HIV-infected patients.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Oncology
Nicola Giesen, Elena Busch, Enrico Schalk, Gernot Beutel, Maria M. Ruethrich, Marcus Hentrich, Bernd Hertenstein, Hans H. Hirsch, Meinolf Karthaus, Yascha Khodamoradi, Philipp Koehler, William Kruger, Michael Koldehoff, Robert Krause, Sibylle C. Mellinghoff, Olaf Penack, Michael Sandherr, Ruth SeggeWiss-Bernhardt, Karsten Spiekermanny, Rosanne Sprute, Jannik Stemler, Florian Weissinger, Bernhard Woermann, Hans-Heinrich Wolf, Oliver A. Cornely, Christina T. Rieger, Marie von Lilienfeld-Toal
Summary: The novel coronavirus SARS-CoV-2 and associated infectious disease COVID-19 present a significant challenge to healthcare systems worldwide, with cancer patients being identified as a high-risk population. The rapid development of vaccines and therapeutic agents against COVID-19 offers new options for improving care and protection of cancer patients. However, ongoing epidemiological changes and the emergence of new virus variants require constant revisions and adaptations of prophylaxis and treatment strategies to address these new challenges.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Infectious Diseases
Sofie Schumacher, Jon Salmanton-Garcia, Andrea Liekweg, Muriel Rolfes, Danila Seidel, Sibylle C. Mellinghoff, Oliver A. Cornely
Summary: This study investigates the impact of an intensified influenza vaccination campaign in a maximum-care hospital on influenza vaccination coverage in healthcare workers during the COVID-19 pandemic in 2020/21. The campaign, which involved a mobile vaccination team and a central vaccination site, led to a significant increase in vaccination coverage among healthcare workers, especially among nurses.
Article
Immunology
Alessandro Busca, Jon Salmanton-Garcia, Francesco Marchesi, Francesca Farina, Guldane Cengiz Seval, Jaap Van Doesum, Nick C. De Jonge, Nathan C. Bahr, Johan Maertens, Joseph S. Meletiadis, Nicola S. Fracchiolla, Barbora Weinbergerova, Luisa Verga, Zdenek Racil, Moraima Jimenez, Andreas Glenthoj, Ola Blennow, Alina Daniela Tanase, Martin Schoenlein, Lucia Prezioso, Nina F. Khanna, Rafael F. Duarte, Pavel Zak, Marcio Nucci, Marina Machado, Austin Kulasekararaj, Ildefonso Espigado, Elizabeth De Kort, Jose-Maria Ribera-Santa Susana, Monia Marchetti, Gabriele Magliano, Iker Falces-Romero, Osman Ilhan, Emanuele Ammatuna, Sofia Zompi, Panagiotis Tsirigotis, Anastasia Antoniadou, Giovanni Paolo Maria Zambrotta, Anna Nordlander, Linda Katharina Karlsson, Michaela Hanakova, Giulia Dragonetti, Alba Cabirta, Caroline Berg Venemyr, Stefanie Graefe, Jens Van Praet, Athanasios Tragiannidis, Verena Petzer, Alberto Lopez-Garcia, Federico Itri, Ana Groh, Eleni Gavriilaki, Michelina Dargenio, Laman A. Rahimli, Oliver A. Cornely, Livio Pagano
Summary: This multicenter retrospective study analyzed the outcome and risk factors for mortality in 326 adult HSCT patients who developed COVID-19. The results showed that age, comorbidities, active hematologic disease, timing from transplant, and severity of the infection were associated with a higher risk of mortality. The overall mortality rate was 21%, with COVID-19 being the main or secondary cause of death in 16% of the patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Jannik Stemler, Christina Toebben, Cornelia Lass-Floerl, Joerg Steinmann, Katharina Ackermann, Peter-Michael Rath, Michaela Simon, Oliver Andreas Cornely, Philipp Koehler
Summary: The review provides an overview of the management of invasive aspergillosis caused by non-fumigatus Aspergillus species. It discusses diagnostic and therapeutic differences and similarities compared to A. fumigatus for species such as A. flavus, A. terreus, A. niger, and A. nidulans. These species exhibit varying resistance to antifungal drugs and have different clinical manifestations.
Article
Infectious Diseases
Julia Jeck, Florian Jakobs, Melina S. Kurte, Oliver A. Cornely, Florian Kron
Summary: This study conducts a cost-of-illness analysis of Candida infections, finding that the treatment of candidiasis is costly and reducing ICU length of stay can lead to significant cost savings.
JAC-ANTIMICROBIAL RESISTANCE
(2023)
Article
Infectious Diseases
Oliver A. Cornely, Helmut Ostermann, Philipp Koehler, Daniel Teschner, Endrik Limburg, William G. Kramer, Sara H. Barbat, Margaret Tawadrous, Michael R. Hodges
Summary: This study evaluated the tolerability, safety, and pharmacokinetics of Fosmanogepix in AML patients. The results showed that Fosmanogepix was safe and well tolerated in patients undergoing chemotherapy, and its safety and pharmacokinetic profiles were comparable to healthy volunteers.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Public, Environmental & Occupational Health
Sibylle C. Mellinghoff, Caroline Bruns, Markus Albertsmeier, Juliane Ankert, Louis Bernard, Sofia Budin, Camille Bataille, Annika Y. Classen, Florian B. Cornely, Elodie Couve-Deacon, Maria Fernandez Ferrer, Jesus Fortun, Alicia Galar, Eva Grill, Thomas Guimard, Juergen A. Hampl, Sebastian Wingen-Heimann, Juan P. Horcajada, Felix Koehler, Carolin Koll, Joan Mollar, Patricia Munoz, Mathias W. Pletz, Jule Rutz, Jon Salmanton-Garcia, Harald Seifert, Ferdinand Serracino-Inglott, Alex Soriano, Jannik Stemler, Janne J. Vehreschild, Tim O. Vilz, Jan-Hendrik Naendrup, Oliver A. Cornely, Blasius J. Liss
Summary: This study retrospectively investigated the incidence and risk factors of S. aureus SSI in various surgical disciplines in Europe, and found a low infection rate. The study provides a method for utilizing big data in epidemiological research.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Health Care Sciences & Services
Sibylle Mellinghoff, Gero von Gersdorff, Caroline Bruns, Kerstin Albus, Vassiliki Dimitriou, Angela Steinbach, Mathias Schaller, Jorg Janne Vehreschild, Oliver A. Cornely, Blasius Janusch Liss
Summary: This study aims to compare the pneumonia rates between recently vaccinated patients and patients vaccinated more than 2 years ago, and to determine the dynamics of antipneumococcal antibody titers in hemodialysis patients. The results will increase physician adherence to current recommendations and provide evidence for future guidelines.
JMIR RESEARCH PROTOCOLS
(2023)
Editorial Material
Health Care Sciences & Services
Rosanne Sprute, Seraina Duda, Andrea Liekweg, Michaela Simon, Oliver A. Cornely
LANCET REGIONAL HEALTH-EUROPE
(2023)