期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 37, 期 1, 页码 147-171出版社
IOS PRESS
DOI: 10.3233/JAD-130452
关键词
Aging; cognition; episodic memory; executive functions; meta-analysis; neuroendocrinology; vitamin D
资金
- Canadian Institutes for Health and Research - Institute of Aging (CIHR-IA)
- Servier Institute in France
- Canadian Institutes 596 for Health and Research - Institute of Aging [CIHR-597]
- Drummond Foundation
- Physician Services Incorporated Foundation of Canada (PSI)
- CIHR
Background: Hypovitaminosis D is associated with global cognitive impairment in adults. It remains unclear which domain-specific cognitive functions are affected with hypovitaminosis D. Objective: To systematically review and quantitatively synthesize the association of serum 25-hydroxyvitamin D (25OHD) concentrations with episodic memory and executive functions in adults. Methods: A Medline and PsycINFO (R) libraries search was conducted on May 2012, with no limit of date, using the Medical Subject Headings (MeSH) terms Vitamin D OR Hydroxycholecalciferols combined with the MeSH terms Memory OR Memory Disorders OR Executive Function OR Attention OR Cognition OR Cognition disorders OR Dementia OR Alzheimer disease OR Neuropsychological Tests. Fixed-effects meta-analysis was performed from 12 eligible studies using an inverse-variance method. Results: Of the 285 selected studies, 14 observational studies (including 3 prospective cohort studies) and 3 interventional studies met the selection criteria. All were of good quality. The number of participants ranged from 44-5,692 community-dwellers (0-100% women). In the pooled analysis, although episodic memory disorders showed only modest association with lower 25OHD concentrations (summary effect size of the difference (ES) =-0.09 [95% CI:-0.16;-0.03]), associations of greater magnitude were found with executive dysfunctions (processing speed: mean difference of Trail Making Test (TMT)-A score = 4.0 [95% CI: 1.20;6.83]; mental shifting: mean difference of TMT-B score = 12.47 [95% CI: 6.78; 18.16]; information updating tests: ES =-0.31 [95% CI:-0.5;-0.09]). The pooled risk of incident decline of TMT-B score was OR = 1.25 [95% CI: 1.05; 1.48] in case of initial lower 25OHD concentrations. Vitamin D repletion resulted in improved executive functions (ES =-0.50 [95% CI:-0.69;-0.32] for before-and-after comparison), but exhibited no difference with control groups (ES = 0.14 [95% CI:-0.04; 0.32] for between-group comparison after intervention). Conclusion: Lower serum 25OHD concentrations predict executive dysfunctions, especially on mental shifting, information updating and processing speed. The association with episodic memory remains uncertain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据