期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 68, 期 -, 页码 ii25-ii35出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkt142
关键词
broad-spectrum antibacterial therapy; generalized peritonitis; non-interventional studies; glycylcycline antibiotics
资金
- Pfizer [NCT00488488, NCT00799591, NCT00827541]
- Pfizer International Operations
Tigecycline is a broad-spectrum antibiotic approved for the treatment of complicated intra-abdominal infections (cIAIs). The efficacy of tigecycline when administered as monotherapy or in combination with other antibacterials in the treatment of cIAIs in routine clinical practice is described. Individual patient-level data were pooled from five European observational studies (July 2006 to October 2011). A total of 785 cIAI patients who received tigecycline were included (mean age 63.114.0 years). Of these, 56.6 were in intensive care units, 65.6 acquired their infection in hospital, 88.1 had at least one comorbidity and 65.7 had secondary peritonitis. The mean Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores at the beginning of treatment were 16.97.6 (n614) and 7.04.2 (n108), respectively, indicating high disease severity. Escherichia coli (41.8), Enterococcus faecium (40.1) and Enterococcus faecalis (21.1) were the most frequently isolated pathogens; 49.1 of infections were polymicrobial and 17.5 were due to resistant pathogens. Overall, 54.8 (n430) received tigecycline as monotherapy and 45.2 (n355) as combination therapy for a mean duration of 10.6 days. Clinical response rates at the end of treatment were 77.4 for all patients (567/733), 80.6 for patients who received tigecycline as monotherapy (329/408), 75.2 for patients with a nosocomial infection (354/471), 75.8 for patients with an APACHE II score 15 (250/330) and 54.2 (32/59) for patients with a SOFA score 7. In these real-life studies, tigecycline, alone and in combination, achieved favourable clinical response rates in patients with cIAI with a high severity of illness.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据