Article
Infectious Diseases
Gianuario Fortunato, Ivone Vaz-Moreira, Ina Gajic, Celia M. Manaia
Summary: This study found that the dissemination of carbapenem resistance genes in Pseudomonas aeruginosa is influenced by the phylogenomic features of the strains. The blaVIM-2 gene is mainly found in Europe, while the blaNDM-1 gene is mainly found in Asia. There are significant differences in functional protein/enzyme annotations between blaVIM-2 and blaNDM-1 genes. The results confirm the importance of phylogeny in the spread of antibiotic resistance genes.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
Qian Zhao, Yu Feng, Zhiyong Zong
Summary: Klebsiella pneumoniae strains carrying both carbapenem resistance and hypervirulence genes pose a severe threat to human health. This study reports a novel type of hvCRKP strain, which emerged from the carbapenem-susceptible hypervirulent K. pneumoniae lineage and exhibits unique characteristics compared to other strains. The findings reveal a new mechanism of genetic transfer and emphasize the need for rigorous monitoring and novel countermeasures to curb plasmid-mediated transmission of hvCRKP.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Theodoros Karampatakis, Charalampos Zarras, Styliani Pappa, Eleni Vagdatli, Elias Iosifidis, Emmanuel Roilides, Anna Papa
Summary: This study genetically characterized four ST39 CRKP isolates simultaneously producing VIM-1 and KPC-2, obtained in a Greek tertiary hospital. The isolates were pandrug-resistant or extensively drug-resistant, and carried multiple antimicrobial resistance genes and plasmids. The analysis revealed a close clonal relatedness among the isolates.
MICROBIAL PATHOGENESIS
(2022)
Article
Microbiology
Felipe Alberto-Lei, Carolina S. S. Nodari, Ana Paula Streling, Francisco O. O. Bessa-Neto, Andre V. Siqueira, Rodrigo Cayo, Ana Cristina Gales
Summary: In this study, a multidrug-resistant Pseudomonas juntendi clinical isolate carrying bla(BKC-1) and a class 1 integron containing multiple resistance gene cassettes was characterized. This finding confirms the ability of Pseudomonas putida group isolates to acquire antimicrobial resistance determinants and act as resistance reservoirs.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Guoye Liu, Huimin Qian, Jingwen Lv, Benshun Tian, Changjun Bao, Hong Yan, Bing Gu
Summary: The study revealed an increasing trend of antimicrobial resistance in nontyphoidal Salmonella in Jiangsu, China, particularly towards colistin. Plasmid-mediated resistance genes play a significant role in these bacteria, with mcr-1-positive strains predominantly found in children under 7 years old.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Marita Vedovelli Cardozo, Apostolos Liakopoulos, Michael Brouwer, Arie Kant, Lucas Jose Luduverio Pizauro, Mariana Monezi Borzi, Dik Mevius, Fernando Antonio de Avila
Summary: This study in Sao Paolo, Brazil, investigated the phylogenetic diversity and epidemiology of ESBL-producing E. coli and K. pneumoniae from chicken, chicken meat, and human clinical isolates. The ESBL genes were characterized and their location determined on plasmids. The study found genetic diversity in isolates from chickens, chicken meat, and human feces, suggesting possible transmission of ESBL-producing pathogens from chickens to humans.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Maria Helena Rigatto, Fabiano Ramos, Andressa Barros, Silvia Pedroso, Isabelli Guasso, Luciana Goncalves, Pedro Bergo, Alexandre P. Zavascki
Summary: This study investigated the effects of double-, single-, and none-carbapenem-containing antimicrobial regimens on the treatment of patients with carbapenem-resistant Enterobacterales bloodstream infections. The results showed that single-carbapenem regimens were associated with a lower risk of mortality compared to regimens without carbapenem, while double-carbapenem regimens did not show any significant benefit.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Vineet Dubey, Kuldip Devnath, Vivek K. Gupta, Gazal Kalyan, Mangal Singh, Ashish Kothari, Balram Ji Omar, Ranjana Pathania
Summary: This study evaluated the efficacy of the FDA-approved drug disulfiram in combination with meropenem against MBL-expressing carbapenem-resistant Acinetobacter baumannii. The results demonstrated a synergistic interaction between disulfiram and meropenem, particularly against NDM and IMP-producing A. baumannii. The combination therapy showed improved bacterial clearance in mice models of infection and pneumonia.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Immunology
Xi Li, Weizhong Wang, Xi Jin, Xiaofan Zhang, Xuehan Zou, Qiang Ma, Qingfeng Hu, Haijun Huang, Yuexing Tu
Summary: In this study, two NDM-1-producing CRKP ST11 strains carrying tmexCD2-toprJ2 gene clusters were identified. These gene clusters are likely to spread into clinical high-risk CRKP clones, exacerbating the antimicrobial resistance crisis. In addition, the co-occurrence of bla(NDM-1), bla(KPC-2), and tmexCD2-toprJ2 in a single strain was found, which will undoubtedly accelerate the formation of superdrug-resistant bacteria. Therefore, effective control measures should be implemented to prevent the further dissemination of such organisms in clinical settings.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Shuqing Wang, Huanhuan Dong, Meiqi Wang, Wenbo Ma, Yue Cheng, Junliang Zhou, Yongming Cheng, Hui Xu, Xiaochen Yu
Summary: This study investigated the epidemiological characteristics and drug resistance mechanisms of carbapenem-resistant Klebsiella pneumoniae (CRKP) in Northern China. The results showed that ST11 was the most frequent clonal type and KPC-2 was the predominant carbapenemase in CRKP strains.
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2022)
Article
Immunology
John Cao, Yanina Dubrovskaya, Justin Siegfried, Arnold Decano, Dana Mazo, Sarah Hochman, Ioannis M. Zacharioudakis, Jonathan So, Sadie Solomon, John Papadopoulos, Kassandra Marsh
Summary: This retrospective study compared the treatment strategies for TZP-NS/CRO-S E coli or K pneumoniae infections in noncritically ill adults. The results showed no significant difference in clinical outcomes between patients who received carbapenem and those who received carbapenem-sparing agents.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Andrew N. Murtha, Misha Kazi, Richard D. Schargel, Trevor Cross, Conrad Fihn, Vincent Cattoir, Erin E. Carlson, Joseph M. Boll, Tobias Dorr
Summary: Antibiotic tolerance is an important factor contributing to treatment failure and the emergence of multidrug-resistant bacteria. This study uncovers a novel role of the PhoPQ two-component system in promoting antibiotic tolerance in Enterobacterales. The findings highlight the potential of targeting this mechanism to enhance the effectiveness of antibiotics against tolerant bacteria.
Article
Microbiology
Alessandra Piccirilli, Sabrina Cherubini, Anna Maria Azzini, Evelina Tacconelli, Giuliana Lo Cascio, Laura Maccacaro, Alda Bazaj, Laura Naso, Gianfranco Amicosante, Mariagrazia Perilli
Summary: This study identified thirteen K. pneumoniae lineages spreading among long-term care facilities in Northern Italy, with the prevalence of ST307, ST512, and ST37 as major lineages. The most widespread resistance genes in these facilities were bla(KPC-2), bla(KPC-3), bla(KPC-9), bla(SHV-11), bla(SHV-28), bla(CTX-M-15), bla(OXA-1), bla(OXA-9), bla(OXA-23), qnrS1, qnrB19, qnrB66, aac(6 ')-Ib-cr, and fosA. Additionally, KPC carbapenemases were found to be the most common beta-lactamases.
Article
Genetics & Heredity
Rauf Salamzade, Abigail L. Manson, Bruce J. Walker, Thea Brennan-Krohn, Colin J. Worby, Peijun Ma, Lorrie L. He, Terrance P. Shea, James Qu, Sinead B. Chapman, Whitney Howe, Sarah K. Young, Jenna Wurster, Mary L. Delaney, Sanjat Kanjilal, Andrew B. Onderdonk, Cassiana E. Bittencourt, Gabrielle M. Gussin, Diane Kim, Ellena M. Peterson, Mary Jane Ferraro, David C. Hooper, Erica S. Shenoy, Christina A. Cuomo, Lisa A. Cosimi, Susan S. Huang, James E. Kirby, Virginia M. Pierce, Roby P. Bhattacharyya, Ashlee M. Earl
Summary: This study developed a new method to trace the spread of antibiotic resistance genes among different bacterial hosts and revealed the epidemiology of antibiotic resistance in patients and healthcare networks.
Article
Chemistry, Multidisciplinary
Catherine L. Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K. Colenso, Christopher J. Schofield, Adrian J. Mulholland, James Spencer
Summary: KPC-2 is a carbapenemase that confers resistance to β-lactam antibiotics in Gram-negative pathogens. The flexible a-loop in KPC-2 plays a role in catalytic activity, while carbapenemase activity is mainly due to efficient deacylation of the A2-enamine acyl-enzyme tautomer. Quantum mechanics/molecular mechanics simulations reveal the specific reactivity of the two isomers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Infectious Diseases
R. Izdebski, J. Fiett, P. Urbanowicz, A. Baraniak, L. P. G. Derde, M. J. M. Bonten, Y. Carmeli, H. Goossens, W. Hryniewicz, C. Brun-Buisson, S. Brisse, M. Gniadkowski
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2015)
Article
Infectious Diseases
Yoav Barnea, Anat Lerner, Asaf Aizic, Shiri Navon-Venezia, Eleanor Rachi, Michael W. Dunne, Sailaja Puttagunta, Yehuda Carmeli
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2016)
Article
Infectious Diseases
C. C. Papagiannitsis, R. Izdebski, A. Baraniak, J. Fiett, M. Herda, J. Hrabak, L. P. G. Derde, M. J. M. Bonten, Y. Carmeli, H. Goossens, W. Hryniewicz, C. Brun-Buisson, M. Gniadkowski
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2015)
Article
Veterinary Sciences
Sharon Tirosh-Levy, Amir Steinman, Yehuda Carmeli, Eyal Klement, Shiri Navon-Venezia
PREVENTIVE VETERINARY MEDICINE
(2015)
Article
Microbiology
Ella Kaplan, Noa Sela, Adi Doron-Faigenboim, Shiri Navon-Venezia, Edouard Jurkevitch, Eddie Cytryn
FRONTIERS IN MICROBIOLOGY
(2015)
Article
Microbiology
Kira Kondratyeva, Ayala Wollman, Gabi Gerlitz, Shiri Navon-Venezia
JOURNAL OF MEDICAL MICROBIOLOGY
(2017)
Article
Surgery
Yoav Barnea, Dennis C. Hammond, Yuval Geffen, Shiri Navon-Venezia, Keren Goldberg
AESTHETIC SURGERY JOURNAL
(2018)
Article
Infectious Diseases
Amos Adler, Omar Hussein, Debby Ben-David, Samira Masarwa, Shiri Navon-Venezia, Mitchell J. Schwaber, Yehuda Carmeli
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2015)
Article
Infectious Diseases
R. Izdebski, A. Baraniak, M. Herda, J. Fiett, M. J. M. Bonten, Y. Carmeli, H. Goossens, W. Hryniewicz, C. Brun-Buisson, M. Gniadkowski
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2015)
Article
Infectious Diseases
Tal Brosh-Nissimov, Shiri Navon-Venezia, Nathan Keller, Sharon Amit
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Clinical Neurology
Nina Feinstein, Reuven Tyk, Olga Touloumi, Roza Lagoudaki, Yehuda Goldberg, Oryan Agranyoni, Shiri Navon-Venezia, Abram Katz, Nikolaos Grigoriadis, Tamir Ben-Hur, Ofira Einstein
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2019)
Article
Agriculture, Dairy & Animal Science
Anat Shnaiderman-Torban, Yossi Paitan, Haia Arielly, Kira Kondratyeva, Sharon Tirosh-Levy, Gila Abells-Sutton, Shiri Navon-Venezia, Amir Steinman
Article
Microbiology
Anat Shnaiderman-Torban, Amir Steinman, Gal Meidan, Yossi Paitan, Wiessam Abu Ahmad, Shiri Navon-Venezia
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Edward Bormashenko, Irina Legchenkova, Shiri Navon-Venezia, Mark Frenkel, Yelena Bormashenko
Summary: The impact of different plasma treatments on medical grade polyvinylchloride in terms of wettability and chemical composition was studied. Corona plasma treatment significantly enhanced its hydrophilic properties, while oxidation was hardly correlated with hydrophobic recovery, mainly attributable to the bulk mobility of polymer chains.
APPLIED SCIENCES-BASEL
(2021)
Review
Microbiology
Shiri Navon-Venezia, Kira Kondratyeva, Alessandra Carattoli
FEMS MICROBIOLOGY REVIEWS
(2017)