期刊
JOURNAL OF ANTIBIOTICS
卷 61, 期 1, 页码 1-6出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2008.101
关键词
cyslabdan; imipenem potentiator; methicillin-resistant; Staphylococcus aureus; MRSA; structural elucidation
Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, was isolated from the culture broth of Streptomyces sp. K04-0144 by Diaion HP-20 and ODS column chromatographies and preparative HPLC. The structure of cyslabdan was elucidated by spectroscopic analyses including NMR. The compound has a labdane-type diterpene skeleton connecting with an N-acetyleysteine via thioether linkage.
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