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Nutrition & Dietetics
Mohammad Taghi Beigmohammadi, Sama Bitarafan, Alireza Abdollahi, Laya Amoozadeh, Faeze Salahshour, Maedeh Mahmoodi Ali, Danesh Soltani, Zoya Asl Motallebnejad
Summary: This study compared the serum level of micronutrients in COVID-19 patients, and found that lower levels of vitamin D, zinc, and magnesium were associated with disease severity and inflammatory markers.
Article
Medicine, Research & Experimental
Xiaoyue Yang, Rui Hu, Yajun Zhu, Zhen Wang, Yilin Hou, Kangkang Su, Xiaoyu He, Guangyao Song
Summary: This article conducted a meta-analysis on the association between vitamin B12 levels and diabetic retinopathy in patients with type 2 diabetes. The study found a significant correlation between low serum vitamin B12 levels and the risk of diabetic retinopathy, especially in East Asian, South Asian, and mixed populations.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Laila Meija, Anna Piskurjova, Ksenija Nikolajeva, Olga Aizbalte, Roberta Rezgale, Aivars Lejnieks, Vinita Cauce
Summary: This cross-sectional study in Latvia evaluated the vitamin D levels and intake of pregnant women. The results showed that a minority of pregnant women had sufficient vitamin D, and diet did not significantly affect vitamin D levels. Therefore, a recommended daily intake of 63 mcg (2500 IU) of vitamin D during pregnancy is proposed to maintain optimal levels.
Article
Medicine, General & Internal
Anna Walawska-Hrycek, Weronika Galus, Eugeniusz Hrycek, Aleksandra Kaczmarczyk, Ewa Krzystanek
Summary: The study indicated that low-dose vitamin D supplementation can normalize serum levels in patients with RRMS and increase levels of anti-inflammatory cytokines, maintaining a beneficial anti-inflammatory cytokine profile.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alma Prtina, Nela Raseta Simovic, Tatjana Milivojac, Milorad Vujnic, Milkica Grabez, Dragan Djuric, Milos P. Stojiljkovic, Valentina Soldat Stankovic, Miodrag J. Colic, Ranko Skrbic
Summary: High doses of vitamin D supplementation in psoriatic patients with vitamin D deficiency led to significant improvements in clinical symptoms, reduced levels of Hcy and folate, decreased pro-inflammatory cytokines, and increased anti-inflammatory cytokines. This suggests that vitamin D supplementation could be a potential preventive and therapeutic strategy to reduce systemic inflammation in psoriatic patients.
Article
Medicine, General & Internal
Wei-Jing Zhao, Xin-Yi Xia, Jun Yin
Summary: The study found that vitamin D deficiency is independently associated with a higher risk of DPN and DN in T2DM patients, but not DR. Additionally, vitamin D deficiency may serve as a potential predictor for both the occurrence and severity of DPN and DN.
CHINESE MEDICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Sadaf Jamal Gilani, May Nasser Bin-Jumah, Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Muhammad Afzal, Sami Alzarea, Nadeem Sayyed, Imran Kazmi
Summary: The study aimed to confirm the anti-diabetic activity and mechanism of rosinidin in a laboratory setting. Treatment with rosinidin showed positive effects on diabetes, including lower blood glucose levels, increased serum insulin levels, and improved pancreatic function in rats induced with streptozotocin.
Article
Biochemistry & Molecular Biology
Mehmet Caliskan, Murat Dabak, Kenan Cagri Tumer
Summary: It is important to understand the immunological response characteristics of newborn calf diarrhea caused by various pathogens. Cytokines play a key role in regulating immune responses. Changes in circulatory cytokine levels are valuable for understanding the disease process. Vitamin D has immunomodulatory effects and may be involved in the immune response in calf diarrhea.
Article
Medicine, Research & Experimental
Hisato Kobayashi, Xinmin Zha, Keiko Nagase, So Inamura, Minekatsu Taga, Yoshitaka Aoki, Hideaki Ito, Osamu Yokoyama
Summary: Hyperinsulinemia is an important causative factor of prostate enlargement in type 2 diabetes (T2D), however, clinically prostate weight increases during hypoinsulinemic condition. This study suggests that chronic ischemia caused by T2D leads to oxidative stress, resulting in prostate enlargement through upregulation of several cytokines and growth factors. Treatment with phosphodiesterase 5 inhibitor (PDE5i) improves prostate ischemia and might prevent enlargement via suppression of cytokines and growth factors in T2D.
Article
Nutrition & Dietetics
Dana A. A. Bader, Anas Abed, Beisan A. A. Mohammad, Ahmad Aljaberi, Ahmad Sundookah, Maha Habash, Ahmad R. R. Alsayed, Mohammad Abusamak, Sami Al-Shakhshir, Mahmoud Abu-Samak
Summary: This research evaluated the effects of high-dose cholecalciferol supplements on selected circulating cytokines associated with cytokine storms in adults with vitamin D deficiency. The results showed that the supplementation significantly increased the levels of certain cytokines. However, further trials are needed to clarify the potential benefits of the supplementation during cytokine storms.
Article
Biochemistry & Molecular Biology
Beydolah Shahouzehi, Mostafa Eghbalian, Hossein Fallah, Soheil Aminizadeh, Yaser Masoumi-Ardakani
Summary: This study found that miR-33 expression significantly increased in pre-diabetic individuals and was positively correlated with pre-diabetic state, sex, and FBS. Furthermore, in individuals with high physical activity, there were no diabetic subjects, indicating a potential role of miR-33 in monitoring pre-diabetes onset and progression.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Nutrition & Dietetics
Lara S. Boerenkamp, Birgit L. M. G. Gijsbers, Erik-Jan Ververs, Eva M. S. Pijpers, Bart Spaetgens, Aniek de Coninck, Wilfred T. V. Germeraad, Will K. W. H. Wodzig, Lotte Wieten, Gwendolyn N. Y. van Gorkom, Catharina H. M. J. van Elssen
Summary: This study investigated the levels of serum and intracellular vitamin C in hospitalized COVID-19 patients and found lower serum vitamin C levels in severe and critical cases. The study suggests that intracellular vitamin C levels decrease during COVID-19 infection, while serum levels remain relatively stable. These findings highlight the importance of further research on the role and mechanisms of intracellular vitamin C in COVID-19 infection.
Article
Biochemistry & Molecular Biology
Hongjuan Wang, Huan Chen, Yaning Fu, Min Liu, Jingni Zhang, Shulei Han, Yushan Tian, Hongwei Hou, Qingyuan Hu
Summary: This study investigates the expression levels of cytokines and chemokines in the serum of healthy male volunteers, including non-smokers, current smokers, and ex-smokers. The results show that the expression levels of certain cytokines increase after smoking and continue to increase after quitting smoking. Understanding the physiological production of these cytokines could help evaluate the early development of smoking-related chronic diseases and cancers.
Article
Endocrinology & Metabolism
Junxiong Ma, Jun Liu, Yu Chen, Hailong Yu, Liangbi Xiang
Summary: The study showed the therapeutic potential of myricetin in the management of diabetic peripheral neuropathy (DPN), suggesting it can improve impaired neural functions and reduce the generation of harmful molecules such as advanced glycation end-products (AGEs) and reactive oxygen species (ROS).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hamed Hajizadeh Tekmeh, Birgul Vanizor Kural, Sevil Kor, Meltem Arikan Malkoc, Esin Yulug, Abdulkadir Kutlu, Ismail Abidin, Asim Orem
Summary: This study aimed to investigate the effects of L-Theanine (LTN) on the levels of BDNF, insulin, and adipocytokines in the hippocampus of diabetic rats. The results showed that LTN treatment significantly decreased leptin and adiponectin levels in hippocampal tissues, while having no significant effect on other parameters. LTN was found to have the potential to reduce hippocampal degeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
