Article
Food Science & Technology
Didier Tardieu, Maria Matard-Mann, Pi Nyvall Collen, Philippe Guerre
Summary: The study analyzed the effects of FB on hepatic and plasma sphingolipidome in chickens, showing that alterations in sphingolipids can lead to toxic manifestations and can potentially serve as a biomarker of exposure to FB.
Article
Biochemistry & Molecular Biology
Sara C. Di Rienzi, Elizabeth L. Johnson, Jillian L. Waters, Elizabeth A. Kennedy, Juliet Jacobson, Peter Lawrence, Dong Hao Wang, Tilla S. Worgall, J. Thomas Brenna, Ruth E. Ley
Summary: Studies using germfree animals as controls have shown that the gut microbiome mediates diet-induced obesity. The microbial colonization status affects fatty acid levels and liver sphingolipid pools, regardless of the diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mateusz Matwiejuk, Hanna Mysliwiec, Bartlomiej Lukaszuk, Marta Lewoc, Hend Malla, Piotr Mysliwiec, Jacek Dadan, Adrian Chabowski, Iwona Flisiak
Summary: Psoriasis is a complex chronic immunologically mediated disease that affects the skin, nails, and joints. Abnormal levels of sphingolipids significantly differ between psoriatic skin and healthy skin, suggesting their potential role in the pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Samar M. M. Hammad, Olivia C. Harden, Dulaney A. Wilson, Waleed O. Twal, Paul J. Nietert, Jim C. Oates
Summary: SLE is a chronic autoimmune disease with African American SLE patients showing higher levels of certain sphingolipids, which are correlated with the severity of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Philippe Guerre, Angelique Travel, Didier Tardieu
Summary: Fumonisins can alter the concentration of specific sphingolipid categories in turkeys, while deoxynivalenol and zearalenone have minimal effects on sphingolipids. These findings help explain the relative resistance of turkeys to fumonisins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shinji Yamashita, Mikio Kinoshita, Teruo Miyazawa
Summary: Sphingolipids, as constituents of cell and vacuole membranes in eukaryotic cells, play a critical role acquired from daily diets, especially affecting intestinal health. Animal- and plant-derived foods contain different types of sphingolipids, influencing intestinal health, lipid metabolism, and skin disorders. Despite low absorption ratios, dietary sphingolipids have various functions and structures that contribute to health benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Vadim S. S. Pokrovsky, Veronika I. I. Ivanova-Radkevich, Olga M. M. Kuznetsova
Summary: Sphingolipids are complex lipids composed of a sphingoid base bound to a fatty acid. Recent interest in sphingolipid metabolism has increased due to the diverse effects demonstrated by sphingolipids with a similar chemical structure. The involvement of sphingolipids in regulating apoptosis and cell proliferation makes them critically important in tumor progression, and enzymes and receptors related to sphingolipid metabolism are potential targets for antitumor therapy.
BIOCHEMISTRY-MOSCOW
(2023)
Article
Biochemistry & Molecular Biology
Christiane Muehle, Johannes Kornhuber
Summary: The activity of neutral sphingomyelinase (NSM) has been detected in human serum and plasma samples, which hydrolyzes fluorescently labeled sphingomyelin to ceramide. This discovery could lead to the development of new biomarkers or therapeutic targets for diseases affected by sphingolipid derangements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aaron W. Beger, Beatrix Dudzik, Randall L. Woltjer, Paul L. Wood
Summary: Sphingolipids play important roles in neural tissue and are associated with neurological diseases such as Parkinson's disease and Lewy body disease. Mass spectrometry analysis revealed significant alterations in sphingolipid levels, particularly in the putamen, providing evidence for their involvement in neuronal cell death in these diseases.
Review
Biochemistry & Molecular Biology
Mateusz Matwiejuk, Hanna Mysliwiec, Adrian Chabowski, Iwona Flisiak
Summary: Psoriasis is a complex, chronic, immunologically mediated disease that is associated with numerous other diseases. It can cause impairment of quality of life and may be associated with depressive disorders. The pathophysiology of psoriasis and its comorbidities is not fully understood yet, and disrupted metabolism of sphingolipids may be the link between them.
Article
Nutrition & Dietetics
Jahangir Iqbal, Abeer Al Otaibi, Sindiyan Alshaikh Mubarak, Ali Alqarni, Ahmed Bakillah
Summary: ABCC10 is involved in the synthesis and efflux of GlcCer, with its inhibition affecting both processes.
Review
Biochemistry & Molecular Biology
Lisa Peters, Wolfgang M. Kuebler, Szandor Simmons
Summary: Atherosclerosis is a global health issue, and understanding the underlying cellular and molecular mechanisms like sphingolipids is crucial for disease treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Gianna Fote, Jie Wu, Mark Mapstone, Fabio Macciardi, Massimo S. Fiandaca, Howard J. Federoff
Summary: The study evaluated plasma SM species in LOAD patients, finding a significant reduction of the metabolite SM OHC14:1 in preclinical AD patients. This suggests that plasma sphingomyelin levels may play a significant role in early diagnosis of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Benjamin Lidgard, Nisha Bansal, Leila R. Zelnick, Andrew N. Hoofnagle, Amanda M. Fretts, William T. Longstreth, Michael G. Shlipak, David S. Siscovick, Jason G. Umans, Rozenn N. Lemaitre
Summary: The study found that circulating sphingolipids partially mediate the associations between eGFR and cardiovascular events. Altered sphingolipid metabolism may be a novel mechanism for heart failure in patients with CKD.
Review
Agriculture, Multidisciplinary
Tatsuya Sugawara
Summary: Sphingolipids are common components in eukaryotic organisms and can be found in various food sources. They have been noted for their potential physiological functions, particularly in improving skin barrier function. These lipids have also been studied for their potential role in preventing diseases such as cancer and metabolic syndrome. However, the mechanisms underlying their health-improving effects, especially their metabolic fates, are still not fully understood. Further research is needed to clarify the impact of dietary sphingolipids on human health.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Juraj Sprung, Mariana L. Laporta, David S. Knopman, Ronald C. Petersen, Michelle M. Mielke, Clifford R. Jack, David P. Martin, Andrew C. Hanson, Darrell R. Schroeder, Phillip J. Schulte, Scott A. Przybelski, Diana J. Valencia Morales, Toby N. Weingarten, Prashanthi Vemuri, David O. Warner
Summary: This study found that hospitalization in older adults is associated with accelerated cortical thinning, amyloid accumulation, and white matter hyperintensities (WMH) increases, especially in medical hospitalizations. However, these changes were modest and did not translate to an increased risk of crossing the abnormality threshold.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
B. Gwen Windham, Michael E. Griswold, Radhikesh Ranadive, Kevin Sullivan, Thomas H. Mosley, Michelle M. Mielke, Clifford R. Jack, Dave Knopman, Ron Petersen, Prashanthi Vemuri
Summary: This study aimed to examine if the association between cerebral perfusion and gait speed is influenced by systolic blood pressure and age. The results showed that poorer cerebral perfusion is associated with slower gait speeds, particularly with older age, while higher perfusion can significantly attenuate age-related differences in gait speed.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Fabrice Lucien, Eduardo E. Benarroch, Aidan Mullan, Farwa Ali, Bradley F. Boeve, Michelle M. Mielke, Ronald C. Petersen, Yohan Kim, Cole Stang, Emanuele Camerucci, Owen A. Ross, Zbigniew K. Wszolek, David Knopman, James Bower, Wolfgang Singer, Rodolfo Savica
Summary: This study explored the potential of using alpha-synuclein-positive extracellular vesicles and PARP-1 activity as non-invasive markers for Parkinson's disease. The results showed that patients with higher levels of alpha-synuclein extracellular vesicles had higher disease severity scores, and longitudinal studies are needed to evaluate their role as markers of disease progression.
Article
Rheumatology
Chanakya Kodishala, Cassondra A. Hulshizer, Vanessa L. Kronzer, John M. Davis III, Vijay K. Ramanan, Maria Vassilaki, Michelle M. Mielke, Cynthia S. Crowson, Elena Myasoedova
Summary: This study assessed the risk factors for dementia in patients with rheumatoid arthritis (RA). The findings showed that older age, rheumatoid nodules, hypertension, joint swelling, cardiovascular diseases, and psychological issues were associated with an increased risk of dementia.
JOURNAL OF RHEUMATOLOGY
(2023)
Correction
Biochemistry & Molecular Biology
Michelle M. Mielke, Jeffrey L. Dage, Ryan D. Frank, Alicia Algeciras-Schimnich, David S. Knopman, Val J. Lowe, Guojun Bu, Prashanthi Vemuri, Jonathan Graff-Radford, Clifford R. Jack, Ronald C. Petersen
Letter
Rheumatology
Chanakya Kodishala, Cassondra A. Hulshizer, Vanessa L. Kronzer, John M. Davis III, Vijay K. Ramanan, Maria Vassilaki, Michelle M. Mielke, Cynthia S. Crowson, Elena Myasoedova
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Clinical Neurology
Clifford R. Jack Jr, Heather J. Wiste, Alicia Algeciras-Schimnich, Dan J. Figdore, Christopher G. Schwarz, Val J. Lowe, Vijay K. Ramanan, Prashanthi Vemuri, Michelle M. Mielke, David S. Knopman, Jonathan Graff-Radford, Bradley F. Boeve, Kejal Kantarci, Petrice M. Cogswell, Matthew L. Senjem, Jeffrey L. Gunter, Terry M. Therneau, Ronald C. Petersen
Summary: Staging the severity of Alzheimer's disease pathology is important for therapeutic trials and clinical prognosis. Biomarkers such as amyloid and tau PET can be used for disease staging, but plasma biomarkers would be more practical.
Article
Geriatrics & Gerontology
Ronald L. Simons, Mei Ling Ong, Steven R. H. Beach, Man-Kit Lei, Robert Philibert, Michelle M. Mielke
Summary: This study examines the impact of racism on African Americans' risk for dementia. It found that low socioeconomic status and discrimination predicted self-reported cognitive decline 19 years later. Depression, accelerated aging, and chronic illness were identified as potential mediating pathways.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Clinical Neurology
Michelle M. M. Mielke, Ryan D. D. Frank, Luke R. R. Christenson, Julie A. A. Fields, Walter A. A. Rocca, Vesna D. D. Garovic
Summary: This study found that women with a history of hypertensive disorders of pregnancy (HDP), especially those with preeclampsia/eclampsia (PE/E), are more likely to experience cognitive decline in later life.
Article
Genetics & Heredity
Ronald L. Simons, Mei Ling Ong, Man-Kit Lei, Steven R. H. Beach, Yue Zhang, Robert Philibert, Michelle M. Mielke
Summary: A recent study developed a new epigenetic measure of aging using human cortex tissue called cortical clock (CC). This CC outperformed existing blood-based epigenetic clocks in predicting brain age and neurological degeneration. The study also found that loneliness and BDNFm were robust predictors of accelerated CC-Bd, suggesting a link between brain health and overall aging of the organism.
Article
Clinical Neurology
Jillian K. Lee, Ryan D. Frank, Luke R. Christenson, Julie A. Fields, Walter A. Rocca, Michelle M. Mielke
Summary: A study of 2458 women found that the length of reproductive window was not associated with cognition, higher parity was associated with greater cognitive decline, hormonal contraception use was associated with less decline in cognition, and menopausal hormone therapy use was associated with greater decline in cognition except visuospatial.
ALZHEIMERS & DEMENTIA
(2023)
Article
Peripheral Vascular Disease
Virginia A. Dines, Andrea G. Kattah, Amy L. Weaver, Lisa E. Vaughan, Alanna M. Chamberlain, Suzette J. Bielinski, Michelle M. Mielke, Vesna D. Garovic
Summary: This study found that both in utero exposure to HDP and maternal chronic hypertension are independently associated with an increased risk of chronic hypertension in offspring. When both risk factors are present, there is a 2.4-fold increase in the risk of hypertension in offspring.
Article
Clinical Neurology
Ethan D. Moser, Sheila M. Manemann, Nicholas B. Larson, Jennifer L. St Sauver, Paul Y. Takahashi, Michelle M. Mielke, Walter A. Rocca, Janet E. Olson, Veronique L. Roger, Alan T. Remaley, Paul A. Decker, Jill M. Killian, Suzette J. Bielinski
Summary: This study aims to investigate the association between lipid variability and the risk of AD/ADRD. The study found that individuals with higher variability in total cholesterol and triglyceride levels had an increased risk of developing AD/ADRD. Further research is needed to understand the underlying mechanisms of this association.
Article
Cell Biology
Clara Vila-Castelar, Chinedu Udeh-Momoh, Neelum T. Aggarwal, Michelle M. Mielke
Summary: Studies have found sex and/or gender differences in Alzheimer's disease, but little research has been conducted on other dementias. This article highlights the sex and gender differences in other forms of dementia, explores sociocultural factors, and provides a framework for future global studies.
Article
Clinical Neurology
Clifford R. Jack, Terry M. Therneau, Emily S. Lundt, Heather J. Wiste, Michelle M. Mielke, David S. Knopman, Jonathan Graff-Radford, Val J. Lowe, Prashanthi Vemuri, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunter, Ronald C. Petersen
Summary: This study aimed to investigate the long-term associations between various factors and the risk of dementia and mortality in individuals without dementia. The results showed that high amyloid PET, APOE epsilon 4 genotype, older age, and cardiovascular/metabolic conditions were associated with an increased hazard of dementia. The absolute risk of dementia was higher in women compared to men, while the combination of APOE epsilon 4 non-carrier with normal amyloid was more protective in women than men.
BRAIN COMMUNICATIONS
(2022)