Article
Veterinary Sciences
Kiyotaka Arai, Takamasa Itoi, Natsuki Akashi, Masahiro Miyabe, Keisuke Sugimoto, Akira Matsuda, Noritaka Maeta, Teppei Kanda, Kenji Kutara
Summary: This study performed diffusion tensor imaging (DTI) scans on adult Beagle dogs and analyzed DTI parameters in different regions. The results showed that DTI parameters significantly decreased in the caudal direction, but were not significantly correlated with vertebral levels. These findings contribute to the development of a clinical reference for evaluating spinal cord in dogs using DTI parameters.
VETERINARY SCIENCES
(2023)
Review
Endocrinology & Metabolism
Cong Zhou, Jie Li, Man Dong, Liangliang Ping, Hao Lin, Yuxin Wang, Shuting Wang, Shuo Gao, Ge Yu, Yuqi Cheng, Xiufeng Xu
Summary: This meta-analysis examined white matter microstructural alterations in patients with type 2 diabetes mellitus and found reductions in fractional anisotropy in the left inferior network, corpus callosum, and left olfactory cortex. Additionally, a negative correlation was observed between fractional anisotropy in the corpus callosum and BMI in the patient group.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Alexis Reymbaut, Alex Valcourt Caron, Guillaume Gilbert, Filip Szczepankiewicz, Markus Nilsson, Simon K. Warfield, Maxime Descoteaux, Benoit Scherrer
Summary: Diffusion tensor imaging provides increased sensitivity to microstructural tissue changes compared to conventional anatomical imaging, but presents limited specificity. To address this issue, the DIAMOND model subdivides voxel content into diffusion compartments and estimates compartmental non-central matrix-variate Gamma distributions of diffusion tensors. Incorporating tensor-valued diffusion encoding, the Magic DIAMOND model demonstrates improved accuracy in estimating brain microstructural features, particularly in regions of fiber crossing.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Endocrinology & Metabolism
Xiaoyan Hu, Min Kuang, Bo Peng, Yang Yang, Wei Lin, Wenbo Li, Yinghua Wu
Summary: The study aimed to investigate the value of diffusion tensor imaging in assessing renal injury in a rat model of preclinical diabetic nephropathy. Results showed that DN rats exhibited hyperglycemia, polyuria, and renal damage, with increased apparent diffusion coefficients and decreased fractional anisotropy values in the cortex and medulla compared to the NC group. Diffusion tensor imaging may be useful for early, non-invasive, quantitative detection, and therapy monitoring of diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Alberto Failla, Lauryna Filatovaite, Xiaowan Wang, Sampsa Vanhatalo, Jeroen Dudink, Linda S. de Vries, Manon Benders, Nathan Stevenson, Maria Luisa Tataranno
Summary: The study aimed to investigate the association between bursting interhemispheric synchrony (bIHS) and microstructural development of the corpus callosum (CC) in extremely preterm infants during the first week of life. Results indicated that early cortical synchrony may be affected by morphine, but is not associated with the microstructural development of the CC.
HUMAN BRAIN MAPPING
(2022)
Review
Neuroimaging
Rahil Rahimi, Mahsa Dolatshahi, Fatemeh Abbasi-Feijani, Sara Momtazmanesh, Giulia Cattarinussi, Mohammad Hadi Aarabi, Lorenzo Pini
Summary: The pathophysiology of migraine as a headache disorder is still undetermined, but DTI studies have provided valuable insights into the microstructural changes associated with this disease. Alterations in diffusion parameters have been observed in various brain regions, including white matter tracts, subcortical areas, and the cortex. These changes show variability across migraine cycle phases, and are also observed in patients with depressive/anxiety symptoms. However, there are inconsistent findings regarding the differences between chronic and episodic migraine. Overall, migraine is associated with microstructural changes in widespread regions of the brain, which may reflect neuronal damage and plasticity mechanisms.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Biology
Kanza Awais, Ziga Snoj, Erika Cvetko, Igor Sersa
Summary: Magnetic resonance Diffusion Tensor Imaging (DTI) is a powerful imaging technique that can evaluate the microstructural environment of highly anisotropic tissues. In this study, DTI microscopy at 9.4 T magnetic field was used to assess the human median peripheral nerve ex vivo, providing detailed information about diffusion eigenvalues, mean diffusivity, and fractional anisotropy in different regions of the nerve.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Xie, Yan Zhang, Yihao Yao, Dong Liu, Bo Chen, Wenzhen Zhu
Summary: The characteristics of optic nerve impairment in neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) patients were assessed using fractional anisotropy (FA). The study found that FA values were significantly decreased in the optic nerves of NMOSD patients, especially in the posterior segment. FA values in the anterior and middle segments of the optic nerve were also decreased in MS patients. Significant differences in FA values were observed in the posterior segment between NMOSD and MS patients. The combination of FA and signal intensity ratio (SIR) showed good diagnostic performance in distinguishing between NMOSD and MS.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Christine Chin-jung Hsieh, Yu-Chun Lo, Ssu-Ju Li, Ting-Chun Lin, Ching-Wen Chang, Ting-Chieh Chen, Shih-Hung Yang, Yi-Chao Lee, You-Yin Chen
Summary: Tuberous sclerosis complex is a rare hereditary disease characterized by neuropsychiatric symptoms, with limited effectiveness of current pharmacological treatments. Curcumin may help improve learning and memory deficits, while DTI is a sensitive tool for monitoring neuropathological changes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiyoon Yoo, Leevi Kerkela, Patrick W. Hales, Kiran K. Seunarine, Christopher A. Clark
Summary: This study successfully implemented a multidimensional diffusion-encoding protocol to image the microstructure of the healthy hippocampus at high resolution, revealing orientation dispersion in hippocampal tissue. The reproducibility of q-space trajectory imaging metrics was comparable to DTI, providing reference values for microstructural metrics in the healthy hippocampus.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Rau, Pia M. Jungmann, Thierno D. Diallo, Marco Reisert, Elias Kellner, Michel Eisenblaetter, Fabian Bamberg, Matthias Jung
Summary: Quantitative MRI techniques, such as diffusion microstructure imaging (DMI), can provide additional information about muscular function and microstructure, potentially serving as a potential biomarker for young athletes.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Timothy T. Griffiths, Robert Flather, Irvin Teh, Hamied A. Haroon, David Shelley, Sven Plein, Grainne Bourke, Ryckie G. Wade
Summary: This study compared the DTI metrics of healthy adults and patients with CuTS, finding that diffusion in the ulnar nerve of CuTS patients was more isotropic.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Donnie Cameron, David A. Reiter, Fatemeh Adelnia, Ceereena Ubaida-Mohien, Christopher M. Bergeron, Seongjin Choi, Kenneth W. Fishbein, Richard G. Spencer, Luigi Ferrucci
Summary: Diffusion-tensor magnetic resonance imaging (DT-MRI) can objectively measure muscle characteristics and provide insights into age-related changes. In this study, DT-MRI was used to examine the microstructure and architecture of skeletal muscle in a large healthy aging cohort. The results showed age-related differences in muscle structure and differences in microstructure among different muscles.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sergey Buldyrev, Xiangyi Meng, Timothy G. Reese, Farzad Mortazavi, Douglas L. Rosene, H. Eugene Stanley, Van J. Wedeen
Summary: The study investigates whether the dependence of dMRI Q-ball signal on interpulse time Delta can decode smaller brain structures, particularly to distinguish between independently bundled axons in different directions and closely interwoven axons. Simulation results suggest that f(4) (Delta) can detect the thickness of axon layers in the white matter, leading to recommendations for optimal dMRI experiment design.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Maurizio Bergamino, Ryan R. Walsh, Ashley M. Stokes
Summary: Standard DTI and FW-DTI both showed decreased FA in AD, but higher AxD and RD were observed with standard DTI. The FW index was significantly elevated in AD, emphasizing the impact of free water on standard DTI in neurodegenerative pathologies. FW-DTI provided improved consistency in DTI metrics related to WM integrity in Alzheimer's disease.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Michael Orth, Carole Wagnon, Elisabeth Neumann-Dunayevska, Christoph Phillipp Kaller, Stefan Kloeppel, Beat Meier, Katharina Henke, Jessica Peter
Summary: The role of hemispheric lateralization in the prefrontal cortex in memory formation, especially for emotionally valenced information, is debated. By modulating the activity of the left or right dorsolateral prefrontal cortex during encoding, the study found that enhancing left DLPFC activity improved encoding and free recall performance, particularly for semantically processed words. Additionally, left DLPFC stimulation increased memory formation for positive content, while right DLPFC stimulation increased memory formation for negative content. The study suggests that hemispheric laterlization plays a role in establishing successful episodic memories.
Article
Psychology, Multidisciplinary
Nadine Schmidt, Maximilian Haas, Christine Krebs, Stefan Kloppel, Matthias Kliegel, Jessica Peter
Summary: In laboratory time-based prospective memory tasks, older adults perform worse than younger adults. Less frequent clock checking due to executive function problems may be responsible. This study aimed to investigate the role of clock checking in older adults' time-based prospective memory and whether executive functions would be associated with clock checking and time-based prospective memory. The results showed that time-based prospective memory declined with age due to less frequent clock checking. The link between executive functions and clock checking or time-based prospective memory was only found when not controlling for age.
CURRENT PSYCHOLOGY
(2023)
Article
Clinical Neurology
Depypere Herman, Vergallo Andrea, Lemercier Pablo, Lista Simone, Benedet Andrea, Ashton Nicholas, Cavedo Enrica, Zetterberg Henrik, Blennow Kaj, Vanmechelen Eugeen, Hampel Harald
Summary: This study suggests that menopause hormonal replacement therapy may have a significant impact on reducing the risk of developing Alzheimer's disease, especially for women at genetic risk.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Alessandro Galgani, Francesco Lombardo, Nicola Martini, Andrea Vergallo, Luca Bastiani, Harald Hampel, Hana Hlavata, Filippo Baldacci, Gloria Tognoni, Daniele De Marchi, Irene Ghicopulos, Sara De Cori, Francesca Biagioni, Carla Letizia Busceti, Roberto Ceravolo, Ubaldo Bonuccelli, Dante Chiappino, Gabriele Siciliano, Francesco Fornai, Nicola Pavese, Filippo Sean Giorgi
Summary: This study used LC-MRI to investigate the involvement of the pontine nucleus Locus Coeruleus (LC) in Alzheimer's disease progression and its association with prognosis and cognitive performance in amnestic Mild Cognitive Impairment. The findings suggest that reductions in LC-MRI parameters may be predictive of clinical progression in Mild Cognitive Impairment and support the role of LC degeneration in the continuum of Alzheimer's disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Developmental
Stella Guldner, Anna S. Sarvasmaa, Herve Lemaitre, Jessica Massicotte, Helene Vulser, Ruben Miranda, Pauline Bezivin-Frere, Irina Filippi, Jani Penttila, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Buechel, Patricia J. Conrod, Sylvane Desrivieres, Herta Flor, Vincent Frouin, Juergen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Frauke Nees, Dimitri Papadopoulos-Orfanos, Michael N. Smolka, Gunter Schumann, Eric Artiges, Marie-Laure Paillere Martinot, Jean-Luc Martinot
Summary: Sleep is crucial for neural maturation and emotion regulation in adolescents, and can have long-term effects on white matter development and affective processing in at-risk individuals. This study examined the relationship between sleep patterns and internalizing problems in adolescents aged 14-19 years. The results showed that increased weekend sleep duration and variability in sleep duration between weekdays and weekends were associated with improved white matter development and decreased internalizing problems. These findings suggest that catch-up sleep on weekends may serve as a protective strategy against the negative effects of insufficient sleep.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Elisa Canu, Veronica Castelnovo, Paola M. Rancoita, Michela Leocadi, Alessandra Lamanuzzi, Edoardo Gioele Spinelli, Silvia Basaia, Nilo Riva, Barbara Poletti, Federica Solca, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Sharon Abrahams, Massimo Filippi, Federica Agosta
Summary: This study aims to investigate the relationship between verbal fluency index (Vfi) and motor impairment in amyotrophic lateral sclerosis (ALS). The study found that Vfi is highly effective in distinguishing ALS patients with and without executive dysfunction and is associated with brain structural features of ALS patients.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Editorial Material
Clinical Neurology
Joseph Therriault, Michel J. Grothe
Article
Clinical Neurology
Niels Okkels, Jacob Horsager, Miguel Labrador-Espinosa, Pernille L. Kjeldsen, Malene F. Damholdt, Janne Mortensen, Karsten Vestergard, Karoline Knudsen, Katrine B. Andersen, Tatyana D. Fedorova, Casper Skjaerbaek, Hanne Gottrup, Allan K. Hansen, Michel J. Grothe, Per Borghammer
Summary: Cholinergic changes are highly relevant in the progression of dementia with Lewy bodies. This study found significant loss of cholinergic terminals in newly diagnosed patients with dementia with Lewy bodies, which correlated with atrophy of cholinergic cell clusters in the basal forebrain. The study also suggests that cholinergic system degeneration is linked with brain metabolism and degeneration of other neurotransmitter systems.
Article
Clinical Neurology
Massimo Filippi, Giordano Cecchetti, Annachiara Cagnin, Camillo Marra, Flavio Nobili, Lucilla Parnetti, Federica Agosta
Summary: Currently, no disease-modifying therapies are available for Alzheimer's disease (AD) in Europe. However, evidence from clinical trials suggests that anti-beta amyloid (Aβ) monoclonal antibodies (mAbs) may be authorized for marketing in the near future. A group of prominent AD clinical experts in Italy met to discuss patient selection and management strategies, recognizing the need for significant changes in dementia care to implement disease-modifying therapies. They emphasized the importance of a biological diagnosis using amyloid- and tau-related biomarkers, as well as specialized diagnostic work-up and exclusion criteria assessment by neurology specialists. The experts also proposed a reorganization of dementia and cognitive decline centers into three levels with defined tasks and requirements.
JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Loredana Storelli, Elisabetta Pagani, Martina Rubin, Monica Margoni, Massimo Filippi, Maria A. A. Rocca
Summary: This study developed an accurate and easily implementable method for automatic choroid plexus segmentation in multiple sclerosis using T1-weighted and FLAIR MRI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Teuta Domi, Paride Schito, Giacomo Sferruzza, Tommaso Russo, Laura Pozzi, Federica Agosta, Paola Carrera, Nilo Riva, Massimo Filippi, Angelo Quattrini, Yuri Matteo Falzone
Summary: This study aims to outline the clinical features of SOD1-ALS patients by comparing them to patients without ALS major gene variants and patients with variants in other major ALS genes. Defining the SOD1-ALS phenotype can assist clinicians in identifying patients who should be prioritized for genetic testing.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Massimo Filippi, Camilla Cividini, Silvia Basaia, Edoardo G. G. Spinelli, Veronica Castelnovo, Michela Leocadi, Elisa Canu, Federica Agosta
Summary: This study aimed to evaluate the impact of aging on the functional connectivity of pivotal regions in the human brain connectome and to examine whether these effects influence the overall functional and structural changes of the brain. By analyzing functional connectivity and cortical thinning data, it was found that aging leads to changes in functional connectivity of key regions and affects the structural alterations of specific brain regions.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
M. Petracca, A. Carotenuto, C. Scandurra, M. Moccia, L. Rosa, S. Arena, A. Ianniello, A. Nozzolillo, M. Turrini, L. M. Streito, G. Abbadessa, M. Cellerino, S. Bucello, E. Ferraro, M. Mattioli, A. Chiodi, M. Inglese, S. Bonavita, M. Clerico, C. Cordioli, L. Moiola, F. Patti, L. Lavorgna, M. Filippi, G. Borriello, E. D. Amico, C. Pozzilli, V. Brescia Morra, R. Lanzillo
Summary: This study investigated the impact of different cut-offs in the MSISQ-19 on the prevalence of sexual dysfunction (SD) and associated risk factors in people with MS. Depending on the chosen cut-off, 45% to 54% of individuals with MS reported SD. SD defined as an MSISQ-19 score >30 was associated with age, cognition, and anxiety, while SD defined as a score >3 on any MSISQ-19 item was associated with motor disability and cognition. These findings highlight the importance of considering the chosen cut-off when planning studies and interpreting data.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Editorial Material
Clinical Neurology
Massimo Filippi, Roberta Balestrino, Federica Agosta
FRONTIERS IN NEUROLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Roberto Teggi, Bruno Colombo, Iacopo Cangiano, Omar Gatti, Mario Bussi, Massimo Filippi
Summary: Meniere's disease and vestibular migraine (VM) are two common inner ear disorders. Recurrent Vestibular Symptoms-Not Otherwise Specified (RVS-NOS) refers to patients who experience recurring episodes of vertigo but do not fulfill the criteria for either disease. This study aimed to compare RVS-NOS with VM in terms of clinical history, bedside examination, and family history. The findings showed similarities between the two disorders, including age of onset, duration of attacks, motion sickness, and family history. However, some aspects suggest that RVS-NOS may be a heterogeneous disorder.
AUDIOLOGY RESEARCH
(2023)
