Article
Agriculture, Dairy & Animal Science
L. Dong, H. M. Li, S. N. Wang, T. L. Wang, L. H. Yu, H. R. Wang
Summary: The study found that Meishan neonatal piglets had lower birth weights but higher intestinal barrier function compared to crossbred piglets, showing greater disease resistance and antioxidant enzyme activity.
Article
Biochemistry & Molecular Biology
Hao Zhang, Ping Zheng, Daiwen Chen, Bing Yu, Jun He, Xiangbing Mao, Jie Yu, Yuheng Luo, Junqiu Luo, Zhiqing Huang, Hui Yan
Summary: The study showed that (L)-arginine has beneficial effects on low-birth-weight piglets by enhancing antioxidant capacity and improving mitochondrial functions to alleviate intestinal dysfunction, but has no significant effects on intestinal health in normal-birth-weight piglets.
Article
Nutrition & Dietetics
Shiyu Tao, Yi Xiong, Zhenyu Wang, Yujun Wu, Na Li, Yu Pi, Dandan Han, Jiangchao Zhao, Junjun Wang
Summary: The study revealed that LBW piglets had lower microbial diversity in the intestines compared to NBW piglets, while exhibiting higher concentrations of 3OC12-HSL which was negatively correlated with specific microbial populations.
JOURNAL OF NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
Jiaojiao Chen, Yi Song, Daiwen Chen, Bing Yu, Jun He, Xiangbing Mao, Zhiqing Huang, Junqiu Luo, Jie Yu, Yuheng Luo, Hui Yan, Ping Zheng
Summary: Low birth-weight (LBW) piglets exhibit abnormal development of the small intestine, characterized by decreased length and weight, decreased villus height/crypt depth index in the jejunum, and reduced gene expression of tight junction proteins, antioxidant enzymes, and mitochondrial-related genes. These abnormalities may be caused by impaired morphology and functions of mitochondria in the jejunum.
Article
Nutrition & Dietetics
Xiangyu Zhang, Yujun Wu, Xiaoyi Liu, Xu Lin, Yisi Liu, Luyuan Kang, Hao Ye, Zhenyu Wang, Yingying Ma, Zhaolai Dai, Dongsheng Che, Yu Pi, Lianqiang Che, Junjun Wang, Dandan Han
Summary: This study investigates the role of macrophages in intestinal inflammation in low-birth-weight piglets and mice. The results show that genes involved in intestinal barrier function and inflammatory cytokines are dysregulated in low-birth-weight animals. Macrophages are polarized towards a pro-inflammatory phenotype, contributing to intestinal inflammation.
JOURNAL OF NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Grace Yoon, Laurie A. Davidson, Jennifer S. Goldsby, Destiny A. Mullens, Ivan Ivanov, Sharon M. Donovan, Robert S. Chapkin
Summary: The study compared the transcriptional profiles of exfoliated cells with that of the ileal and colonic mucosa, finding that exfoliated cells in the distal colon may reflect mucosal signatures of more proximal regions of the gut.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Editorial Material
Biology
Stephanie M. Holm, John Balmes
Summary: Pollution from landscape fires, increasing due to climate change, leads to lower birthweights in babies in low- and middle-income countries.
Article
Fisheries
Michal Stosik, Beata Tokarz-Deptula, Wieslaw Deptula
Summary: The paper discusses the issue of intestinal mucosa immunity in teleost fish. The organization and functional properties of the elements that determine this immunity are reviewed according to current data. The knowledge of intestinal mucosal immunity in teleost fish has great potential for practical applications in the field of epidemiological safety.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Chen Yuan, Penghao Zhang, Yuxin Jin, Abid Ullah Shah, En Zhang, Qian Yang
Summary: This study compared the morphological and immunological differences in the small intestine of neonatal and weaned piglets, revealing that the small intestine of weaned piglets had better structure and immune components compared to neonatal piglets, which could help prevent intestinal infectious diseases.
Article
Nutrition & Dietetics
Zeyang Li, Quentin L. Sciascia, Solvig Goers, Nga Nguyen, Farahnaz Rayatdoost Baghal, Johannes Schregel, Armin Tuchscherer, Juergen Zentek, Cornelia C. Metges
Summary: This study found that neonatal glutamine supplementation can improve growth and milk intake in low birth weight piglets, and also affect lipid and amino acid metabolism.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Agriculture, Dairy & Animal Science
Michael O. Wellington, Lucas A. Rodrigues, Qiao Li, Bingqi Dong, Josiane C. Panisson, Chengbo Yang, Daniel A. Columbus
Summary: The study found that birth weight and nutrient utilization affect intestinal development in neonatal pigs. Low birth weight may lead to reduced feed intake and further impairment of intestinal development. Birth weight had a greater impact on intestinal development in the early stages, while nutrient level became significant later on.
Article
Virology
Chen Yuan, Yuchen Li, En Zhang, Yuxin Jin, Qian Yang
Summary: PEDV can survive in blood-derived CD3(+) T cells for several hours and prefers CD4(+) T cells over CD8(+) T cells. Viral transmission is mediated by cell-to-cell contact between mesenteric lymph-node-derived CD3(+) T cells, but not in blood-derived CD3(+) T cells.
Article
Veterinary Sciences
Yue Wang, Yusheng Qin, Wei Zhao, Fusheng Yao, Wenjing Wang, Xiao Hu, Linghua Cheng, Lei An, Jianhui Tian
Summary: Sildenafil dietary supplementation improves the reproductive performance of sows and gilt and enhances the growth performance of neonatal piglets. Sildenafil supplementation during the mid-to-late gestation period shows the most significant improvement in litter performance.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Engineering, Biomedical
Rebecca Donahue, Jugal Kishore Sahoo, Sara Rudolph, Ying Chen, David L. Kaplan
Summary: Mucus is a hydrogel that protects the body's surfaces and plays a role in defense against pathogens. Dysfunction of the gut mucus barrier is associated with diseases. Current methods for studying mucus have limitations. Therefore, there is a need for mucus-mimetic hydrogels that accurately reflect the human epithelial environment for research on disease and microbiome interactions.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Agriculture, Dairy & Animal Science
Bryony S. Tucker, Kiro R. Petrovski, Jessica R. Craig, Rebecca S. Morrison, Robert J. Smits, Roy N. Kirkwood
Summary: Piglets experience a significant temperature drop after birth, and the time taken to recover can affect their survival and growth. Rectal temperature is currently the best method for monitoring temperature, but it is invasive and stressful. This study investigated the use of infrared measurements of surface temperature as a substitute for rectal temperature in piglets. The results showed that surface temperature had a similar pattern to rectal temperature but was greatly influenced by the environment and cannot be recommended as a complete replacement for rectal temperature measurement.
Article
Rehabilitation
An De Groef, Ann Hallemans, Nick Gebruers, Jill Meirte, Wim Saeys, Steven Truijen, Vincent Haenen, Charlotte Johnson, Lotte Meert, Lies Peeters, Erik Fransen, Mira Meeus, Lies Durnez
Summary: The study investigates the impact of the COVID-19 lockdown measures on the general health status of patients with chronic health conditions in Belgium. The results show that a significant number of adults and children reported a worsening of their health status during the lockdown. Negative personal factors and unhelpful health behavior were associated with a worse health status.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Agriculture, Dairy & Animal Science
Kevin Van Tichelen, Sara Prims, Miriam Ayuso, Celine Van Kerschaver, Mario Vandaele, Jeroen Degroote, Steven Van Cruchten, Joris Michiels, Chris Van Ginneken
Summary: This study evaluated the effects of orally supplementing different bioactive compounds on the resilience and survival of low birth weight piglets. The results showed that the evaluated compounds, at the given dosages, were unable to improve the parameters and even had a negative effect on survival in piglets supplemented with short-chain fructo-oligosaccharides.
Article
Biology
Aleksandra Nijak, Eline Simons, Bert Vandendriessche, Dieter Van de Sande, Erik Fransen, Ewa Sieliwonczyk, Ilse Van Gucht, Emeline Van Craenenbroeck, Johan Saenen, Hein Heidbuchel, Peter Ponsaerts, Alain J. Labro, Dirk Snyders, Winnok De Vos, Dorien Schepers, Maaike Alaerts, Bart L. Loeys
Summary: Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) are a valuable tool for cardiovascular research. This study evaluated two protocols for differentiating iPSCs into cardiomyocytes and found that both protocols resulted in a high percentage of differentiated cells with typical cardiac characteristics. One protocol showed better accessibility for experiments and expressed more cardiac-specific markers.
Article
Substance Abuse
Tim Boogaerts, Maarten Quireyns, Maarten De Prins, Bram Pussig, Hans De Loof, Catharina Mathei, Bert Aertgeerts, Virginie Van Coppenolle, Erik Fransen, Adrian Covaci, Alexander L. N. van Nuijs
Summary: This study examined the changes in stimulant use during the first wave of the COVID-19 pandemic in Belgium using wastewater-based epidemiology (WBE). The results showed an increase in amphetamine and cocaine use during the lockdown period, while the consumption of MDMA remained stable. The study suggests that strict restrictive measures had limited impact on stimulant consumption.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2022)
Correction
Clinical Neurology
Elise Van Breedam, Aleksandra Nijak, Tamariche Buyle-Huybrecht, Julia Di Stefano, Marlies Boeren, Jonas Govaerts, Alessandra Quarta, Tine Swartenbroekx, Eva Z. Jacobs, Bjorn Menten, Rik Gijsbers, Peter Delputte, Maaike Alaerts, Behrouz Hassannia, Bart Loeys, Zwi Berneman, Jean-Pierre Timmermans, Philippe G. Jorens, Tom Vanden Berghe, Erik Fransen, An Wouters, Winnok H. De Vos, Peter Ponsaerts
Article
Environmental Sciences
Rafael R. Maes, Geert Potters, Erik Fransen, Rowan Van Schaeren, Silvia Lenaerts
Summary: Air pollution caused by transportation contributes to the major risk of air quality to human health worldwide. Adding oxygenated compounds into diesel fuel can effectively reduce the content of nitrogen oxides and particulate matter in exhaust gases. Methanol shows the best performance in reducing NO content by 56%, isopropanol reduces NO2 by 50%, and ethanol decreases PM by 63%. However, adding alcohols to biodiesel did not improve NOx emissions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Catho Schoenmaekers, Chloe De Laet, Ludmila Kornilova, Dmitrii Glukhikh, Steven Moore, Hamish MacDougall, Ivan Naumov, Erik Fransen, Leander Wille, Steven Jillings, Floris L. Wuyts
Summary: Otoliths, as primary gravity sensors, play a crucial role in controlling ocular counter-roll (OCR) and gaze stabilization. Prolonged spaceflight has been found to decrease OCR, particularly in first-time flyers. However, experienced cosmonauts exhibit better adaptation after G-transitions.
Article
Agriculture, Dairy & Animal Science
Kevin Van Tichelen, Sara Prims, Miriam Ayuso, Lieselotte Van Bockstal, Celine Van Kerschaver, Mario Vandaele, Jeroen Degroote, Steven Van Cruchten, Joris Michiels, Chris Van Ginneken
Summary: The increase in litter sizes of sows over the past three decades has resulted in higher proportions of low birth weight piglets and increased pre-weaning mortality. This study investigated the use of a dense milk replacer to improve the performance of low birth weight piglets. The results showed no significant effect of the milk replacer on the survival or performance of the piglets, suggesting that perinatal management is more important for their survival than supplementation.
Article
Surgery
Valerie Verkest, Laura Pingnet, Galathea Van Hout, Erik Fransen, Frank Declau
Summary: The study aimed to evaluate the aesthetic and functional outcomes of patients treated with dorsal T-bar preservation (TDP) versus dorsal split component reduction (SCR). The results showed similar aesthetic outcomes between both techniques after 6 months postoperatively. However, the functional outcomes in the TDP group were comparable to the SCR group at 6 months postoperatively. In conclusion, TDP is a versatile cartilage-sparing method that allows for aesthetic adaptation of the middle vault without compromising the keystone area.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Pharmacology & Pharmacy
Allan Valenzuela, Miriam Ayuso, Laura Buyssens, Chloe Bars, Chris Van Ginneken, Yann Tessier, Steven Van Cruchten
Summary: This study evaluated the effects of various ASO sequences and modifications on platelets in adult and juvenile Gottingen minipigs. The results were compared to human data and showed remarkable similarities, validating the use of Gottingen minipigs for ASO safety testing. The differential abundance of GPVI and PF4 in minipigs provides insight into ASO-induced thrombocytopenia in pediatric patients.
Review
Biochemistry & Molecular Biology
Karen Leys, Marina-Stefania Stroe, Pieter Annaert, Steven Van Cruchten, Sebastien Carpentier, Karel Allegaert, Anne Smits
Summary: Perinatal asphyxia (PA) continues to have significant morbidity and mortality rates. Therapeutic hypothermia (TH) is the only effective treatment for neonates with moderate to severe hypoxic-ischemic encephalopathy after PA. Additional pharmacotherapy may be necessary for these neonates, and both PA and TH can affect physiology and, consequently, pharmacokinetics (PK) and pharmacodynamics (PD).
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Article
Hematology
Valerie-Anne Chantrain, Anthe Foubert, Mira Meeus, Catherine Lambert, Sebastien Lobet, Philip Maes, Erik Fransen, Lies Durnez, Cedric Hermans, Nathalie Anne Roussel
Summary: This study compared joint status, pain, and health-related quality of life (HR-QoL) between elderly individuals with mild, moderate/severe haemophilia and healthy elderly individuals. The results showed that moderate/severe haemophilia patients had worse joint status, higher pain severity, and poorer HR-QoL compared to mild haemophilia patients and healthy individuals. Some mild haemophilia patients also showed joint abnormalities, pain, functional limitations, and poor HR-QoL, but did not significantly differ from healthy controls.
Article
Medicine, Research & Experimental
Bart's Jongers, An Hotterbeekx, Kenny Bielen, Philippe Vervliet, Jan Boddaert, Christine Lammens, Erik Fransen, Geert Baggerman, Adrian Covaci, Herman Goossens, Surbhi Malhotra-Kumar, Philippe G. Jorens, Samir Kumar-Singh
Summary: In mechanically ventilated patients, there are significant differences in urine metabolites between VAP-PA and VAP caused by other bacteria as well as non-VAP timepoints. We have identified 3 highly upregulated and highly specific metabolites in VAP-PA that are completely absent in pre-infection timepoints and the VAP-non-PA group.
BIOMARKER INSIGHTS
(2022)