Review
Immunology
Xiaopeng Tang, Kangning Xiong, Rejun Fang, Meijun Li
Summary: Weaning is a critical period in pig production, but it often causes stress for piglets due to separation from the sow, changes in diet and living environment, and social challenges. This stress leads to changes in the piglets' small intestine, disrupting digestion and absorption, damaging intestinal barrier function, and resulting in reduced feed intake, increased diarrhea rate, and growth retardation. Understanding the effects of weaning stress on intestinal health is important for developing nutritional strategies to alleviate weaning stress.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Yanhong Yong, Junyu Li, Dongliang Gong, Tianyue Yu, Lianyun Wu, Canying Hu, Xiaoxi Liu, Zhichao Yu, Xingbin Ma, Ravi Gooneratne, A. M. Abd El-Aty, Jinjun Chen, Xianghong Ju
Summary: This study investigated the RIP1/RIP3-ERK1/2 signaling pathway in heat-stressed pigs and found that it regulates the expression of tight junction proteins. Heat stress induced changes in intestinal morphology and protein expression in pigs, providing insights into the underlying mechanisms of intestinal barrier function.
JOURNAL OF THERMAL BIOLOGY
(2021)
Review
Immunology
Yingman Liu, Wenxuan Huang, Jiaqi Wang, Jiaojiao Ma, Manman Zhang, Xiaoying Lu, Jie Liu, Yurong Kou
Summary: Periodontal disease, considered a common inflammatory disease, is believed to contribute to the development of gastrointestinal diseases and other systemic diseases by affecting the intestinal barrier through periodontal pathogens. This review summarizes studies on the effects of periodontal pathogens on the intestinal barrier, potentially shedding light on the link between periodontitis and gastrointestinal diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Xiaoling Chen, Tianlei Qiao, Zhengyu Mao, Gang Jia, Hua Zhao, Guangmang Liu, Zhiqing Huang
Summary: The experiment investigated the effects of caffeic acid on bacteria, short-chain fatty acids (SCFA), and gene expression in weaning piglets' colons. The results showed that caffeic acid increased the levels of SCFA, as well as the number of beneficial bacteria and decreased harmful bacteria. Additionally, caffeic acid also increased the expression of tight junction proteins and anti-inflammatory genes, while decreasing the expression of pro-inflammatory genes.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Veterinary Sciences
Ruibiao Wang, Yuheng Zhang, Jingbo Zhen, Jinpeng Zhang, Zixuan Pang, Xuewei Song, Lihao Lin, Feng Sun, Yixin Lu
Summary: This study explored the effect of exosomes derived from Trichinella spiralis infective larvae (TsExos) on the barrier function of porcine small intestinal epithelial cells (IPEC-J2). The results showed that TsExos ingestion decreased cell viability, increased FITC-dextran content, lactate dehydrogenase and reactive oxygen species levels. TsExos also induced apoptosis, nuclear pyknosis, and nuclear rupture. In addition, TsExos disrupted tight junctions and altered gene expression.
VETERINARY RESEARCH
(2022)
Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, Research & Experimental
Haishan Wu, Rong Huang, Jinjin Fan, Ning Luo, Xiao Yang
Summary: Low potassium diet may increase intestinal permeability, leading to bacterial translocation, suspected to be due to impaired intestinal epithelial barrier and biological barrier.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jingru Guo, Jing Xu, Leichong Chen, Zhuo Chen, Huijie Hu, Junshu Nie, Jianbin Yuan, Li Ma, Jingjing Lu, Hong Ji, Bin Xu
Summary: This study revealed that chronic cold exposure damages the ileal epithelial barrier and induces endoplasmic reticulum stress. Knockout of SIRT2 alleviates ileal injury via enhanced autophagy. Autophagy can restore the expression of ZO-1 under stress.
Article
Cell Biology
Yuju Kim, Yunna Lee, Gwangbeom Heo, Sihyun Jeong, Soyeong Park, Jin-Wook Yoo, Yunjin Jung, Eunok Im
Summary: The study found that PAR2-induced autophagy can maintain mucosal barrier integrity by regulating intestinal epithelial permeability, possibly through the β-arrestin-ERK1/2 pathway. Therefore, regulating PAR2 can be a suitable strategy for treating intestinal diseases.
Article
Biochemistry & Molecular Biology
Ya-Nan Gao, Song-Li Li, Xue Yang, Jia-Qi Wang, Nan Zheng
Summary: The study found that lactoferrin (LF) can reduce the increased intestinal permeability caused by aflatoxin M1 (AFM1) and repair the damaged intestinal barrier. In addition, the research revealed that LF acts through regulating multiple pathways related to intestinal cell survival and intestinal integrity. These findings suggest that LF may be a potential option for treating compromised intestinal barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Nguyen Thi Thanh Tinh, Gertrude Cynthia Sitolo, Yoshinari Yamamoto, Takuya Suzuki
Summary: This study demonstrates that lemon peel powder can alleviate intestinal inflammation and barrier defects in colitic mice by protecting tight junction barriers and suppressing inflammatory reactions. Acetate and n-butyrate produced from the microbial metabolism of dietary fibers in lemon peel powder play a role in reducing colitis.
Article
Gastroenterology & Hepatology
Luz del Carmen Martinez-Sanchez, Phuong Anh Ngo, Rashmita Pradhan, Lukas-Sebastian Becker, David Boehringer, Despina Soteriou, Marketa Kubankova, Christine Schweitzer, Tatyana Koch, Veronika Thonn, Lena Erkert, Iris Stolzer, Claudia Guenther, Christoph Becker, Benno Weigmann, Monika Klewer, Christoph Daniel, Kerstin Amann, Stefan Tenzer, Raja Atreya, Martin Bergo, Cord Brakebusch, Alastair J. M. Watson, Jochen Guck, Ben Fabry, Imke Atreya, Markus F. Neurath, Rocio Lopez-Posadas
Summary: Abnormal cell shedding is associated with intestinal barrier dysfunction and inflammatory bowel diseases. Deletion of PGGTase and RAC1 in intestinal epithelial cells leads to cell overcrowding and epithelial leakage, resulting in chronic intestinal inflammation. RAC1 plays a crucial role in regulating cytoskeletal dynamics, cell mechanics, and intestinal cell shedding.
Article
Engineering, Environmental
Yuan Cui, Qianqian Xiao, Zhenyu Wang, Qiong Zhang, Yuetong Liu, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei
Summary: The study found that the novel brominated flame retardant BTBPE causes damage to the intestine by activating the IRX3/NOS2 axis, leading to necroptosis and disruption of tight junctions. Blocking the IRX3/NOS2 axis can inhibit necroptosis and restore tight junctions. Additionally, BTBPE exposure also induces inflammation and loss of the mucous layer in the intestine.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Review
Gastroenterology & Hepatology
Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: This review discusses the recent advances in understanding the role of gut microbial metabolites in regulating intestinal barrier function. While the mechanisms of action of these metabolites are still being explored, they likely impact gut barrier function through shared pathways. Utilizing beneficial microbiota and their metabolites to restore pathophysiological balance may prove to be a valuable therapeutic tool amidst advancing technology and expanding knowledge.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Environmental Sciences
Mengxing Cui, Qianmei He, Ziwei Wang, Yongjiang Yu, Huan Gao, Ziqi Liu, Honghao Peng, Han Wang, Xue Zhang, Daochuan Li, Liping Chen, Xiumei Xing, Yongmei Xiao, Wen Chen, Qing Wang
Summary: Micro/nano-plastics (MPs/NPs) can induce intestinal toxicity by increasing permeability and decreasing tight junction proteins expression. The expression of MUC2 is elevated in response to 20 nm PS-NPs, alleviating their cytotoxicity. HO1/p38/IL-10 pathway plays a role in the regulation of MUC2 expression. This study provides valuable insight into the mechanism and potential risk of intestinal toxicity induced by nanoplastics.
ENVIRONMENTAL POLLUTION
(2023)