期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 34, 期 4, 页码 1051-1059出版社
IOS PRESS
DOI: 10.3233/JAD-122188
关键词
Alzheimer's disease; A beta PP/PS1 transgenic mouse model; longitudinal studies; magnetic resonance spectroscopy; sex differences
资金
- Department of Pathology (LUMC)
- Internationale Stichting Alzheimer Onderzoek (ISAO)
- Centre for Medical Systems Biology (CMSB)
Epidemiological studies indicate that the incidence of Alzheimer's disease (AD) is higher inwomen than in men. There is evidence that changes in metabolites in the brain associated with the development of AD are present earlier than structural brain changes. The effect of sex on the metabolic profile during the development of AD has not yet been studied. In this study we longitudinally monitored and compared in vivo metabolic changes in male and female A beta PPswe, PSEN1dE9 transgenic mice brains using magnetic resonance spectroscopy. Our results show a lower level of glutamate as well as of N-acetylaspartate (NAA) in transgenic mice. The decline in NAA with age was more apparent in female mice. The level of taurine was higher in female mice and showed a faster decline over time. In conclusion, our study is the first to suggest that changes in the metabolic profile during AD development are influenced by sex.
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