Article
Medicine, Research & Experimental
Thanh Phuong Pham Nguyen, Colleen M. Brensinger, Warren B. Bilker, Sean Hennessy, Charles E. Leonard
Summary: The study aimed to confirm or refute previous DDI signals, indicating a potential association between clopidogrel and eszopiclone or zolpidem with serious bleeding. However, due to statistical imprecision, a clear conclusion could not be drawn. Further examination is needed for the associations of other hypnotics with serious bleeding.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Microbiology
Jeremy Ardanuy, Robert Johnson, Carly Dillen, Louis Taylor, Holly Hammond, Stuart Weston, Matthew Frieman
Summary: Pyronaridine triphosphate has demonstrated efficacy in inhibiting SARS-CoV-2 infection and reducing lung inflammation in both cellular and animal models. It can be combined with current COVID-19 treatments to further inhibit viral infections. Pyronaridine represents a promising therapeutic option for COVID-19 and future coronavirus outbreaks.
Article
Pharmacology & Pharmacy
Kaleen N. N. Hayes, Tara Gomes, Mina Tadrous
Summary: Traditional methods to standardize exposures in pharmacoepidemiologic studies may be insufficient for capturing drug class effects, especially when dealing with multiple medications, formulations, and administration routes. This study introduced a dose conversion method using an example study on antipsychotic use among older adults with dementia, demonstrating its feasibility for quantifying and presenting drug exposures in complex medication classes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ronaldo Jose Faria, Francisca Janiclecia Rezende Cordeiro, Jessica Barreto Ribeiro dos Santos, Juliana Alvares-Teodoro, Augusto Afonso Guerra Junior, Francisco de Assis Acurcio, Michael Ruberson Ribeiro da Silva
Summary: This study compared the use of conventional synthetic disease-modifying antirheumatic drugs in the treatment of psoriatic arthritis. The results showed that methotrexate was the most frequently used drug, with lower cost and slightly lower persistence, making it the drug with the best cost per response ratio.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Rogerio Hoefler, Gustavo Magno Baldin Tiguman, Tais Freire Galvao, Ines Ribeiro-Vaz, Marcus Tolentino Silva
Summary: This study investigated the trends in antidepressant sales in Brazil from 2014 to 2020. The results showed a significant increase in antidepressant sales, mainly driven by higher prescriptions of serotonin reuptake inhibitors and other antidepressant classes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Microbiology
Edward C. Holmes, Aeron C. Hurt, Zuzana Dobbie, Barry Clinch, John S. Oxford, Pedro A. Piedra
Summary: Influenza poses a significant burden on society and healthcare systems. Antiviral resistance can lead to uncertainty among prescribers and policy makers. Antiviral treatment generally provides clinical benefit and resistant viruses are usually associated with reduced fitness.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Microbiology
Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Sarah K. Stevens, Chloe De Vita, Bert Vanmechelen, Piet Maes, Bettina Trueb, Nadine Ebert, Volker Thiel, Steven De Jonghe, Laura Vangeel, Dorothee Bardiot, Andreas Jekle, Lawrence M. Blatt, Leonid Beigelman, Julian A. Symons, Pierre Raboisson, Patrick Chaltin, Arnaud Marchand, Johan Neyts, Jerome Deval, Koen Vandyck
Summary: Paxlovid is the first oral antiviral approved for the treatment of SARS-CoV-2 infection. Research has identified mutations in the 3CLpro protease that may lead to resistance against Paxlovid. These findings are important for guiding the use of novel antiviral drugs.
Article
Infectious Diseases
Luis Fernando Valladales-Restrepo, Juan Alberto Ospina-Cano, Brayan Stiven Aristizabal-Carmona, Diana Fiorella Lopez-Caicedo, Melissa Toro-Londono, Andres Gaviria-Mendoza, Manuel Enrique Machado-Duque, Jorge Enrique Machado-Alba
Summary: The inappropriate use of antifungals in Colombia is associated with greater antimicrobial resistance, costs, adverse events, and worse clinical outcomes. A study found that over a quarter of patients in Colombia use antifungals in unapproved indications, and there is widespread inappropriate use of ketoconazole.
Article
Multidisciplinary Sciences
Raquel Boff da Costa, Marisa Boff Costa, Larisse Longo, Daniela Elisa Miotto, Gustavo Hirata Dellavia, Matheus Trucollo Michalczuk, Mario Reis Alvares-da-Silva
Summary: The study revealed that comorbidities, comedications, and drug-drug interactions are common in patients with hepatitis C, even when using second-generation drugs, indicating a significant risk.
Review
Infectious Diseases
Sandra Abdul Massih, Ahizechukwu C. Eke
Summary: Direct-Acting Antiviral Agents (DAAs) have the potential to be an effective and safe treatment option for women with hepatitis C. However, limited pharmacokinetic and safety data currently prevents their use during pregnancy. Available studies have shown no significant changes in pharmacokinetics and no major safety concerns in women with hepatitis C, suggesting that DAAs could become a preferred option for treating HCV during pregnancy and eliminating perinatal transmission.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Immunology
Robin K. Avery, Sophie Alain, Barbara D. Alexander, Emily A. Blumberg, Roy F. Chemaly, Catherine Cordonnier, Rafael F. Duarte, Diana F. Florescu, Nassim Kamar, Deepali Kumar, Johan Maertens, Francisco M. Marty, Genovefa A. Papanicolaou, Fernanda P. Silveira, Oliver Witzke, Jingyang Wu, Aimee K. Sundberg, Martha Fournier
Summary: In this randomized comparative study, Maribavir was found to be more effective than investigator-assigned treatment for refractory cytomegalovirus infections. Maribavir also had fewer adverse effects in terms of nephrotoxicity, myelotoxicity, and treatment discontinuations.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Endocrinology & Metabolism
Anton Pottegard, Lars Christian Lund, Daniel Pilsgaard Henriksen, Lars Folkestad, Maja Hellfritzsch, Jesper Hallas, Kasper Bruun Kristensen
Summary: The study did not find an increased risk of splanchnic vein thrombosis associated with the use of DPP-4 inhibitors based on a population-based new-user cohort study.
DIABETES OBESITY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Joseph E. Blais, Yue Wei, Kevin K. W. Yap, Hassan Alwafi, Tian-Tian Ma, Ruth Brauer, Wallis C. Y. Lau, Kenneth K. C. Man, Chung Wah Siu, Kathryn C. B. Tan, Ian C. K. Wong, Li Wei, Esther W. Chan
Summary: From 2008 to 2018, global consumption of Lipid-modifying agents, particularly statins, has increased. While the relationship between LMA consumption and cholesterol concentrations remains unclear, the trends in LMA use globally align with international lipid guidelines and show an increase in consumption of low-density lipoprotein lowering therapies. Country-level patterns of LMA use and total and non-HDL cholesterol varied considerably.
Article
Biochemistry & Molecular Biology
Jameel M. Abduljalil, Abdo A. Elfiky, El-Sayed T. A. Sayed, Maha M. AlKhazindar
Summary: This study predicted the structure of the L protein of Nipah virus and identified potential inhibitors for the RNA-dependent RNA polymerase. Norov-29 showed the highest binding affinity and purine nucleotide analogs were found to be a potential scaffold for effective antiviral drugs against Nipah virus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Letter
Medicine, General & Internal
Masaki Imai, Mutsumi Ito, Maki Kiso, Seiya Yamayoshi, Ryuta Uraki, Shuetsu Fukushi, Shinji Watanabe, Tadaki Suzuki, Ken Maeda, Yuko Sakai-Tagawa, Kiyoko Iwatsuki-Horimoto, Peter J. Halfmann, Yoshihiro Kawaoka
Summary: The antiviral agents bebtelovimab and mAb combinations tested in the study did not neutralize the SARS-CoV-2 omicron subvariants BQ.1.1 and XBB, while remdesivir, molnupiravir, and nirmatrelvir demonstrated efficacy against both subvariants in vitro.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Rheumatology
Leonid Dvoretsky, Anna Torgashina, Svetlana Rachina, Nelli Dubrovskaya, Girindu Hewathanthirige
Summary: This case report describes a 45-year-old male patient with Adult Still's Disease and pulmonary involvement. The patient presented with continuous fever, failure to respond to antibiotics, skin rashes, musculoskeletal syndrome, and pharyngitis. Lung examination revealed bronchopulmonary lymphadenopathy, interstitial changes, and dense foci, while laboratory tests showed neutrophilic leukocytosis, elevated ALT, AST, and inflammatory markers. Treatment with methylprednisolone and methotrexate led to the complete regression of symptoms and normalization of laboratory tests, as well as partial regression of the lung findings on CT scan.
CURRENT RHEUMATOLOGY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Katoo M. M. Muylle, Sven van Laere, Luigi Pannone, Samuel Coenen, Carlo de Asmundis, Alain G. G. Dupont, Pieter Cornu
Summary: By developing and validating a risk prediction model considering patient- and drug-related factors, the QT-DDI alerting was significantly improved, leading to more appropriate stratification with increased accuracy and precision.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Economics
Xiao Li, Joke Bilcke, Alike W. van der Velden, Robin Bruyndonckx, Samuel Coenen, Emily Bongard, Muirrean de Paor, Slawomir Chlabicz, Maciek Godycki-Cwirko, Nick Francis, Rune Aabenhus, Heiner C. Bucher, Annelies Colliers, An De Sutter, Ana Garcia-Sangenis, Dominik Glinz, Nicolay J. Harbin, Katarzyna Kosiek, Morten Lindbaek, Christos Lionis, Carl Llor, Reka Miko-Pauer, Ruta Radzeviciene Jurgute, Bohumil Seifert, Par-Daniel Sundvall, Pia Touboul Lundgren, Nikolaos Tsakountakis, Theo J. Verheij, Herman Goossens, Christopher C. Butler, Philippe Beutels
Summary: This study aimed to evaluate the cost-effectiveness of adding oseltamivir to primary care in Europe for treating influenza-like illness (ILI) in adults/adolescents and children. The results showed that adding oseltamivir to primary care is likely to be cost-effective from the healthcare payers' perspective, and cost-saving from a societal perspective in adults/adolescents.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Review
Oncology
Stephanie Jordaens, Karen Zwaenepoel, Wiebren Tjalma, Christophe Deben, Koen Beyers, Vanessa Vankerckhoven, Patrick Pauwels, Alex Vorsters
Summary: This review aimed to explore the use of urine sampling as a liquid biopsy for noninvasive cancer research. The analysis found that many publications did not report the preanalytical parameters of urine samples, despite the importance of standardization. Urine is being used for various cancer types and contains different analytes. Standard practice protocols and further research are needed to enhance the clinical utility of urine in cancer research and detection.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Harald Christian Langaas, Oyvind Salvesen, Roar Dyrkorn, Hege Salvesen Blix, Olav Spigset
Summary: An academic detailing intervention was found to increase the utilization of metformin and improve the prescription patterns of other type 2 diabetes medications. However, for a complex subject like type 2 diabetes, more time should be reserved for the visit.
SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE
(2023)
Article
Medicine, General & Internal
Julie Domen, Jan Yvan Jos Verbakel, Niels Adriaenssens, Beatrice Scholtes, Bart Peeters, Robin Bruyndonckx, An De Sutter, Stefan Heytens, Ann van den Bruel, Isabelle Desombere, Pierre Van Damme, Herman Goossens, Laetitia Buret, Els Duysburgh, Samuel Coenen
Summary: A study validated a rapid serological test for SARS-CoV-2 antibodies in healthcare providers in Belgium. The results showed that the test underestimated or overestimated the true seroprevalence in the population.
Review
Medicine, General & Internal
Svetlana Rachina, Yuliya Belkova, Anastasia Shchendrygina, Aleksandr Suvorov, Denis Bourgeois, Marina Karuk, Violetta Sitnikova, Nikita Dyatlov
Summary: This systematic review and meta-analysis aimed to evaluate the efficacy and safety of prophylactic, intermediate, and therapeutic dose anticoagulation in critically ill COVID-19 patients admitted to the ICU. The analysis showed that the different dosing regimens had no significant impact on short-term mortality and venous thromboembolism incidence, but had an effect on pulmonary embolism occurrence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Akke Vellinga, Addiena Luke-Currier, Nathaly Garzon-Orjuela, Rune Aabenhus, Marilena Anastasaki, Anca Balan, Femke Boehmer, Valerija Bralic Lang, Slawomir Chlabicz, Samuel Coenen, Ana Garcia-Sangenis, Anna Kowalczyk, Lile Malania, Angela Tomacinschii, Sanne R. van der Linde, Emily Bongard, Christopher C. Butler, Herman Goossens, Alike W. van der Velden
Summary: This study examined the antibiotic prescribing for respiratory tract infections in general practices across European countries. The findings showed that some countries did not meet the appropriate prescribing standards for certain types of infections, and the antibiotic usage rates differed among countries, with Denmark and Spain having lower rates compared to others.
Article
Health Care Sciences & Services
Paul Little, Nick A. Francis, Beth Stuart, Gilly O'Reilly, Natalie Thompson, Taeko Becque, Alastair Hay, Kay Wang, Michael Sharland, Anthony Harnden, Guiqing Yao, James Raftery, Shihua Zhu, Joseph Little, Charlotte Hookham, Kate Rowley, Joanne Euden, Kim Harman, Samuel Coenen, Robert C. Read, Catherine Woods, Christopher C. Butler, Saul N. Faust, Geraldine Leydon, Mandy Wan, Kerenza Hood, Jane Whitehurst, Samantha Richards-Hall, Peter Smith, Michael Thomas, Michael Moore, Theo Verheij
Summary: This study aims to evaluate the clinical effectiveness and cost-effectiveness of amoxicillin for uncomplicated lower respiratory tract infections in children. The results show that amoxicillin has no significant impact on clinical symptoms and resource utilization. It is suggested that parents and clinicians need better access to information and communication.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Infectious Diseases
Helene Vermeulen, Niel Hens, Lucy Catteau, Boudewijn Catry, Samuel Coenen
Summary: A significant decrease in community antibiotic consumption in Europe was observed during the COVID-19 pandemic, with a decrease in seasonal variation as well.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
K. P. Haralampova, N. A. Cherkasova, S. A. Rachina, S. M. Nasruloeva
Summary: This article examines international and European registries of infectious endocarditis and the observational studies based on them. It analyzes the methods of data collection, results, and conclusions. The prospects of using the registries for research, improving healthcare quality, and estimating costs are discussed.
Article
Immunology
Bruno Salaun, Jonathan De Smedt, Charlotte Vernhes, Annick Moureau, Deniz Oner, Arangassery Rosemary Bastian, Michel Janssens, Sunita Balla-Jhagjhoorsingh, Jeroen Aerssens, Christophe Lambert, Samuel Coenen, Christopher C. Butler, Simon B. Drysdale, Joanne G. Wildenbeest, Andrew J. Pollard, Peter J. M. Openshaw, Louis Bont, RESCEU Investigators
Summary: Cellular immunity plays a primary role in preventing symptomatic RSV infections in older adults, according to a study. T-cell data were found to be more predictive of RSV infection than functional antibody data.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Nurgul Ablakimova, Gaziza A. Smagulova, Svetlana Rachina, Aigul Z. Mussina, Afshin Zare, Nadiar M. Mussin, Asset A. Kaliyev, Reza Shirazi, Nader Tanideh, Amin Tamadon
Summary: This study conducts a bibliometric analysis of research on antimicrobial resistance (AMR) among pneumonia pathogens from 2013 to 2023. The findings reveal an increase in research output and emphasize the importance of collaborative studies. The analysis also identifies key journals, leading countries and institutions, as well as common microorganisms. It underscores the significance of knowledge dissemination and evidence-based interventions in addressing this public health challenge.
Article
Infectious Diseases
Nurgul Ablakimova, Aigul Z. Mussina, Gaziza A. Smagulova, Svetlana Rachina, Meirambek S. Kurmangazin, Aigerim Balapasheva, Dinara Karimoldayeva, Afshin Zare, Mahdi Mahdipour, Farhad Rahmanifar
Summary: This cross-sectional study examined the microbial landscape and antibiotic resistance patterns in patients with bacterial pneumonia, specifically investigating the impact of COVID-19. Sputum samples from individuals with bacterial pneumonia, including COVID-19 positive and negative patients, were analyzed. The study found a low isolation rate of Streptococcus pneumoniae, a classic cause of bacterial pneumonia, in the sputum samples, and a higher frequency of multidrug-resistant pathogens in non-COVID-19 patients, suggesting the potential influence of the pandemic on antimicrobial resistance.
Article
Infectious Diseases
Alieke van der Hoeven, Martha T. van der Beek, Vincent Bekker, Erin Meijers, Marco J. R. Ivens, Els Wessels, Aloysius C. M. Kroes, Stefan A. Boers
Summary: Bacterial meningitis in infants is a life-threatening condition, and conventional bacterial culture may not always detect the causative microorganisms. The addition of 16S rRNA sequencing greatly improves the identification of bacterial meningitis.
INFECTIOUS DISEASES AND THERAPY
(2023)
