Article
Nutrition & Dietetics
Luma Melo, Karen Tilmant, Amit Hagar, James E. Klaunig
Summary: Chronic endurance exercise is beneficial in preventing and treating metabolic diseases by modifying hepatic gene expression and pathways. The mouse exercise model used in the study helps understand the effects of exercise on human diseases.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Kawther S. EL-Gendy, Nagat M. Aly, Fatma H. Mahmoud, Dina Abed Allah
Summary: Acetamiprid is an effective insecticide, but sublethal doses of it pose toxic risks to the liver and kidneys. Quercetin can alleviate the harmful effects of acetamiprid.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Xing Li, Tuo Li, Zhenpeng Wang, Jinchao Wei, Jianan Liu, Yangyang Zhang, Zhenwen Zhao
Summary: The study revealed that PFOS mainly accumulates in the liver of animals and can cross the blood-brain barrier to cause neurotoxicity. The impact of PFOS is mainly concentrated on glycerophospholipid and sphingolipid metabolism. Additionally, the synthesis of phosphatidylcholine may serve as a self-protection mechanism in response to PFOS-induced inflammation.
Article
Biology
Omaima Nasir
Summary: The study demonstrated the hepatoprotective and nephroprotective effects of Acorus calamus, which reduced food intake, body weight, plasma electrolyte concentration, and increased electrolyte excretion in urine. Biochemical findings indicated hepatoprotective effects of AC, while histopathological changes showed its nephroprotective nature.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Food Science & Technology
Zixin Zhu, Qiuyun Shi, Jianwei Wu, Kangli He, Jianguo Feng, Sa Dong
Summary: Acetamiprid (ACE) is a widely used chemical in vegetables to control pests, but its residues pose a threat to human health. To rapidly detect ACE residues in vegetables, researchers have developed an indirect competitive chemiluminescence enzyme immunoassay (ic-CLEIA), which is simple, sensitive, and accurate.
Article
Environmental Sciences
Mohsen Shamsi, Maliheh Soodi, Shirin Shahbazi, Ameneh Omidi
Summary: The study found that Acetamiprid reduces glutamate levels, affects the expression of NMDA receptor subunits in the hippocampus, leading to impaired memory consolidation at low doses, and loss of neural cells in the dentate gyrus area at high doses.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Microbiology
Ye Rin Park, Hae Lee Lee, Ji Ye Hyun, Jieun Choi, Ji Hyun Moon, Byung Yong Kim, Seung-Jo Yang, Je Hee Lee, Byoung Kook Kim, Tae-Sik Park, Ki Tae Suk, Do Yup Lee
Summary: This study investigates the therapeutic effects of human gut-derived Bacteroides species on liver cirrhosis in a mouse model. The results show that Bacteroides treatment improves liver function and hepatic fibrosis biomarkers. Metabolomic analysis reveals distinctive profiles in fecal samples, with propionic acid identified as a potential key metabolite for therapeutic effects. Microbiome analysis shows that Akkermansia muciniphila is retained in the Bacteroides-treated group. This study demonstrates that Bacteroides species, particularly B. dorei, ameliorate liver cirrhosis by modulating the metabolic and microbial environment within the gut-liver axis.
MICROBIOLOGY SPECTRUM
(2023)
Article
Environmental Sciences
Heba Nageh Gad El-Hak, Rasha A. Al-Eisa, Lamia Ryad, Ekramy Halawa, Nahla S. El-Shenawy
Summary: This study investigated the effects of acetamiprid and azoxystrobin on male rats. It found that these pesticides disrupted oxidative and metabolic processes, leading to testis damage. Nitric oxide levels increased while enzyme activity and hormone levels decreased. The structure of testis and liver, as well as sperm parameters, were also affected.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Changzhou Cai, Huailu Ma, Jin Peng, Xiang Shen, Xinghua Zhen, Chaohui Yu, Pumin Zhang, Feng Ji, Jiewei Wang
Summary: Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a key role in combating oxidative stress by regulating anti-oxidation gene expression. The deubiquitinase USP25 binds to KEAP1 and prevents its own degradation, leading to the stabilization of NRF2. This study demonstrates that inhibiting or genetically eliminating USP25 attenuates liver damage and reduces mortality rates caused by acetaminophen (APAP) overdose-induced oxidative stress in mice.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Hirokatsu Saito, Yusuke Furukawa, Takahiro Sasaki, Satoshi Kitajima, Jun Kanno, Kentaro Tanemura
Summary: This study investigated the effects of low-level, chronic neonicotinoid exposure in early life on the brain functions of adult mice. Results showed that early exposure to neonicotinoids led to impaired learning and memory, as well as a decrease in the number of neural stem cells and astrocyte cells in the hippocampus.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Immunology
Fuqiang Pan, Huiting Du, Weiguo Tian, Huihui Xie, Bochao Zhang, Wanzhen Fu, Yunsheng Li, Yinghui Ling, Yunhai Zhang, Fugui Fang, Ya Liu
Summary: The study aimed to investigate the effects of immunocastration on the development of the immune system in rats. Rats were immunized with gonadotropin-releasing hormone (GnRH) and samples were collected periodically. The results showed that GnRH immunization led to increased antibody titers, reduced testosterone concentration, and changes in immune markers and cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Cigdem Sevim, Erol Akpinar, Emrah Hicazi Aksu, Ali Dogan Omur, Serkan Yildirim, Mehtap Kara, Ismail Bolat, Aristides Tsatsakis, Robin Mesnage, Kirill S. S. Golokhvast, Sevgi Karabulut Uzuncakmak, Rabia Nilufer Ersoylu
Summary: The study aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. Acetamiprid and imidacloprid caused degeneration and necrosis of spermatocytes, severe edema of the intertubular region, and hyperemia. This was accompanied by increased oxidative stress and apoptosis. Saccharomyces boulardii supplementation mitigated these toxic effects.
Article
Nutrition & Dietetics
Daniela N. Zambrano, Jingjie Xiao, Jorge L. S. Soares, Carla M. Prado, Maria Cristina Gonzalez
Summary: This study aimed to explore the associations between muscle mass and muscle radiodensity with muscle strength in patients with liver cirrhosis. The results showed positive correlations between muscle mass and muscle strength, and negative correlations between age and disease severity and muscle strength. Multivariable analyses revealed significant associations between comorbidities, disease severity, and muscle mass with muscle strength.
Article
Oncology
Federica Innocenti, Sara Di Persio, Marilena Taggi, Roberta Maggio, Pina Lardo, Vincenzo Toscano, Rita Canipari, Elena Vicini, Antonio Stigliano
Summary: Mitotane (MTT) is the preferred treatment for adrenocortical carcinoma. This study aimed to evaluate the impact of MTT on male gonadal function and propose a sperm cryopreservation program for male patients of childbearing age. The results showed that MTT negatively affects the male reproductive system, including changes in testicular tissue morphology and reductions in sperm concentration and quality.
Article
Endocrinology & Metabolism
Shiguan Wang, Shanze Chen, Jianfeng Sun, Pan Han, Bowen Xu, Xinying Li, Youquan Zhong, Zaichao Xu, Peng Zhang, Ping Mi, Cuijuan Zhang, Lixiang Li, Haiyan Zhang, Yuchen Xia, Shiyang Li, Mathias Heikenwalder, Detian Yuan
Summary: Wang et al. found that the RNA methyltransferase Mettl3 contributes to hepatic sphingolipid homeostasis by promoting RNA decay of the sphingomyelinase Smpd3 during postnatal liver development, with Mettl3 deficiency leading to ceramide accumulation and liver developmental defects.
