Article
Geriatrics & Gerontology
Yuda Huang, Yongzhi Shan, Wen Qin, Guoguang Zhao
Summary: This study investigated the modulation of APOE on cerebral atrophy and its role in the conversion from cognitive normal (CN) to dementia using a voxel-wise whole-brain perspective. The results revealed that APOE epsilon 4 carriers showed faster-accelerated atrophy in the left hippocampus compared to noncarriers, and both CN2D epsilon 4 carriers and noncarriers exhibited a faster atrophic speed than CN epsilon 4 carriers. These findings were replicated in a sub-sample with strict demographic matching.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Sandra den Hoedt, Simone M. Crivelli, Frank P. J. Leijten, Mario Losen, Jo A. A. Stevens, Marina Mane-Damas, Helga E. de Vries, Jochen Walter, Mina Mirzaian, Eric J. G. Sijbrands, Johannes M. F. G. Aerts, Adrie J. M. Verhoeven, Pilar Martinez-Martinez, Monique T. Mulder
Summary: The study found that sex is a stronger determinant of brain ceramide levels in mice than APOE genotype, AD background, or age. Whether these differences impact AD neuropathology in men and women remains to be investigated.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Madia Lozupone, Bruno Pietro Imbimbo, Claudia Balducci, Filomena Lo Vecchio, Paola Bisceglia, Raffaela Rita Latino, Maurizio Leone, Vittorio Dibello, Vincenzo Solfrizzi, Antonio Greco, Antonio Daniele, Mark Watling, Davide Seripa, Francesco Panza
Summary: This article discusses the role of human apolipoprotein E (apoE) in the pathophysiology of Alzheimer's disease (AD), describing its impact on brain homeostasis, neuroinflammation, blood-brain barrier permeability, glial function, synaptogenesis, oral/gut microbiota, neural networks, amyloid beta deposition, and tau-mediated neurodegeneration. It also provides updates on different therapeutic approaches targeting apoE in AD treatment.
ALZHEIMERS & DEMENTIA
(2023)
Review
Pharmacology & Pharmacy
Benjamin R. Troutwine, Laylan Hamid, Colton R. Lysaker, Taylor A. Strope, Heather M. Wilkins
Summary: Genetic variation in the APOE gene is associated with the risk of Alzheimer's disease. The APOE epsilon 4 alleles are the strongest genetic risk factor for late onset sporadic AD, while the APOE epsilon 2 alleles have lower risk and the APOE epsilon 3 alleles have neutral risk.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Cell Biology
Alexander M. Kulminski, Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskaya, Alzheimer's Disease Neuroimaging Initiative Alzheimers Dis Neuroimaging Initiative
Summary: This study examined the associations of APOE alleles and polygenic profiles with cerebrospinal fluid and plasma biomarkers, revealing differential effects of specific alleles on different biomarkers.
Article
Neurosciences
Alexander P. Gabrielli, Ian Weidling, Amol Ranjan, Xiaowan Wang, Lesya Novikova, Subir Roy Chowdhury, Blaise Menta, Alexandra Berkowicz, Heather M. Wilkins, Kenneth R. Peterson, Russell H. Swerdlow
Summary: Mitochondrial dysfunction can activate APOE expression by altering transcription factors and stress signaling pathways, thereby influencing the biology of the APOE gene and apoE protein.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cell Biology
Alexander M. Kulminski, Ethan Jain-Washburn, Ian Philipp, Liang He, Yury Loika, Elena Loiko, Olivia Bagley, Svetlana Ukraintseva, Anatoliy Yashin, Konstantin Arbeev, Eric Stallard, Mary F. Feitosa, Nicole Schupf, Kaare Christensen, Irina Culminskaya
Summary: Age-related diseases are complex polygenic traits with intricate genetic architectures. We examined the impact of multiple combinations of genotypes on the chances of living to older ages and found that specific combinations of genetic variants were associated with increased risk for Alzheimer's disease and decreased survival chances.
Article
Chemistry, Multidisciplinary
Dylan Mah, Yanan Zhu, Guowei Su, Jing Zhao, Ashely Canning, James Gibson, Xuehong Song, Eduardo Stancanelli, Yongmei Xu, Fuming Zhang, Robert J. Linhardt, Jian Liu, Lianchun Wang, Chunyu Wang
Summary: Apolipoprotein E (ApoE)'s epsilon 4 allele is the most important genetic risk factor for late onset Alzheimer's Disease (AD). Heparan sulfate (HS) on the cell surface acts as a cofactor for the interaction between ApoE and LRP1, as well as the prion-like spread of tau pathology between cells. 3-O-sulfated HS has been linked to AD through its interaction with tau, and increased levels of 3-O-sulfated HS and 3-O-sulfotransferases have been observed in the AD brain. This study characterizes the interactions between ApoE and HS in different ApoE isoforms, and suggests that the interplay between 3-O-sulfated HS, tau, and ApoE isoforms may modulate AD risk.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Clinical Neurology
Amin Haghani, Max Thorwald, Todd E. Morgan, Caleb E. Finch
Summary: Little is known about gene-environment interactions for Alzheimer's disease risk factors. This study reveals novel connections among the APOE network, air pollution, and age-related diseases. Both humans and mice show coordinated responses to air pollution exposure in the cerebral cortex and age-related decline in APOE cluster expression in vulnerable brain regions.
ALZHEIMERS & DEMENTIA
(2021)
Review
Neurosciences
Yanhui Zhang, Huiling Gao, Wei Zheng, He Xu
Summary: Alzheimer's disease is the most common type of dementia in elderly individuals, and there is currently no effective disease-modifying treatment. Imbalance in brain metal ions has been found to be closely related to the onset and progression of Alzheimer's disease. Recent evidence suggests that interactions between brain metal ions and apolipoprotein E may be one of the mechanisms for neurodegeneration.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Shanshan Zhang, Sajid Asghar, Chenqi Zhu, Junxiu Ye, Ling Lin, Liu Xu, Ziyi Hu, Zhipeng Chen, Feng Shao, Yanyu Xiao
Summary: This study presents a multi-functional delivery system (APND-3) designed to address the issues of poor drug delivery to the brain in Alzheimer's disease (AD) treatment. The system, based on a novel peptide (MOP) with self-assembling properties, significantly enhances the delivery of MOP to the brain, reducing A beta deposition and improving neurological outcomes in AD model mice.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Clinical Neurology
Xiao-Yu Ji, Xin-Yuan Peng, Hai-Liang Tang, Hui Pan, Wei-Tang Wang, Jie Wu, Jian Chen, Nai-Li Wei
Summary: The APOE4 gene variant is the most significant genetic risk factor for Alzheimer's disease, promoting its initiation and progression. The high affinity of the APOE4 allele to triglycerides and cholesterol, leading to differences in lipid metabolism, has a widespread impact on neurons, microglia, and astrocytes. Phenotypic classification of Alzheimer's patients based on APOE4 carrier status is hypothesized to aid research, diagnosis, and treatment, as it has been found to have phenotypic differences and varied responses to treatment.
Article
Clinical Neurology
Amin Gharbi-Meliani, Aline Dugravot, Severine Sabia, Melina Regy, Aurore Fayosse, Alexis Schnitzler, Mika Kivimaki, Archana Singh-Manoux, Julien Dumurgier
Summary: The study found that APOE ε4 carriers have poorer cognition and higher risk of dementia in old age. Heterozygous ε4 carriers have cognitive advantage in midlife and show poorer cognitive scores after the age of 75.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Jeyashree Alagarsamy, Anja Jaeschke, David Y. Hui
Summary: A preponderance of evidence suggests that the deficiency and polymorphisms of apolipoprotein E (apoE) are associated with the pathogenesis of various chronic diseases. The APOE gene is polymorphic, with three major alleles encoding different apoE isoforms. ApoE is involved in the clearance of atherogenic lipoproteins and also regulates cell functions through interactions with receptors. This review article focuses on the contribution of apoE deficiency or polymorphisms to cardiovascular disease, metabolic disease, and neurological disorders through lipoprotein transport-dependent and -independent mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Geriatrics & Gerontology
Yanting Chen, Yanfang He, Jinling Han, Wenyan Wei, Feng Chen
Summary: This article summarizes the dysfunction of blood-brain barrier (BBB) in Alzheimer's disease (AD) and the relationships and mechanisms between BBB dysfunction and related risk factors. It also discusses the current status and future directions of therapeutic strategies targeting the BBB for AD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Joanna Norton, Manuela Pastore, Matthew Hotopf, Andre Tylee, Anthony Mann, Marie-Laure Ancelin, Jorge Palacios
Summary: Depression is a widely recognized risk factor for recurrent cardiac events (RCEs), but findings on anxiety have been inconsistent and not previously reported using a time-dependent approach. This study found that anxiety, especially in the short-term, is an important preventable and potentially causal risk factor for RCEs, even when adjusted for depression.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Fabienne Cyprien, Claudine Berr, Jerome J. Maller, Chantal Meslin, Melissa Gentreau, Thibault Mura, Audrey Gabelle, Philippe Courtet, Karen Ritchie, Marie-Laure Ancelin, Sylvaine Artero
Summary: This study found that late-life cynical hostility is associated with increased risk of Alzheimer's disease and structural neuroimaging markers of AD. High cynical hostility is related to white matter alterations, specifically smaller anterior corpus callosum volume, and higher risk for AD.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Ophthalmology
Chloe Chamard, Helena Huguet, Alain M. Bron, Catherine Creuzot-Garcher, Erika Nogue, Max Villain, Nicolas Nagot, Isabelle Carriere, Thibault Mura, Vincent Daien
Summary: This study found a decrease of around one quarter in the delivery of intraocular pressure-lowering agents after cataract extraction, with approximately one quarter of patients experiencing a long-term interruption in medication use.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Clinical Neurology
Noemie Letellier, Laure-Anne Gutierrez, Corinne Pilorget, Fanny Artaud, Alexis Descatha, Anna Ozguler, Marcel Goldberg, Marie Zins, Alexis Elbaz, Claudine Berr
Summary: This study found that occupational exposure to formaldehyde has long-term detrimental effects on cognitive health in a relatively young population, including impairments in global cognitive function and various cognitive domains.
Article
Health Care Sciences & Services
Eloi Debourdeau, Chloe Charmard, Isabelle Carriere, Julien Plat, Max Villain, Lucile Boivineau, Romain Altwegg, Vincent Daien
Summary: This study found that the severity of Crohn's disease is associated with alterations in retinal microcirculation. Patients with severe CD showed significantly reduced foveal avascular zone area, superficial macular capillary plexus vessel density, and parafoveal thickness compared to controls. The foveal avascular zone area was also significantly lower in severe CD patients compared to moderate CD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Jeanne Duchesne, Laure-Anne Gutierrez, Isabelle Carriere, Thibault Mura, Jie Chen, Danielle Vienneau, Kees de Hoogh, Catherine Helmer, Benedicte Jacquemin, Claudine Berr, Marion Mortamais
Summary: This study found a link between higher exposure to PM2.5 and accelerated decline in global cognition in a large population-based cohort of French elderly individuals. No significant associations were detected for other pollutants or specific cognitive domains.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Clinical Neurology
Dinuli Nilaweera, Rosanne Freak-Poli, Caroline Gurvich, Karen Ritchie, Isabelle Chaudieu, Marie-Laure Ancelin, Joanne Ryan
Summary: This study found that multiple adverse childhood events are associated with worse psychomotor speed and verbal fluency in later life, especially in women. Early-life abuse/maltreatment and poverty/financial difficulties were associated with worse psychomotor speed.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Surgery
Eloi Debourdeau, Gabriel Gardes, David Nocca, Isabelle Carriere, Christophe Chiquet, Max Villain, Camille Roubille, Guilhem Du Cailar, Mathieu Sardinoux, Vincent Daien, Pierre Fesler
Summary: This study demonstrates that retinal microvascular phenotype improves during the first year after bariatric surgery, with decreased central retinal vein equivalent and increased arteriole-to-venule ratio. Factors associated with retinal microvascular plasticity include male sex, high baseline weight, and absence of diabetes.
Article
Nutrition & Dietetics
Tagrid Alharbi, Joanne Ryan, Rosanne Freak-Poli, Danijela Gasevic, Jacqueline Scali, Karen Ritchie, Marie-Laure Ancelin, Alice J. Owen
Summary: Changes in body weight in older adults may be associated with increased mortality risk. Significant weight loss of 5% or more is linked to higher all-cause and cardiovascular disease mortality risk, while weight gain does not increase mortality risk.
Article
Ophthalmology
Chloe Chamard, Jerome J. Maller, Nicolas Menjot, Eloi Debourdeau, Virginie Nael, Karen Ritchie, Isabelle Carriere, Vincent Daien
Summary: This study investigated the association between visual function and cortical thickness in older adults, finding that vision loss was associated with thinning of the right insula cortex. The reduced insula thickness may lead to increased cognitive burden in the ageing brain.
Article
Nutrition & Dietetics
Jeanne Bardinet, Virginie Chuy, Isabelle Carriere, Cedric Galera, Camille Pouchieu, Cecilia Samieri, Catherine Helmer, Audrey Cougnard-Gregoire, Catherine Feart
Summary: This study aimed to assess the association between adherence to the Mediterranean Diet (MeDi) and the risk of depressive symptoms among older French adults. The findings suggest a potential benefit of greater adherence to the MeDi in reducing the risk of depressive symptoms, although the results may depend on the definition of depressive symptoms.
Article
Clinical Neurology
Marie-Laure Ancelin, Isabelle Jaussent, Karen Ritchie, Alain Besset, Joanne Ryan, Yves Dauvilliers
Summary: This study examines the association between BDNF variants and promoter I methylation with sleep disturbances in older adults. The results show that wake time after sleep onset (WASO) is associated with four SNPs in participants not taking psychotropic drugs, while the associations are either not significant or in the reverse direction in participants taking drugs. Higher BDNF methylation levels are found in participants with long WASO, and this varies depending on psychotropic drug use.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Jessica Gong, Katie Harris, Darren M. Lipnicki, Erico Castro-Costa, Maria Fernanda Lima-Costa, Breno S. Diniz, Shifu Xiao, Richard B. Lipton, Mindy J. Katz, Cuiling Wang, Pierre-Marie Preux, Maelenn Guerchet, Antoine Gbessemehlan, Karen Ritchie, Marie-Laure Ancelin, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Mary H. Kosmidis, Antonio Guaita, Elena Rolandi, Annalisa Davin, Oye Gureje, Stella Trompet, Jacobijn Gussekloo, Steffi Riedel-Heller, Alexander Pabst, Susanne Rohr, Suzana Shahar, Devinder Kaur Ajit Singh, Nurul Fatin Malek Rivan, Martin van Boxtel, Sebastian Kohler, Mary Ganguli, Chung-Chou Chang, Erin Jacobsen, Mary Haan, Ding Ding, Qianhua Zhao, Zhenxu Xiao, Kenji Narazaki, Tao Chen, Sanmei Chen, Tze Pin Ng, Xinyi Gwee, Katya Numbers, Karen A. Mather, Marcia Scazufca, Antonio Lobo, Concepcion De-la-Camara, Elena Lobo, Perminder S. Sachdev, Henry Brodaty, Maree L. Hackett, Sanne A. E. Peters, Mark Woodward
Summary: This meta-analysis of data from 21 cohorts across six continents found that women have a higher risk of developing dementia than men, especially in low- and lower-middle-income economies. Longer education and former alcohol use are stronger risk factors for dementia in men than in women, while other risk factors have similar effects in both genders.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychiatry
Aoshuang Zhou, Marie-Laure Ancelin, Karen Ritchie, Joanne Ryan
Summary: Studies have investigated the potential role of DNA methylation in the enduring effects of early-life stress and trauma on health. This study aimed to explore the association between childhood adversity and BDNF promoter methylation in older adults. Results showed no strong evidence of a long-term association between childhood abuse/maltreatment or financial difficulties/poverty and BDNF methylation in older individuals. Differential methylation at some CpG sites was observed for war/natural disaster, but these findings were not significant after correction for multiple testing. Further large prospective studies are needed to examine DNA methylation across the genome.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Clemence Cavailles, Isabelle Carriere, Maude Wagner, Jean-Francois Dartigues, Claudine Berr, Yves Dauvilliers, Isabelle Jaussent
Summary: Given the complex relationship between sleep and neurodegenerative processes, this study aimed to examine the association between sleep parameters and dementia incidence, and characterize the trajectories of sleep patterns before dementia diagnosis. The findings revealed that long sleep duration and earlier bedtime may impact dementia incidence. Trajectories of sleep durations and time in bed showed faster increases in dementia cases compared with controls up to 12 years before dementia onset.
