Article
Agriculture, Dairy & Animal Science
Hamada Elwan, Chao Xie, L. P. Miao, Xinyang Dong, Xiao-ting Zou, Mohamed Mohany, Mohammed M. Ahmed, Salim S. Al-Rejaie, S. S. Elnesr
Summary: In ovo injection of Met provides a promising method to reduce embryotoxicity caused by AFB1 in broiler chicks. It enhances liver and kidney functions, reduces oxidative stress, and significantly affects key gene expressions, ultimately leading to less apoptotic cells in liver tissues.
Article
Biochemistry & Molecular Biology
Shuang Gu, Chaoliang Wen, Junying Li, Honghong Liu, Qiang Huang, Jiangxia Zheng, Congjiao Sun, Ning Yang
Summary: This study selected four different breeds of chickens to investigate the temporal expression patterns of key regulatory genes during embryonic muscle development, providing a foundation for understanding the regulation mechanisms. The highest expression level of Myomaker, a crucial gene for myoblast fusion, occurred from embryonic days 13 to 15, with Cornish breed showing the highest expression level. The MYOD gene may play an important role after hatching. Histomorphology analysis suggested that the myofibers were largely complete by embryonic day 17 due to increased expression of MSTN and decreased expression of Myomaker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Panpan Lu, Thanidtha Morawong, Amonrat Molee, Wittawat Molee
Summary: This study evaluated the effects of in ovo feeding of L-arginine on breast muscle weight, muscle morphology, amino acid profile, and gene expression of muscle development in slow-growing chickens. The results showed that in ovo feeding did not affect breast muscle weight and muscle morphology, but did alter amino acid profile and gene expression.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
S. Yalcin, M. Aksit, S. Ozkan, M. Hassanzadeh, G. Bilgen, I. B. Helva, G. T. Izzetoglu, J. Buyse, M. C. Yilmaz
Summary: The study found that increasing the incubation temperature can increase the body weight and fiber area of broiler chickens, reduce plasma triacylglycerol levels, but have different effects on the expression of vascular endothelial growth factor A and myogenin genes, as well as meat quality.
BRITISH POULTRY SCIENCE
(2022)
Article
Cell Biology
Bodor Fallatah, Muhammad Shuaib, Sabir Adroub, Andreu Paytuvi-Gallart, Francesco Della Valle, Seba Nadeef, Chiara Lanzuolo, Valerio Orlando
Summary: This study elucidates the role of Ago1 in skeletal muscle differentiation, showing that it directly controls global H3K27 acetylation and eRNA-CBP interactions to support enhancer-driven gene activation. Specifically required for MyoD and downstream myogenic gene activation, Ago1 depletion leads to failure of CBP acetyltransferase activation and blocking of the myogenic program, establishing its role in epigenome regulation and developmental programs.
Article
Biochemical Research Methods
Isabelle Bichindaritz, Guanghui Liu, Christopher Bartlett
Summary: The study proposes an adaptive multi-task learning method for survival prediction of breast cancer patients using multi-modal learning, achieving more effective results compared to existing approaches. By combining different gene features, reducing dimensions, and introducing auxiliary loss, an ordinal Cox hazards model is built to predict patients' survival risk.
Article
Agriculture, Dairy & Animal Science
Craig W. Maynard, Elizabeth Gilbert, Frances Yan, Mark A. Cline, Sami Dridi
Summary: This study investigated the effects of DL-methionine (DL-Met), 2-hydroxy-4-(methylthio)butanoic acid (HMTBa), and S-(5'-adenosyl)-L-methionine chloride (SAM) on growth performance, plasma metabolites, and hypothalamic neuropeptide expression in broilers. The results showed that DL-Met and HMTBa share a common downstream pathway (ORX), but also have different central pathways (NPY-MCT for HMTBa and mTOR-AMPK for methionine).
Article
Agriculture, Dairy & Animal Science
Kimberly B. Wellmann, Jongkyoo Kim, Phil M. Urso, Zachary K. Smith, Bradley J. Johnson
Summary: The experiment examined changes in myogenic gene expression and muscle fiber characteristics with different dietary vitamin A supplementation levels, and the results suggest that these changes are independent of the vitamin A status in yearling cattle.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Sandra G. Velleman
Summary: The structure of the broiler breast muscle has changed in modern commercial broilers, with increased muscle fiber diameters, decreased circulatory supply, and decreased connective spacing between fibers. Satellite cells, responsible for muscle growth and repair, have been found to undergo changes that limit their ability to regenerate damaged muscle fibers. These cellular changes are likely linked to myopathies such as Wooden Breast.
Article
Cell & Tissue Engineering
Congshan Sun, Suraj Kannan, In Young Choi, HoTae Lim, Hao Zhang, Grace S. Chen, Nancy Zhang, Seong-Hyun Park, Carlo Serra, Shama R. Iyer, Thomas E. Lloyd, Richard M. Lovering, Su Bin Lim, Peter Andersen, Kathryn R. Wagner, Gabsang Lee, Chulan Kwon
Summary: Human pluripotent stem cell (hPSC)-derived myogenic progenitor cell (MPC) transplantation can contribute to muscle fiber regeneration in mice, providing a proof of principle for future hPSC-based cell therapy for muscle disorders.
Article
Cell Biology
Qi Zhu, Feng Liang, Shufang Cai, Xiaorong Luo, Tianqi Duo, Ziyun Liang, Zuyong He, Yaosheng Chen, Delin Mo
Summary: KDM4A deficiency in skeletal muscle impairs muscle formation and regeneration, and inhibits myogenic cell proliferation and differentiation.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Nobuko Katoku-Kikyo, Ellen Paatela, Daniel L. Houtz, Britney Lee, Dane Munson, Xuerui Wang, Mohammed Hussein, Jasmeet Bhatia, Seunghyun Lim, Ce Yuan, Yoko Asakura, Atsushi Asakura, Nobuaki Kikyo
Summary: This study demonstrates that the circadian master regulators Per1 and Per2 play essential roles in regulating myoblast differentiation and muscle regeneration by controlling the activation of Igf2 and key genes in the differentiation process. The circadian epigenetic priming creates a preferred time window for initiating myoblast differentiation, with muscle regeneration being faster when initiated at night due to higher expression of Per1, Per2, and Igf2 compared to morning.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Doaa Ibrahim, Hanan S. Al-Khalaifah, Ahmed Abdelfattah-Hassan, Haitham Eldoumani, Safaa I. Khater, Ahmed H. Arisha, Sally A. M. Mohamed, Tamer Ahmed Ismail, Samar A. Tolba
Summary: The study demonstrated that administration of GHBP at 200 mu g/kg positively regulated gene expression related to muscle growth and muscle-specific myomiRs in broiler chicks, accelerating their growth by enhancing skeletal muscle development. This was evidenced by upregulation of certain genes and downregulation of others, leading to improved weight gain and feed conversion ratio. Additionally, the effects on myofiber characteristics were observed, with the largest myofiber sizes and areas achieved in the 200 mu g/kg GHBP group.
Article
Respiratory System
Carme Casadevall, Antonio Sancho-Munoz, Ignacio Vicente, Sergi Pascual-Guardia, Mireia Admetllo, Joaquim Gea
Summary: This study investigated the effects of the vascular systemic environment from stable and exacerbated COPD patients on the myogenic behavior of human muscle precursor cells (MPC) in vitro. The findings suggest that the vascular systemic environment during an acute exacerbation has a mitotic effect on MPCs without altering myogenic differentiation outcome. However, after Methylprednisolone treatment of acute exacerbated COPD patients, this mitotic effect is further amplified, but it is followed by a deficient differentiation capacity.
RESPIRATORY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Tannaz Norizadeh Abbariki, Zita Gonda, Denise Kemler, Pavel Urbanek, Tabea Wagner, Margarethe Litfin, Zhao-Qi Wang, Peter Herrlich, Olivier Kassel
Summary: The temporary upregulation of nTRIP6 during the transition from proliferation to differentiation plays a critical role in preventing premature differentiation in muscle stem cells, contributing to the temporal control of myogenesis. Knocking out the Trip6 gene in satellite cells leads to deregulated skeletal muscle regeneration dynamics in mice, highlighting the importance of dynamic changes in nTRIP6 expression.
SCIENTIFIC REPORTS
(2021)