Article
Veterinary Sciences
Damarius S. Fleming, Laura C. Miller, Jiuyi Li, Albert Van Geelen, Yongming Sang
Summary: PRRSV is a major obstacle in commercial swine production, and a novel vaccine shows promise for improved immunity and protection.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Plant Sciences
Jordan T. T. VanderBurgt, Ondre Harper, Christopher P. P. Garnham, Susanne E. E. Kohalmi, Rima Menassa
Summary: This research aimed to display antigenic portions of the M and GP5 proteins on the surface of tobacco mosaic virus-like particles. The modified tobacco mosaic virus coat protein (TMVc) was expressed in Nicotiana benthamiana plants and resulted in self-assembly and surface display of the M-GP5 epitope.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Microbiology
Xin-xin Chen, Songlin Qiao, Rui Li, Jing Wang, Xuewu Li, Gaiping Zhang
Summary: By studying how PRRSV evades host immune responses, we can understand that the virus establishes long-term infection through various complex mechanisms, which is a major obstacle in controlling PRRS disease. Understanding the exact mechanisms of PRRSV immune evasion will contribute to the development of novel antiviral strategies.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Tiphany Chrun, Emmanuel A. Maze, Kelly J. Roper, Eleni Vatzia, Basudev Paudyal, Adam McNee, Veronica Martini, Tanuja Manjegowda, Graham Freimanis, Adrian Silesian, Noemi Polo, Becky Clark, Emily Besell, Georges Booth, Brigid Veronica Carr, Matthew Edmans, Alejandro Nunez, Surapong Koonpaew, Nanchaya Wanasen, Simon P. P. Graham, Elma Tchilian
Summary: Porcine respiratory disease is commonly caused by co-infections of swine influenza A (swIAV) and porcine reproductive and respiratory syndrome (PRRSV) viruses. However, the immune responses and pathogenesis of these co-infections have not been well studied. In this study, pigs were co-infected with swIAV H3N2 and PRRSV-2, and it was found that the clinical disease was not worsened and viral load was reduced in the co-infected animals. Additionally, the development of virus-specific adaptive immune responses was not impaired. These findings suggest that simultaneous swIAV H3N2/PRRSV-2 co-infection does not negatively affect host immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Marek Sinkora, Miroslav Toman, Katerina Stepanova, Hana Stepanova, Lenka Leva, Jana Sinkorova, Romana Moutelikova, Jiri Salat, Dagmar Srutkova, Martin Schwarzer, Simon Sinkora, Helena Kupcova Skalnikova, Katerina Nechvatalova, Tomas Hudcovic, Petra Hermanova, Sarka Pfeiferova, Mirka Kratochvilova, Lenka Kavanova, Blanka Dusankova, Marek Sinkora
Summary: PRRSV invades the thymus and alters the immune response, resulting in chronic infection. Infected pigs produce antibodies that are unable to neutralize the virus, leading to the inability of the immune system to eliminate the virus.
MICROBES AND INFECTION
(2023)
Article
Immunology
Sophie Duerlinger, Christian Knecht, Spencer Sawyer, Gyula Balka, Marianne Zaruba, Till Ruemenapf, Christian Kraft, Poul Henning Rathkjen, Andrea Ladinig
Summary: This study assessed the efficacy of a modified live PRRSV-1 vaccine in weaned piglets experimentally infected with PRRSV strain AUT15-33. Results showed that vaccination increased average daily weight gain, reduced viral shedding in oral fluids and tissue samples, as well as reduced the severity of lung lesions.
Article
Immunology
Lise K. Kvisgaard, Lars E. Larsen, Charlotte S. Kristensen, Frederic Paboeuf, Patricia Renson, Olivier Bourry
Summary: This study evaluated the pathogenicity of a vaccine-derived recombinant Porcine reproductive and respiratory syndrome virus 1 strain (Horsens strain) in SPF pigs and compared it with a reference strain. The findings indicated that all vaccinated groups had lower viral loads in serum compared to the unvaccinated group challenged with the Horsens strain. The recombinant Horsens strain showed infection capabilities comparable to or exceeding typical PRRSV-1 strains but with less virulence.
Article
Immunology
Tiphany Chrun, Emmanuel A. Maze, Eleni Vatzia, Veronica Martini, Basudev Paudyal, Matthew D. Edmans, Adam McNee, Tanuja Manjegowda, Francisco J. Salguero, Nanchaya Wanasen, Surapong Koonpaew, Simon P. Graham, Elma Tchilian
Summary: The study indicated that co-infection of PRRSV-2 and swine influenza H3N2 virus weakened the protective effect of PRRS modified live virus vaccine while enhancing antibody responses. In contrast, co-infection in non-immunized animals helped reduce viral load and potentiate T cell responses. The upregulation of inhibitory cytokines gene expression in vaccinated pigs' lungs may have influenced responses to H3N2 and PRRSV-2.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Takumi Terada, Takeya Morozumi, Emi Wada, Shin Sukegawa
Summary: This study successfully adapted two immune-based methods, ICM and cell-based ELISA, to IPKMs for quantitative measurement of neutralizing antibody titers against field strains of PRRSV-2.
JOURNAL OF VIROLOGICAL METHODS
(2022)
Article
Veterinary Sciences
Gerard E. Martin-Valls, Yanli Li, Ivan Diaz, Esmeralda Cano, Silvana Sosa-Portugal, Enric Mateu
Summary: Respiratory diseases in weaned pigs are commonly caused by viruses and bacteria, and this study investigated the presence of eleven viruses in nasal swabs collected from nurseries suspected of swine influenza A virus (swIAV). The study found that PRCV, SOV, and PCMV were more likely to be found in swIAV-positive nurseries, and PCV3, PRRSV, and PCMV were the most frequently detected agents at the herd level. The data contributes to the understanding of the complex etiology and epidemiology of respiratory diseases in weaners.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Agriculture, Dairy & Animal Science
Qin Luo, Yajie Zheng, Hang Zhang, Zhiyu Yang, Huiyang Sha, Weili Kong, Mengmeng Zhao, Nina Wang
Summary: Research on the GP5 protein is crucial for the diagnosis, prevention, and control of porcine reproductive and respiratory syndrome virus (PRRSV). We provide a summary of its genetic variation, immunity, replication, apoptosis, virulence, and interaction with viral and host proteins, which lays a foundation for understanding PRRSV replication mechanisms and vaccine development.
Article
Infectious Diseases
Danielle Gava, Luizinho Caron, Rejane Schaefer, Virginia Santiago Silva, Rudi Weiblen, Eduardo Furtado Flores, Marcelo de Lima, Guilherme Zaha Takeda, Janice Reis Ciacci-Zanella
Summary: This study conducted testing on various porcine biological samples in Brazil and found very few samples tested positive for PRRSV antibodies initially, but upon retesting, all samples turned out to be negative, indicating no conclusive evidence of PRRSV infection in these pigs. Further reinforcement of surveillance program is important to prevent the introduction and dissemination of PRRSV in Brazil.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Microbiology
Jingjing Wang, Mengsi Zhang, Xiaochun Cui, Xiang Gao, Weifeng Sun, Xinna Ge, Yongning Zhang, Xin Guo, Jun Han, Lei Zhou, Hanchun Yang
Summary: This study provides direct scientific evidence for the reversion to virulence of PRRS MLV and offers valuable clues for exploring its molecular mechanism.
MICROBIOLOGY SPECTRUM
(2022)
Article
Genetics & Heredity
Zhiqing Zhang, Hang Zhang, Qin Luo, Yajie Zheng, Weili Kong, Liangzong Huang, Mengmeng Zhao
Summary: Since its isolation in China in 1995, the porcine reproductive and respiratory syndrome virus (PRRSV) has been mutating into highly pathogenic strains. This study investigated the prevalence and genetic variation of nonstructural protein 1 (NSP1) in the main strain prevalent in China, PRRSV-2. The results showed that NSP1 is a stable hydrophobic protein with high nucleotide and amino acid similarity among different strains. The study lays the foundation for understanding the nature and genetic variation of NSP1 and future vaccine development.
Article
Microbiology
Laura A. Constance, James B. Thissen, Crystal J. Jaing, Kevin S. McLoughlin, Raymond R. R. Rowland, Nick V. L. Sera, Ada G. Cino-Ozuna, Megan C. Niederwerder
Summary: Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) are significant pathogens in swine, often causing respiratory disease and reduced weight gain. This study identified gut microbiome characteristics associated with improved outcomes in PRRS vaccinated pigs following a polymicrobial respiratory challenge, suggesting a role for the gut microbiome in PRRS vaccine efficacy.
VETERINARY MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Sung Yong Jang, Jaeyoung Heo, Mi Ri Park, Min-Ho Song, Jong Nam Kim, Sung Ho Jo, Do-Youn Jeong, Hak Kyo Lee, Younghoon Kim, Sangnam Oh
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2017)
Article
Agriculture, Dairy & Animal Science
ShuDong Liu, MinHo Song, Won Yun, JiHwan Lee, ChangHee Lee, WooGi Kwak, NamSoo Han, HyeunBum Kim, JinHo Cho
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2018)
Article
Food Science & Technology
Jeehwan Choe, Juri Lee, Kyung Jo, Cheorun Jo, Minho Song, Samooel Jung
Article
Agriculture, Dairy & Animal Science
Robin B. Guevarra, Sang Hyun Hong, Jin Ho Cho, Bo-Ra Kim, Jiwon Shin, Jun Hyung Lee, Bit Na Kang, Young Hwa Kim, Suphot Wattanaphansak, Richard E. Isaacson, Minho Song, Hyeun Bum Kim
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2018)
Article
Agriculture, Dairy & Animal Science
Yanhong Liu, Dong Yong Kil, Victor G. Perez-Mendoza, Minho Song, James E. Pettigrew
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2018)
Article
Multidisciplinary Sciences
Yanhong Liu, Jeehwan Choe, Jeong Jae Lee, Junsu Kim, Joy M. Campbell, Javier Polo, Joe D. Crenshaw, James E. Pettigrew, Minho Song
Article
Agriculture, Dairy & Animal Science
Won Yun, Min Ho Song, Ji Hwan Lee, Chang Hee Lee, Seo Young Oh, Woo Gi Kwak, Doo Wan Kim, Hyeun Bum Kim, Jin Ho Cho
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2019)
Article
Agriculture, Dairy & Animal Science
Kwangwook Kim, Peng Ji, Minho Song, Tung M. Che, David Bravo, James E. Pettigrew, Yanhong Liu
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
Hyunjin Kyoung, Jeong Jae Lee, Jin Ho Cho, Jeehwan Choe, Joowon Kang, Hanbae Lee, Yanhong Liu, Younghoon Kim, Hyeun Bum Kim, Minho Song
Summary: Dietary glutamic acid can influence the growth performance and health of weaned pigs by modulating nutrient digestibility, intestinal morphology, ileal gene expression of tight junction proteins and cytokines, immune responses, and microbial community in the gut.
Article
Agriculture, Dairy & Animal Science
Han-Jin Oh, Yei-Ju Park, Jae Hyoung Cho, Min-Ho Song, Bon-Hee Gu, Won Yun, Ji-Hwan Lee, Ji-Seon An, Yong-Ju Kim, Jun-Soeng Lee, Sheena Kim, Hyeri Kim, Eun Sol Kim, Byoung-Kon Lee, Byeong-Woo Kim, Hyeun Bum Kim, Jin-Ho Cho, Myung-Hoo Kim
Summary: Piglets, especially during the weaning stage, are vulnerable to diseases like post-weaning diarrhea due to incomplete immune system development and stress responses. Zinc oxide (ZnO) is commonly used in piglet diets to prevent diarrhea and aid in immune system development. However, due to environmental concerns and potential toxicity, nano-sized ZnO has shown promise as an alternative to traditional ZnO supplementation.
Article
Agriculture, Dairy & Animal Science
Jeong Jae Lee, Hyunjin Kyoung, Jin Ho Cho, Jeehwan Choe, Younghoon Kim, Yanhong Liu, Joowon Kang, Hanbae Lee, Hyeun Bum Kim, Minho Song
Summary: Dietary yeast cell wall can improve growth performance and intestinal health of weaned pigs by enhancing gut health, leading to higher average daily gain, improved apparent ileal digestibility of DM and energy, and reduced diarrhea frequency.
Article
Agriculture, Dairy & Animal Science
Yong Ju Kim, Min Ho Song, Ji Hwan Lee, Han Jin Oh, Se Yeon Chang, Jae Woo An, Young Bin Go, Dong Cheol Song, Hyun Ah Cho, Byoung Kon Lee, Seok Hyeon Cho, Hyeun Bum Kim, Jin Ho Cho
Summary: The study showed that replacing a portion of animal fat with at least 4% FFA in broiler diets can increase growth performance and nutrient digestibility in broiler nutrition.
Article
Agriculture, Dairy & Animal Science
Han Jin Oh, Myung Hoo Kim, Min Ho Song, Ji Hwan Lee, Yong Ju Kim, Se Yeon Chang, Jae Woo An, Young Bin Go, Dong Cheol Song, Hyun Ah Cho, Min Ji Kim, Hyeun Bum Kim, Jin Ho Cho
Summary: The study suggests that a combination of inorganic and organic zinc at a ratio of 500:500 mg/kg, along with a low-protein diet containing essential oil, protease, and xylanase, can effectively replace high-dose ZnO and improve growth performance, nutrient digestibility, and gut health in weaned piglets.
Article
Agriculture, Dairy & Animal Science
Jeehwan Choe, Sheena Kim, Jin Ho Cho, Jeong Jae Lee, Sangwoo Park, Byeonghyeon Kim, Junsu Kim, Samuel K. Baidoo, Sangnam Oh, Hyeun Bum Kim, Minho Song
ANIMAL SCIENCE JOURNAL
(2018)
Article
Agriculture, Dairy & Animal Science
Jonggun Kim, Jaepil Kim, Younghoon Kim, Sangnam Oh, Minho Song, Jee Hwan Choe, Kwang-Youn Whang, Kwang Hyun Kim, Sejong Oh
ANIMAL SCIENCE JOURNAL
(2018)