Article
Cardiac & Cardiovascular Systems
Ku-Chi Tsao, Yuh-Charn Lin, Yi-Ting Chen, Shih-Lei Lai, Ruey-Bing Yang
Summary: This study demonstrates the critical cooperation between SCUBE1 and SCUBE2 in regulating angiogenic cell behaviors and the formation of functional vessels during zebrafish embryonic development.
CARDIOVASCULAR RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yoke Chin Chai, San Kit To, Susan Simorgh, Samantha Zaunz, Yingli Zhu, Karan Ahuja, Alix Lemaitre, Roya Ramezankhani, Bernard K. van der Veer, Keimpe Wierda, Stefaan Verhulst, Leo A. van Grunsven, Vincent Pasque, Catherine Verfaillie
Summary: This study created a vascularized concentroid brain model using pluripotent stem cells and endothelial cells, which closely resembles the fetal human brain. This model facilitates the study of neurovascular development, neural cell migration, and vascularization strategies for brain mimics.
Article
Agriculture, Dairy & Animal Science
Maciej Zdun
Summary: The rostral epidural rete mirabile is a structure composed of small arterial vessels that anastomose with each other at the base of the cranial cavity. It helps decrease the temperature of the brain, protects the body from thermal stress, and plays a crucial role in body-water balance and neuropeptide transfer. Comparison of this structure in pigs and hippopotamuses showed differences in shape and blood supplies.
Article
Chemistry, Multidisciplinary
Dominic Rutsche, Monica Nanni, Simon Rudisser, Thomas Biedermann, Marcy Zenobi-Wong
Summary: This study introduces a new collagen derivative with multiple recognition peptides for enzyme-mediated crosslinking, enabling the co-engineering of human blood and lymphatic microcapillaries. The study further demonstrates the formation of luminal structures and the maturation markers of bioengineered capillaries both in vitro and in vivo. The versatile collagen derivative is also utilized for spatially defined polymer compositions with pro- and anti-angiogenic properties, as well as the formation of vascularization independent from fibroblasts.
ADVANCED MATERIALS
(2023)
Article
Physiology
Joana T. Rosa, Paul Eckhard Witten, Ann Huysseune
Summary: The translation discusses the relationship between osteoblasts and odontoblasts, as well as the diverse tooth attachment modes and tissue properties in mammals and teleost fish. There is a debate about the nature of the bone of attachment tissue and the cells secreting it, with scpp5 expression helping to characterize the cells involved in the process. The findings suggest that the bone of attachment in zebrafish shares characteristics of both bone and dentin, and may be better termed as dentinous bone.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Sport Sciences
Ole Kristian Berg, Fredrik Paulsberg, Clara Brabant, Keyvan Arabsolghar, Sigrid Ronglan, Nina Bjornsen, Tom Torhaug, Fredrik Granviken, Sigmund Gismervik, Jan Hoff
Summary: The study demonstrated that adding high-intensity rotator cuff exercises is a feasible intervention in patients with chronic SAPS, improving endurance performance significantly more than usual care alone and showing positive effects on shoulder pain and disability.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Polymer Science
Roni Cohen, Ester-Sapir Baruch, Itai Cabilly, Assaf Shapira, Tal Dvir
Summary: Appropriate vascularization is crucial for the survival and function of tissues. Researchers have developed a modified ECM bioink to print large blood vessels with capillary beds using induced pluripotent stem cells derived endothelial cells (iPSCs-ECs).
Review
Medicine, Research & Experimental
Ahmad Hoseinzadeh, Hamed Ghoddusi Johari, Mohammad Hossein Anbardar, Lobat Tayebi, Ehsan Vafa, Milad Abbasi, Ahmad Vaez, Ali Golchin, Ali Mohammad Amani, Ali Jangjou
Summary: Angiogenesis is a critical biological process that plays a crucial role in various physiological activities and disease treatments. Traditional angiogenic therapies have limitations, making the development of new pro-angiogenic and anti-angiogenic substances essential.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Computer Science, Artificial Intelligence
Yufeng Zhou, Tiange Zou, Changshi Liu, Hongxia Yu, Liangyong Chen, Jiafu Su
Summary: This paper investigates the dynamic decision-making problem of blood supply chain under blood shortage conditions, proposing a blood collection decision-making method based on the EWA strategy. Models for blood transshipment and allocation planning are established, and a DESS framework is designed for simulation experiments. The results show that safety stock, target stock level, and demand fluctuation range have significant impacts on the control effect of blood inventory.
APPLIED SOFT COMPUTING
(2021)
Article
Biochemical Research Methods
Adriana Gaia Cairelli, Renee Wei-Yan Chow, Julien Vermot, Choon Hwai Yap
Summary: In this study, the researchers focused on understanding the fluid mechanics associated with embryonic heart trabeculae in zebrafish. They used image-based computational fluid dynamics (CFD) simulations to quantify the fluid dynamics and found that the endocardial wall shear stress (WSS) exceeded previous estimations reported in the literature. They also discovered that a squeeze flow effect within the intra-trabecular spaces accounted for most of the WSS magnitude, rather than the shear interaction with the flow in the main ventricular chamber. The trabecular structures were found to be responsible for the high spatial variability and oscillatory nature of WSS. Additionally, they identified the presence of embryonic hemogenic cells within the intra-trabecular spaces, which increased the endocardial WSS. These findings highlight the complexity of embryonic heart fluid mechanics and provide valuable insights for future studies on the biological effects of these fluid forces.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Review
Cell Biology
Raj Bose, Soumyabrata Banerjee, Gary L. Dunbar
Summary: Brain organoids are important in vitro tools for modeling various aspects of brain development and disorders, providing insights into the molecular mechanisms involved in neurological diseases. Models derived from induced pluripotent stem cells (iPSCs), including 2D, 3D, and blood-brain barrier models, have advantages in disease modeling and can be used to develop vascularized and functional 3D models of brain processes. The applications of brain organoids for modeling major neurodegenerative diseases and neurodevelopmental disorders are also explored in this review.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Nishtha Ranawat, Ichiro Masai
Summary: Microglia are brain-resident macrophages that colonize specific brain regions during development, such as the retina. They use blood vessels as pathways and depend on neuronal differentiation for proper migration. Factors like IL34 also play a role in microglial precursor colonization of the retina.
Article
Veterinary Sciences
Maciej Zdun, Oleg P. Melnyk, Oleksii O. Melnyk, Maria Nabzdyk
Summary: This study aims to describe the blood supply pathways to the cranial cavity and the arterial circle of the brain in the Patagonian mara. The arterial circle is formed by rostral cerebral arteries, caudal communicating arteries, and the basilar artery. Blood supply to the brain occurs through the basilar artery, internal carotid artery, and internal ophthalmic artery.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Clinical Neurology
Armin Thron, Peter Stoeter, Jasmin Schiessl, Andreas Prescher
Summary: This study aimed to improve understanding of the development of spinal cord arterial supply in higher mammals by examining prenatal development in cattle. Results showed that the establishment of the unpaired anterior spinal artery in cattle fetuses goes through multiple reconfiguration procedures before achieving its final design, including regression of the anteromedian tract and emergence of longitudinally anastomosing sulcal/central arteries. Researchers concluded that previous focus on early embryonic development missed the profound remodeling of vascular architecture in the early fetal period.
CLINICAL NEURORADIOLOGY
(2022)
Article
Geriatrics & Gerontology
Patsira Warinsiriruk, Chananya Tantitham, Wichai Cherdshewasart, S. Abbas Shobeir, Jittima Manonai
Summary: This study compared the effects of 6% Pueraria mirifica vaginal gel with placebo gel on postmenopausal women. The results showed that the Pueraria mirifica group had decreased arterial resistance index, increased vaginal maturation index and vaginal health index compared to the placebo group.
