Editorial Material
Biochemistry & Molecular Biology
Yu-Ying Chen, Thomas V. O'Halloran
Summary: Zinc is crucial for living organisms, and it has been discovered that the ZNG1 family of GTPases function as metallochaperones, directly transferring zinc to and activating methionine aminopeptidases which play essential roles in protein modification during or after translation.
Review
Cell Biology
Aidan W. Porter, Jeffrey L. Brodsky, Teresa M. Buck
Summary: All cell types respond to stress by inducing protective pathways, with the endoplasmic reticulum (ER) being particularly sensitive to stress. The unfolded protein response (UPR) is a specialized ER stress response pathway that protects against damaged proteins and toxic chemicals. Recent research has linked ER stress and the UPR to acute kidney injury (AKI), a common disease in hospitalized individuals.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gary Loughran, Alla D. Fedorova, Yousuf A. Khan, John F. Atkins, Pavel Baranov
Summary: The research article discusses the discovery of ribosomal frameshifting in the bacterial CopA gene and its occurrence in the human ortholog ATP7B. However, further examination of the evidence raises doubts about the validity of this claim, as well as the interference of other factors in the experimental results.
Article
Nutrition & Dietetics
Yun Liu, Ji Miao
Summary: This paper summarizes the effects of defective copper homeostasis on heart disease and discusses potential underlying molecular mechanisms.
Article
Chemistry, Multidisciplinary
Kengo Hanaya, Kaho Yamoto, Kazuaki Taguchi, Kazuaki Matsumoto, Shuhei Higashibayashi, Takeshi Sugai
Summary: The chemical modification of proteins is an effective technique for manipulating protein properties and functions. This paper proposes a simple method using a copper(II)-mediated aldol reaction to selectively modify the N-terminus of peptides and proteins.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Microbiology
Nitanshu Garg, Aidan J. Taylor, Federica Pastorelli, Sarah E. Flannery, Phillip J. Jackson, Matthew P. Johnson, David J. Kelly
Summary: The study identified new Cco subunits, a previously uncharacterized set of genes linking copper trafficking and Cco activity, and connections with copper ion homeostasis in this important pathogen, Campylobacter jejuni, causing human food-borne bacterial gastroenteritis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Saman Mohammadi, Vahid Mohammadi, Bijan Esmaeilnejad
Summary: The study measured serum levels of acute phase proteins in cattle infected with Babesia bigemina, finding that all APPs showed elevated levels in a parasitemia burden-dependent fashion. There was a strong positive correlation between APPs and SA, while cholinesterase activity showed an inverse correlation with APPs.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Nicolas Bloemeke, Kevin Meighen-Berger, Manuel Hitzenberger, Nina C. Bach, Marina Parr, Joao Pl Coelho, Dmitrij Frishman, Martin Zacharias, Stephan A. Sieber, Matthias J. Feige
Summary: One-third of the human proteome is composed of membrane proteins, which are susceptible to misfolding and require folding assistance from chaperones. Calnexin, an abundant ER chaperone, interacts with a large number of membrane proteins, including misfolded ones, using its lectin domain and transmembrane domain for recognition and binding. This study reveals the widespread role of calnexin in recognizing client proteins in the lipid bilayer and highlights its importance in supporting membrane protein biogenesis.
Review
Immunology
Shelley Bhattacharya, Chayan Munshi
Summary: C-reactive protein (CRP) is an important member of the acute phase protein family and has its origin in the animal kingdom. CRP plays a key role in inflammation and immune diseases, with functions including complement activation, phagocytosis, and regulation of cytokine production. The structure of CRP shows some relatedness among different species, while invertebrates rely on the multifunctionality of CRP for evolutionary success.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Lisa Zuily, Nora Lahrach, Rosi Fassler, Olivier Genest, Peter Faller, Olivier Seneque, Yann Denis, Marie-Pierre Castanie-Cornet, Pierre Genevaux, Ursula Jakob, Dana Reichmann, Marie-Therese Giudici-Orticoni, Marianne Ilbert
Summary: With the increase of antibiotic drug resistance, alternative antibacterial treatment strategies are needed. This study found that copper treatment causes protein aggregation, and bacteria rely on molecular chaperone systems to protect themselves from copper-induced protein aggregation.
Editorial Material
Cell Biology
Xinyu Ma, Min Zhang, Liang Ge
Summary: This recent study identifies CCT2 as a new type of aggrephagy receptor that specifically facilitates the autophagic clearance of solid protein aggregates. The findings also reveal the parallel action of multiple aggrephagy pathways in removing different types of protein aggregates.
Article
Biochemistry & Molecular Biology
Yovana Cabrera, Ganeko Bernardo-Seisdedos, Leire Dublang, David Albesa-Jove, Natalia Orozco, Ana Rosa Viguera, Oscar Millet, Arturo Muga, Fernando Moro
Summary: This study reveals the role of Apg2 in regulating the activity of human Hsc70, and its C-terminal extension acts as a fine-tuner of substrate remodeling ability in the chaperone system.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Anwar Sadat, Satyam Tiwari, S. Sunidhi, Aseem Chaphalkar, Manisha Kochar, Mudassar Ali, Zainab Zaidi, Akanksha Sharma, Kanika Verma, Kannan Boosi Narayana Rao, Manjul Tripathi, Asmita Ghosh, Deepika Gautam, Atul, Arjun Ray, Koyeli Mapa, Kausik Chakraborty
Summary: The surface charge properties of the GroEL/ES chaperonin cavity, especially the negative charges, play a crucial role in its ability to assist protein folding. However, the negative-charge density varies significantly among different bacterial species and is lowest in eukaryotic GroEL/ES homologs. The chaperoning mechanism of GroEL may have changed during evolution to accommodate different mutations on their substrates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Mengyang Niu, Changjian Bao, Junyi Zhan, Xiaomeng Yue, Jianwen Zou, Nana Su, Jin Cui
Summary: This study elucidated the biological function of Cd-related gene BcHIPP16 and demonstrated its role in nutrient metal Cu and heavy metal Cd uptake in plants. Through expression experiments in yeast and Arabidopsis, it was confirmed that BcHIPP16 contributes to Cu and Cd accumulation and sensitivity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biochemistry & Molecular Biology
Anna G. Mankovich, Brian C. Freeman
Summary: Heat shock protein 90 (Hsp90), a highly conserved molecular chaperone, not only maintains the stability of metastable proteins, but also plays a crucial role in protein transport. The specific contributions of Hsp90 to protein transport are still not well defined, despite numerous connections with factors involved in this process.