Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Peng-Long Li, Mei Li, Zhenya Wang, Xiao-Ming Wang, Shuai-Yang Liu, Song Tian, Zhou-Xiang Wang, Xu Cheng, Yufeng Hu, Peng Zhang, Zhi-Gang She, Hailong Yang, Hongliang Li, Xiao-Jing Zhang
Summary: This study aims to identify promising drug candidates by targeting PPAR gamma for adipogenesis-based metabolic homeostasis and clarify the detailed mechanisms. Magnolol was identified as a potent adipogenesis activator by stabilizing PPAR gamma, providing a new avenue for the therapy of adipogenesis-related metabolic disorder.
Article
Agriculture, Dairy & Animal Science
N. A. Janovick, H. M. Dann, J. J. Loor, J. K. Drackley
Summary: This study investigated the impact of prepartum energy intake on liver function and metabolism. The results showed that excessive energy intake before parturition had detrimental effects on the expression of genes related to liver function, specifically postpartum. Additionally, it was found that overnutrition prepartum could lead to liver inflammation and lipid accumulation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Plant Sciences
Haoyang Zou, Yiyao Gong, Haiqing Ye, Cuiping Yuan, Tiezhu Li, Jie Zhang, Li Ren
Summary: This study summarizes the physiological importance and clinical significance of PPARs and reviews the experimental evidence that natural products mediate metabolic syndrome via PPARs. The majority of currently described natural compounds are mild PPAR-selective agonists with therapeutic effects that are equivalent to synthetic medicines but less harmful adverse effects. Conclusion: PPAR agonists can be combined with natural products to treat and prevent metabolic syndrome.
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xi Chen, Zhiqiang Ma, Peng Chen, Xiuli Song, Weihua Li, Xuefeng Yu, Junhui Xie
Summary: A Chinese FPLD3 patient with a novel PPARG gene mutation is described in this article. This case emphasizes the importance of physical examination and genetic testing in young patients with severe metabolic syndromes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo
Summary: This review discusses the roles of peroxisome proliferator-activated receptors (PPARs) alpha, beta, and gamma in transcriptional regulation, energy metabolism, inflammation regulation, cellular development, and differentiation. PPAR signaling pathways play important roles in the development of viral, bacterial, and parasitic infectious diseases. The review also explores the potential therapeutic uses of PPAR agonists/antagonists in infectious disease treatment.
Review
Gastroenterology & Hepatology
Henrique Souza-Tavares, Carolline Santos Miranda, Isabela Macedo Lopes Vasques-Monteiro, Cristian Sandoval, Daiana Araujo Santana-Oliveira, Flavia Maria Silva-Veiga, Aline Fernandes-da-Silva, Vanessa Souza-Mello
Summary: The intersection of obesity and COVID-19 has become a global concern. Obesity rates have tripled since 1975, leading to significant health costs. Adipose tissue plays a crucial role in obesity-related impairments, leading to insulin resistance and inflammation. Obesity affects the pancreas, increasing the risk of type 2 diabetes, and the liver, leading to hepatic steatosis. Peroxisome proliferator-activated receptors (PPARs) activation shows potential in managing these metabolic diseases by alleviating insulin resistance and promoting fat oxidation.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Oncology
Gang Huang, Wei Jiang, Weiyong Xie, Wei Lu, Weimin Zhu, Zhenhan Deng
Summary: PPARs regulate cartilage homeostasis and reduce inflammation in OA, deficiency of PPARs may accelerate OA progression. PPAR agonists can inhibit catabolic and inflammatory factors synthesis, reducing cartilage lesions development in OA.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Chemistry, Medicinal
Long Cheng, Lu Shi, Changhao He, Chen Wang, Yinglan Lv, Huimin Li, Yongcheng An, Hongyu Dai, Yuhui Duan, Huilin Zhang, Yan Huang, Wanxin Fu, Yanyan Meng, Baosheng Zhao
Summary: The study found that rutin can activate thermogenesis in brown and white adipose tissue by increasing the concentration of short-chain fatty acids, thereby improving obesity and diabetes.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yiyi Ma, Minglu Wang, Shuaishuai Guo, Tong Li, Xiaodong Liu, Limei Zhao
Summary: Valproic acid (VPA) is widely used in the treatment of epilepsy, but its potential hepatotoxicity is a major concern. This study aimed to investigate the biomarkers and mechanisms of VPA-induced liver injury in epileptic children. Metabolomic analysis revealed that VPA disrupts fatty acid beta-oxidation (beta-FAO) and leads to the accumulation of serum long-chain acylcarnitines (LCACs). Additionally, the study found that fenofibrate (Feno) can improve beta-FAO and protect against VPA-induced hepatotoxicity by activating PPAR alpha.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Enrico D'Aniello, Pietro Amodeo, Rosa Maria Vitale
Summary: This review provides an overview of discovery, optimization, and structure-activity relationship studies on PPAR modulators from marine sources, as well as the structural and computational studies that led to their identification and/or elucidation, and rationalization of their mechanisms of action.
Review
Biochemistry & Molecular Biology
Lin Peng, Huixia Yang, Yao Ye, Zhi Ma, Christina Kuhn, Martina Rahmeh, Sven Mahner, Antonis Makrigiannakis, Udo Jeschke, Viktoria von Schonfeldt
Summary: PPARs play vital roles in pregnancy, and dysfunctions of PPARs may lead to various related pregnancy diseases such as recurrent miscarriage and preeclampsia. This review discusses the impact of regulating PPARs on trophoblast physiological conditions and explores the underlying mechanisms of PPARs in controlling pregnancy-related processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
H. Y. Chung, Y. J. Choi, H. N. Park, M. E. Davis
GENETICS AND MOLECULAR RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
J. Zhang, Y. Suh, Y. M. Choi, P. R. Chen, M. E. Davis, K. Lee
Article
Food Science & Technology
Joonki Hong, Duwan Kim, Kyuho Cho, Soojin Sa, Sunho Choi, Younghwa Kim, Juncheol Park, Gilberto Silber Schmidt, Michael E. Davis, Hoyoung Chung
Article
Food Science & Technology
Yoonjeong Choi, Michael E. Davis, Hoyoung Chung
Article
Agriculture, Dairy & Animal Science
M. E. Davis, P. A. Lancaster, J. J. Rutledge, L. V. Cundiff
JOURNAL OF ANIMAL SCIENCE
(2016)
Article
Agriculture, Dairy & Animal Science
M. E. Davis, P. A. Lancaster, J. J. Rutledge, L. V. Cundiff
JOURNAL OF ANIMAL SCIENCE
(2018)
Article
Agriculture, Dairy & Animal Science
J. Zhang, Y. Suh, Y. M. Choi, J. Ahn, M. E. Davis, K. Lee
Article
Biochemistry & Molecular Biology
Hoyoung Chung, Michael Davis
Article
Agriculture, Dairy & Animal Science
P. A. Lancaster, G. E. Carstens, J. J. Michal, K. M. Brennan, K. A. Johnson, M. E. Davis
JOURNAL OF ANIMAL SCIENCE
(2014)
Article
Multidisciplinary Sciences
Jibin Zhang, Jinsoo Ahn, Yeunsu Suh, Seongsoo Hwang, Michael E. Davis, Kichoon Lee
Article
Environmental Sciences
Ahmet Yilmaz, Nehad Mohamed, Kara A. Patterson, Yan Tang, Konstantin Shilo, Miguel A. Villalona-Calero, Michael E. Davis, Xiao-Ping Zhou, Wendy Frankel, Gregory A. Otterson, Weiqiang Zhao
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2014)
Article
Environmental Sciences
Ahmet Yilmaz, Nehad Mohamed, Kara A. Patterson, Yan Tang, Konstantin Shilo, Miguel A. Villalona-Calero, Michael E. Davis, Xiaoping Zhou, Wendy Frankel, Gregory A. Otterson, Howard D. Beall, Weiqiang Zhao
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2014)
Article
Agriculture, Dairy & Animal Science
Phillip A. Lancaster, Luis O. Tedeschi, Zach Buessing, Michael E. Davis
Summary: This study evaluated the ability of different milk yield and forage intake equations to predict calf feed intake and weaning weight, finding that some equations performed better than others but still need further refinement, especially to account for breed variation.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Phillip A. Lancaster, Michael E. Davis, Luis O. Tedeschi, Jack J. Rutledge, Larry Cundiff
Summary: The objective of this study was to evaluate a mathematical nutrition model to estimate the feed intake and biological efficiency of mature beef cows. The study found that the CVDSbc model provides reasonable predictions of feed intake and biological efficiency of mature beef cows, but further refinement is recommended to improve the accuracy of predictions.
TRANSLATIONAL ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Phillip A. Lancaster, Michael E. Davis, Jack J. Rutledge, Larry Cundiff
Summary: The study found that feed efficiency traits were poorly correlated across production segments, but moderately repeatable across production cycles.
TRANSLATIONAL ANIMAL SCIENCE
(2021)