期刊
JOURNAL OF ANTIBIOTICS
卷 63, 期 6, 页码 303-308出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2010.35
关键词
aqabamycins A-G; aromatic nitro compounds; indazoles; maleimide-5-oxime; marine Vibrio sp.
资金
- German Ministry of Education and Research (BMBF) [03F0348A]
The structures of secondary metabolites with antibacterial and cytotoxic activities produced by a marine Vibrio strain from the Red Sea were elucidated. Aqabamycin A (1a) and seven further nitro-substituted maleimide derivates named aqabamycins B-G (1b-f and 2) were obtained together with 12 known metabolites, 3-nitro-1H-indazole (3), indazole-3-carbaldehyde (4), 3-nitro-4-hydroxycinnamic acid, 4-hydroxycinnamic acid, 3-nitro-4-hydroxybenzaldehyde, phenyl-2-bis-indolylmethane (5a), turbomycin B (5b), vibrindole A (6), phenylacetic acid, 3-hydroxybenzoic acid, benzoic acid and 1,4-dithiane (7). Some of the known metabolites (for example, 3, 4 and 7) are described in this study for the first time as natural products. Their structures were elucidated based on 1D and 2D NMR, MS spectra and by comparison with synthetic material. The Journal of Antibiotics (2010) 63, 303-308; doi:10.1038/ja.2010.35; published online 30 April 2010
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