Review
Biochemistry & Molecular Biology
Dvyne Nosaka, Jeffery R. Wickens
Summary: Cholinergic interneurons of the striatum play a role in signaling by releasing acetylcholine. The prevailing theory suggests that these interneurons transmit signals through volume transmission rather than rapid synaptic transmission, as supported by evidence and mathematical modeling. The temporospatial distribution of acetylcholine is found to be short-range and short-lived, dominated by diffusion. The signaling is consistent with point-to-point transmission and allows faithful transmission of spike timing to the postsynaptic cell. Further evidence is needed for a better understanding of synaptic transmission by cholinergic interneurons in the striatum.
Article
Neurosciences
Noorya Yasmin Ahmed, Yadollah Ranjbar-Slamloo, Alice Shaam Al Abed, Lingxiao Gao, Yovina Sontani, Alexandre RCom-H'Cheo-Gauthier, Ehsan Arabzadeh, Nathalie Dehorter
Summary: This study reveals that Er81 is expressed in CINs and its specific ablation leads to prominent changes in their molecular, morphologic, and electrophysiological features, particularly amplifying intrinsic delayed-rectifier and hyperpolarization-activated currents. The expression of Er81 is crucial for normal CIN pause and time-locked responses to sensorimotor inputs in awake mice.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Avery F. McGuirt, Michael R. Post, Irena Pigulevskiy, David Sulzer, Ori J. Lieberman
Summary: This study found that the spontaneous activity, currents contribution, and I-NaP of ChI increase significantly during postnatal development in mice. Additionally, the interaction between ChI activity and DA release exists during the juvenile period.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Luca Pancotti, Lisa Topolnik
Summary: This article reviews the evidence regarding the modulatory effects of acetylcholine (ACh) on dendritic computations in three subtypes of hippocampal interneurons: fast-spiking parvalbumin-positive (PV+) cells, somatostatin-expressing (SOM+) oriens lacunosum moleculare cells, and vasoactive intestinal polypeptide-expressing (VIP+) interneuron-selective interneurons. The distribution and actions of cholinergic receptors on these interneurons are discussed, along with the potential modulation of dendritic Ca2+ signaling and neuronal activity. The article suggests that cholinergic modulation can shape dendritic integration and plasticity in interneurons in a cell type-specific manner, which is important for understanding their contribution to large-scale network activity.
Review
Anatomy & Morphology
Laxmi Kumar Parajuli, Masato Koike
Summary: EM is essential for visualizing synaptic morphology and quantifying synaptic transmission parameters. Automated EM tools have improved throughput for imaging and reconstructing dendritic segments effectively.
FRONTIERS IN NEUROANATOMY
(2021)
Review
Cell Biology
Lauren A. Poppi, Khue Tu Ho-Nguyen, Anna Shi, Cynthia T. Daut, Max A. Tischfield
Summary: Cholinergic interneurons in the striatum play crucial roles in various neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. Re-examining the dysfunction of these interneurons may provide key insights into underlying pathogeneses. Future studies can explore the function and connectivity of striatal cholinergic interneurons using new tools and approaches to better understand the mechanisms of related disorders.
Article
Multidisciplinary Sciences
Jin Tang, Yaodong Wu, Lingyao Kong, Weiwei Wang, Yutao Chen, Yihao Wang, Y. Soh, Yimin Xiong, Mingliang Tian, Haifeng Du
Summary: This study used differential phase contrast scanning transmission electron microscopy to investigate nanoscale magnetic objects in Kagome ferromagnet Fe3Sn2 nanostructures, revealing that these magnetic objects can be attributed to the integral magnetizations of two types of complex 3D magnetic bubbles with depth-modulated spin twisting. While magnetic configurations obtained using high-resolution TEM are generally considered as two-dimensional, the results suggest the importance of the integral magnetizations of underestimated 3D magnetic structures in 2D TEM magnetic characterizations.
NATIONAL SCIENCE REVIEW
(2021)
Article
Neurosciences
Yuqi Ren, Yang Liu, Minmin Luo
Summary: The striatum is involved in various behaviors and its D1-type projection neurons are directly electrically coupled to cholinergic interneurons (ChIs), in addition to chemical transmission. Activation of D1 neurons promotes basal activity of ChIs through gap junctions, contributing to the maintenance of ChIs' tonically active firing patterns.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Zan Xu, Joshua B. Foster, Rashelle Lashley, Xueqin Wang, Emily Benson, Grahame Kidd, Chien-Liang Glenn Lin
Summary: A pyridazine derivative compound, LDN/OSU-0215111-M3, has been found to enhance cognitive functions in mouse models of Alzheimer's disease by activating perisynaptic astrocytic process (PAP) and improving synaptic plasticity. It has been shown to increase the size of tertiary apical dendrites, the volume of mushroom spines, and the proportion of spines containing spine apparatus. Additionally, proteomic analysis suggests involvement of the phospholipase D signaling pathway.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Etsuko Suzuki, Toshihiko Momiyama
Summary: Acetylcholine can inhibit the release of GABA from striatal medium spiny neurons onto cholinergic interneurons by activating presynaptic M1 muscarine receptors, and this inhibitory effect of acetylcholine on GABA release is not mediated by retrograde cannabinoid cascade.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Chemistry, Physical
Sreejith Raveendran, Anindito Sen, Toru Maekawa, D. Sakthi Kumar
Summary: The study explores the deleterious effects of therapeutic gold nanocages on the subcellular organelles of MCF7 cells, demonstrating significant localization of the nanocarriers within specific organelles leading to their destruction within 96 hours.
Article
Materials Science, Paper & Wood
Masahisa Wada, Sayuri Wakiya, Kayoko Kobayashi, Satoshi Kimura, Motomitsu Kitaoka, Ryosuke Kusumi, Fumiko Kimura, Tsunehisa Kimura
Summary: Enzymatic synthesis was used to produce cellulose oligomers with azido groups, which were then used to create cellulose microcrystal suspensions with exposed azido groups on the surface. The microcrystals, in a crystalline form of cellulose II, were several micrometers in length and had a thickness of 5.1-5.2 nm.
Article
Multidisciplinary Sciences
Zhiyuan Ding, Si Gao, Weina Fang, Chen Huang, Liqi Zhou, Xudong Pei, Xiaoguo Liu, Xiaoqing Pan, Chunhai Fan, Angus Kirkland, Peng Wang
Summary: This study demonstrates the use of electron ptychography to recover high contrast phase information from a DNA origami scaffold without staining. The results show that electron ptychography can simultaneously resolve the organic and inorganic components in the DNA scaffold, with higher contrast compared to conventional transmission electron microscopy.
NATURE COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Jiwon Jeong, Niels Cautaerts, Gerhard Dehm, Christian H. Liebscher
Summary: This study introduces a novel 4D-STEM technique utilizing a CMOS detector to automatically perform orientation mapping with diffraction spot patterns. Compared to traditional methods, the CMOS data significantly reduce false indexing and enhance reliability, while also improving angular resolution by masking reflections close to the direct beam. Fine details, such as nanograins and sub-grain boundaries, can be resolved with a sub-degree angular resolution.
MICROSCOPY AND MICROANALYSIS
(2021)
Article
Chemistry, Physical
Jin-Hu Dou, Maxx Q. Arguilla, Yi Luo, Jian Li, Weizhe Zhang, Lei Sun, Jenna L. Mancuso, Luming Yang, Tianyang Chen, Lucas R. Parent, Grigorii Skorupskii, Nicole J. Libretto, Chenyue Sun, Min Chieh Yang, Phat Vinh Dip, Edward J. Brignole, Jeffrey T. Miller, Jing Kong, Christopher H. Hendon, Junliang Sun, Mircea Dinca
Summary: Researchers have successfully grown single crystals of 2D metal-organic frameworks up to 200 µm in size by balancing in-plane and out-of-plane interactions, revealing anisotropic transport and a clear correlation between conductivity and the nature of the metal cation in the sheets.
Article
Neurosciences
Rachel J. Sizemore, Rong Zhang, Naili Lin, Liping Goddard, Timothy Wastney, Louise C. Parr-Brownlie, John N. J. Reynolds, Dorothy E. Oorschot
JOURNAL OF COMPARATIVE NEUROLOGY
(2016)
Article
Neurosciences
Stella H. Cameron, Amr J. Alwakeel, Liping Goddard, Catherine E. Hobbs, Emma K. Gowing, Elizabeth R. Barnett, Sarah E. Kohe, Rachel J. Sizemore, Dorothy E. Oorschot
MOLECULAR AND CELLULAR NEUROSCIENCE
(2015)
Article
Neurosciences
Manfred J. Oswald, Jan M. Schulz, Wolfgang Kelsch, Dorothy E. Oorschot, John N. J. Reynolds
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Article
Anatomy & Morphology
Benjamin E. Aghoghovwia, Dorothy E. Oorschot
JOURNAL OF ANATOMY
(2016)
Article
Endocrinology & Metabolism
Michael W. Pankhurst, Rebecca L. Kelley, Rachel L. Sanders, Savana R. Woodcock, Dorothy E. Oorschot, Nicola J. Batchelor
JOURNAL OF ENDOCRINOLOGY
(2018)
Review
Clinical Neurology
Ashraf R. Amer, Dorothy E. Oorschot
PEDIATRIC NEUROLOGY
(2018)
Article
Clinical Neurology
Eric H. Kim, Doris C. V. Thu, Lynette J. Tippett, Dorothy E. Oorschot, Virginia M. Hogg, Richard Roxburgh, Beth J. Synek, Henry J. Waldvogel, Richard L. M. Faull
ANNALS OF NEUROLOGY
(2014)
Article
Clinical Neurology
Doris C. V. Thu, Dorothy E. Oorschot, Lynette J. Tippett, Alissa L. Nana, Virginia M. Hogg, Beth J. Synek, Ruth Luthi-Carter, Henry J. Waldvogel, Richard L. M. Faull
Article
Neurosciences
Melissa D. Barry, Laura J. Boddington, Kajsa M. Igelstroem, Jason P. Gray, Jon Shemmell, Kuei Y. Tseng, Dorothy E. Oorschot, John N. J. Reynolds
EXPERIMENTAL NEUROLOGY
(2014)
Article
Neurosciences
Dorothy E. Oorschot, Logan Voss, Matthew V. Covey, Liping Goddard, William Huang, Penny Birchall, David K. Bilkey, Sarah E. Kohe
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Manfred J. Oswald, Dorothy E. Oorschot, Jan M. Schulz, Janusz Lipski, John N. J. Reynolds
JOURNAL OF PHYSIOLOGY-LONDON
(2009)
Article
Neurosciences
Dorothy E. Oorschot, Naili Lin, Benjamin H. Cooper, John N. J. Reynolds, Huayu Sun, Jeffery R. Wickens
Article
Neurosciences
Dorothy E. Oorschot
Article
Materials Science, Multidisciplinary
Dorothy E. Oorschot
IMAGE ANALYSIS & STEREOLOGY
(2011)