Article
Veterinary Sciences
Haihua Li, Xuejiao Liu, Zhiyuan Shang, Jiayun Qiao
Summary: This study demonstrated that probiotic Clostridium butyricum attenuates inflammation induced by enterotoxigenic Escherichia coli by regulating intestinal villi injury and the activation of the toll-like receptor signaling pathway.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Environmental Sciences
Andong Zha, Ruiqi Tu, Ming Qi, Jing Wang, Bie Tan, Peng Liao, Chenchen Wu, Yulong Yin
Summary: The study showed that dietary supplementation of MOSS had beneficial effects on ETEC-induced diarrhea in weaned piglets, increasing growth performance, reducing diarrhea incidence, and regulating intestinal microbiota composition. MOSS also decreased inflammation and oxidative stress, and improved intestinal barrier function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Microbiology
Mohamed Rhouma, Charlotte Braley, William Theriault, Alexandre Thibodeau, Sylvain Quessy, Philippe Fravalo
Summary: The study revealed that the ETEC:F4 strain challenge significantly affected the diversity and composition of piglet fecal microbiota, while treatment with colistin sulfate only reduced the populations of E. coli/Shigella during the treatment period.
Article
Agriculture, Dairy & Animal Science
Zhezhe Tian, Jiaming Chen, Tongbin Lin, Junhua Zhu, Haoyang Gan, Fang Chen, Shihai Zhang, Wutai Guan
Summary: Lysozyme-cinnamaldehyde conjugates (LC) supplementation showed positive effects in treating piglets infected with enterotoxigenic Escherichia coli (ETEC). LC diet reduced rectal temperature and fecal scores, improved intestinal barrier and immune function, decreased inflammation, and enhanced intestinal microbiota diversity.
Article
Multidisciplinary Sciences
Justin X. Boeckman, Sarah Sprayberry, Abby M. Korn, Jan S. Suchodolski, Chad Paulk, Kenneth Genovese, Raquel R. Rech, Paula R. Giaretta, Anna K. Blick, Todd Callaway, Jason J. Gill
Summary: Post-weaning enteropathies in swine caused by pathogenic E. coli, such as post-weaning diarrhea (PWD) or edema disease (ED), continue to be a significant concern for the swine industry. This study aimed to induce clinical signs of post-weaning disease in a piglet model using different doses of a pathogenic E. coli strain and evaluated various markers to monitor the disease state. The findings suggest that chronic dosing with a lower pathogen dose can mimic acute dosing, indicating that high pathogen doses may not be necessary for disease induction in the piglet model.
SCIENTIFIC REPORTS
(2022)
Article
Veterinary Sciences
Xinyu Mao, Yuxing Wu, Runwen Ma, Lei Li, Leping Wang, Yizhou Tan, Ziyong Li, Hui Liu, Kaiou Han, Yajie Cao, Yinan Li, Hao Peng, Xun Li, Chuanhuo Hu, Xiaoye Wang
Summary: The study found that oral microencapsulated phage A221 had a good therapeutic effect on bacterial diarrhea in weaned piglets infected with E. coli. It significantly increased the daily weight gain of piglets, reduced the bacterial load of tissues and intestinal lesions.
BMC VETERINARY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuankang Zhou, Yuheng Luo, Bing Yu, Ping Zheng, Jie Yu, Zhiqing Huang, Xiangbing Mao, Junqiu Luo, Hui Yan, Jun He
Summary: The study found that dietary beta-glucan (BGL) supplementation has a protective effect on intestinal epithelium exposed to enterotoxigenic Escherichia coli (ETEC). BGL supplementation improves intestinal absorption, reduces inflammation, enhances intestinal immunity and antioxidant capacity, and improves intestinal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Kwangwook Kim, Minho Song, Yanhong Liu, Peng Ji
Summary: Enterotoxigenic Escherichia coli (ETEC) infection-induced post-weaning diarrhea is a major health issue in newly weaned pigs, leading to the overuse of antimicrobial drugs. Nutritional intervention is an effective alternative practice to reduce reliance on antibiotics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Juan Xu, Zhen Jia, Shu Xiao, Cimin Long, Leli Wang
Summary: This study aimed to investigate the effects of pathogenic enterotoxigenic Escherichia coli (ETEC) on growth performance, jejunal microbial profile, jejunal morphology, and goblet cell distribution in weaning piglets. The results showed that the ETEC challenge resulted in decreased growth performance and increased diarrhea rate in the piglets. The jejunum was found to be the main segment of the intestine that was affected by ETEC, with changes in goblet cell distribution. Furthermore, the ETEC group had alterations in the microbial composition in their intestines.
Review
Microbiology
Tanya J. Laird, Sam Abraham, David Jordan, John R. Pluske, David J. Hampson, Darren J. Trott, Mark O'Dea
Summary: Enterotoxigenic Escherichia coli (ETEC) strains causing post-weaning diarrhoea (PWD) in piglets have developed resistance to traditional antimicrobials, leading to a shift towards newer antimicrobials of higher public health significance. Studies on bacteriophage therapy, probiotics, and postbiotics have shown promise as alternative treatments for ETEC infection in pigs.
VETERINARY MICROBIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Seong-Won Lee, Chang-Min Jung, Kyung-Hyo Do, Wan-Kyu Lee, Kwang-Won Seo
Summary: This study aimed to determine how the route of antimicrobial administration affected the growth performance of weaned piglets. The results showed that administering antimicrobials through drinking water is advantageous for pig farming, and the route of administration did not significantly affect antimicrobial resistance rates.
Article
Biochemical Research Methods
L. H. B. Hansen, B. Nielsen, E. J. Boll, L. Skjot-Rasmussen, A. Wellejus, L. Jorgensen, C. Lauridsen, N. Canibe
Summary: The findings suggest that when selecting probiotic strains for suckling piglets as a prophylactic strategy towards post-weaning diarrhea, it is advantageous to choose a multi-species product including strains with different modes of action in order to increase the likelihood of achieving beneficial effects in vivo.
JOURNAL OF MICROBIOLOGICAL METHODS
(2021)
Article
Microbiology
Cynthia Jinno, Xunde Li, Yanhong Liu
Summary: This study aimed to characterize the effects of ETEC infection, supplementing B. subtilis DSM 25841, or carbadox on intestinal microbiota of pigs. The results indicated that AGP reduced the relative abundance of beneficial bacteria in the intestines, while DFM had higher relative abundance of beneficial bacteria in some intestinal segments.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Kevin Jerez-Bogota, Martin Jensen, Ole Hojberg, Paul Cormican, Peadar G. Lawlor, Gillian E. Gardiner, Nuria Canibe
Summary: Antibiotic and zinc oxide restrictions have prompted the search for alternatives to combat intestinal pathogens, such as enterotoxigenic Escherichia coli (ETEC), which causes postweaning diarrhea (PWD) in pigs. This study found that dietary supplementation with garlic and apple pomace or blackcurrant can limit ETEC proliferation, reduce PWD, and positively affect the fecal microbiota's diversity, composition, and stability.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Microbiology
Cynthia Jinno, Kwangwook Kim, Braden Wong, Emma Wall, Ravichandran Sripathy, Yanhong Liu
Summary: The objective of this study was to investigate the effects of supplementation of botanical blends (BB) on the gut microbiota and metabolomic profiles in pigs infected with Escherichia coli. The results showed that supplementing 100 ppm BB1 increased the relative abundances of Enterobacteriaceae and Escherichia-Shigella in the ileum, and the relative abundances of Bacteroidota and Prevotellaceae in the cecum. Supplementing 100 ppm BB2 upregulated serum pinitol on day 4 post-inoculation and serum cholesterol and aminomalonic acids on day 21 post-inoculation. Addition of 50 ppm BB2 reduced asparagine in the ileal mucosa on day 5 post-inoculation.
Meeting Abstract
Peripheral Vascular Disease
Ruozhi Zhao, Ehsan Khafipour, Shadi Sepehri, Trust Beta, Garry X. Shen
ATHEROSCLEROSIS SUPPLEMENTS
(2018)
Article
Multidisciplinary Sciences
S. P. Ndou, H. M. Tun, E. Kiarie, M. C. Walsh, E. Khafipour, C. M. Nyachoti
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
T. G. Kiros, H. Derakhshani, E. Pinloche, R. D'Inca, Jason Marshall, E. Auclair, E. Khafipour, A. van Kessel
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Rachelle N. M. Govia, Kenzie D. Birse, Shadi Sepehri, Ehsan Khafipour, Savas M. Menticoglou, Adam D. Burgener, Vanessa Poliquin
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2018)
Article
Agriculture, Dairy & Animal Science
J. C. Plaizier, M. Danesh Mesgaran, H. Derakhshani, H. Golder, E. Khafipour, J. L. Kleen, I. Lean, J. Loor, G. Penner, Q. Zebeli
Article
Agriculture, Dairy & Animal Science
Seyed Mohsen Hosseini, Mohsen Danesh Mesgaran, Ali Reza Vakili, Abbas Ali Naserian, Ehsan Khafipour
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
(2019)
Review
Pediatrics
Shirin Moossavi, Kozeta Miliku, Shadi Sepehri, Ehsan Kha Fi Pour, Meghan B. Azad
FRONTIERS IN PEDIATRICS
(2018)
Article
Microbiology
Shirin Moossavi, Shadi Sepehri, Bianca Robertson, Lars Bode, Sue Goruk, Catherine J. Field, Lisa M. Lix, Russell J. de Souza, Allan B. Becker, Piushkumar J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Theo J. Moraes, Diana L. Lefebvre, Malcolm R. Sears, Ehsan Khafipour, Meghan B. Azad
CELL HOST & MICROBE
(2019)
Article
Microbiology
Ruidong Mi, Rakesh Patidar, Annemieke Farenhorst, Zhangbin Cai, Shadi Sepehri, Ehsan Khafipour, Ayush Kumar
FEMS MICROBIOLOGY LETTERS
(2019)
Article
Microbiology
Elnaz Azad, Kelsey B. Fehr, Hooman Derakhshani, Robert Forster, Surya Acharya, Ehsan Khafipour, Emma McGeough, Tim A. McAllister
Article
Microbiology
J. C. Plaizier, P. Azevedo, B. L. Schurmann, P. Gorka, G. B. Penner, E. Khafipour
Article
Agriculture, Dairy & Animal Science
Jan C. Plaizier, Anne-Mette Danscher, Paula A. Azevedo, Hooman Derakhshani, Pia H. Andersen, Ehsan Khafipour
Summary: High-yielding dairy cows require high-grain diets to meet their energy demands, but excessive grain feeding can lead to subacute ruminal acidosis (SARA) and disrupt the taxonomic composition and functionality of the microbial populations in the digestive tract. Our study found that SARA altered the populations of various bacterial taxa attached to the epithelia in the digestive tract, potentially reducing the beneficial effects of these bacteria and increasing the risk of pathogenic invasion. The effects of SARA were most pronounced in the rumen and large intestine, with differing impacts on the small intestine, highlighting the need for further research on the consequences of dysbiosis caused by SARA.
Article
Agriculture, Dairy & Animal Science
J. Guo, L. Xu, H. Khalouei, K. Fehr, V. Senaratne, J. E. Ghia, I. Yoon, E. Khafipour, J. C. Plaizier
Summary: Subacute ruminal acidosis (SARA) is a metabolic disorder in dairy cows that is associated with dysbiosis of rumen and hindgut microbiomes, translocation of immunogenic compounds from the gut lumen into blood circulation, and systemic inflammatory response. This study found that Saccharomyces cerevisiae fermentation products (SCFP) can attenuate the inflammation resulting from SARA episodes by stabilizing the rumen environment and reducing proinflammatory status.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Nutrition & Dietetics
Shirin Moossavi, Faisal Atakora, Kozeta Miliku, Shadi Sepehri, Bianca Robertson, Qing Ling Duan, Allan B. Becker, Piushkumar J. Mandhane, Stuart E. Turvey, Theo J. Moraes, Diana L. Lefebvre, Malcolm R. Sears, Padmaja Subbarao, Catherine J. Field, Lars Bode, Ehsan Khafipour, Meghan B. Azad
FRONTIERS IN NUTRITION
(2019)
Article
Multidisciplinary Sciences
E. Azad, H. Derakhshani, R. J. Forster, R. J. Gruninger, S. Acharya, T. A. McAllister, E. Khafipour
SCIENTIFIC REPORTS
(2019)