Article
Biochemistry & Molecular Biology
Yu Chen, Zhengyi Zhen, Lingjiang Chen, Hao Wang, Xuhui Wang, Xiaoxiang Sun, Zhiwei Song, Haiyan Wang, Yizi Lin, Wenjun Zhang, Guizhu Wu, Ying Jiang, Zhiyong Mao
Summary: Aging is accompanied by decreased DNA repair capacity, which contributes to age-associated functional decline in multiple tissues. Hormone signaling disruption, associated with reproductive organ dysfunction, is an early event of tissue degeneration, but its impact on DNA repair in nonreproductive organs is unclear. This study shows that the downregulation of XRCC4 expression, involved in DNA repair, is mediated through transcriptional mechanisms. The androgen receptor directly binds to and enhances the activity of the XRCC4 promoter, stabilizing the genome. DHT treatment reverses senescence-associated phenotypes, providing a potential avenue for aging interventions.
Review
Endocrinology & Metabolism
Nadia Y. Edelsztein, Clara Valeri, Maria M. Lovaisa, Helena F. Schteingart, Rodolfo A. Rey
Summary: Anti-Mullerian hormone (AMH) is a biomarker of immature Sertoli cells, which is regulated by specific transcription factors and plays a role in the regression of Mullerian ducts in males. AMH is highly expressed before puberty and then downregulated. FSH increases AMH output, while intratesticular levels of androgens and estrogens also regulate AMH secretion.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Hongwei Duan, Longfei Xiao, Wenbo Ge, Shanshan Yang, Yuting Jiang, Jianshu Lv, Junjie Hu, Yong Zhang, Xingxu Zhao, Yongli Hua
Summary: The study found that 5 alpha-reductases and androgen receptors are expressed in ovine ovaries, with the expression of 5 alpha-reductases increasing as follicles develop, while androgen receptor levels decrease. FSH and LH can upregulate 5 alpha-reductases in sheep granulosa cells, leading to a reduction in DHT levels and an increase in estradiol synthesis.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Article
Biochemistry & Molecular Biology
Marton A. Kiss, Miroslav Perina, Laura Bereczki, Adam Baji, Jakub Belicek, Radek Jorda, Eva Frank
Summary: Dysfunction of the androgen receptor signalling axis is important in prostate cancer development and progression. A series of A-ring-fused pyridine compounds were synthesized, and one derivative, 1d, showed AR antagonistic activity and inhibited the survival and proliferation of AR-positive PCa cell lines. Molecular modelling revealed the binding mode and crucial interactions of this compound.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fidel Orlando Buendia-Gonzalez, Martha Legorreta-Herrera
Summary: Androgens are steroids that regulate various processes in the body, including reproduction, metabolism, and immune response. The main androgens are testosterone, dihydrotestosterone (DHT), and dehydroepiandrosterone (DHEA). These hormones have concentration-dependent effects on the immune response and can both suppress and promote it. DHEA and testosterone have similar effects in activating regulatory T cells and suppressing the Th17-type immune response, but testosterone suppresses inflammation while DHEA promotes it.
Article
Biochemistry & Molecular Biology
Kaitao Li, Yang Sun, Shizhao Liu, Yi Zhou, Qian Qu, Gaofeng Wang, Jin Wang, Ruosi Chen, Zhexiang Fan, Bingcheng Liu, Yuning Li, Xiaoyan Mao, Zhiqi Hu, Yong Miao
Summary: The study found that miR-221 significantly suppressed hair growth and proliferation in AGA patients. Mechanistic analysis revealed that AR directly promoted miR-221 transcription, leading to the inactivation of the MAPK pathway in DPCs and the PI3K/AKT pathway in DSCs. MiR-221 could serve as a novel biomarker and potential therapeutic target for treating AGA.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ja Yeon Park, Woo Yong Park, Gahee Song, Se Jin Jung, Beomsu Kim, Minji Choi, Sang Hee Kim, Jinbong Park, Hyun Jeong Kwak, Kwang Seok Ahn, Jun Hee Lee, Jae-Young Um
Summary: This study aimed to investigate the therapeutic effects of Panax ginseng water extract (PGWE) on benign prostatic hyperplasia (BPH) and its potential in treating side effects related to finasteride (Fi), an FDA-approved drug for BPH. The results showed that PGWE alleviated BPH symptoms and downregulated androgen-related factors. PGWE also induced prostatic cell apoptosis and improved sperm count in BPH rats. Furthermore, PGWE protected against Fi-induced sperm loss without compromising the therapeutic effects of Fi on BPH. These findings suggest that PGWE could be an alternative therapeutic agent for BPH.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chiara Chiodo, Catia Morelli, Fabiola Cavaliere, Diego Sisci, Marilena Lanzino
Summary: This article reviews the challenges of breast cancer prevention and highlights the role of steroid hormones and their receptors in the development of the disease. It specifically focuses on the impact of androgens and their receptor on breast tissue and their correlation to breast cancer risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ik Jun Moon, Hae Kyeong Yoon, Doyeun Kim, Myung Eun Choi, Seung Hee Han, June Hyun Park, Sun Woo Hong, Hyesoo Cho, Dong-Ki Lee, Chong Hyun Won
Summary: This study evaluated the therapeutic potential of a cell-penetrating, AR-targeting asiRNA for AGA treatment, which effectively downregulated AR expression, prevented DHT-mediated hair changes, and promoted hair growth in mouse models.
MOLECULAR PHARMACEUTICS
(2023)
Article
Urology & Nephrology
David Julian Arias-Chavez, Patrick Mailloux-Salinas, Jessica Ledesma-Aparicio, Elihu Campos-Perez, Omar Noel Medina-Campos, Jose Pedraza-Chaverri, Guadalupe Bravo
Summary: The therapeutic effect of a combination of tomato lipidic extract (STE) and selenium (Se) on rats with prostatic hyperplasia (PH) was evaluated, and its possible mechanisms of action and synergism versus finasteride were observed. The results demonstrated that the combination of STE + Se had a greater therapeutic effect in reducing prostate weight, glandular hyperplasia, oxidative stress, dihydrotestosterone (DHT) and androgen receptor (AR) expression compared to finasteride.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
David Julian Arias-Chavez, Patrick Mailloux-Salinas, Jessica Ledesma-Aparicio, Elihu Campos-Perez, Omar Noel Medina-Campos, Jose Pedraza-Chaverri, Guadalupe Bravo
Summary: This study evaluated the therapeutic effect of a tomato lipidic extract in combination with selenium on rats with prostatic hyperplasia, and observed its possible mechanisms of action and synergism with finasteride. The results showed that the combination of tomato lipidic extract and selenium had a greater therapeutic effect compared to finasteride, without increasing prooxidant activity.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Oncology
Laila Alsawalha, Mamoun Ahram, Mohammad S. Abdullah, Ozlem Dalmizrak
Summary: Enzalutamide enhances the chemosensitivity of triple-negative breast cancer cells to doxorubicin through the apoptosis pathway, while reducing the chemoresistance induced by DHT. The apoptosis pathway involves the regulation of apoptosis genes including mcl1, bcl2, and bid.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Mingxiao Feng, Sara Divall, Dustin Jones, Vaibhave Ubba, Xiaomin Fu, Ling Yang, Hong Wang, Xiaofeng Yang, Sheng Wu
Summary: The study found that the androgen receptor in the liver does not play a role in the reproductive dysfunction induced by high androgen levels, while DHT-treated LivARKO female mice still experienced reproductive issues.
FRONTIERS IN ENDOCRINOLOGY
(2022)