期刊
ACTA BIOMATERIALIA
卷 26, 期 -, 页码 34-44出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2015.08.025
关键词
Nanocomposites; Elastomer; Poly(glycerol sebacate); Two-dimensional (2D) silicates; Bone regeneration
Poly(glycerol sebacate) (PGS) has been proposed for tissue engineering applications owing to its tough elastomeric mechanical properties, biocompatibility and controllable degradation. However, PGS shows limited bioactivity and thus constraining its utilization for musculoskeletal tissue engineering. To address this issue, we developed bioactive, highly elastomeric, and mechanically stiff nanocomposites by covalently reinforcing PGS network with two-dimensional (2D) nanosilicates. Nanosilicates are ultrathin nanomaterials and can induce osteogenic differentiation of human stem cells in the absence of any osteogenic factors such as dexamethasone or bone morphogenetic proteins-2 (BMP2). The addition of nanosilicate to PGS matrix significantly enhances the mechanical stiffness without affecting the elastomeric properties. Moreover, nanocomposites with higher amount of nanosilicates have higher in vitro stability as determined by degradation kinetics. The increase in mechanical stiffness and in vitro stability is mainly attributed to enhanced interactions between nanosilicates and PGS. We evaluated the in vitro bioactivity of nanocomposite using preosteoblast cells. The addition of nanosilicates significantly enhances the cell adhesion, support cell proliferation, upregulate alkaline phosphates and mineralized matrix production. Overall, the combination of high mechanically stiffness and elastomericity, tailorable degradation profile, and the ability to promote osteogenic differentiation of PGS-nanosilicate can be used for regeneration of bone. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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