期刊
JOURNAL OF ANATOMY
卷 219, 期 1, 页码 18-32出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1469-7580.2011.01392.x
关键词
cell cycle; glutamate; NG2 glia; oligodendrocytes; proliferation; synaptic transmission
资金
- Centre for Integrative Neuroscience (Deutsche Forschungsgemeinschaft) [EXC 307]
- Christiane Nusslein-Volhard Foundation
Progenitor cells expressing proteoglycan NG2 (also known as oligodendrocyte precursor cells or polydendrocytes) are widespread in the grey and white matter of the CNS; they comprise 8-9% of the total cell population in adult white matter, and 2-3% of total cells in adult grey matter. NG2 cells have a complex stellate morphology, with highly branched processes that may extend more than 100 mu m around the cell body. NG2 cells express a complex set of voltage-gated channels, AMPA/kainate and/or gamma-aminobutyric acid (GABA)(A) receptors, and receive glutamatergic and/or GABAergic synaptic input from neurons. In every region of the brain NG2 cells are found as proliferative cells, and the fraction of actively cycling NG2 cells is quite high in young as well as in adult animals. During development NG2 cells either differentiate into myelinating oligodendrocytes (and possibly also few astrocytes and neurons) or persist in the brain parenchyma as NG2 cells. This review highlights new findings related to the morphological and electrophysiological changes of NG2 cells, and the fate of synaptic input between neurons and NG2 cells during proliferation and differentiation of these cells in the neonatal and adult nervous system of rodents.
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