期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 62, 期 5, 页码 948-950出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkn341
关键词
A. allosaccharophila; QnrS2; environment
资金
- Ministere de l'Education Nationale et de la Recherche [UPRES-EA3539]
- Universite Paris XI, France
- Swiss National Science Foundation
- National Research Program 'Antibiotic resistance' [NRP49]
- European Community [DRESP2, LSHM-CT-2005-018705]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- PDEE [3682/07-2]
Objectives: To search for plasmid-mediated qnr genes among waterborne environmental Aeromonas spp. recovered from Switzerland. Methods: Isolates presenting MICs of nalidixic acid or ciprofloxacin >= 1 mg/L were screened for qnr genes by a multiplex PCR approach followed by sequencing. Plasmids were transferred by transformation, and further analysis of the genetic structures surrounding the qnrS2 gene was carried out by PCR and sequencing. Results: A qnrS2 gene was identified from a single Aeromonas allosaccharophila isolate (Lugano lake, Lugano), as part of a mobile insertion cassette located on a broad host range IncU-type plasmid. This plasmid co-harboured a class 1 integron containing the aac(6 ')-Ib-cr, bla(OXA-1), catB3 and arr-3 gene cassettes. Conclusions: These findings strengthen further the role of Aeromonas spp. as a reservoir of antimicrobial resistance determinants in the environment.
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