Article
Automation & Control Systems
Mengting Lin, Zhaoke Ning, Bin Li, Kai Zhang
Summary: This paper investigates the adaptive dual model predictive control (DMPC) method for linear systems with constant parametric uncertainties. The method utilizes online set-membership identification and recursive least squares to shrink the uncertain parameter set and considers the dual effect represented by the parameters' prediction error in the optimization problem for improving performance and reducing the impact of uncertainties.
IET CONTROL THEORY AND APPLICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Ryan T. McGuire, Travis Lundrigan, Joshua W. M. MacMillan, Katherine N. Robertson, Arun A. Yadav, Mark Stradiotto
Summary: This article introduces a new efficient protocol for the C-N cross-coupling of amides and (pseudo)halide-substituted acetophenones. The reaction can be conducted at room temperature and employs nickel catalysts and organic amine bases. Stoichiometric experiments support a Ni-0/II pathway, and the combination of DBU/NaTFA enables room-temperature amide cross-couplings.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Pharmacology & Pharmacy
Elena Contreras-Garcia, Carmen Lozano, Cristina Garcia-Iriepa, Marco Marazzi, Arthur H. Winter, Carmen Torres, Diego Sampedro
Summary: Controlling the activity of pharmaceutical agents using light has the potential to enhance selectivity, reduce adverse effects, and minimize environmental impact. This study presents photoreleasable quinolones that can be activated by visible/NIR light, protected by BODIPY photocages, and regain antimicrobial activity upon light irradiation. A computational study reveals the importance of explicit solvent molecules in the reaction mechanism and the role of solvent-assisted photodissociation. The light-controlled activity of these compounds has been evaluated on quinolone-susceptible E. coli, demonstrating a significant change in antimicrobial activity.
Article
Chemistry, Medicinal
Phelelisiwe S. Dube, Lesetja J. Legoabe, Audrey Jordaan, Omobolanle J. Jesumoroti, Tendamudzimu Tshiwawa, Digby F. Warner, Richard M. Beteck
Summary: Nitro based DprE1 inhibitors show potent anti-tubercular activity, while quinolone-based antibiotics have good PK properties. Combining the structures of these two types of compounds has led to the design of novel DprE1 inhibitors. Compound 25 from a series of nitroquinolone-3-carboxamide derivatives achieved the highest anti-tubercular activity with a molecular weight of 399 Da and ClogP value of 2.7.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Till Reinhardt, Kyu M. Lee, Lukas Niederegger, Corinna R. Hess, Stephan A. Sieber
Summary: This study reveals a new dual mode of action for antimicrobial drugs. These drugs not only directly inhibit the key enzyme topoisomerase IV responsible for bacterial DNA replication, but also cause damage to bacterial DNA and proteins through the production of harmful reactive species via reductive activation.
ACS CHEMICAL BIOLOGY
(2022)
Article
Automation & Control Systems
Daniel Arnstrom, Alberto Bemporad, Daniel Axehill
Summary: The article introduces a dual active-set solver suitable for embedded model predictive control applications, which is efficient, easily warm started, and simple to code. The exact worst-case computational complexity of the solver can be determined offline and ill-conditioned problems can be handled robustly through outer proximal-point iterations.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2022)
Article
Automation & Control Systems
Zihao Liu, Arash M. Dizqah, Jose M. Herreros, Joschka Schaub, Olivier Haas
Summary: The paper proposes a nonlinear Economic Model Predictive Control (eMPC) strategy for airpath management of diesel engines, which aims to minimize NOx, soot, and pumping loss simultaneously. By computing set points online based on engine operating conditions and state feedback, the eMPC demonstrates improved performance compared to traditional controllers.
CONTROL ENGINEERING PRACTICE
(2021)
Article
Automation & Control Systems
Pengfei Li, Yu Kang, Yun-Bo Zhao, Tao Wang
Summary: This article proposes a novel control framework for a class of discrete-time perturbed nonlinear system, which incorporates a local controller and a remote controller to achieve stability. By introducing a new Lyapunov function, the input-to-state practical stability is established in relation to the optimal MPC value function. Simulation results demonstrate the effectiveness of the proposed control scheme.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2021)
Article
Automation & Control Systems
Shengli Du, Mingming Zhao, Xue-Fang Wang, Honggui Han, Junfei Qiao
Summary: In this article, a dual-mode event-triggered predictive control method is proposed for nonlinear systems with bounded disturbances. The method consists of two triggering mechanisms, namely the hybrid threshold-based event-triggered model predictive control mechanism and the event-triggered linear quadratic regulator mechanism. The feasibility and practical stability analysis of the designed strategy are presented, along with simulations to demonstrate the correctness and feasibility of the designed algorithms.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2023)
Article
Automation & Control Systems
Jianzhong Zhu
Summary: The increase of renewable energy sources connected to the grid has increased flexibility requirements in thermal power plant operations. The dynamic behavior of the boiler-turbine unit changes significantly at different operating conditions due to severe nonlinearity and various disturbances. Building uncertainties in modeling make it difficult to definitively understand the changes, hindering control efforts. The proposed dual-mode fuzzy predictive control strategy aims to achieve disturbance suppression and improve nonlinear dynamic behavior in the boiler-turbine unit.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2021)
Article
Engineering, Electrical & Electronic
Marcos Blanco, Dionisio Ramirez, Mohammad Ebrahim Zarei, Mahima Gupta
Summary: This paper introduces a new dual Multivector Model Predictive Control (MMPC) for power converters of floating Oscillating Water Column (OWC) wave energy converters. The proposed control system provides fast dynamic response to handle variable torque and velocity, achieving outstanding tracking of references.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2021)
Article
Automation & Control Systems
Christian Kloeppelt, Julian Berberich, Frank Allgoewer, Matthias A. Mueller
Summary: This paper presents a data-driven model predictive control (MPC) scheme that can stabilize unknown linear time-invariant systems by predicting the future system behavior using Willems' lemma. The scheme includes a state-feedback MPC based on input-state data and constraint tightening, and extensions for output feedback control.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2022)
Article
Chemistry, Multidisciplinary
Carlos Salazar, Cesar Martin, Adriana Aguirre, Parisa Eslambolchilar, Victor Asanza
Summary: Physical inactivity poses a significant threat to public health, and the COVID-19 pandemic has further reduced physical activity levels due to restrictions. This study proposes physical activity interventions using mobile devices and control engineering principles. The model is based on the fluid analogy of Social Cognitive Theory and validated using data from a real intervention. The inclusion of new technology, such as phone-based ecological momentary assessments and simulations with logical reward conditions, enhances the understanding of behavior change interventions.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Organic
Meiqian Hu, Shuai Zhang, Changsheng Qin, Hongsheng Nie, Zhicheng Xiong, Xiaoyu Shi, Yumiao Zhao, Mingzhe Li, Shoucai Wang, Fanghua Ji, Guangbin Jiang
Summary: This work presents an efficient method for C3-H halogenation of quinoline-4(1H)-ones using electrochemical reactions with potassium halides serving as both halogenating agents and electrolytes. The protocol allows for the rapid synthesis of various halogenated quinoline-4(1H)-ones with unique regioselectivity and a wide range of substrates, utilizing convenient and environmentally friendly electrolysis in an undivided cell. Mechanistic studies reveal that halogen radicals play a crucial role in activating the N-H bonds in quinolones.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Microbiology
Barbara A. Brown Elliott, Richard J. Wallace
Summary: NTM infections, especially those caused by MAC and M. abscessus complex, are on the rise globally. Delafloxacin showed promising activity against certain NTM strains, particularly M. abscessus and M. fortuitum groups, indicating its potential utility in treating NTM infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
