Review
Infectious Diseases
Shantelle Claassen-Weitz, Katherine Y. L. Lim, Christopher Mullally, Heather J. Zar, Mark P. Nicol
Summary: The study found an association between upper respiratory tract bacteria and lower respiratory tract infection in young children, with H. influenzae and Klebsiella spp. showing higher detection rates in cases. Further longitudinal studies are needed to better understand the pathogenesis of childhood lower respiratory tract infections.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Microbiology
Jasna Rodman Berlot, Uros Krivec, Tatjana Mrvic, Rok Kogoj, Darja Kese
Summary: This study found that in children, infection with Mycoplasma pneumoniae P1-2 genotype may lead to more severe lower respiratory tract infections. Children infected with P1-2 had higher baseline C-reactive protein levels and were more likely to be hospitalized compared to P1-1 infected children. The P1 genotype could potentially be used as a predictor for the severity of Mycoplasma pneumoniae lower respiratory tract infections.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Rodrigo C. Menezes, Isabella B. B. Ferreira, Luciana Sobral, Stefania L. Garcia, Hugo N. Pustilnik, Mariana Araujo-Pereira, Bruno B. Andrade
Summary: This study aimed to identify the clinical features associated with viral pathogens responsible for severe lower respiratory tract infections (LRTI) in children. The study found that different viral agents have distinct associations with clinical features in children.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2024)
Article
Oncology
Yun Zhang, Haonan Ning, Wenyu Zheng, Jing Liu, Fuhai Li, Junfei Chen
Summary: In children with hematological malignancies and lower respiratory tract infections, the lung microbiome shows decreased diversity and increased pathogenic function, antimicrobial resistance, and unfavorable environment tolerance. Alpha diversity, beta diversity, and Proteobacteria may serve as negative predictors for hospitalization course while Firmicutes may act as a positive predictor.
FRONTIERS IN ONCOLOGY
(2022)
Article
Microbiology
Malini Shariff, Elizabeth Ramengmawi
Summary: This study aimed to investigate anaerobes causing respiratory tract infections and their antibiotic susceptibility. The results showed variable resistance of many anaerobic bacteria to most classes of antibiotics.
Article
Biophysics
Claas Strodthoff, Toni Kahkonen, Richard H. Bayford, Tobias Becher, Inez Frerichs, Merja Kallio
Summary: This study aimed to investigate the bronchodilator effect on respiratory mechanics during intensive care using electrical impedance tomography (EIT) and assess the feasibility of EIT in this context. The results showed that continuous monitoring with EIT could help optimize the treatment of lower respiratory tract infections in pediatric intensive care units. EIT-based regional expiratory time constants could provide an objective assessment of the effects of bronchodilators and other respiratory therapies.
PHYSIOLOGICAL MEASUREMENT
(2022)
Article
Nutrition & Dietetics
Yuting Chen, Jiran Shen, Ye Wu, Man Ni, Yujie Deng, Xiaoya Sun, Xinqi Wang, Tao Zhang, Faming Pan, Zhiru Tang
Summary: A two-sample Mendelian randomization analysis found that genetically predicted an extra daily cup of tea intake was causally associated with a decreased risk of bronchiectasis, pneumonia, and influenza and pneumonia.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Virology
Fiseha Wadilo, Adey Feleke, Meseret Gebre, Wude Mihret, Tamrayehu Seyoum, Kalkidan Melaku, Rawliegh Howe, Andargachew Mulu, Adane Mihret
Summary: This study aimed to determine and estimate the etiological contribution of respiratory viruses to lower respiratory tract infections (LRTIs) in children under 5 years in Ethiopia. The results showed that RSV, Influenza A, and PIV 1 viruses were significantly associated with LRTIs in this population. Therefore, the importance of developing prevention strategies and effective vaccines against these viruses in Ethiopia is emphasized.
Article
Respiratory System
Jaana Keto, Thijs Feuth, Miika Linna, Tarja Saaresranta
Summary: Sleep apnea is associated with an increased risk of lower respiratory tract infections within one year before and after diagnosis. Chronic comorbidities have a significant impact on the risk and recurrence of lower respiratory tract infections in sleep apnea patients.
BMC PULMONARY MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Lingling Hong, Yuqing Chen, Ling Ye
Summary: This study utilized bioinformatics analysis to investigate the impact of community-acquired pneumonia (CAP) on lung microbiota diversity, identifying potential biomarkers for respiratory tract diseases. Klebsiella pneumoniae and Bacillus cereus were found to be associated with increased severity of LRTI, suggesting their potential as diagnostic biomarkers. These findings offer insights for understanding and treating lung microbiota in LRTI patients with a history of pneumonia.
Article
Virology
Fu-Lu Chu, Chen Li, Li Chen, Bo Dong, Yang Qiu, Yiqing Liu
Summary: This study investigated the prevalence of viruses and risk factors associated with pediatric intensive care unit (PICU) admission among patients hospitalized for acute lower respiratory tract infections (ALRI). The results showed that human rhinovirus (HRV) had the highest detection rate, the viral infection rate was highest in winter, and respiratory syncytial virus (RSV) infection and comorbidities were associated with the need for PICU admission.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Pablo J. Bertrand, Yaneisi Vazquez, Andrea A. Beckhaus, Liliana A. Gonzalez, Ana Maria Contreras, Marcela Ferres, Oslando Padilla, Claudia A. Riedel, Alexis M. Kalergis, Susan M. Bueno
Summary: The study suggests that IL-8 and IL-33 are significantly increased in lower respiratory tract infections caused by RSV and could be potential biomarkers for clinical severity in children with LRTIs.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Environmental Sciences
Adekunle G. Fakunle, Nkosana Jafta, Alex Bossers, Inge M. Wouters, Warner van Kersen, Rajen N. Naidoo, Lidwien A. M. Smit
Summary: In Ibadan, Nigeria, a study found that the microbial composition in residential environments is associated with lower respiratory tract infections (LRTI) in children, specifically the bacterial and fungal microbiota in airborne dust. The study recruited 98 hospitalized children under the age of five with LRTI and matched them with 99 community-based controls without LRTI. The results showed a significant association between the bacterial community in indoor airborne dust and childhood LRTI.
ENVIRONMENTAL RESEARCH
(2023)
Review
Nutrition & Dietetics
Emma J. Derbyshire, Philip C. Calder
Summary: Upper and lower respiratory tract infections are common globally, with antibiotic overuse leading to the emergence of superbugs resistant to their effects. Immunonutrition, particularly through vitamin D supplementation, shows potential in reducing antibiotic reliance by modulating immune function and reducing the risk of respiratory infections. Further high-quality trials are needed to explore this potential further.
FRONTIERS IN NUTRITION
(2021)
Article
Infectious Diseases
Sophia Hawas, Jilong Qin, Sandra Wiedbrauk, Kathryn Fairfull-Smith, Makrina Totsika
Summary: Urinary tract infections (UTIs) are common bacterial infections with high recurrence rates. In this study, a new therapeutic compound was evaluated in multiple preclinical models and showed promising antibiofilm activity.
Article
Gastroenterology & Hepatology
Josbert J. Keller, Rogier E. Ooijevaar, Christian L. Hvas, Elisabeth M. Terveer, Simone C. Lieberknecht, Christoph Hogenauer, Perttu Arkkila, Harry Sokol, Oleksiy Gridnyev, Francis Megraud, Patrizia K. Kump, Radislav Nakov, Simon D. Goldenberg, Reetta Satokari, Sergiy Tkatch, Maurizio Sanguinetti, Giovanni Cammarota, Andrey Dorofeev, Olena Gubska, Gianluca Laniro, Eero Mattila, Ramesh P. Arasaradnam, Shiv K. Sarin, Ajit Sood, Lorenza Putignani, Laurent Alric, Simon M. D. Baunwall, Juozas Kupcinskas, Alexander Link, Abraham G. Goorhuis, Hein W. Verspaget, Cyriel Ponsioen, Georgina L. Hold, Herbert Tilg, Zain Kassam, Ed J. Kuijper, Antonio Gasbarrini, Chris J. J. Mulder, Horace R. T. Williams, Maria J. G. T. Vehreschild
Summary: Faecal microbiota transplantation is gaining attention as an emerging therapeutic option, with stool banks being established within European regulatory frameworks to provide an important treatment choice for patients.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Review
Microbiology
R. E. Ooijevaar, E. van Nood, A. Goorhuis, E. M. Terveer, J. van Prehn, H. W. Verspaget, Y. H. van Beurden, M. G. W. Dijkgraaf, J. J. Keller
Summary: Research suggests that in patients with recurrent Clostridioides difficile infection, long-term follow-up after fecal microbiota transplantation (FMT) does not show new adverse health issues, and no deaths directly attributable to FMT were identified.
Review
Gastroenterology & Hepatology
Manu P. Bilsen, Merel M. C. Lambregts, Joffrey van Prehn, Ed J. Kuijper
Summary: Recent studies have shown some effectiveness of fecal microbiota transplantation (FMT) for decolonization of multidrug-resistant organisms (MDRO), but questions remain regarding its true efficacy, optimal route of administration, role of antibiotics pre and post-FMT, and efficacy in different patient populations. Further research is needed to explore the observed decrease in MDRO infections post-FMT.
CURRENT OPINION IN GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Sam Nooij, Quinten R. Ducarmon, Jeroen F. J. Laros, Romy D. Zwittink, Jason M. Norman, Wiep Klaas Smits, Hein W. Verspaget, Josbert J. Keller, Elisabeth M. Terveer, Ed J. Kuijper
Summary: The study found that pks+ E coli was more prevalent and abundant in patients with rCDI, and FMT played a role in the persistence or eradication of pks+ E coli in patients. However, transmission of pks+ E coli from donors to patients is unlikely.
Article
Infectious Diseases
Valentijn A. Schweitzer, Inger van Heijl, Wim G. Boersma, Wouter Rozemeijer, Kees Verduin, Marco J. Grootenboers, Sanjay U. C. Sankatsing, Akke K. van der Bij, Winnie de Bruijn, Heidi S. M. Ammerlaan, Ilse Overdevest, J. M. Milena Roorda-van der Vegt, Elske M. Engel-Dettmers, Florence E. Ayuketah-Ekokobe, Michiel B. Haeseker, J. Wendelien Dorigo-Zetsma, Paul D. van der Linden, C. H. Edwin Boel, Jan J. Oosterheert, Cornelis H. van Werkhoven, Marc J. M. Bonten
Summary: In a study conducted in 12 hospitals in the Netherlands, it was found that a multifaceted antibiotic stewardship intervention can effectively reduce the use of broad-spectrum antibiotics in patients with moderately severe community-acquired pneumonia, while maintaining patient safety.
LANCET INFECTIOUS DISEASES
(2022)
Review
Public, Environmental & Occupational Health
Cornelis Adrianus De Pijper, Jenny Lea Schnyder, Cornelis Stijnis, Abraham Goorhuis, Martin Peter Grobusch
Summary: Severe thrombocytopenia is a rare but life-threatening complication of ZVI, with immune-induced thrombocytopenia as the main pathophysiological mechanism. Further research is needed to determine the optimal treatment strategy for this complication due to a lack of cases.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Medicine, General & Internal
Saskia Briede, Harriet M. R. van Goor, Titus A. P. de Hond, Sonja E. van Roeden, Judith M. Staats, Jan Jelrik Oosterheert, Frederiek van den Bos, Karin A. H. Kaasjager
Summary: The study found that there was no difference in the frequency of code status documentation or discussion in COVID-19 patients compared to patients before the pandemic. However, treatment limitations were more prevalent in patients with COVID-19, especially 'no intubation' and 'no intensive care admission'.
Article
Medicine, General & Internal
Jesper M. Weehuizen, Rik van Spronsen, Andy I. M. Hoepelman, Chantal P. Bleeker-Rovers, Jan Jelrik Oosterheert, Peter C. Wever
Summary: This retrospective study analyzed the association between previous Coxiella burnetii infection and outcome in COVID-19 patients in the Netherlands. The results showed that previous C. burnetii infection did not influence the risk of ICU admission and/or mortality for patients with COVID-19 presenting at the emergency department.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Titus A. P. de Hond, Gurbey Ocak, Leonie Groeneweg, Jan Jelrik Oosterheert, Saskia Haitjema, Meriem Khairoun, Karin A. H. Kaasjager
Summary: The early recognition of acute kidney injury (AKI) is crucial to improve outcomes. Inflammation is found to play an important role in AKI and mortality. This study investigates the association between certain inflammatory hematological ratios and outcomes in patients with suspected infection at the emergency department. The results show that the neutrophil-to-lymphocyte ratio (NLR), segmented-neutrophil-to-monocyte ratio (SMR), and neutrophil-lymphocyte-platelet ratio (NLPR) are independently associated with AKI and mortality within 30 days.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Titus A. P. de Hond, Jan Jelrik Oosterheert, Susan J. M. Van Hemert-Glaubitz, Ruben E. A. Musson, Karin A. H. Kaasjager
Summary: Early recognition of sepsis is crucial for treatment and prevention of complications. The diagnostic value of PSP in the emergency department (ED) for sepsis is limited and cannot be used as a single marker.
Article
Biology
Sjoerd de Vries, Thijs ten Doesschate, Joan E. E. Tott, Judith W. Heutz, Yvette G. T. Loeffen, Jan Jelrik Oosterheert, Dirk Thierens, Edwin Boel
Summary: Urinalysis has low specificity and may lead to unnecessary antibiotic treatment and antibiotic resistance. By combining urinalysis results with other parameters, UTI can be effectively predicted. The developed CDSS system is more accurate in predicting UTI than urinalysis or urine culture.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Infectious Diseases
Daan W. Notermans, Annelot F. Schoffelen, Fabian Landman, Cornelia C. H. Wielders, Sandra Witteveen, Varisha A. Ganesh, Marga Van Santen-Verheuvel, Sabine C. de Greeff, Ed J. Kuijper, Antoni P. A. Hendrickx
Summary: Urine-associated Escherichia coli ST38 producing OXA-244 harboring putative uropathogenicity factors emerged in the Netherlands.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Ishani Wickramage, Zhong Peng, Soumyadeep Chakraborty, Celine Harmanus, Ed J. Kuijper, Sally Alrabaa, Wiep Klaas Smits, Xingmin Sun
Summary: Clostridioides difficile has a complex relationship with antibiotics, as they can both increase the risk of infection and be the primary treatment for C. difficile infection (CDI). This study identified two clinical isolates of C. difficile with elevated resistance to vancomycin and rifaximin, as well as mutations related to resistance. The findings highlight the importance of surveillance in understanding antibiotic resistance and developing effective treatment strategies.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
P. M. C. Klein Klouwenberg, W. van der Kuil, A. J. van Griethuysen, M. Hendriks, E. J. Kuijper, D. W. Notermans, A. F. Schoffelen, ISIS AR Study Grp
Summary: Using data from the Dutch national surveillance system for antimicrobial resistance, this study found discrepancies in minimum inhibitory concentrations of aminoglycosides measured by the automated testing systems VITEK2 and Phoenix. The Phoenix system showed higher MICs and an annual increase in resistance for certain species. These findings have implications for the clinical treatment of sepsis patients.
MICROBIOLOGY SPECTRUM
(2023)
Article
Health Care Sciences & Services
Karuna E. W. Vendrik, Amoe Baktash, Jelle J. Goeman, Celine Harmanus, Daan W. Notermans, Sabine C. de Greeff, Ed J. Kuijper
Summary: This study found a higher proportion of severe CDI cases during the second wave of COVID-19, which was partially caused by delayed diagnostics possibly due to decreased patient visits or restricted hospital referral.
LANCET REGIONAL HEALTH-EUROPE
(2022)
