Article
Environmental Sciences
Nicoletta Makowska, Katarzyna Bresa, Ryszard Koczura, Anna Philips, Katarzyna Nowis, Joanna Mokracka
Summary: The study revealed the presence of dangerous antibiotic-resistant pathogens such as MRSA and VRE in urban sewage, with their frequency increasing during wastewater treatment. Furthermore, wastewater treatment was found to increase the relative abundance of mecA and virulence genes, indicating the existence of pathogenic bacteria in the effluent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Immunology
Karim Khader, Alun Thomas, W. Charles Huskins, Vanessa Stevens, Lindsay T. Keegan, Lindsay Visnovsky, Matthew H. Samore
Summary: The study found limited evidence that contact precautions implemented in ICUs reduced transmission of MRSA or VRE, with significant differences in transmission dynamics and clearance rates between the two pathogens. ICU-level factors were not found to be associated with the effects of contact precautions.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Chemistry, Medicinal
Nelson E. Masota, Knut Ohlsen, Lorenz Meinel, Ulrike Holzgrabe
Summary: The ongoing threat of antimicrobial resistance and multidrug-resistant pathogens calls for increased efforts in the search for novel treatment options. This study synthesized a series of gluco-vanillin derivatives and found that compounds containing 2,4- and 3,5-dichlorophenylamino group coupled to a glucovanillin moiety exhibited optimum antibacterial activities. These derivatives showed moderate and broad-spectrum activities against reference and multidrug-resistant strains.
Article
Integrative & Complementary Medicine
Farkhonde Karimi, Amir Azadi, Navid Omidifar, Nima Montazeri Najafabady, Fatemeh Mohammadi, Radmehr Kazemi, Ahmad Gholami
Summary: This study aimed to design a new stable formulation of Lactobacillus for overcoming resistant infections. The optimum formulation based on glycerol showed desirable pharmaceutical properties and promising antibacterial potential. This formulation could be a treatment option for antibiotic-resistant species.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Chemistry, Medicinal
Anish Parmar, Rajamani Lakshminarayanan, Abhishek Iyer, Eunice Tze Leng Goh, Tsz Ying To, Joey Kuok Hoong Yam, Liang Yang, Enas Newire, Maria C. Robertson, Stephen H. Prior, Eefjan Breukink, Annemieke Madder, Ishwar Singh
Summary: Teixobactin analogues with simplified structures, consisting of commercially available hydrophobic amino acid residues and various combinations of arginines, showed potent antibacterial activity against a broad range of Gram-positive bacteria, including MRSA and VRE strains. These analogues also demonstrated strong antibiofilm activity against Staphylococcus species associated with chronic infections, providing insights for the synthesis of highly potent Teixobactin analogues to combat resistant bacterial infections and biofilms.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Infectious Diseases
Sophie Reissier, Vincent Cattoir
Summary: Streptogramins, especially pristinamycin, can be considered as potential alternatives for the treatment of Gram-positive infections due to their rapid bactericidal activity and low prevalence of resistance among clinical isolates. Despite the effectiveness of quinupristin-dalfopristin in treating severe Gram-positive bacterial infections demonstrated in several studies, its clinical use remains limited mainly due to poor tolerance.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Infectious Diseases
Evan J. Zasowski, Maryam Ali, Ada Anugo, Nayle Ibragimova, Kierra M. Dotson, Bradley T. Endres, Khurshida Begum, M. Jahangir Alam, Kevin W. Garey
Summary: This study aimed to develop predictive indices for multidrug-resistant organism (MDRO) gut colonization in patients with Clostridioides difficile infection (CDI). They compared the predictive performance of a regression-based risk score with two other simplified risk stratification approaches. The results showed that a simplified approach using prior healthcare exposure and receipt of prior antibiotics was as effective as individual patient/antibiotic risk modeling in identifying patients at risk for MDRO gut colonization.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Microbiology
Fabian Rojas-Larios, Bernardo Alfonso Martinez-Guerra, Luis Esau Lopez-Jacome, Enrique Bolado-Martinez, Maria del Rosario Vazquez-Larios, Maria del Consuelo Velazquez-Acosta, Daniel Romero-Romero, Christian Daniel Mireles-Davalos, Sandra Quintana-Ponce, Jose Manuel Feliciano-Guzman, Jose Miguel Perez-Hernandez, Yoselin Paola Correa-Leon, Eduardo Lopez-Gutierrez, Eduardo Rodriguez-Noriega, Esteban Gonzalez-Diaz, Elena Victoria Choy-Chang, Juan Pablo Mena-Ramirez, Victor Antonio Monroy-Colin, Alfredo Ponce-de-Leon-Garduno, Margarita Alcaraz-Espejel, Laura Karina Aviles-Benitez, Luis Javier Quintanilla-Cazares, Eloisa Ramirez-Alanis, Juan Manuel Barajas-Magallon, Cecilia Padilla-Ibarra, Maria Bertha Ballesteros-Silva, Noe Antonio Atanacio-Sixto, Cecilia Teresita Morales-de-la-Pena, Mario Galindo-Mendez, Talia Perez-Vicelis, Guillermo Jacobo-Baca, Martha Irene Moreno-Mendez, Maria de la Luz Mora-Pacheco, Maricruz Gutierrez-Brito, Xochitl Yadira Sanchez-Godinez, Norberta Vianey Navarro-Vargas, Luz Elena Mercado-Bravo, Alejandro Delgado-Barrientos, Maria Asuncion Santiago-Calderon, Ismelda Lopez-Ovilla, Alejandro Molina-Chavarria, Joaquin Rincon-Zuno, Rafael Franco-Cendejas, Sandra Miranda-Mauricio, Isabel Cristina Marquez-Avalos, Maribel Lopez-Garcia, Lizbeth Soraya Duarte-Miranda, Carlos Miguel Cetina-Umana, Irma Elena Barroso-Herrera-y-Cairo, Laura Isabel Lopez-Moreno, Elvira Garza-Gonzalez
Summary: We analyzed antimicrobial resistance (AMR) data of clinical isolates from 43 centers in Mexico, including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus faecium, and Staphylococcus aureus. The study investigated the site of care, patient age, and clinical specimen type to determine AMR patterns. The findings revealed that ICU patients had the highest AMR in E. coli, K. pneumoniae, and P. aeruginosa isolates, while non-ICU patients had higher AMR in A. baumannii isolates. The oldest age group showed the highest AMR in E. coli, E. faecium, and S. aureus, while the 19-59 age group had the highest AMR in A. baumannii and P. aeruginosa. Additionally, higher AMR was observed in E. coli, K. pneumoniae, and P. aeruginosa isolates from blood specimens, and the most frequently detected carbapenemase-encoding gene in E. coli was blaNDM (84%).
Article
Environmental Sciences
Christiane Schreiber, Nicole Zacharias, Sarah M. Essert, Felix Wasser, Heike Mueller, Esther Sib, Tabea Precht, Marijo Parcina, Gabriele Bierbaum, Ricarda M. Schmithausen, Thomas Kistemann, Martin Exner
Summary: The emergence of antibiotic-resistant clinically relevant facultative pathogenic bacteria in the environment has become a major global health challenge, with standardized methods for detection limited to clinical investigations. By proposing standardized cultivation methods, this study achieved effective detection of clinically-relevant antibiotic resistant bacteria in aquatic environmental samples, enhancing accuracy and efficiency in detection.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Xiaoxi Liu, Sho Tashiro, Yuki Igarashi, Wataru Takemura, Nana Kojima, Takumi Morita, Marina Hayashi, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto
Summary: The study aimed to determine the pharmacokinetic/pharmacodynamic (PK/PD) indices of tedizolid action on vancomycin-resistant enterococci (VRE) and the mechanisms underlying the PK/PD indices differences of tedizolid against VRE and methicillin-resistant Staphylococcus aureus (MRSA). The results showed that tedizolid exhibited bactericidal effects against VRE and MRSA, but the potency and duration varied between the two strains.
PHARMACEUTICAL RESEARCH
(2023)
Article
Infectious Diseases
Anders Skyrud Danielsen, Petter Elstrom, Hanne-Merete Eriksen-Volle, Solveig Hofvind, David W. Eyre, Oliver Kacelnik, Jorgen Vildershoj Bjornholt
Summary: Surveillance has shown an increase in multidrug-resistant organisms (MDROs), even in low-prevalent settings like Norway, including among individuals with cancer. This study aimed to describe the epidemiology of MDROs in cancer patients in Norway from 2008 to 2018 by combining existing data sources. The findings highlight the need for effective infection control and surveillance, as there was an unfavorable trend in the incidence and resistance of Gram-negative bacteria.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Food Science & Technology
David Perez-Boto, Matilde D'Arrigo, Ana Garcia-Lafuente, Daniel Bravo, Aida Perez-Baltar, Pilar Gaya, Margarita Medina, Juan L. Arques
Summary: The presence of Staphylococcus aureus in dry-cured meat-processing facilities was investigated, and it was found that S. aureus was detected in 3.8% of surfaces. The occurrence of S. aureus was higher during processing (4.8%) than after cleaning and disinfection (1.4%). Various sequence types (STs) of S. aureus were identified, and enterotoxin genes and antimicrobial resistance were also observed. The study highlights the potential health risks for consumers due to the presence of S. aureus with virulence determinants and multidrug-resistant strains.
Article
Microbiology
Hui-Hui Yeo, Chung-Wei Shiau, Yu-Hsuan Jao, Tsai-Wen Wan, Hao-Chieh Chiu
Summary: This study found that oleic acid enhances the activity of the antibacterial agent SC5005 against Staphylococcus aureus and MRSA strains. Specifically, cis-form unsaturated fatty acids, such as docosahexaenoic acid (DHA), synergistically increase the potency of SC5005. The combination of SC5005 and DHA can effectively eradicate MRSA planktonic and persister cells, as well as biofilms.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mallika Kumarihamy, Siddharth Tripathi, Premalatha Balachandran, Bharathi Avula, Jianping Zhao, Mei Wang, Maria M. Bennett, Jin Zhang, Mary A. Carr, K. Michael Lovell, Ocean Wellington, Mary E. Marquart, N. P. Dhammika Nanayakkara, Ilias Muhammad
Summary: In this study, a series of novel machaeridiol analogs were synthesized and evaluated for their inhibitory activities against MRSA, VRE, and cancer signaling pathways. Compounds 5 and 11 showed strong antibacterial activity against MRSA, while compound 14 exhibited strong inhibition against cancer signaling pathways.
Article
Biochemistry & Molecular Biology
Viktoria Rungelrath, Frank R. DeLeo
Summary: Staphylococcus aureus is a major cause of bacterial infections worldwide, with resistance to antibiotics and the ability to evade host defenses. Research has identified certain virulence molecules of S. aureus as therapeutic targets. Treatment options for methicillin-resistant S. aureus are limited, highlighting the need for further research to develop new therapies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Arianna I. Celis, Bennett R. Streit, Garrett C. Moraski, Ravi Kant, Timothy D. Lash, Gudrun S. Lukat-Rodgers, Kenton R. Rodgers, Jennifer L. DuBois
Article
Microbiology
Garrett C. Moraski, Yong Cheng, Sanghyun Cho, Jeffrey W. Cramer, Alexander Godfrey, Thierry Masquelin, Scott G. Franzblau, Marvin J. Miller, Jeffery Schorey
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2016)
Article
Chemistry, Multidisciplinary
Arianna I. Celis, George H. Gauss, Bennett R. Streit, Krista Shisler, Garrett C. Moraski, Kenton R. Rodgers, Gudrun S. Lukat-Rodgers, John W. Peters, Jennifer L. DuBois
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Biochemistry & Molecular Biology
Garrett C. Moraski, Lowell D. Markley, Mayland Chang, Sanghyun Cho, Scott G. Franzblau, Chang Hwa Hwang, Helena Boshoff, Marvin J. Miller
BIOORGANIC & MEDICINAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Cheng Ji, Weimin Lin, Garrett C. Moraski, Jane A. Thanassi, Michael J. Pucci, Scott G. Franzblau, Ute Moellmann, Marvin J. Miller
BIOORGANIC & MEDICINAL CHEMISTRY
(2012)
Article
Chemistry, Medicinal
Gustavo P. Silveira, Misael Ferreira, Luciano Fernandes, Garrett C. Moraski, Sanghyun Cho, Changhwa Hwang, Scott G. Franzblau, Marcus M. Sa
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2012)
Article
Chemistry, Medicinal
Garrett C. Moraski, Allen G. Oliver, Lowell D. Markley, Sanghyun Cho, Scott G. Franzblau, Marvin J. Miller
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2014)
Article
Chemistry, Multidisciplinary
Rohit Tiwari, Garrett C. Moraski, Viktor Krchnak, Patricia A. Miller, Mariangelli Colon-Martinez, Eliza Herrero, Allen G. Oliver, Marvin J. Miller
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2013)
Article
Multidisciplinary Sciences
Juliane Ollinger, Mai Ann Bailey, Garrett C. Moraski, Allen Casey, Stephanie Florio, Torey Alling, Marvin J. Miller, Tanya Parish
Article
Multidisciplinary Sciences
Yong Cheng, Garrett C. Moraski, Jeffrey Cramer, Marvin J. Miller, Jeffrey S. Schorey
Article
Chemistry, Medicinal
Garrett C. Moraski, Lowell D. Markley, Jeffrey Cramer, Philip A. Hipskind, Helena Boshoff, Mai A. Bailey, Torey Aing, Juliane Ollinger, Tanya Parish, Marvin J. Miller
ACS MEDICINAL CHEMISTRY LETTERS
(2013)
Article
Biochemistry & Molecular Biology
Nikola Kenjic, Matthew R. Hoag, Garrett C. Moraski, Carol A. Caperelli, Graham R. Moran, Audrey L. Lamb
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Chemistry, Multidisciplinary
Sarah M. Hopfner, Bei Shi Lee, Nitin P. Kalia, Marvin J. Miller, Kevin Pethe, Garrett C. Moraski
Summary: The study discusses the structure-activity-relationships of 22 new N-phenethyl-quinazolin-4-yl-amines targeting cyt-bd, which were synthesized and screened against three mycobacterial strains. Two compounds, 12a and 19a, were found to be more active against all three strains compared to the naturally derived cyt-bd inhibitor aurachin D.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Sarah M. Hopfner, Bei Shi Lee, Nitin P. Kalia, Marvin J. Miller, Kevin Pethe, Garrett C. Moraski
Summary: The study reports the inhibitory activity of a class of thieno[3,2-d]pyrimidin-4-amine compounds against cytochrome bd, and initial analysis of their structure-activity relationship. In experiments, some compounds displayed good inhibitory activity against Mycobacterium tuberculosis.
RSC MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Garrett C. Moraski, Ryan Bristol, Natalie Seeger, Helena I. Boshoff, Patricia Siu-Yee Tsang, Marvin J. Miller
