Article
Endocrinology & Metabolism
Sini Toppala, Laura L. Ekblad, Matti Viitanen, Juha O. Rinne, Antti Jula
Summary: The study found that higher 2-hour glucose values in the OGTT were associated with worse performance in the word-list delayed recall test after 10 years. This suggests that 2-hour glucose values may predict a decline in episodic memory 10 years later.
Article
Cardiac & Cardiovascular Systems
Zhen Zhou, Joanne Ryan, Michael E. Ernst, Sophia Zoungas, Andrew M. Tonkin, Robyn L. Woods, John J. McNeil, Christopher M. Reid, Andrea J. Curtis, Rory Wolfe, Jo Wrigglesworth, Raj C. Shah, Elsdon Storey, Anne Murray, Suzanne G. Orchard, Mark R. Nelson
Summary: The study found that statin therapy in adults aged 65 and older was not associated with incident dementia, MCI, or declines in individual cognition domains. The impact of statin lipophilicity and baseline neurocognitive ability on these associations was also explored. Further confirmation from ongoing randomized trials is needed.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Clinical Neurology
Andrea E. Zuelke, Alexander Pabst, Melanie Luppa, Susanne Roehr, Hanna Seidling, Anke Oey, Maria Isabel Cardona, Iris Blotenberg, Alexander Bauer, Solveig Weise, Isabel Zoellinger, Linda Sanftenberg, Christian Brettschneider, Juliane Doehring, Laura Lunden, David Czock, Walter E. Haefeli, Birgitt Wiese, Wolfgang Hoffmann, Thomas Frese, Jochen Gensichen, Hans-Helmut Koenig, Hanna Kaduszkiewicz, Jochen Rene Thyrian, Steffi G. Riedel-Heller
Summary: In a cluster-randomized trial conducted in Germany, a multidomain intervention was found to have no effect on global cognitive performance among older adults at risk for dementia. However, it improved health-related quality of life and reduced depressive symptoms.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Teresa Pardo-Moreno, Himan Mohamed-Mohamed, Antonio Rivas-Dominguez, Victoria Garcia-Morales, Ruben A. Garcia-Lara, Sami Suleiman-Martos, Beatriz Bermudez-Pulgarin, Juan Jose Ramos-Rodriguez
Summary: Life expectancy has increased but age-associated diseases, especially dementia, have become more prevalent. The development of dementia is influenced by various risk factors, including metabolic pathologies such as obesity and diabetes. However, a high level of education and moderate physical activity are protective factors against cognitive impairment and dementia. In this study, we assessed the metabolic composition of mentally healthy individuals aged 60-90 with high academic degrees. The results indicated that excess body fat was associated with poorer cognitive maintenance, while higher muscle mass percentage was associated with better cognitive abilities.
Review
Environmental Sciences
Juana Maria Delgado-Saborit, Valentina Guercio, Alison M. Gowers, Gavin Shaddick, Nick C. Fox, Seth Love
Summary: This review critically examines the epidemiological evidence of associations between exposure to ambient air pollutants and cognitive performance, cognitive decline, and risk of developing dementia. The evidence consistently shows associations between chronic exposure to air pollution and reduced cognitive function, as well as increased risk of cognitive decline and dementia. Neuroimaging studies also report brain structure changes related to air pollution exposure, suggesting a causal relationship between air pollution and cognitive impairment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Medicine, General & Internal
Leicia Iris de Assuncao Prado, Ana Lucia Junger, Leonardo Ferreira Caixeta, Matias Noll, Cesar de Oliveira, Erika Aparecida Silveira
Summary: This study aims to assess the effectiveness of treating dementia and cognitive decline with methylfolate supplementation in older adults. The main outcomes analyzed will be dementia and changes in cognitive function. Secondary outcomes, such as inflammatory markers and folic acid levels, will also be assessed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Srishti Shrestha, Xiaoqian Zhu, Stephanie J. London, Kevin J. Sullivan, Pamela L. Lutsey, B. Gwen Windham, Michael E. Griswold, Thomas H. Mosley Jr
Summary: The study found that higher forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were associated with reduced risk of dementia. Each 1-liter increase in FEV1 and FVC was associated with a 0.08 and 0.05 standard deviation reduction in cognitive decline, respectively.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Cell Biology
Josh Turknett, Thomas R. Wood
Summary: This article highlights the importance of lifestyle and environment in the development of Alzheimer's Disease. It suggests that previous approaches focusing solely on biological processes have been inadequate, and calls for a holistic approach that incorporates cognitive demand as a primary factor for intervention.
Article
Geriatrics & Gerontology
Chih-Kuang Liang, Wei-Ju Lee, An-Chun Hwang, Chu-Sheng Lin, Ming-Yueh Chou, Li-Ning Peng, Ming-Hsien Lin, Liang-Kung Chen
Summary: The study focused on the efficacy of a 12-month multidomain intervention for older adults with physio-cognitive decline syndrome (PCDS), showing significant improvements in cognitive performance and frailty scores, particularly for PCDS patients with cognitive dysfunction.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Behavioral Sciences
Felipe Jacques Sanches, Jessica Cardia de Melo, Sabrina Palha Ferreira, Luzia Aparecida Trinca, Omar Gurrola Arambula, Flavia Helena Pereira Padovani, Arthur Oscar Schelp, Rogerio Martins Amorim
Summary: Episodic memory in elderly dogs declines similar to humans, regardless of gender and size, which may be related to the physiological aging process or preclinical pathological manifestation of cognitive impairment. Further studies are needed to evaluate episodic-like memory in dogs with canine cognitive dysfunction syndrome to better understand its physiological and pathological behavior in canine species.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Geriatrics & Gerontology
Patricia Grasso
Summary: This review examines the role of leptin in energy balance, glycemic regulation, and cognitive function, and explores its involvement in maintaining the homeostatic harmony of these physiologies. The effects of exercise on leptin levels and the results of clinical application of leptin to metabolic disease and neurologic dysfunction are summarized. Additionally, pre-clinical evidence suggests the potential use of synthetic peptide leptin mimetics in resolving leptin resistance, insulin resistance in type 2 diabetes, and insulin resistance associated with certain neurologic deficits.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Marina Maffoni, Antonia Pierobon, Cira Fundaro
Summary: This paper proposes a new screening tool called MASCoD, with English and Italian versions, and explores its preliminary adoption on a pilot sample. The tool shows promise in helping professionals make differential diagnosis and predict the risk of developing severe cognitive impairment over time, allowing for personalized care. It is brief, easily embeddable in usual clinical assessment, and can be administered by different professionals.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Neurosciences
Qiong-Yao Li, Xue-Mei Li, He-Ying Hu, Ya-Hui Ma, Ya-Nan Ou, An-Yi Wang, Lan Tan, Jin-Tai Yu
Summary: This study conducted a meta-analysis and systematic review to investigate the associations of lung function decline with the risks of cognitive impairment and dementia. The results showed that poorer pulmonary function was significantly associated with a higher risk of dementia. Individuals with lung disease had a higher combined risk of dementia and cognitive impairment. These findings have implications for the prevention of cognitive disorders and the promotion of brain health.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Jinhee Shin, Eunhee Cho
Summary: This study assessed the patterns and risk factors associated with cognitive decline in community-dwelling Korean adults. The results showed that older age, female gender, lower education level, no religious status, and living in a small city were factors associated with a higher risk of cognitive decline. On the other hand, regular exercise, non-drinking status, and active social engagements reduced the risk of cognitive decline.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Geriatrics & Gerontology
Feifei Jia, Yanyan Li, Min Li, Fenglin Cao
Summary: The study found that cognitive reserve can attenuate the association between subjective cognitive decline and the risk of developing dementia. Particularly in the low cognitive reserve group, the association between subjective cognitive decline and dementia was more significant.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
