Article
Cardiac & Cardiovascular Systems
Robert M. Carey, Jackson T. Wright, Sandra J. Taler, Paul K. Whelton
Summary: This review summarizes important findings on prevention, detection, and management of hypertension since 2017, analyzing research published between 2018 and 2021. The studies cover various aspects including blood pressure measurement, risk assessment, treatment targets, with the potential to increase awareness and control of hypertension.
CIRCULATION RESEARCH
(2021)
Editorial Material
Multidisciplinary Sciences
Elena Garralda, Scott A. Laurie, Lesley Seymour, Elisabeth G. E. de Vries
Summary: Early detection of immunotherapy-induced tumor response is crucial, but therapy-induced pseudoprogression can make it complicated. A consensus guideline called iRECIST, a modification of RECIST version 1.1, was developed. This article explores the next steps required to test its validity and proposes novel approaches for response criteria.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Jeffrey J. Olson
Summary: This study updated the evidence-based guidelines for management of progressive glioblastoma by searching medical literature from July 1, 2012 through March 31, 2019 and formulating recommendations based exclusively on evidence rather than expert opinion.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Immunology
Prasad T. Oommen, Timmy Strauss, Karen Baltruschat, Ivan Foeldvari, Christoph Deuter, Gerd Ganser, Johannes-Peter Haas, Claas Hinze, Dirk Holzinger, Anton Hospach, Hans-Iko Huppertz, Arnold Illhardt, Michael Jung, Tilmann Kallinich, Ariane Klein, Kirsten Minden, Kirsten Monkemoller, Sonja Mrusek, Ulrich Neudorf, Gregor Dueckers, Tim Niehues, Matthias Schneider, Philipp Schoof, Angelika Thon, Michael Wachowsky, Norbert Wagner, Susanne Bloedt, Michael Hofer, Klaus Tenbrock, Catharina Schuetz
Summary: This article summarizes the recent update of the interdisciplinary, consensus-based German guidelines on the management of juvenile idiopathic arthritis (JIA). Through multi-disciplinary and consensus participation, therapeutic principles and recommendations were proposed, providing physicians with evidence-based tailored treatment approaches.
CLINICAL IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Arne Astrup, Nina Teicholz, Faidon Magkos, Dennis M. Bier, J. Thomas Brenna, Janet C. King, Andrew Mente, Jose M. Ordovas, Jeff S. Volek, Salim Yusuf, Ronald M. Krauss
Summary: Research in the past decade has shown a lack of rigorous evidence to support continued recommendations to limit saturated fats or replace them with polyunsaturated fats. However, recent U.S. Dietary Guidelines still recommend limiting saturated fats to 10% of total energy intake without considering the findings of these studies. This recommendation also overlooks the important effects of the food matrix and overall dietary pattern when consuming saturated fatty acids.
Review
Oncology
Marie-Lea Gauci, Cynthia Aristei, Jurgen C. Becker, Astrid Blom, Veronique Bataille, Brigitte Dreno, Veronique Del Marmol, Ana M. Forsea, Maria C. Fargnoli, Jean-Jacques Grob, Fabio Gomes, Axel Hauschild, Christoph Hoeller, Catherine Harwood, Nicole Kelleners-Smeets, Roland Kaufmann, Aimilios Lallas, Josep Malvehy, David Moreno-Ramirez, Ketty Peris, Giovanni Pellacani, Philippe Saiag, Alexander J. Stratigos, Ricardo Vieira, Iris Zalaudek, Alexander C. J. van Akkooi, Paul Lorigan, Claus Garbe, Celeste Lebbe
Summary: Merkel cell carcinoma is a rare and aggressive skin cancer with distinct molecular subtypes. Risk factors include age, UV exposure, and immunosuppression. Diagnosis is confirmed through histopathology and immunohistochemistry. Treatment options include surgery, radiation therapy, and immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Oncology
Michelle Bradbury, Brian Hutton, Ana-Alicia Beltran-Bless, Mashari Alzahrani, Thomas Lariviere, Ricardo Fernandes, Mohammed F. K. Ibrahim, Katherine Cole, John Hilton, Lisa Vandermeer, Risa Shorr, Gail Larocque, Mark Clemons
Summary: A systematic review was conducted on the pharmacological interaction between tamoxifen and antidepressants. The review found no consistent evidence suggesting that concurrent use of these medications has negative impacts on clinical outcomes. The current evidence-based guidelines should be updated accordingly to avoid unnecessary changes in treatment.
CLINICAL BREAST CANCER
(2022)
Article
Allergy
Antonella Muraro, Margitta Worm, Cherry Alviani, Victoria Cardona, Audrey DunnGalvin, Lene Heise Garvey, Carmen Riggioni, Debra de Silva, Elizabeth Angier, Stefania Arasi, Abdelouahab Bellou, Kirsten Beyer, Diola Bijlhout, Maria Beatrice Bilo, Carsten Bindslev-Jensen, Knut Brockow, Montserrat Fernandez-Rivas, Susanne Halken, Britt Jensen, Ekaterina Khaleva, Louise J. Michaelis, Hanneke N. G. Oude Elberink, Lynne Regent, Angel Sanchez, Berber J. Vlieg-Boerstra, Graham Roberts
Summary: The updated guideline on anaphylaxis emphasizes early recognition and prompt use of intramuscular adrenaline as first-line management. It also recommends comprehensive training for people at risk of anaphylaxis and improving healthcare professionals' management skills. Additionally, the urgent need for clinical trials to improve patient management in anaphylaxis is highlighted.
Review
Oncology
Tomasz Dzierzanowski, Sebastiano Mercadante
Summary: Constipation is a common problem in cancer patients, but it is often underdiagnosed due to the lack of clear diagnostic criteria. Managing constipation in cancer patients requires a multifaceted approach, including dietary, behavioral, and pharmacological interventions. Prevention of opioid-induced constipation is crucial. Non-pharmacological measures like hydration, nutrition, and using a commode or footstool should be considered. Traditional laxatives are not recommended for treating opioid-induced constipation, while peripherally acting mu-opioid receptor antagonists are the preferred option.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
James Buxbaum, Bashar Qumseya, Sachin Wani
Summary: Despite the lack of consensus criteria for the diagnosis of cholangitis, the BILE criteria appears to be a promising approach in identifying high-risk patients. Further validation studies are needed to confirm its diagnostic performance and ability to prevent unnecessary ERCP.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Raj Shah, Sagarika Satyavada, Michael Kurin, Mayada Ismail, Zachary L. Smith, Perica Davitkov, Gerard Isenberg, Gottumukkala S. Raju, Ashley Faulx, Yngve Falck-Ytter, Amitabh Chak
Summary: This study created a unique and effective educational platform based on evidence-based medicine principles to address the lack of evidence-based endoscopy teaching platforms. The platform incorporates low fidelity simulation and was well-received by participants, indicating a strong desire for this type of educational product. It fills a gap in available tools for endoscopy education.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Health Care Sciences & Services
Holger J. Schunemann, Ignacio Neumann, Monica Hultcrantz, Romina Brignardello-Petersen, Linan Zeng, M. Hassan Murad, Ariel Izcovich, Gian Paolo Morgano, Tejan Baldeh, Nancy Santesso, Carlos Garcia Cuello, Lawrence Mbuagbaw, Gordon Guyatt, Wojtek Wiercioch, Thomas Piggott, Hans De Beer, Marco Vinceti, Alexander G. Mathioudakis, Martin G. Mayer, Reem Mustafa, Tommaso Filippini, Alfonso Iorio, Robby Nieuwlaat, Maura Marcucci, Pablo Alonso Coello, Stefanos Bonovas, Daniele Piovani, George Tomlinson, Elie A. Akl
Summary: This article introduces a new approach by GRADE for assessing uncertainty, which involves rating down by one, two, or three levels based on serious, very serious, and extremely serious concerns. The approach includes identifying thresholds and using them to evaluate imprecision, while also providing guidance on addressing implausible large effects and trivial or no effects.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Maciej Kubala, Benjamin Essayagh, Hector I. Michelena, Maurice Enriquez-Sarano, Christophe Tribouilloy
Summary: Patients with mitral valve prolapse (MVP) may develop ventricular arrhythmias, and the association between these two conditions is still not fully understood.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Petros Perros, Krishnarajah Nirantharakumar, Laszlo Hegedues
Summary: Clinicians typically advise hypothyroid patients to maintain normal serum TSH levels, but recent research suggests that mortality rates increase when serum TSH levels are either elevated or reduced outside the normal range. Therefore, optimal control of serum TSH is crucial for patients undergoing L-T4 replacement therapy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Gastroenterology & Hepatology
Hitoshi Yoshiji, Sumiko Nagoshi, Takemi Akahane, Yoshinari Asaoka, Yoshiyuki Ueno, Koji Ogawa, Takumi Kawaguchi, Masayuki Kurosaki, Isao Sakaida, Masahito Shimizu, Makiko Taniai, Shuji Terai, Hiroki Nishikawa, Yoichi Hiasa, Hisashi Hidaka, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike
Summary: The latest edition of the clinical practice guidelines for liver cirrhosis includes new background and future research questions, as well as updates based on international standards and recent findings. It covers various aspects of liver cirrhosis treatment, complication management, and clinically important issues, incorporating the latest information and references to international guidelines.
JOURNAL OF GASTROENTEROLOGY
(2021)
