Article
Infectious Diseases
Marzia Cinthi, Sonia Nina Coccitto, Simona Fioriti, Gianluca Morroni, Serena Simoni, Carla Vignaroli, Chiara Francesca Magistrali, Elisa Albini, Andrea Brenciani, Eleonora Giovanetti
Summary: This study investigates the genetic elements and transferability of linezolid resistance genes in enterococci from manure in a swine farm in Italy. The study found that these enterococci carry both cfr(D) and poxtA2 genes, which are located on a plasmid that is similar to a transposon in Staphylococcus aureus. The presence of these genes in swine manure highlights the importance of control measures to prevent their spread to other species.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Loren Dejoies, Mohamed Sassi, Sacha Schutz, Julie Moreaux, Asma Zouari, Sophie Potrel, Anais Collet, Maxime Lecourt, Gabriel Auger, Vincent Cattoir
Summary: The study revealed the prevalence of poxtA gene in clinical enterococci in France since 2016, mostly in E. faecium and independently from optrA. Plasmids carrying poxtA also often co-carried resistance genes to phenicols and tetracyclines, potentially co-selected through veterinary use.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Cell Biology
Adam M. Jorgensen, Anastasiya Gorkun, Naresh Mahajan, Kelsey Willson, Cara Clouse, Claire G. Jeong, Mathew Varkey, Mingsong Wu, Stephen J. Walker, Joseph A. Molnar, Sean V. Murphy, Sang Jin Lee, James J. Yoo, Shay Soker, Anthony Atala
Summary: Bioprinting is a promising method for generating skin substitutes that mimic the structure of natural skin. In this study, bioprinted skin constructs were successfully transplanted onto wounds in mice and pigs, promoting wound healing and skin regeneration.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Critical Care Medicine
Melissa J. Grigsby, Tajia L. Green, Debora Lim, Kiho Cho, David G. Greenhalgh
Summary: A hyperactive hGR variant, G459V, was identified with stronger response to stress and steroid treatment compared to standard hGR, and unexpectedly increased activity when treated with the hGR antagonist RU486.
Review
Microbiology
Yassine Merad, Hichem Derrar, Zoubir Belmokhtar, Malika Belkacemi
Summary: Superficial and cutaneous aspergillosis is a rare fungal disease that primarily affects the outer layers of the skin, nails, and the outer auditory canal, especially in immunocompromised patients. These fungal infections are typically acquired through traumatic inoculation or inhalation of fungal spores. Lesions are categorized into otomycosis, onychomycosis, and cutaneous aspergillosis.
Article
Chemistry, Multidisciplinary
Alexey Galushchinskiy, Yajun Zou, Jokotadeola Odutola, Pavle Nikacevic, Jian-Wen Shi, Nikolai Tkachenko, Nuria Lopez, Pau Farras, Oleksandr Savateev
Summary: Graphitic carbon nitride (g-CN) is a transition metal free semiconductor that mediates photocatalytic reactions through proton-coupled electron transfer (PCET) mechanism. The active sites for PCET are identified as the 'triangular pockets' on the edge facets of g-CN. Using excited state PCET, g-CN can selectively cleave X-H bonds with approximately 100 kcal mol(-1) bond dissociation free energy (BDFE), leading to the formation of 1,3-oxazolidine-2,4-diones.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Zheng Zhang, Zhi-Hao Zhang, Feng Zhou, Jian Zhou
Summary: The study introduces a sequential catalytic reaction method for the synthesis of chiral compounds with high enantioselectivity, utilizing asymmetric transfer hydrogenation-carboxylative cyclization. The resulting chiral 2-oxazolidinones can be further elaborated into useful chiral beta-fluoroalkyl beta-amino alcohols, highlighting the potential applications of this strategy in organic synthesis. Additionally, this research showcases the utilization of CO2 as a C1 synthon in catalytic asymmetric sequential reactions, demonstrating the carboxylative cyclization of alpha-fluoroalkyl propargylamines.
Article
Chemistry, Medicinal
Parteek Prasher, Tanisqa Mall, Mousmee Sharma
Summary: Carbamate group is used for designing prodrugs with improved stability against enzyme hydrolysis. Cyclic carbamates, with a unique hydrogen-bonding acceptor atom, show higher metabolic stability compared to acyclic carbamates. The metabolic stability of carbamates is influenced by the degree of substitution at the nitrogen atom and enables the design of various carbamate drugs or prodrugs.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Critical Care Medicine
Heather Cleland, Dasamal Tharanga Fernando, Belinda J. Gabbe
Summary: This study describes the incidence and characteristics of hospital presentations and deaths due to burn injury in the Australian state of Victoria from 2008 to 2017. The study found that the risk, types, and outcomes of burn injuries vary by age and gender. There was limited evidence of a decrease in burn injury rates in some sub-groups. Therefore, appropriate and effective prevention strategies are needed to avoid burn injuries.
Article
Medicine, Research & Experimental
Audrey R. N. Ndukwe, Sophia Hawas, Jilong Qin, Sandra Wiedbrauk, Makrina Totsika, Nathan R. B. Boase, Kathryn E. Fairfull-Smith
Summary: Infectious diseases caused by bacterial pathogens are a major cause of death worldwide. Biofilms, which are difficult to treat bacterial communities, are implicated in persistent infections. Hybridization of antibiotics is considered a promising strategy to combat biofilm infections. This study focused on the synthesis and modification of oxazolidinones, with the aim of extending their useful lifetime and improving their efficacy against MRSA biofilms. The results showed that the modification of antibiotics with a dispersal agent was effective in eradicating MRSA biofilms and overcoming antibiotic resistance.
MOLECULAR PHARMACEUTICS
(2023)
Article
Microbiology
Dereje A. Negatu, Wassihun Wedajo Aragaw, Julianna Cangialosi, Veronique Dartois, Thomas Dick
Summary: New oxazolidinones are being developed for the treatment of tuberculosis and NTM infections, as a safer alternative to linezolid and tedizolid. This study compared the mitochondrial toxicity and efficacy against mycobacterial pathogens of approved and novel oxazolidinones. The results suggest that TBI-223 and sutezolid show promise for the treatment of tuberculosis and NTM lung disease caused by Mycobacterium kansasii.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Food Science & Technology
Shengjun Tang, Runshi Yang, Qingping Wu, Yu Ding, Zhi Wang, Jumei Zhang, Tao Lei, Shi Wu, Feng Zhang, Weipei Zhang, Liang Xue, Youxiong Zhang, Xianhu Wei, Rui Pang, Juan Wang
Summary: This study identified the presence of the optrA gene in Campylobacter jejuni collected from retail meat in China, marking the first discovery of this gene in the species. The optrA-positive strains were found to be genetically homogeneous based on molecular analysis, indicating potential concerns for food safety. Additionally, the optrA gene was found to be located on a chromosome-borne multidrug resistance genomic island along with the tet(O) gene, forming translocatable units that could facilitate the spread of resistance genes. Measures need to be implemented to prevent the dissemination of such units and strains in other Gram-negative bacteria and food chains.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Critical Care Medicine
Hui Min Grace Tan, Luther Chung, Xin Ying Chong, Janna Joethy, Si Jack Chong
Summary: The study introduced a mnemonic (B.U.R.N.S.) to facilitate first aid education for burns, showing significant improvement in burn first aid knowledge among medical professionals. The mnemonic was easy to understand and recall, with potential for wider implementation to enhance burns first aid awareness and education.
Article
Microbiology
Chang-Wei Lei, Xuan Chen, Si-Yi Liu, Tian-Yi Li, Yanpeng Chen, Hong-Ning Wang
Summary: The spread of the phenicol-oxazolidinone-tetracycline resistance gene poxtA in enterococci isolates from different healthy pigs in a swine farm in China is mainly driven by both clonal spread and horizontal transfer. Although only 11 isolates were found to harbor the poxtA gene, it poses a significant public health threat due to decreased susceptibility to multiple antibiotics commonly used in both human and veterinary medicine.
VETERINARY MICROBIOLOGY
(2021)
Article
Immunology
Cecilia Godoy Carvalhaes, Helio Silva Sader, Paul Richard Rhomberg, Mariana Castanheira, Sean DeVries, Rodrigo Elisandro Mendes
Summary: This study assessed the activity of tedizolid and comparator agents against clinical surveillance isolates collected from pediatric patients with skin and skin structure infection in the United States. The results showed that tedizolid had high inhibitory activity against Staphylococcus aureus and MRSA isolates, and other antibiotics also displayed high susceptibility in different age groups and methicillin resistance profiles.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Critical Care Medicine
Guillaume Geri, Lucie Guillemet, Florence Dumas, Julien Charpentier, Marion Antona, Virginie Lemiale, Wulfran Bougouin, Lionel Lamhaut, Jean-Paul Mira, Christophe Vinsonneau, Alain Cariou
INTENSIVE CARE MEDICINE
(2015)
Article
Critical Care Medicine
Jean-Pierre Quenot, Christine Binquet, Christophe Vinsonneau, Saber-David Barbar, Sandrine Vinault, Valerie Deckert, Stephanie Lemaire, Ali Ait Hassain, Remi Bruyere, Bertrand Souweine, Laurent Lagrost, Christophe Adrie
INTENSIVE CARE MEDICINE
(2015)
Letter
Microbiology
V. Jullien, B. Blanchet, M. Benyamina, M. Tod, C. Vinsonneau
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2012)
Article
Critical Care Medicine
C. Vinsonneau, M. Benyamina, M. T. Baixench, J. Stephanazzi, C. Augris, S. Grabar, A. Paugam, D. Wassermann
Review
Critical Care Medicine
Francois Ravat, Ronan Le-Floch, Christophe Vinsonneau, Pierre Ainaud, Marc Bertin-Maghit, Herve Carsin, Gerard Perro
Review
Pharmacology & Pharmacy
Benoit Blanchet, Vincent Jullien, Christophe Vinsonneau, Michel Tod
CLINICAL PHARMACOKINETICS
(2008)
Article
Infectious Diseases
S. Perbet, A. Soummer, C. Vinsonneau, A. Vandebrouck, T. Rackelboom, J. Etienne, A. Cariou, J. -D. Chiche, J. -P. Mira, J. Charpentier
Article
Critical Care Medicine
Alain Cariou, Michael R. Pinsky, Mehran Monchi, Ivan Laurent, Christophe Vinsonneau, Jean-Daniel Chiche, Julien Charpentier, Jean-Francois Dhainaut
INTENSIVE CARE MEDICINE
(2008)
Article
Critical Care Medicine
Jean-Pierre Quenot, Herve Mentec, Francois Feihl, Djillali Annane, Christian Melot, Philippe Vignon, Christian Brun-Buisson
INTENSIVE CARE MEDICINE
(2008)
Article
Critical Care Medicine
Jean-Francois Augusto, Vincent Lassalle, Pierre Fillatre, Dominique Perrotin, Ferhat Meziani, Maleka Schenck-Dhif, Pierre Edouard Bollaert, Damien du Cheyron, Gaetan Beduneau, Christophe Vinsonneau, Christophe Guitton, Nicolas Lerolle
INTENSIVE CARE MEDICINE
(2012)
Article
Urology & Nephrology
Alexey Girshovich, Christophe Vinsonneau, Joelle Perez, Sophie Vandermeersch, Marie-Christine Verpont, Sandrine Placier, Chantal Jouanneau, Emmanuel Letavernier, Laurent Baud, Jean-Philippe Haymann
KIDNEY INTERNATIONAL
(2012)
Article
Physiology
C. Vinsonneau, A. Girshovich, M. Ben M'rad, J. Perez, L. Mesnard, S. Vandermersch, S. Placier, E. Letavernier, L. Baud, J. -P. Haymann
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2010)
Article
Critical Care Medicine
Christophe Ridel, David Osman, Lucile Mercadal, Nadia Anguel, Thierry Petitclerc, Christian Richard, Christophe Vinsonneau
INTENSIVE CARE MEDICINE
(2007)
Article
Critical Care Medicine
Kianoush Kashani, Ali Al-Khafaji, Thomas Ardiles, Antonio Artigas, Sean M. Bagshaw, Max Bell, Azra Bihorac, Robert Birkhahn, Cynthia M. Cely, Lakhmir S. Chawla, Danielle L. Davison, Thorsten Feldkamp, Lui G. Forni, Michelle Ng Gong, Kyle J. Gunnerson, Michael Haase, James Hackett, Patrick M. Honore, Eric A. J. Hoste, Olivier Joannes-Boyau, Michael Joannidis, Patrick Kim, Jay L. Koyner, Daniel T. Laskowitz, Matthew E. Lissauer, Gernot Marx, Peter A. McCullough, Scott Mullaney, Marlies Ostermann, Thomas Rimmele, Nathan I. Shapiro, Andrew D. Shaw, Jing Shi, Amy M. Sprague, Jean-Louis Vincent, Christophe Vinsonneau, Ludwig Wagner, Michael G. Walker, R. Gentry Wilkerson, Kai Zacharowski, John A. Kellum