Article
Infectious Diseases
Jerome Ory, Quang Le Minh, Hung Phan Tien, Vinh Vu Hai, Elodie Careno, Tatiana Price, Alexandre Andrieux, Julien Crouzet, Catherine Dunyach-Remy, Didier Laureillard, Jean-Philippe Lavigne, Albert Sotto
Summary: This study examined the changes in surgical site infection rates before and after the implementation of antibiotic stewardship programs and infection control measures in a Vietnamese tertiary care hospital. The results showed a decrease in surgical site infection rates after the implementation of these programs, although the difference was not statistically significant. Comprehensive infection control education and policies are needed in Vietnamese hospitals to prevent surgical site infections.
Article
Microbiology
Alba Ruedas-Lopez, Isaac Alonso-Garcia, Cristina Lasarte-Monterrubio, Paula Guijarro-Sanchez, Eva Gato, Juan Carlos Vazquez-Ucha, Juan Andres Vallejo, Pablo Arturo Fraile-Ribot, Begona Fernandez-Perez, David Velasco, Jose Maria Gutierrez-Urbon, Marina Oviano, Alejandro Beceiro, Concepcion Gonzalez-Bello, Antonio Oliver, Jorge Arca-Suarez, German Bou
Summary: This study aimed to analyze the resistance mechanisms of ceftolozane-tazobactam and ceftazidime-avibactam in multidrug-resistant or extensively drug-resistant P. aeruginosa isolates. The findings revealed that most of the resistant isolates were recovered after treatment with ceftolozane-tazobactam or ceftazidime-avibactam. Chromosomal mutations and specific gene substitutions were identified as the main resistance mechanisms. The study emphasized the potential selection of MDR/XDR P. aeruginosa strains producing certain variants or metallo-beta-lactamases by cephalosporin/beta-lactamase inhibitors, and encouraged judicious use of these agents.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
T. Sevin, C. Daniau, S. Alfandari, E. Piednoir, C. Dumartin, H. Blanchard, L. Simon, A. Berger-Carbonne, S. Le Vu
Summary: This study analyzed antimicrobial prescription patterns for various healthcare-associated infections (HAIs) in France based on 2017 data, highlighting the importance of tailoring treatments to specific pathogens and their resistance profiles. The findings underscore the need for personalized antimicrobial stewardship efforts in combating HAIs.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Pharmacology & Pharmacy
Alicia Rodriguez-Alarcon, Manuela de Mena, Soukaina Sara Alanti, Daniel Echeverria-Esnal, Luisa Sorli, Elena Sendra, Adela Benitez-Cano, Estela Membrilla, Francesc Cots, Robert Guerri-Fernandez, Ramon Adalia, Juan Pablo Horcajada, Fernando Escolano, Santiago Grau, Silvia Gomez-Zorrilla
Summary: This study compared the clinical outcomes of patients with penicillin allergy labels (PAL) managed with antibiotic desensitization versus those who received alternative non-beta-lactam antibiotic treatments. Desensitization was not associated with worse clinical outcomes, despite more severe patients in this group.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Shijie Yao, Jianfeng Ye, Qing Yang, Yaru Hu, Tianyang Zhang, Lei Jiang, Salvator Munezero, Kuangfei Lin, Changzheng Cui
Summary: Hospital wastewater contains a variety of human antibiotics and pathogens, with a lack of research on pollutants at treatment plants. Different hospitals showed varying levels of antibiotics and ARGs in their wastewater. The study revealed the co-occurrence of antibiotics, ARGs, and antibiotic-resistant pathogens in hospital wastewater.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Infectious Diseases
Mohammad H. Alshaer, Nicole Maranchick, Kaitlin M. Alexander, Kayihura Manigaba, Bethany R. Shoulders, Timothy W. Felton, Sumith K. Mathew, Charles A. Peloquin
Summary: The aim of this study was to evaluate the association between early and cumulative β-lactam pharmacokinetic/pharmacodynamic (PK/PD) parameters and therapy outcomes in bloodstream infection (BSI). Multiple regression analysis revealed that achieving a higher percentage of free concentration above the four times the minimum inhibitory concentration (fT/4 xMIC ) at both 0-24 hours and 0-7 days significantly predicted negative blood culture results on day 7.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Iwona E. Glowacka, Magdalena Grabkowska-Druzyc, Graciela Andrei, Dominique Schols, Robert Snoeck, Karolina Witek, Sabina Podlewska, Jadwiga Handzlik, Dorota G. Piotrowska
Summary: A novel series of N-substituted cis- and trans-3-aryl-4-(diethoxyphosphoryl)azetidin-2-ones were synthesized and evaluated for antiviral activity against various DNA and RNA viruses, with some compounds showing moderate inhibitory effects. Additionally, some of the azetidin-2-ones exhibited slight cytostatic activity against certain cancerous cell lines. Furthermore, compound trans-11f was identified as an adjuvant of oxacillin, enhancing its efficacy against a highly resistant S. aureus strain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Victoria Palin, William Welfare, Darren M. Ashcroft, Tjeerd Pieter van Staa
Summary: The study found that shorter and longer antibiotic courses have equal effectiveness in reducing infection-related hospitalizations. Therefore, stewardship programs should recommend shorter antibiotic courses for acute infections. No variation by infection-type was observed in this study.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Ankur Midha, Victor Hugo Jarquin-Diaz, Friederike Ebner, Ulrike Lober, Rima Hayani, Arkadi Kundik, Alessio Cardilli, Emanuel Heitlinger, Sofia Kirke Forslund, Susanne Hartmann
Summary: The study compared the intestinal microbiome of the parasitic nematode Ascaris suum with its host, revealing that the parasite has a less diverse microbiome than the host, and the host shows reduced microbiome diversity at the site of parasite infection. The microbiome composition of the host at the infection site significantly influences the microbiome composition of the parasite.
Article
Infectious Diseases
Angela Dramowski, Alexander M. Aiken, Andrea M. Rehman, Yolandi Snyman, Sandra Reuter, Hajo Grundmann, J. Anthony G. Scott, Marlieke E. A. de Kraker, Andrew Whitelaw
Summary: This study aimed to examine the impact of third-generation cephalosporin (3GC) resistance on clinical outcomes in patients with Enterobacteriaceae bloodstream infections (BSIs) in a hospital in South Africa. The study found that 3GC resistance was associated with non-concordant initial therapy and increased mortality rate.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Review
Multidisciplinary Sciences
Tobias Dorr
Summary: This article examines the tolerance of bacteria to cell wall-active antibiotics, including its manifestations, mechanisms, and clinical significance, defines tolerance and detection methods, discusses the mechanism of action of these antibiotics, and explores how bacteria mitigate the potentially lethal effects to become tolerant.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Critical Care Medicine
Alexis Tabah, Niccolo Buetti, Quentin Staiquly, Stephane Ruckly, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Andrew Conway Morris, Matteo Bassetti, Kostoula Arvaniti, Jeffrey Lipman, Ricard Ferrer, Haibo Qiu, Jose-Artur Paiva, Pedro Povoa, Liesbet De Bus, Jan De Waele, Farid Zand, Mohan Gurjar, Adel Alsisi, Khalid Abidi, Hendrik Bracht, Yoshiro Hayashi, Kyeongman Jeon, Muhammed Elhadi, Francois Barbier, Jean-Francois Timsit
Summary: This study investigated hospital-acquired bloodstream infections (HA-BSI) in 2600 adult patients from 333 ICUs in 52 countries. HA-BSI were frequently caused by Gram-negative, carbapenem-resistant, and difficult-to-treat pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy, resulting in high mortality rates.
INTENSIVE CARE MEDICINE
(2023)
Article
Chemistry, Medicinal
Rachel Berndsen, Taylor Cunningham, Lauren Kaelin, Makayla Callender, W. Dexter Boldog, Brianna Viering, Ashley King, Najwa Labban, Julie A. Pollock, Heather B. Miller, Meghan S. Blackledge
Summary: Antibiotic-resistant infections are a global concern causing millions of deaths annually. Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections and is increasingly responsible for difficult-to-treat community-acquired infections. Antibiotic adjuvants, small molecules that enhance antibiotic efficacy through non-toxic mechanisms, show promise as novel therapeutics. Screening for low-molecular-weight compounds identified brominated carbazoles as lead compounds that potentiate beta-lactam antibiotics against medically relevant strains of MRSA by dampening the transcription of key resistance genes. These lead compounds represent novel scaffolds for the development of antibiotic adjuvants.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Medicine, General & Internal
Filippo Gavi, Barbara Fiori, Carlo Gandi, Marco Campetella, Riccardo Bientinesi, Filippo Marino, Daniele Fettucciari, Francesco Rossi, Stefano Moretto, Rita Murri, Francesco Pierconti, Marco Racioppi, Emilio Sacco
Summary: The COVID-19 pandemic did not have a significant impact on the incidence of antimicrobial resistance (AMR) in our urology department. However, the overall prevalence of AMR and multi-drug resistant organisms (MDROs) remains high compared to European AMR.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Mostapha El Edelbi, Joelle Hassanieh, Nancy Malaeb, Antoine Abou Fayad, Rola F. Jaafar, Ahmad Sleiman, Abdelkader Abedelrahim, Zeina Kanafani, Ghassan M. Matar, Ahmad Zaghal
Summary: Bearded male healthcare workers in the operating room have a significantly higher facial bacterial load compared to nonbearded workers, but there was no statistical significance in meropenem resistance. Chlorohexidine was effective in inhibiting the growth of all strains, including the meropenem-resistant isolates.