Review
Food Science & Technology
Inmaculada Ramirez-Macias, Esteban Orenes-Pinero, Anny Camelo-Castillo, Jose Miguel Rivera-Caravaca, Cecilia Lopez-Garcia, Francisco Marin
Summary: This review analyzes the impact of changes in gut microbiota and their metabolites on coronary artery diseases. The bacterial composition in the intestinal microbiota is altered in patients with coronary artery disease, with a decrease in Bacteroidetes and an increase in Firmicutes. Trimethylamine-N-oxide plays a crucial role in atherosclerosis and may act as a predictor of cardiovascular risk. Additionally, alternative treatments such as probiotics, prebiotics, diet modulation, and fecal transplantation are discussed. The influence of lipid-lowering treatments on the gut microbiota and its association with resistance or sensitivity to these treatments is also analyzed.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Medicine, General & Internal
Anny Camelo-Castillo, Jose Miguel Rivera-Caravaca, Esteban Orenes-Pinero, Inmaculada Ramirez-Macias, Vanessa Roldan, Gregory Y. H. Lip, Francisco Marin
Summary: The efficacy and safety of vitamin K antagonists (VKAs) as oral anticoagulants (OACs) depend on the quality of anticoagulation control, which may be influenced by gut microbiota through various mechanisms. Future research could potentially lead to the use of bacterial signatures or microbial metabolites as biomarkers to predict anticoagulation quality and the development of intervention strategies involving modulating gut microbiota.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
Maria Martinez-Villar, Antonio Tello-Montoliu, Agustin Olea, Angel Pujante, Daniel Saura, Silvia Martin, Nereo Venero, Ana Carneiro-Mosquera, Nuria Ruiz de Pascual, Noelia Valero, Miguel Martinez-Herrera, Inmaculada Ramirez-Macias, Juan Antonio Vilchez, Miguel Garcia Navarro, Gonzalo de la Morena, Domingo Pascual
Summary: This study aimed to investigate the relationship between ventricular global longitudinal strain (GLS) and ultrasound lung comets (ULC) formation in military divers. The results showed an increase in pulmonary vasoconstriction markers after diving, but no ventricular contractile dysfunction was observed.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matilde Ortiz-Gonzalez, Ignacio Perez-Victoria, Inmaculada Ramirez-Macias, Nuria de Pedro, Angel Linde-Rodriguez, Victor Gonzalez-Menendez, Victoria Sanchez-Martin, Jesus Martin, Ana Soriano-Lerma, Olga Genilloud, Virginia Perez-Carrasco, Francisca Vicente, Jose Maceira, Carlos A. Rodrigues-Poveda, Jose Maria Navarro-Mari, Fernando Reyes, Miguel Soriano, Jose A. Garcia-Salcedo
Summary: Sleeping sickness is a serious health concern in sub-Saharan Africa and there is currently no vaccine available. Researchers have discovered a new compound, curvicollide D, that shows strong inhibitory effects on Trypanosoma brucei and can induce cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Javier Martin-Escolano, Clotilde Marin, Maria J. Rosales, Anastasios D. Tsaousis, Encarnacion Medina-Carmona, Ruben Martin-Escolano
Summary: This Review provides a comprehensive update on our understanding of Chagas disease, including the current life cycle, new morphological forms, and genetic diversity of the parasite, as well as identifying intervention points in the life cycle where new drugs and treatments could achieve a parasitic cure.
ACS INFECTIOUS DISEASES
(2022)
Article
Oncology
Victoria Sanchez-Martin, Maria del Carmen Plaza-Calonge, Ana Soriano-Lerma, Matilde Ortiz-Gonzalez, Angel Linde-Rodriguez, Virginia Perez-Carrasco, Inmaculada Ramirez-Macias, Marta Cuadros, Jose Gutierrez-Fernandez, Javier Murciano-Calles, Juan Carlos Rodriguez-Manzaneque, Miguel Soriano, Jose Antonio Garcia-Salcedo
Summary: Gallic acid, as a natural phenolic compound, interacts with DNA G-quadruplexes, particularly targeting G-quadruplexes in ribosomal DNA and CMYC oncogene, leading to antitumoral effects in colorectal cancer.
Article
Parasitology
Ruben Martin-Escolano, Gregorio Perez-Cordon, Vicente J. Aran, Clotilde Marin, Manuel Sanchez-Moreno, Maria Jose Rosales
Summary: This study evaluated the activity of 10 5-nitroindazole derivatives against Acanthamoeba. The results showed the effectiveness of these compounds against both trophozoites and cysts, with derivative 8 showing the highest activity on cysts. These 5-nitroindazole derivatives may be a promising alternative for more efficient treatments against A. castellani infection.
Article
Architecture
Manuel De-Miguel-Sanchez, Carlos Gonzalez Duque, Pilar Chias Navarro, Tomas Abad Balboa
Summary: This study focuses on the layout and proportions of the assembly hall at Universidad de Alcala in the 16th century, and identifies it as a Renaissance theater inspired by Roman models. The hexagonal pattern of the coffered ceiling represents a unique formal exploration. This uncommon masterpiece can be seen as a proposal for the recovery of classical intellect and architecture.
NEXUS NETWORK JOURNAL
(2023)
Article
Parasitology
Ruben Martin-Escolano, Maria Jose Rosales, Clotilde Marin
Summary: The T. cruzi Arequipa strain is characterized and evaluated as a model for drug discovery in Chagas disease. The study provides insights into the infection characteristics and benznidazole susceptibility of this strain, suggesting its potential for screening new compounds with anti-parasitic properties.
Article
Cell Biology
Paul T. Manna, Lael D. Barlow, Inmaculada Ramirez-Macias, Emily K. Herman, Joel B. Dacks
Summary: This study used a transcriptomics-based approach to identify gene products associated with contractile vacuoles (CVs) in Dictyostelium discoideum. The approach was validated by confirming the upregulation of known CV-associated gene products and finding enrichment of endosomal and vacuolar gene products. An upregulated SNARE protein (NPSNB) was found to be associated with CVs, suggesting its role in CV function. These findings provide important insights into the deep evolution of eukaryotic organelles.
JOURNAL OF CELL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ruben Martin-Escolano, Daniel Molina-Carreno, Javier Martin-Escolano, M. Paz Clares, Cristina Galiana-Rosello, Jorge Gonzalez-Garcia, Nuria Cirauqui, Jose M. Llinares, Maria Jose Rosales, Enrique Garcia-Espana, Clotilde Marin
Summary: Chagas disease, caused by Trypanosoma cruzi, is a potentially fatal infection that was previously limited to Latin America but has now become widespread globally. This study identified new effective agents against T. cruzi and evaluated their efficacy in vivo. Compound 15 was identified as a potential candidate for the development of new therapies for Chagas disease.
Review
Green & Sustainable Science & Technology
Michelangelo Scorpio, Davide Carleo, Martina Gargiulo, Pilar Chias Navarro, Yorgos Spanodimitriou, Parinaz Sabet, Massimiliano Masullo, Giovanni Ciampi
Summary: This paper investigates the role of subjective assessments in lighting research using immersive virtual reality. The findings reveal the usefulness of immersive virtual reality as a tool for lighting research and design, while also identifying the limitations that need to be addressed.
Article
Pharmacology & Pharmacy
Alvaro Martin-Montes, Alvaro Martinez-Camarena, Alberto Lopera, Irene Bonastre-Sabater, M. Paz Clares, Begona Verdejo, Enrique Garcia-Espana, Clotilde Marin
Summary: In order to find effective and side effect-free treatments for all clinical forms of Leishmaniasis, a series of synthetic azamacrocycles were tested against three Leishmania species. Some of the compounds showed leishmanicidal activity and reduced parasite infectivity and dividing ability. Mechanism studies suggested that these compounds altered parasite metabolic pathways and inhibited parasitic Fe-SOD activity.
Article
Chemistry, Medicinal
Livio Racane, Lucija Pticek, Sanja Kostrun, Silvana Raic-Malic, Martin Craig Taylor, Michael Delves, Sam Alsford, Francisco Olmo, Amanda Fortes Francisco, John M. Kelly
Summary: We designed and synthesized a series of symmetric benzothiazole derivatives and evaluated their efficacy against Trypanosoma brucei and Plasmodium falciparum. One compound showed high selectivity and trypanocidal activity, curing mice infected with trypanosomiasis. It also exhibited activity against the malaria parasite.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Proceedings Paper
Architecture
Pilar Chias, Tomas Abad, Lucas Fernandez-Trapa
Summary: This study examines the lighting and ventilation techniques of Mannerist architecture through a detailed analysis of the kitchen area in the Monastery of El Escorial. Utilizing a mixed methodology and a 3D model, the research demonstrates the impact of sunlight from the lantern and the double facade.
ARCHITECTURAL GRAPHICS: GRAPHICS FOR KNOWLEDGE AND PRODUCTION, VOL 2
(2022)