Review
Biochemistry & Molecular Biology
Pavel P. Tregub, Anton S. Averchuk, Tatyana Baranich, Maria Ryazanova, Alla B. Salmina
Summary: The remodeling of cerebral microvessels has a significant impact on brain plasticity and neurodegenerative diseases. Abnormal neoangiogenesis and microvascular regression are associated with blood-brain barrier breakdown, neuroinflammation, and dysfunction of the neurovascular unit. This review summarizes the mechanisms of blood vessel regression and pruning, and discusses novel approaches to modulating cerebral remodeling and preventing aberrant microvascular activity in chronic neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Kimia Sadat Hashemi, Mohadese Koohi Aliabadi, Arian Mehrara, Elham Talebi, Ali Akbar Hemmati, Radin Dabbagh Rezaeiye, Mohammad Javad Ghanbary, Maryam Motealleh, Behnaz Dayeri, Shayan Khalili Alashti
Summary: This study utilized microarray bioinformatic analysis to identify potential biomarkers of AD by analyzing six microarray datasets of AD patients and control groups. The results identified CXCR4, TGFB1, ITGB1, MYH11, and SELE genes as hub genes in this study. These genes were significantly enriched in actin cytoskeleton regulation, ECM-receptor interaction, and hypertrophic cardiomyopathy. Additionally, multiple miRNAs exhibited significant interactions with most of the hub genes.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Amaya Urdanoz-Casado, Javier Sanchez-Ruiz de Gordoa, Maitane Robles, Miren Roldan, Maria Victoria Zelaya, Idoia Blanco-Luquin, Maite Mendioroz
Summary: Genetic variants in the TREM2 gene, which is related to microglia, have been found to be risk factors for Alzheimer's disease (AD). This study discovered a new type of non-coding RNA called circular RNAs (circRNAs), which originate from TREM2. A specific circRNA called circTREM2_1 was identified in the entorhinal cortex of both control subjects and AD patients, and the expression level of TREM2 mRNA was found to be elevated in AD patients compared to controls. These findings provide insights into the innate immune response in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C. Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki
Summary: This study investigated the effect of apoE4 on brain A,B42 accumulation in an AD mouse model. The results showed a linear increase in A,B42 levels in apoE4 mice and a rapid increase in A,B42 levels in 21-month-old apoE3 mice. Furthermore, the study identified genes that may regulate brain A,B burden and AD progression through their association with apoE gene expression.
NEUROBIOLOGY OF AGING
(2023)
Article
Neurosciences
Daniel Felsky, Ismael Santa-Maria, Mehmet Ilyas Cosacak, Leon French, Julie A. Schneider, David A. Bennett, Philip L. De Jager, Caghan Kizil, Giuseppe Tosto
Summary: Identifying ancestry-specific molecular profiles of late-onset Alzheimer's Disease (LOAD) in brain tissue is crucial to understand novel mechanisms and develop effective interventions in non-European, high-risk populations. We performed gene differential expression (DE) and consensus network-based analyses in RNA-sequencing data of postmortem brain tissue from 39 Caribbean Hispanics (CH). Our findings provide insights into the shared and specific genetic factors associated with LOAD in different ancestral populations.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Emily R. Mahoney, Logan Dumitrescu, Annah M. Moore, Francis E. Cambronero, Philip L. De Jager, Mary Ellen Koran, Vladislav A. Petyuk, Rena A. S. Robinson, Sandeep Goyal, Julie A. Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman
Summary: The study revealed that the VEGF gene family plays a complex role in neuroprotection and is associated with cognitive performance, cognitive decline, and Alzheimer's disease pathology.
MOLECULAR PSYCHIATRY
(2021)
Article
Computer Science, Artificial Intelligence
Zohre Moattar Husseini, Mohammad Hossein Fazel Zarandi, Abbas Ahmadi
Summary: Microarray technology allows for the measurement of expression levels for thousands of genes in different samples simultaneously. This paper proposes adaptive interval type2-possibilistic C-means and adaptive interval type2-possibilistic fuzzy C-means clustering methods to handle the characteristics and uncertainties of microarray data. The proposed algorithms demonstrate better clustering performance compared to well-known soft clustering methods.
ARTIFICIAL INTELLIGENCE REVIEW
(2023)
Article
Medicine, General & Internal
Blazej Chermula, Wieslawa Kranc, Piotr Celichowski, Boguslawa Stelmach, Hanna Piotrowska-Kempisty, Paul Mozdziak, Leszek Pawelczyk, Robert Zygmunt Spaczynski, Bartosz Kempisty
Summary: This study analyzes the epithelial origin of cumulus and granulosa cells in ovarian follicles, and identifies genes associated with epithelialization processes. The results suggest that these cells originate from the ovarian surface epithelium, and some gene expression profiles may have tumorigenic properties.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Sanjay Arora, Jagdish Singh
Summary: The research demonstrated a brain-targeted nanoparticle delivery system for vgf gene, showing significant transfection in the mouse brain for the treatment of Alzheimer's disease. This method utilized surface functionalization and lipid conjugation for efficient brain-targeted transfection, with promising results in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Wei Kong, Yufang Xu, Shuaiqun Wang, Kai Wei, Gen Wen, Yaling Yu, Yuemin Zhu
Summary: Traditional linear models in traditional image genetics fail to capture the dynamic changes in brain phenotype and connectivity data over time. In this study, we proposed a novel method called DS-HBTGSCCA that combines Deep Subspace reconstruction and Hypergraph-Based Temporally-constrained Group Sparse Canonical Correlation Analysis. This method effectively captures the deep association between longitudinal phenotypes and genotypes by utilizing dynamic high-order correlation between brain regions.
Article
Neurosciences
Oscar Ramos-Campoy, Albert Llado, Beatriz Bosch, Mireia Ferrer, Agnes Perez-Millan, Miguel Vergara, Laura Molina-Porcel, Laura Fort-Aznar, Ricardo Gonzalo, Fermin Moreno-Izco, Guadalupe Fernandez-Villullas, Mircea Balasa, Raquel Sanchez-Valle, Anna Antonell
Summary: This study investigates gene expression profiles in different forms of Alzheimer's disease (AD) and frontotemporal dementia (FTD) using brain tissue and lymphoblastoid cell lines (LCLs). The findings reveal common altered pathways such as inflammation, glial cell differentiation, synaptic signaling, metabolism, and mitochondrial dysfunction in these diseases. The use of LCLs provides a potential method for studying early immune system and inflammation as well as neural features in neurodegenerative dementias.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kandasamy Kathirvel, Lester Karen, Ravinarayanan Haribalaganesh, Ramasamy Krishnadas, Veerappan Muthukkaruppan, Brian Lane, David A. Simpson, Kasia Goljanek-Whysall, Carl Sheridan, Devarajan Bharanidharan, Colin E. Willoughby, Srinivasan Senthilkumari
Summary: This study investigates the temporal changes in gene expression in response to dexamethasone treatment in human trabecular meshwork cells, and identifies potential therapeutic targets for the management of glucocorticoid-induced ocular hypertension and glaucoma.
SCIENTIFIC REPORTS
(2022)
News Item
Multidisciplinary Sciences
Sara Reardon
Summary: The study indicates that the amyloid-targeting drug candidate has the potential to slow down cognitive decline in certain individuals, but concerns remain regarding its possible side effects.
Article
Geriatrics & Gerontology
Xianxiao Zhou, Jiqing Cao, Li Zhu, Kurt Farrell, Minghui Wang, Lei Guo, Jialiang Yang, Andrew McKenzie, John F. Crary, Dongming Cai, Zhidong Tu, Bin Zhang
Summary: This integrative network biology study identifies molecular signatures and networks underlying brain regional vulnerability to aging in males and females. The findings pave the way for understanding the molecular mechanisms of gender differences in developing neurodegenerative diseases such as Alzheimer's disease (AD).
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sanjay Arora, Takahisa Kanekiyo, Jagdish Singh
Summary: BDNF delivered through lipid-based nanoparticles shows promising results in Alzheimer's Disease animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agriculture, Multidisciplinary
Zeynep Goktas, Yujiao Zu, Mehrnaz Abbasi, Shannon Galyean, Dayong Wu, Zhaoyang Fan, Shu Wang
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Haley Overby, Yang Yang, Xinyun Xu, Shu Wang, Ling Zhao
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2020)
Article
Nanoscience & Nanotechnology
Chathurika S. Dhanasekara, Jia Zhang, Shufang Nie, Guigen Li, Zhaoyang Fan, Shu Wang
Summary: L-NPs exhibit high binding affinity to macrophage CD36 receptor and show 1.4-fold higher accumulation in aortic lesion areas compared to NPs. They co-localize with intimal macrophages and CD36 receptors in aortic lesions, suggesting a potential breakthrough in molecular imaging and targeted treatment of atherosclerosis.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yujiao Zu, Ling Zhao, Lei Hao, Yehia Mechref, Masoud Zabet-Moghaddam, Peter A. Keyel, Mehrnaz Abbasi, Dayong Wu, John A. Dawson, Ruiwen Zhang, Shufang Nie, Naima Moustaid-Moussa, Mikhail G. Kolonin, Alexes C. Daquinag, Luis Brandi, Irfan Warraich, Susan K. San Francisco, Xiaocun Sun, Zhaoyang Fan, Shu Wang
Summary: Research shows targeted nanoparticle delivery of browning agents could induce differentiation of adipose stromal cells into beige adipocytes, leading to decreased fat mass, improved glucose metabolism, and reduced inflammation, providing a transformative technology in combating obesity and its comorbidities.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
W. Li, S. Wang, Z. Fan, S. Li, A. Bernussi, N. Newman
Summary: The study demonstrates the superior performance of functionalized BC separator in suppressing polysulfide shuttling by grafting anionic function groups on cellulose chains. The LSB cells equipped with this separator showed specific capacity above 1,000 mAh/g after 100 cycles at 0.3 degrees C, showcasing its better performance compared to commercial polyolefin-based separators.
MATERIALS TODAY ENERGY
(2021)
Review
Biochemistry & Molecular Biology
Yang Yang, Myah Trevethan, Shu Wang, Ling Zhao
Summary: Naringin and naringenin are subclass of flavonoids that have been shown to have lipid-lowering effects and diverse effects in populations with different health conditions. Recent studies have revealed new mechanisms underlying the hypolipidemic effects of these compounds, as well as their effects on lipid metabolism. In addition, citrus fruits enriched with naringin and naringenin have been studied for their lipid-lowering effects in animal models and human clinical trials. Furthermore, pharmacokinetics studies and the interplays between these flavonoids and gut microbiota have also been summarized.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Mehrnaz Abbasi, Zhaoyang Fan, John A. Dawson, Shu Wang
Summary: Obesity is a serious health problem associated with various complications. Browning white adipose tissue (WAT) to increase energy expenditure has been suggested as a potential obesity treatment. This study used dissolvable microneedles to deliver metformin to subcutaneous WAT and found that it promoted WAT browning and improved energy metabolism, showing promising anti-obesity effects.
Article
Multidisciplinary Sciences
Bing Xu, Fan Li, Wenjing Zhang, Yajuan Su, Ling Tang, Pengsheng Li, Jyotsna Joshi, Aaron Yang, Dong Li, Zhao Wang, Shu Wang, Jingwei Xie, Haiwei Gu, Wuqiang Zhu
Summary: The research findings suggest that FGF1 and CHIR99021 protect the heart against ischemic injury by improving myocardial metabolism, which may have important implications for the treatment of acute myocardial infarction in humans.
Article
Materials Science, Paper & Wood
Wenyue Li, Shu Wang, Zhaoyang Fan, Shiqi Li, Nathan Newman
Summary: This study reports the use of bacterial cellulose (BC) modified by SiO2 nanoparticles (NPs) as a separator material for lithium-metal batteries (LMBs) and lithium-sulfur batteries (LSBs). The composite BC/SiO2 film enables smooth lithium-ion flux, regulated lithium deposition, and suppressed polysulfide shuttling, resulting in improved stability and performance.
Review
Biology
Dong Li, Yura Son, Michelle Jang, Shu Wang, Wuqiang Zhu
Summary: Heart disease is the leading cause of death globally, and the inability of cardiomyocytes in adult mammalian hearts to divide makes the loss of heart muscles after a heart attack usually irreversible. Many novel therapies have been developed for repairing injured myocardium, but delivering therapeutic agents specifically to the injured heart remains a challenge. Nanoparticles are commonly used for targeted drug delivery, and this review provides a comprehensive summary of nanoparticle-based cardiac-specific drug delivery strategies for the treatment of heart diseases.
Article
Nutrition & Dietetics
Jiyoung Bae, Yang Yang, Xinyun Xu, Jamie Flaherty, Haley Overby, Kelsey Hildreth, Jiangang Chen, Shu Wang, Ling Zhao
Summary: Identifying functional brown adipose tissue (BAT) has provided new hope for obesity treatment and prevention. The study found that naringenin (NAR) can promote adipocyte browning and thermogenesis through the activation of PPARγ.
FRONTIERS IN NUTRITION
(2022)
Article
Electrochemistry
Xueyan Lin, Wenyue Li, Xuan Pan, Shu Wang, Zhaoyang Fan
Summary: In this study, a freestanding electrocatalytic sulfur host consisting of hydrogen-treated VO2 nanoparticles anchored on nitrogen-doped carbonized bacterial cellulose aerogels was reported. The hydrogen treatment enabled the formation and stabilization of the metallic rutile phase of VO2, significantly enhancing its catalytic capability. The electrocatalytic performance of this unique structure was characterized and the kinetic barriers between S-8, polysulfides, and Li2S were greatly reduced. As a result, the performance of Li-S batteries in terms of sulfur utilization and charge/discharge rate was greatly improved. This work suggests an effective strategy for developing conductive catalysts based on transition metal oxide (VO2) for Li-S batteries.
Review
Nutrition & Dietetics
Fang Zhou, Tiffany Peterson, Zhaoyang Fan, Shu Wang
Summary: This review discusses the synthesis of phytochemical-based nanoparticles and the application of stabilizers. Nanoparticles can enhance the stability and oral bioavailability of phytochemicals, while stabilizers can improve the stability and characteristics of nanoparticles.
Article
Chemistry, Physical
Rishav Baranwal, Xueyan Lin, Wenyue Li, Xuan Pan, Shu Wang, Zhaoyang Fan
Summary: The advancement of lithium-sulfur batteries is hindered by the challenges of polysulfide shuttling and Li dendrite formation. A polydopamine coated bacterial cellulose separator (PDA@BC) was synthesized to address these challenges, providing physical and chemical traps for polysulfides and controlling the Li+ flux. The results showed superior performance compared to a commercial separator, indicating practical applicability of the synthesized separator.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Engineering, Environmental
Xueyan Lin, Wenyue Li, Vy Nguyen, Shu Wang, Shize Yang, Lu Ma, Yonghua Du, Bin Wang, Zhaoyang Fan
Summary: In this study, Fe single metal atom catalyst was incorporated into the sulfur cathode design, which improved the sulfide reaction kinetics and reduced the shuttle effects of lithium polysulfides, leading to enhanced performance and cycling stability of Li-S batteries.
CHEMICAL ENGINEERING JOURNAL
(2023)