期刊
JOURNAL OF ANTIBIOTICS
卷 66, 期 7, 页码 431-441出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2013.34
关键词
biosynthesis; genome mining; marine actinomycetes; Micromonospora; polyene macrolactam
资金
- State of North Carolina MARBIONC program
- MARBIONC
- North Carolina Biotech Center [2011-IDG-1006]
- [NSF-CHE-1039784]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1039784] Funding Source: National Science Foundation
Through a combination of chemical and molecular analysis, a new polyene macrolactam named micromonolactam was obtained from two marine-derived Micromonospora species. This new polyene metabolite is a constitutional isomer of salinilactam A but contains a different polyene pattern and one cis double bond, in contrast to the all trans structure reported for salinilactam A. The molecular analysis data also established that micromonolactam is a hybrid polyketide derived from 11 polyketide units and a modified glutamate starter unit.
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