Review
Medicine, General & Internal
Young-Sung Kim, Byung-Gun Lim, Young-Ju Won, Seok-Kyeong Oh, Jung-Suk Oh, Soo-Ah Cho
Summary: Through a systematic review, it was found that the efficacy and safety of using Sugammadex to reverse rocuronium-induced NMB in ESRD patients are good, although the recovery to a TOF ratio of 0.9 may take longer. However, further studies are needed due to the limited number of studies and high heterogeneity in some of the results.
MEDICINA-LITHUANIA
(2021)
Article
Anesthesiology
M. Carron, G. Andreatta, E. Pesenti, A. De Cassai, P. Feltracco, F. Linassi, M. Sergi, C. Di Bella, M. Di Bello, F. Neri, C. Silvestre, L. Furian, P. Navalesi
Summary: This retrospective cohort case-control study aimed to compare the effects of sugammadex and neostigmine in reversing neuromuscular block (NMB) in patients undergoing kidney transplantation. The results showed that the sugammadex group had better postoperative kidney function, lower incidence of severe hypoxemia, shorter post-anesthesia care unit stay, and reduced intensive care unit admissions compared to the neostigmine group.
PERIOPERATIVE MEDICINE
(2022)
Article
Anesthesiology
Paulo A. Germano-Filho, Ismar L. Cavalcanti, Angelo J. Q. R. Micuci, Luis G. C. Velarde, Hans D. de Boer, Nubia Vercosa
Summary: The objective of this study was to test the hypothesis that magnesium sulfate after reversal with sugammadex causes recurarization. The study was designed as a single-center, prospective, randomized, double-blind, controlled trial. The results showed that in the magnesium sulfate group, 64% of patients with deep blockade and 73% of patients with moderate blockade experienced recurarization, while in the placebo group, only 7% and 0% of patients experienced recurarization, respectively. This study demonstrated that a single dose of magnesium sulfate led to recurarization in patients who had recovered from rocuronium-induced deep and moderate neuromuscular blockade using sugammadex, and additional sugammadex could reverse prolonged recurarization.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Medicine, Research & Experimental
Cristian Aragon-Benedi, Sara Visiedo-Sanchez, Ana Pascual-Bellosta, Sonia Ortega-Lucea, Rafael Fernandez-Liesa, Javier Martinez-Ubieto
Summary: The study found that using rocuronium in microlaryngeal surgery can provide better surgical conditions, lower doses of remifentanil, shorten awakening time, and reduce complications associated with high doses of remifentanil.
Article
Medicine, General & Internal
Juan Fiorda Diaz, Marco Echeverria-Villalobos, Alan Esparza Gutierrez, Olufunke Dada, Nicoleta Stoicea, Wiebke Ackermann, Mahmoud Abdel-Rasoul, Jarrett Heard, Alberto Uribe, Sergio D. D. Bergese
Summary: This study compared the effectiveness and cost-effectiveness of sugammadex and neostigmine for moderate neuromuscular blockade reversal. The results showed that sugammadex achieved faster reversal without increasing perioperative costs.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Sheng-Kai Hung, Chia-Chi Yeh, Pei-Chi Ting, Cay-Huyen Chen, Ming-Chang Kao
Summary: Although rare, anaphylaxis during anesthesia can be caused by neuromuscular blocking drugs. This case report highlights the potential benefit of using sugammadex as an adjunct treatment option for rocuronium-induced anaphylaxis.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Anesthesiology
Kohji Uzawa, Hiroyuki Seki, Tomoko Yorozu
Summary: In this case, the recommended dose of sugammadex failed to completely reverse the rocuronium-induced neuromuscular blockade, requiring an additional dose of sugammadex to return to normal levels.
BMC ANESTHESIOLOGY
(2021)
Article
Anesthesiology
Sakiko Hiramatsu, Katsuyuki Moriwaki, Miwako Nakao, Yasuo M. Tsutsumi
Summary: This case illustrates that rocuronium can lead to prolonged neuromuscular respiratory paralysis that is resistant to sugammadex in patients with CMT1A and impaired respiratory function. Furthermore, restrictive pulmonary impairment and a low nerve conduction velocity of 20 m/s may be predictive factors for prolonged neuromuscular respiratory paralysis that is resistant to sugammadex in CMT1A patients.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Article
Anesthesiology
Sayomi Tsukada, Sayuri Shimizu, Kiyohide Fushimi
Summary: The study found that using rocuronium reversed by sugammadex in the anaesthetic management of patients with myasthenia gravis undergoing thymectomy did not increase the risk of respiratory complications, and significantly shortened the length of hospital stay.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2021)
Review
Emergency Medicine
Skyler Lentz, Katelin M. Morrissette, Blake A. Porter, Kyle M. DeWitt, Alex Koyfman, Brit Long
Summary: Sugammadex is a newly available medication that rapidly reverses neuromuscular blockade. It can facilitate urgent neurological examinations, but its routine use in failed or difficult airway management is not supported by literature. It is important to prioritize oxygenation and ventilation in such situations.
JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yong Beom Kim, Jae-Moon Choi, Chungon Park, Hey-Ran Choi, Junyong In, Hong-Seuk Yang
Summary: Sevoflurane affects the A1 receptor and delays the recovery from neuromuscular blockade.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Review
Anesthesiology
Sher-Lu Pai, Dennis Grech, Steven Gayer, Leopoldo Rodriguez, Girish P. Joshi, Niraja Rajan
Summary: This study aims to evaluate the clinical utility, patient safety, and financial implications of using rocuronium and sugammadex instead of succinylcholine and dantrolene in class B surgical facilities. The results show that both succinylcholine and rocuronium-sugammadex provide adequate treatment for airway emergencies and rapid spontaneous ventilation, but succinylcholine has a superior economic and clinical profile.
MINERVA ANESTESIOLOGICA
(2023)
Article
Anesthesiology
T. Andrew Bowdle, Kishanee J. Haththotuwegama, Srdjan Jelacic, Sharon T. Nguyen, Kei Togashi, Kelly E. Michaelsen
Summary: Sugammadex dose titration is necessary for effective reversal of neuromuscular blockade after rocuronium administration. Most patients require less than the recommended dose, but some may need more, and recurrent paralysis can occur.
Article
Anesthesiology
Sirkku Ahlstrom, Paula Bergman, Ritva Jokela, Linda Ottensmann, Ari Ahola-Olli, Matti Pirinen, Klaus T. Olkkola, Mari A. Kaunisto, Eija Kalso
Summary: Genetic variation in the SLCO1A2 gene, accounting for 4% of the variation in rocuronium consumption, was identified as a factor influencing rocuronium dosage. However, the underlying mechanism remains unknown.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Editorial Material
Health Care Sciences & Services
Cyrus Motamed
Summary: Sugammadex is used in various emergency situations, including emergency surgery and rapid sequence intubation. The trend of using sugammadex after rocuronium instead of succinylcholine is increasing. In other emergency situations, such as anaphylactic shock caused by rocuronium or when intubation or ventilation is not possible, priority should be given to maintaining ventilation and hemodynamic stability, according to the traditional guidelines. Prompt reversal of neuromuscular blockade should be done if necessary for resuming ventilation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Anesthesiology
M. Vaneker, J. P. Santosa, L. M. Heunks, F. J. Halbertsma, D. G. Snijdelaar, J. van Egmond, I. A. van den Brink, F. M. van de Pol, J. G. van der Hoeven, G. J. Scheffer
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2009)
Article
Anesthesiology
L. Kadic, M. C. Boonstra, M. C. De Waal Malefijt, S. J. Lako, J. van Egmond, J. J. Driessen
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2009)
Article
Anesthesiology
F. G. A. M. van Haren, J. J. Driessen, L. Kadic, J. van Egmond, L. H. D. J. Booij, G. J. Scheffer
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2010)
Article
Anesthesiology
L. M. Staals, J. J. Driessen, J. van Egmond, H. D. de Boer, M. Klimek, E. A. Flockton, M. M. J. Snoeck
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2011)
Article
Anesthesiology
L. E. H. Vanlinthout, L. H. D. J. Booij, J. van Egmond, E. N. Robertson
Letter
Anesthesiology
H. D. de Boer, J. van Egmond, J. J. Driessen, L. H. J. D. Booij
Article
Anesthesiology
Willem-Jan M. Schellekens, Hieronymus W. H. van Hees, Michiel Vaneker, Marianne Linkels, P. N. Richard Dekhuijzen, Gert Jan Scheffer, Johannes G. van der Hoeven, Leo M. A. Heunks
Article
Rehabilitation
Jan-Willem Ek, Jan C. van Gijn, Han Samwel, Jan van Egmond, Frank P. A. J. Klomp, Robert T. M. van Dongen
CLINICAL REHABILITATION
(2009)
Article
Anesthesiology
Lonneke M. Staals, Jan van Egmond, Jacques J. Driessen, Hans D. de Boer, Francien van de Pol, Anton H. Bom, Leo H. D. J. Booij
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2011)
Article
Pharmacology & Pharmacy
Karel-Martijn Kalff, Mohammed El Mouedden, Jan van Egmond, Jan Veening, Leo Joosten, Gert Jan Scheffer, Theo Meert, Kris Vissers
EUROPEAN JOURNAL OF PHARMACOLOGY
(2010)
Article
Biophysics
Mathieu G. Sommers, Jan van Egmond, Leo H. D. J. Booij, Arend Heerschap
NMR IN BIOMEDICINE
(2009)
Article
Anesthesiology
Hendrik van de Meent, Margreet Oerlemans, Almar Bruggeman, Frank Klomp, Robert van Dongen, Rob Oostendorp, Jan Paul Froelke
Letter
Anesthesiology
H. D. De Boer, L. H. D. J. Booij
INDIAN JOURNAL OF ANAESTHESIA
(2013)
Article
Anesthesiology
H. D. de Boer, J. van Egmond, J. J. Driessen, L. H. J. D. Booij
REVISTA ESPANOLA DE ANESTESIOLOGIA Y REANIMACION
(2010)