Article
Immunology
Cheng Wang, Cuiping Zhang, Quan Fu, Nan Zhang, Meng Ding, Zhen Zhou, Xi Chen, Fengmin Zhang, Chunni Zhang, Chen-Yu Zhang, Jun-Jun Wang
Summary: This study identified three piRNAs with significantly increased levels in the serum of patients with brucellosis. The combination of these three piRNAs could serve as a novel blood-based auxiliary tool for detecting brucellosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Plant Sciences
Veronica Amoah, Paul Atawuchugi, Yakubu Jibira, Augustine Tandoh, Paul Poku Sampene Ossei, George Sam, George Ainooson
Summary: The hydroethanolic leaf extract of Lantana camara (LCE) has a prophylactic effect on short-term memory deficit and neuroinflammation induced by scopolamine in zebrafish and mice. LCE improved cognitive impairment and reduced inflammatory response.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Neurosciences
Malin Wennstrom, Shorena Janelidze, K. Peter R. Nilsson, Geidy E. Serrano, Thomas G. Beach, Jeffrey L. Dage, Oskar Hansson
Summary: Recent studies have identified p-tau217 as a potential plasma biomarker for Alzheimer's disease (AD), but its relationship with specific brain pathological events is still unclear. This study found that p-tau217 is mainly found in neurofibrillary tangles and neuropil threads, and differs from other p-tau variants. Individuals with a high likelihood of AD had significantly higher p-tau217 levels in specific brain areas and these levels correlated with amyloid-beta and NFT brain load. Additionally, the levels of p-tau217 in plasma correlated with its concentrations in individuals with amyloid plaques.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Eunmi Ban, Haejin Kwon, Hong Seog Seo, Young Sook Yoo, Eun Joo Song
Summary: This study successfully optimized the conditions for extraction and qRT-PCR, improving miRNA yields while minimizing interference and loss. The research aimed to achieve reliable results by reducing contaminants and maximizing product yields for miRNA analysis in plasma samples.
Article
Plant Sciences
Hong Huang, Haohao Han, Yayun Lei, Huanhuan Qiao, Daobin Tang, Yonghui Han, Zhenpeng Deng, Limin Mao, Xuli Wu, Kai Zhang, Jichun Wang, Changwen Lv
Summary: This study compared the effectiveness of two different grafting methods and selected the optimal one. By diagnosing symptoms and conducting serological detection on 86 host varieties, differences in resistance to sweet potato virus disease were identified. The established detection method can provide a theoretical basis for identification and screening of resistant sweet potato varieties.
Article
Psychiatry
Hao Hu, Lan Tan, Yan-Lin Bi, Wei Xu, Lin Tan, Xue-Ning Shen, Xiao-He Hou, Ya-Hui Ma, Qiang Dong, Jin-Tai Yu
Summary: The study found that hypomethylation of the BIN1 promoter in peripheral blood is associated with early cognitive decline in late-onset Alzheimer's disease (LOAD). Additionally, changes in methylation levels are correlated with alterations in AD-related biomarkers in cerebrospinal fluid, particularly in participants with significant AD biological characteristics and subjective cognitive decline (SCD).
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Oncology
Xingchen Fan, Minmin Cao, Cheng Liu, Cheng Zhang, Chunyu Li, Wenfang Cheng, Shiyu Zhang, Huo Zhang, Wei Zhu
Summary: The study identified miR-142-3p, miR-146a-5p, and miR-151a-5p as potential biomarkers for endometrial cancer in plasma, showing diagnostic value. These miRNAs were significantly overexpressed in EC patients and the 3-miRNA signature had stable diagnostic performance superior to other biomarkers in EC diagnosis. Moreover, miR-151a-5p was found to be elevated in EC plasma exosomes.
Article
Clinical Neurology
Denis S. Smirnov, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Joel Simren, Juan Lantero-Rodriguez, Thomas K. Karikari, Annie Hiniker, Robert A. Rissman, David P. Salmon, Douglas Galasko
Summary: Plasma biomarkers show promise in identifying the pathological features of Alzheimer's Disease. P-tau181 and P-tau231 are diagnostic biomarkers related to AD neuropathological change and can predict future cognitive decline. NfL can predict cognitive decline and is increased in non-AD cases. Plasma A beta 42/40 is a relatively weak predictor of amyloid pathology and may require different assay methods for improvement.
ACTA NEUROPATHOLOGICA
(2022)
Article
Biology
Pattaralawan Sittiju, Parunya Chaiyawat, Dumnoensun Pruksakorn, Jeerawan Klangjorhor, Weerinrada Wongrin, Phichayut Phinyo, Rawikant Kamolphiwong, Areerak Phanphaisarn, Pimpisa Teeyakasem, Prachya Kongtawelert, Peraphan Pothacharoen
Summary: Novel or OS-specific biomarkers from GEO database show promise for developing diagnostic and tumor progression strategies. Three candidate genes, including COL5A2, ezrin, and vimentin, were identified as potential tools for OS detection and disease progression prediction. Liquid biopsy is an interesting non-invasive tool for measuring tumor material, with VIM and ezrin genes associated with EMT and metastasis in OS.
Article
Biochemistry & Molecular Biology
Lourdes Alvarez-Sanchez, Carmen Pena-Bautista, Laura Ferre-Gonzalez, Laura Cubas, Angel Balaguer, Bonaventura Casanova-Estruch, Miguel Baquero, Consuelo Chafer-Pericas
Summary: This study aims to evaluate the use of several plasma biomarkers to develop an early and specific screening method for Alzheimer's disease (AD). The results show that plasma p-Tau181 and GFAP levels are higher in AD dementia patients and have significant correlations with clinical AD characteristics. Plasma NfL levels are higher in frontotemporal dementia (FTD) patients but not significantly correlated with AD. The developed partial least squares (PLS) diagnosis model shows good accuracy in distinguishing AD patients from subjective cognitive impairment (SCI) patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nanoscience & Nanotechnology
Yasin Orooji, Hessamaddin Sohrabi, Nima Hemmat, Fatemeh Oroojalian, Behzad Baradaran, Ahad Mokhtarzadeh, Mohamad Mohaghegh, Hassan Karimi-Maleh
Summary: The emergence of a novel zoonotic coronavirus has led to a need for rapid detection methods, but current technologies are expensive and not easily accessible for on-site testing, presenting a significant global challenge in the fight against COVID-19.
NANO-MICRO LETTERS
(2021)
Article
Clinical Neurology
Kate E. Foley, Zachary Winder, Tiffany L. Sudduth, Barbara J. Martin, Peter T. Nelson, Gregory A. Jicha, Jordan P. Harp, Erica M. Weekman, Donna M. Wilcock
Summary: Protein-based plasma assays show promise in improving accessibility and specificity of molecular diagnostics for dementia. The study found significant associations between Alzheimer's disease and inflammatory biomarkers, suggesting peripheral inflammation plays a role in AD pathology. The strength of biomarker correlations varied across different clinical diagnoses, reflecting changes in cognitive continuum.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Huimin Cai, Yana Pang, Qi Wang, Wei Qin, Cuibai Wei, Ying Li, Tingting Li, Fangyu Li, Qigeng Wang, Yan Li, Yiping Wei, Longfei Jia
Summary: This study found that a combination of six proteins in plasma exosomes can accurately differentiate Alzheimer's disease patients from healthy individuals, suggesting its potential as a novel biomarker for AD diagnosis.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Shiyu Zhang, Cheng Liu, Xuan Zou, Xiangnan Geng, Xin Zhou, XingChen Fan, Danxia Zhu, Huo Zhang, Wei Zhu
Summary: A three-miRNA panel (miR-146a-5p, miR-24-3p, and miR-93-5p) was successfully established in peripheral serum as a non-invasive biomarker for diagnosing prostate cancer. This panel showed stable diagnostic performance in large cohorts and outperformed other miRNA biomarkers in diagnosing PC.
Article
Clinical Neurology
Hyun-Sik Yang, Can Zhang, Becky C. Carlyle, Sherri Y. Zhen, Bianca A. Trombetta, Aaron P. Schultz, Jeremy J. Pruzin, Colleen D. Fitzpatrick, Wai-Ying W. Yau, Dylan R. Kirn, Dorene M. Rentz, Steven E. Arnold, Keith A. Johnson, Reisa A. Sperling, Jasmeer P. Chhatwal, Rudolph E. Tanzi
Summary: The study found that IL-12p70 and IFN-γ are associated with cognitive decline in cognitively unimpaired elderly, and this association may be related to Aβ levels. This suggests that immune dysregulation plays an important role in early-stage cognitive decline.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Shu-Yu Liang, Zuo-Teng Wang, Lan Tan, Jin-Tai Yu
Summary: This article introduces the function and dysfunction of microtubule-associated protein tau in the central nervous system and discusses its role in neurodegenerative diseases, tau phosphorylation-related enzymes and proteins, and its relationship with cell dysfunction. The study of tau neurotoxicity provides new directions for the treatment of tauopathies.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Yi Zhang, Kai-Min Wu, Liu Yang, Qiang Dong, Jin-Tai Yu
Summary: In this article, emerging knowledge on tauopathies from clinical, pathological, genetic, and experimental studies is synthesized to accelerate the development of therapeutics for these diseases. The focus is on depicting pathological characteristics, identifying biomarkers, elucidating the underlying pathogenesis for early diagnosis, and the development of disease-modifying therapies.
MOLECULAR NEURODEGENERATION
(2022)
Article
Environmental Sciences
He-Ying Hu, Ya-Hui Ma, Yue-Ting Deng, Ya-Nan Ou, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu
Summary: This study found an association between residential greenness and dementia incidence, indicating that increasing greenspace can reduce the risk of dementia. The protective effect of greenness may be mediated through the reduction of particulate air pollution.
ENVIRONMENTAL RESEARCH
(2023)
Article
Clinical Neurology
Rong-Ze Wang, Shu-Yi Huang, Hong-Qi Li, Yu-Xiang Yang, Shi-Dong Chen, Jin-Tai Yu
Summary: Using a Mendelian randomization approach, this study found that genetically determined levels of lipids in small LDL were associated with the risk of stroke, especially large-artery atherosclerotic stroke. Higher cholesterol levels in high-density lipoprotein (HDL-C) were associated with the risk of intracerebral haemorrhage. However, no significant association was found between genetic predisposition to circulating metabolites and magnetic resonance imaging markers of cerebral small vessel disease and microstructural injury.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qiaolifan Aerqin, Zuo-Teng Wang, Kai-Min Wu, Xiao-Yu He, Qiang Dong, Jin-Tai Yu
Summary: This review summarizes the progress made in the discovery of reliable Alzheimer's disease (AD) biomarkers using genomics, transcriptomics, proteomics, and metabolomics. The importance of these biomarkers in the diagnosis and treatment of AD is discussed.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, General & Internal
Hui-Fu Wang, Wei Zhang, Edmund T. Rolls, Yuzhu Li, Linbo Wang, Ya-Hui Ma, Jujiao Kang, Jianfeng Feng, Jin-Tai Yu, Wei Cheng
Summary: This study investigated the association of hearing performance with cognitive function, brain structure, and cerebrospinal fluid (CSF) proteins. The findings revealed that poor hearing performance was related to worse cognitive function, brain atrophy, and tau pathology.
Review
Clinical Neurology
Na Zhang, Ke-Liang Chen, Yu-Yuan Huang, Shu-Fen Chen, Qiang Dong, Lan Tan, Jin-Tai Yu
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Neurosciences
Zuo-Teng Wang, Yan Fu, Shi-Dong Chen, Yu-Yuan Huang, Ya-Hui Ma, Yan-Jiang Wang, Lan Tan, Jin-Tai Yu
Summary: This study is the first to identify significant associations between TREM1 rs2062323 and AD risk. The rs2062323T may be involved in AD by regulating the expression of TREM1, TREML1, TREM2, and sTREM2. The TREM family is expected to be a potential therapeutic target for AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Yan Fu, Yan Sun, Zhi-Bo Wang, Dan-Dan Zhang, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study used the American Heart Association's Life's Simple 7 (LS7) metric to define cardiovascular and brain health and found that ideal LS7 cardiovascular health factors are associated with both macrostructural and microstructural markers of brain health. The results suggest that better LS7 profiles are linked to better brain health.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yan Sun, Yu Guo, Hong-Qi Li, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: White matter hyperintensities (WMH) are strongly associated with stroke, dementia, and early mortality. This study investigated the relationship between WMH and circulating metabolites in a large sample of individuals from the UK Biobank. The results showed that several metabolites, including high-density lipoprotein (HDL), fatty acids, and glycoprotein acetyls, were associated with WMH. Age and sex also had a significant influence on these associations. The findings suggest that specific metabolomic features accompany WMH and may provide insights into the implications of WMH in different populations.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Yu He, Shu-Yi Huang, Hui-Fu Wang, Wei Zhang, Yue-Ting Deng, Ya-Ru Zhang, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: Cohort studies have shown inconsistent associations between omega-3 polyunsaturated fatty acids (n-3 PUFA) or fish oil and dementia risk. This study included a large number of participants and found that higher plasma levels of PUFA and fish oil supplementation were associated with a lower risk of developing dementia.
Article
Biochemistry & Molecular Biology
Shu-Yi Huang, Ya-Ru Zhang, Liu Yang, Yu-Zhu Li, Bang-Sheng Wu, Shi-Dong Chen, Jian-Feng Feng, Qiang Dong, Wei Cheng, Jin-Tai Yu
Summary: Identifying circulating metabolites associated with dementia, cognition, and brain volume could provide new insights into the pathogenesis of dementia. This cohort study found 26 metabolites associated with incident dementia, including specific associations with Alzheimer's disease (AD) and vascular dementia (VD). Circulating levels of certain lipoproteins were found to be associated with the risk of AD and AD phenotypes, while another lipoprotein was associated with the risk of VD.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ji-Yun Cheng, Yue-Ting Deng, Jin-Tai Yu
Summary: Through a more robust analysis, we found potential associations between circulating levels of amino acids and the risk of neurodegenerative diseases. Increase in circulating levels of Glutamine (Gln) was associated with lower risk of Alzheimer's disease (AD), while increase in circulating levels of Leucine (Leu) was associated with lower risk of Parkinson's disease (PD). Replication tests further confirmed the potential association between circulating Gln levels and AD risk.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Wei-Shi Liu, Ya-Ru Zhang, Yi-Jun Ge, Hui-Fu Wang, Wei Cheng, Jin-Tai Yu
Summary: This study identified the association between TREM2, temporal lobe, and AD using genetic and transcriptomic data, and explored the complex associations among inflammation, brain structure, and neurodegenerative disorders, particularly AD.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Hai-Shan Jiao, Peng Yuan, Jin-Tai Yu
Summary: Mutations in the TMEM106B gene are risk factors for various neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome biogenesis caused by TMEM106B loss-of-function. However, mutations in TMEM106B increase its expression level, thus the molecular process linking these mutations to the apparent disruption in TMEM106B function remains mysterious.
MOLECULAR NEURODEGENERATION
(2023)
