Review
Anesthesiology
Shane Varughese, Raza Ahmed
Summary: Inhaled anesthetics such as N2O and sevoflurane are potent greenhouse gases and ozone-depleting agents, posing risks to personnel through occupational exposure. Specific measures to reduce occupational exposure and environmental impact, such as efficient ventilation systems and regular monitoring of waste gas concentrations, should be implemented to mitigate these risks.
ANESTHESIA AND ANALGESIA
(2021)
Article
Multidisciplinary Sciences
Marco Ronzani, Simon Woyke, Norbert Mair, Hannes Gatterer, Herbert Oberacher, David Plunser, Thomas Haller, Mathias Stroehle, Christopher Rugg
Summary: Desflurane, isoflurane, and sevoflurane, three commonly used inhaled anesthetics, have varying effects on hemoglobin-oxygen affinity at different doses, but the underlying mechanisms are unclear.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Henriikka Hakomaki, Hannu Kokki, Marko Lehtonen, Juha Rasanen, Hanna-Marja Voipio, Veli-Pekka Ranta, Merja Kokki
Summary: The study on pregnant sheep using extended-release buprenorphine transdermal patch found low transplacental passage of buprenorphine from the mother to the fetus, supporting buprenorphine as an alternative to methadone in opioid maintenance therapy during pregnancy.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Reproductive Biology
Leslie A. Lekatz, Praveen Shukla, Stephen T. O'Rourke, Christopher S. Schauer, Megan L. Van Emon, Kasey R. Maddock-Carlin, Kimberly A. Vonnahme
Summary: This study hypothesized that isocaloric diets low in protein would decrease the sensitivity of caruncular and cotyledonary arteries. The results showed that low protein intake increased the sensitivity of cotyledonary arteries to low doses of potassium chloride, while caruncular arteries of ewes on 80% MP diet were more sensitive to bradykinin compared to ewes on 60% and 100% MP diets.
Article
Obstetrics & Gynecology
Hua Zen Ling, Gavin P. Guy, Alessandra Bisquera, Kypros H. Nicolaides, Nikos A. Kametas
Summary: This study aimed to evaluate the trends in maternal cardiac function, fetal growth, and oxygenation with advancing gestational age in a routine obstetrical population and all ranges of birthweight percentiles. The results showed that there were differences in cardiac adaptation, fetal growth pattern, and oxygenation between different birthweight percentile groups.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Koichi Yuki, Yusuke Mitsui, Miho Shibamura-Fujiogi, Lifei Hou, Kirsten C. Odegard, Sulpicio G. Soriano, Gregory P. Priebe, Sophia Koutsogiannaki
Summary: Isoflurane and sevoflurane, commonly used volatile anesthetics, show immunomodulatory effects and may impact disease progression by attenuating lung injury and inhibiting TLR5 activation. Studies suggest they have a protective effect on gas exchange in patients with cystic fibrosis. Additionally, docking simulations indicate these anesthetics interact with TLR5 and flagellin for potential therapeutic benefits.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Obstetrics & Gynecology
Leena Alanne, Amarnath Bhide, Juulia Lantto, Heikki Huhta, Merja Kokki, Mervi Haapsamo, Ganesh Acharya, Juha Rasanen
Summary: In hypoxic fetuses, nifedipine impairs right ventricular function and reduces its cardiac output. However, the detrimental effects of nifedipine are abolished when normal oxygen levels are restored.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Medicine, General & Internal
Laura Jansen, Bente F. H. Dubois, Markus W. Hollmann
Summary: Every year, millions of patients are diagnosed with cancer and undergo surgical resection with anesthesia. However, a significant number of these patients experience recurrence or metastasis after surgery. The effect of different anesthesia techniques on postoperative outcomes in oncological surgery is still controversial and lacks substantial evidence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Brendan Gill, Jason L. L. Bartock, Emily Damuth, Nitin Puri, Adam Green
Summary: Volatile anesthetics, particularly isoflurane, have been shown to be effective in treating refractory status asthmaticus (SA). In this case report, we describe the use of systemic isoflurane delivered via the extracorporeal membrane oxygenation (ECMO) circuit to treat severe refractory SA in a patient on VV ECMO. This novel approach allowed for successful management of the patient's bronchospasm and ultimately led to decannulation from VV ECMO and extubation.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Caroline Charlier, Julia Dina, Francois Freymuth, Astrid Vabret, Olivier Lortholary, Denise Antona, Marc Lecuit
Summary: Research shows that measles virus can be detected in the saliva and blood of pregnant women, leading to transmission to the fetus during pregnancy, resulting in asymptomatic infection at birth. Despite severe peripartum congenital measles, asymptomatic vertical transmission of the measles virus can occur in early pregnancy.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Chemistry, Multidisciplinary
Davell Carter, Marina Better, Saed Abbasi, Fareeha Zulfiqar, Rachel Shapiro, Laura M. Ensign
Summary: Conception, pregnancy, and childbirth are complex processes that have significant impact on both the mother and fetus. However, there is a lack of safe and effective treatment options in women's health and pregnancy. The physiological changes during menstrual cycle and pregnancy make drug administration and delivery more complicated, and overcoming physiological barriers is also challenging. Nanomedicine offers a unique opportunity to improve safety and minimize side effects by targeting drug delivery to the reproductive tract and other relevant organs in the mother and fetus, and has the potential to improve the management and treatment of infertility, obstetric complications, and fetal conditions.
Article
Medicine, General & Internal
Philipp Daume, Johannes Weis, Hagen Bomberg, Martin Bellgardt, Thomas Volk, Heinrich V. Groesdonk, Andreas Meiser
Summary: This study demonstrates that the use of desflurane with the Mirus (TM) system significantly shortens washout times and leads to faster awakening in critically ill patients after sedation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Taiming Liu, Meijuan Zhang, Avoumia Mourkus, Hobe Schroeder, Lubo Zhang, Gordon G. Power, Arlin B. Blood
Summary: Chronic hypoxia at high altitude alters iron homeostasis and bioactive nitric oxide metabolites (NOx) levels in the fetal circulation. The fetus utilizes iron from non-hematopoietic tissues for erythropoiesis and shows increased bioavailability of NO in response to hypoxic stress at high altitude during gestation.
Article
Thermodynamics
Jan Hojak, Christian Blaeker, Christoph Pasel, Dieter Bathen
Summary: This study investigates the adsorption characteristics of different fluranes on activated carbon at different humidities. The results show that the higher the humidity, the lower the adsorption capacity of the activated carbon. The coadsorption of fluranes and water is influenced by factors such as molecular size, polarizability, and polarity. Mechanistic effects, such as blocking of adsorption sites by water, displacement of water molecules by flurane, and formation of water clusters, are derived from the isotherm data.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2022)
Review
Medicine, General & Internal
Wilfried Gyselaers, Christoph Lees
Summary: This narrative review summarizes the current evidence on the association between maternal low volume circulation and poor fetal growth. It suggests that low intravascular volume may play a role in explaining the relationship between high vascular resistance, hypertension in women with preeclampsia, and fetal growth restriction. The review also discusses the potential benefits of increasing maternal intravascular volume through physical exercise or Nitric Oxide Donors for preventing and managing conditions such as fetal growth restriction and early onset preeclampsia.
FRONTIERS IN MEDICINE
(2022)