Article
Biochemistry & Molecular Biology
Jin Young Jeong, Ki Ryang Na, Jin Ah Shin, Kwang-Sun Suh, Jwa-Jin Kim, Kang Wook Lee, Dae Eun Choi
Summary: This study revealed that collecting duct-specific mitochondrial injury may exacerbate inflammation and fibrosis in chronic kidney disease, and could worsen renal injury induced by unilateral ureteral obstruction (UUO). Mitochondrial damage associated oxidative stress may play a role in worsening UUO-induced renal injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, Ariadna Jazmin Ortega-Lozano, Jose Pedraza-Chaverri
Summary: In the UUO model, overproduction of ROS leads to alterations in signaling pathways, promoting inflammation, oxidative stress, and apoptosis, contributing to fibrosis development. Impairment of mitochondrial metabolism is also involved in this process.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Mei Ying Xuan, Shang Guo Piao, Jun Ding, Qi Yan Nan, Mei Hua Piao, Yu Ji Jiang, Hai Lan Zheng, Ji Zhe Jin, Can Li
Summary: Dapagliflozin alleviates renal fibrosis induced by unilateral ureteral obstruction (UUO) by inhibiting RIP1-RIP3-MLKL-mediated necroinflammation through Wnt3 alpha/beta-catenin/GSK-3 beta signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Stine Julie Tingskov, Michael Schou Jensen, Casper-Emil Tingskov Pedersen, Isabela Bastos Binotti Abreu de Araujo, Henricus A. M. Mutsaers, Rikke Norregaard
Summary: The study found that the selective estrogen receptor modulator tamoxifen has a mitigating effect on renal fibrosis in female, male, and ovariectomized female rats, as well as demonstrating an anti-fibrotic effect in human kidney slices. Gender differences may play a role in drug treatment response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
John D. Imig, Md Abdul Hye Khan, Anna Stavniichuk, Wojciech K. Jankiewicz, Samaneh Goorani, Michael M. Yeboah, Ashraf El-Meanawy
Summary: The incidence of ureter obstruction is increasing and recovery from this kidney injury can lead to long-term consequences such as an increased risk for salt-sensitive hypertension. A study using a RUUO model found that mice with unilateral ureteral obstruction had elevated blood pressure and decreased sodium excretion, along with renal tubular injury, inflammation, decreased vascular density, and renal fibrosis. These findings highlight the importance of addressing ureter obstruction and its potential impact on sodium excretion and hypertension.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fayez T. Hammad, Loay Lubbad, Suhail Al-Salam, Javed Yasin, Mohamed Fizur Nagoor Meeran, Shreesh Ojha, Waheed F. Hammad
Summary: Both ureteral obstruction and hypertension have significant impacts on kidney functions. Reversible ureteral obstruction in hypertensive rats showed exaggerated alterations in renal functions and other parameters of renal injury compared to normotensive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Neslihan Tezcan, Zarife Nigar Ozdemir-Kumral, Naziye Ozkan Yenal, Ozlem T. Cilingir-Kaya, Aysin Tulunay Virlan, Dilek Ozbeyli, Sule Cetinel, Berrak C. Yegen, Mehmet Koc
Summary: The study demonstrates that NES-1 has renoprotective effects and can ameliorate renal fibrosis induced by unilateral ureteral obstruction. The mechanism may involve inhibition of neutrophil infiltration, reduction of oxidative stress, and inflammation. These findings suggest that NES-1 may play a regulatory role in protecting the kidneys against obstruction-induced renal injury.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Pharmacology & Pharmacy
Wenjuan Sun, Chang Hyun Byon, Dong Hyun Kim, Hoon In Choi, Jung Sun Park, Soo Yeon Joo, In Jin Kim, Inae Jung, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Summary: The study demonstrated that MA could alleviate renal fibrosis by regulating the expression of various proteins and interfering with the TGF-beta/Smad and MyD88 signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Yashu Wang, Xinna Deng, Zhaohua Yang, Haijiang Wu
Summary: This study analyzed the development trends of research on UUO-induced renal fibrosis between 2005 and 2022 using bibliometric and visual analysis. The results indicate that the molecular mechanism of UUO-induced renal fibrosis remains a hot topic, with a focus on the inflammatory response and oxidative stress. International cooperation is expected to expand and deepen in the future.
Article
Pharmacology & Pharmacy
Qi Jia, Lin Han, Xiaoyu Zhang, Wenning Yang, Yushan Gao, Yifan Shen, Bing Li, Shuyan Wang, Mingzhen Qin, Scott Lowe, Jianguo Qin, Gaimei Hao
Summary: TLYS decoction showed significant effects on biological processes, cellular components, and molecular functions related to renal fibrosis by regulating lysosome, phagosome, and oxidation pathways. Additionally, TLYS ameliorated mitochondrial dynamics, reduced oxidative stress, and improved mitophagy clearance deficiency in UUO rats, indicating its potential therapeutic effects on chronic kidney disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sanchez-Lozada, Fernando Enrique Garcia-Arroyo, Isabel Amador-Martinez, Marisol Orozco-Ibarra, Francisca Fernandez-Valverde, Jose Pedraza-Chaverri
Summary: Sulforaphane (SFN) confers protection against unilateral ureteral obstruction (UUO)-induced kidney injury by targeting mitochondrial biogenesis and improving lipid metabolism.
Article
Biochemistry & Molecular Biology
Jun Wang, Zhichao Wang, Fan Xia, Qiong Duan, Xiaoping Peng
Summary: Renal interstitial fibrosis is a common pathological process in chronic kidney diseases, and obstructive kidney disease is a frequent cause of renal fibrosis. In this study, atorvastatin was found to decrease YAP and fibrosis-related gene expression, suggesting its potential as a preventive agent for fibrosis associated with obstructive kidney disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Plant Sciences
Yu-Teng Chang, Mu-Chi Chung, Chi-Hao Chang, Kuan-Hsun Chiu, Jeng-Jer Shieh, Ming-Ju Wu
Summary: This study evaluated the effects of protocatechuic aldehyde (PCA) on renal fibrosis. The results showed that PCA could inhibit TGF-beta 1-induced fibrosis and EMT, suggesting it as a potential strategy for preventing organ fibrosis in clinics.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Miaomiao Lu, Hang Li, Wenlin Liu, Xuemei Zhang, Lili Li, Hongli Zhou
Summary: Curcumin has shown promising effects in attenuating renal interstitial fibrosis in UUO rats by inhibiting NLRP3 inflammasome activation, improving mitochondrial function, and promoting autophagy. Its mechanism of action also involves inhibiting the PI3K/AKT/mTOR pathway.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Immunology
Xiaofei Li, Jing Zhao, Said Movahedi Naini, Gianmarco Sabiu, Stefan G. Tullius, Su Ryon Shin, Jonathan S. Bromberg, Paolo Fiorina, George C. Tsokos, Reza Abdi, Vivek Kasinath
Summary: The study revealed that after unilateral ureteral obstruction in the kidney, fibroblastic reticular cells (FRCs) in the kidney-draining lymph node also become fibrogenic, contributing to fibrosis that closely mirrors changes in the kidney. Additionally, immune cell populations in the affected lymph node were significantly higher compared to the unaffected contralateral kidney-draining lymph node. This suggests a possible mechanism for fibrosis involving the TGF beta/TGF beta R signaling pathway, and future studies are needed to delve deeper into this connection between FRCs and lymph node fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Obstetrics & Gynecology
J. A. Deane, Y. Ong, F. L. Cousins, C. E. Gargett
HUMAN REPRODUCTION UPDATE
(2019)
Article
Immunology
Sarah L. Snelgrove, Latasha D. Abeynaike, Sukarnan Thevalingam, James A. Deane, Michael J. Hickey
JOURNAL OF IMMUNOLOGY
(2019)
Article
Anatomy & Morphology
Ricky W. K. Lau, Ali Al-Rubaie, Sheetal Saini, Andrea F. Wise, Sharon D. Ricardo
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2020)
Editorial Material
Biotechnology & Applied Microbiology
James A. Deane
Review
Urology & Nephrology
B. Andre Weinstock, David L. Feldman, Alessia Fornoni, Oliver Gross, Clifford E. Kashtan, Sharon Lagas, Rachel Lennon, Jeffrey H. Miner, Michelle N. Rheault, James F. Simon
KIDNEY INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Bo Wang, Xiaoming Ding, Chenguang Ding, Greg Tesch, Jin Zheng, PuXun Tian, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue
Article
Pharmacology & Pharmacy
Yifang Li, Matthew Shen, Dorota Ferens, Brad R. S. Broughton, Padma Murthi, Sheetal Saini, Robert E. Widdop, Sharon D. Ricardo, Anita A. Pinar, Chrishan S. Samuel
Summary: Combining BM-MSCs and serelaxin provided broader renoprotection than either therapy alone or perindopril, suggesting a potential novel treatment for hypertensive CKD.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Letter
Urology & Nephrology
Ricky Wai Kiu Lau, Craig Fisher, Thanh Kha Phan, Dilara Ceyda Ozkocak, James Selby, Sheetal Saini, Sarvatha Mukundan, Andrea F. Wise, Judith Savige, Ivan Ka Ho Poon, John Haynes, Sharon D. Ricardo
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hannah E. J. Yong, Shiao-Yng Chan, Amlan Chakraborty, Gayathri Rajaraman, Sharon Ricardo, Mohamed Benharouga, Nadia Alfaidy, Frantisek Staud, Padma Murthi
Summary: This review focuses on the impact of viral infections on the placental barrier and the consequences for fetal growth and development. It specifically discusses how Zika, HIV, and SARS-CoV2 affect pregnant women and their offspring, laying the groundwork for developing therapeutics for emerging viruses.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Medicine, Research & Experimental
Yifang Li, Amlan Chakraborty, Brad R. S. Broughton, Dorota Ferens, Robert E. Widdop, Sharon D. Ricardo, Chrishan S. Samuel
Summary: The study demonstrated that combination therapy of RLX and BM-MSCs improved the therapeutic efficacy for hypertensive CKD, while RLX enhanced the renoprotective effects of BM-MSC-EXO.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue
Summary: This study investigated the regulatory function of WISP1 in kidney inflammation. The results showed that WISP1 can induce kidney inflammation and it can be prevented by inhibiting NF-KB. In addition, inhibition of WISP1 can suppress the production of inflammatory cytokines in macrophages and the proliferation of kidney fibroblasts. The increased expression of WISP1 in kidney inflammation models was also confirmed. Therefore, pharmacological blockade of WISP1 shows potential as a novel therapy for kidney inflammation.
Article
Chemistry, Multidisciplinary
Meg L. McFetridge, Ketav Kulkarni, Volker Hilsenstein, Mark P. Del Borgo, Marie-Isabel Aguilar, Sharon D. Ricardo
Summary: Determining the porosity of hydrogels is crucial but SEM sample preparation methods can alter the structure. This study compared three methods of hydrogel preparation for SEM and found that each method preserved different nanoarchitecture and porosity. A hybrid preparation method, including high pressure freezing, freeze substitution without fixative and critical point drying, showed similarity at the nanometre scale but divergence at the micron scale compared to conventional SEM preparation. This study quantified the impact of sample preparation on self-assembling beta(3)-peptide hydrogels and presented a novel hybrid method where chemical fixation can be avoided in conventional SEM.
Article
Genetics & Heredity
Menno ter Huurne, Benjamin L. Parker, Ning Qing Liu, Elizabeth Ling Qian, Celine Vivien, Kathy Karavendzas, Richard J. Mills, Jennifer T. Saville, Dad Abu-Bonsrah, Andrea F. Wise, James E. Hudson, Andrew S. Talbot, Patrick F. Finn, Paolo G. V. Martini, Maria Fuller, Sharon D. Ricardo, Kevin I. Watt, Kathy M. Nicholls, Enzo R. Porrello, David A. Elliott
Summary: This study evaluated the efficacy of nucleoside-modified messenger RNA (modRNA) treatment for Fabry disease and validated it using a human cardiac model generated from induced pluripotent stem cells. The results showed that modRNA treatment restored α-Galactosidase A enzyme activity and reduced glycosphingolipid accumulation, demonstrating its therapeutic potential.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Engineering, Biomedical
Chenguang Ding, Bo Wang, Xiang Feng Lai, Yingcong Guo, Greg Tesch, Xiaoming Ding, Jin Zheng, PuXun Tian, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue
Summary: Renal fibrosis, a common manifestation of chronic kidney disease, can be suppressed by inducing local production of relaxin-2 mRNA in kidney cells. In both in vitro and in vivo experiments, delivery of relaxin-2 mRNA reduced fibrotic gene expression and cell proliferation, inhibiting the development of renal fibrosis. The use of cubosomes as delivery vehicles for relaxin-2 mRNA also alleviated fibrosis and inflammation in a mouse model of renal injury. Therefore, relaxin-2 mRNA shows potential as a novel therapy for inhibiting fibrosis and inflammation in chronic kidney disease.
MATERIALS TODAY BIO
(2023)
Meeting Abstract
Obstetrics & Gynecology
Caroline E. Gargett, Fiona L. Cousins, James A. Deane
REPRODUCTIVE SCIENCES
(2019)