Article
Medicine, General & Internal
Bingshao Liang, Xiaoyun Liang, Fei Gao, Yan Long, Jialiang Mai, Xiaolan Ai, Jielin Wang, Xiurong Gao, Zhile Xiong, Zhuwei Liang, Chao Zhang, Sitang Gong, Zhenwen Zhou
Summary: This study conducted a survey on nasal colonization of Staphylococcus aureus in 2,375 students from five schools in Guangzhou, China, and found a higher prevalence of S. aureus and MRSA in younger children. Penicillin resistance was most common among S. aureus isolates. Multi-locus sequence typing revealed that CC30, CC45, and CC59 were the most prevalent types in the region for S. aureus.
FRONTIERS IN MEDICINE
(2021)
Article
Microbiology
Mejdi Snoussi, Emira Noumi, Nouha Bouali, Abdulrahman S. S. Bazaid, Mousa M. M. Alreshidi, Hisham N. N. Altayb, Kamel Chaieb
Summary: Whole genome sequencing and annotation were used to study the pathogenicity and dissemination of antibiotic-resistant Staphylococcus species. Multiple drug resistance, antimicrobial resistance genes, and mobile genomic islands were identified in the studied clinical S. aureus strains. Plasmid analysis revealed the presence of resistance genes in different plasmid types. The identification of rare plasmid-mediated mecC-MRSA was also noted in some of the isolates.
Review
Immunology
Brittney D. Gimza, James E. Cassat
Summary: Staphylococcus aureus is a common etiologic agent in osteomyelitis, a prevalent invasive disease. Treatment of this infection is challenging due to antimicrobial resistant strains, antibiotic tolerance in staphylococci, and bone remodeling and destruction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Daiyu Li, Yan Ge, Ning Wang, Yun Shi, Gang Guo, Quanming Zou, Qiang Liu
Summary: In this study, a novel chromosomal multidrug efflux pump (SA09310) was identified and characterized in Staphylococcus aureus. The SA09310 pump is responsible for tetracycline resistance and its efflux activity is blocked by the known efflux pump inhibitor CCCP.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Sebastian C. Herren, Markus Huemer, Claudio T. Acevedo, Alejandro Gomez-Mejia, Federica Andreoni, Srikanth Mairpady Shambat, Barbara Hasse, Reinhard Zbinden, Silvio D. Brugger, Annelies S. Zinkernagel
Summary: Antibiotic-tolerant Staphylococcus aureus poses a great challenge to clinicians and microbiological laboratories, with fast and reliable methods such as the replica plating tolerance isolation system (REPTIS) being urgently required for detection. This system was found to be useful in detecting antibiotic tolerance in clinical microbiological routine diagnostics, with high regrowth observed in antibiotics targeting protein synthesis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Felipe Francisco Tuon, Paula Hansen Suss, Joao Paulo Telles, Leticia Ramos Dantas, Nicolas Henrique Borges, Victoria Stadler Tasca Ribeiro
Summary: Staphylococcus aureus is frequently associated with implant-related infections due to its ability to produce biofilms, which make these infections difficult to treat. The effectiveness of different drugs in inhibiting bacterial growth within the biofilm cannot always be accurately interpreted using routine sensitivity tests. This review provides a comprehensive discussion on the genes involved in biofilm formation, quorum sensing, and antimicrobial activity, aiming to benefit researchers working on optimizing the treatment of S. aureus biofilm-associated infections.
Article
Microbiology
Rui Zhao, Xing Wang, Xinhui Wang, Bingyu Du, Kexin Xu, Faming Zhang, Changhong Jiang, Yanfeng Zhao, Yefei Zhu
Summary: This study investigated the molecular characterization of 77 MRSA isolates recovered from hospitalized patients with bloodstream infections in southern China. The results showed high genetic diversity among the isolates and identified different predominant clones and virulence genes in different patient groups.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Gen Li, Mark J. Walker, David M. P. De Oliveira
Summary: This review discusses the epidemiology of vancomycin-resistant Enterococcus and S. aureus in healthcare, community, and agricultural settings, explores vancomycin resistance in the context of van and non-van mediated resistance development, and provides insights into alternative therapeutic approaches aimed at treating drug-resistant Enterococcus and S. aureus infections.
Article
Microbiology
Shiqi Liu, Yixuan Huang, Sean Jensen, Paul Laman, Gertjan Kramer, Sebastian A. J. Zaat, Stanley Brul
Summary: This study reveals the stress-specific nature of persisters and emphasizes the necessity of tailored treatment approaches and the potential of combined therapy.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
J. Jayakumar, V. A. Kumar, L. Biswas, R. Biswas
Summary: Staphylococcus aureus causes various infections and the development of effective anti-staphylococcal agents, such as lysostaphin, is crucial. However, issues with immunogenicity and bio-availability hinder its clinical application.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Infectious Diseases
Mikaeel Young, Danica J. Walsh, Elysia Masters, Vijay Singh Gondil, Emily Laskey, Michael Klaczko, Hani Awad, James McGrath, Edward M. Schwarz, Christian Melander, Paul M. Dunman
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a global healthcare concern. Recent studies have shown that penicillin binding protein 4 (PBP4) is also involved in MRSA resistance. Inhibitors targeting PBP4 may reverse methicillin resistance and inhibit MRSA's ability to cause chronic osteomyelitis.
Article
Infectious Diseases
Danilo Buonsenso, Martina Giaimo, Davide Pata, Alessia Rizzi, Barbara Fiori, Teresa Spanu, Antonio Ruggiero, Giorgio Attina, Marco Piastra, Orazio Genovese, Giovanni Vento, Simonetta Costa, Eloisa Tiberi, Maurizio Sanguinetti, Piero Valentini
Summary: The study focuses on Staphylococcus aureus infection in children, analyzing its antibiotic resistance profile and therapeutic management. The results show high resistance rates to cephalosporins, aminoglycosides, and fluoroquinolones, but no resistance to glycopeptides. Age, presence of devices, and comorbidities are identified as major risk factors associated with antibiotic resistance. Understanding the resistance patterns helps to target therapy effectively while following the principles of antibiotic stewardship is crucial in limiting the spread of antibiotic resistance.
Article
Infectious Diseases
Itziar Diego-Yague, Alberto Mora-Vargas, Jose Manuel Vazquez-Comendador, Beatriz Santamarina-Alcantud, Ana Fernandez-Cruz, Elena Munez-Rubio, Andrea Gutierrez-Villanueva, Isabel Sanchez-Romero, Victor Moreno-Torres, Antonio Ramos-Martinez, Jorge Calderon-Parra
Summary: Oral sequential therapy (OST) in uncomplicated Staphylococcus aureus bacteraemia (SAB) is found to be safe and effective, reducing mortality and microbiological failure.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Infectious Diseases
Nazneen Jahan, Timothy Patton, Meredith O'Keeffe
Summary: Staphylococcus aureus is a pathogenic bacterium that produces a wide range of factors to enhance its invasiveness and resistance to immune attack. The increasing antibiotic resistance of S. aureus poses a challenge to immune protection. Dendritic cells play a central role in inducing immune protection against S. aureus, but the interaction between S. aureus and dendritic cells is disrupted by antibiotic resistance.
Article
Microbiology
Oren Gordon, Dustin A. Dikeman, Roger Ortines, Yu Wang, Christine Youn, Mohammed Mumtaz, Nicholas Orlando, Jeffrey Zhang, Aman Patel, Ethan Gough, Amit Kaushik, Eric L. Nuermberger, Anna M. Upton, Nader Fotouhi, Lloyd S. Miller, Nathan K. Archer
Summary: Staphylococcus aureus is a major cause of bloodstream, skin, and bone infections in humans. The emergence of drug-resistant strains increases the difficulty in treating these infections. This study compared the efficacy of a novel oxazolidinone antibiotic, TBI-223, with linezolid in mouse models of MRSA infection. TBI-223 showed comparable efficacy to linezolid in reducing bacterial burden and disease severity in all three models.
MICROBIOLOGY SPECTRUM
(2022)
