期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 26, 期 3, 页码 413-430出版社
IOS PRESS
DOI: 10.3233/JAD-2011-110194
关键词
Alzheimer's disease; prions; tauons; tauopathies; truncated tau protein
资金
- EU [26240220008]
The paradigm of Alzheimer's disease (AD) is one subject to frequent change: what was thought to be a rare form of pre-senile dementia was revealed as a wide-spread malady; where amyloid-beta was deemed the sole causative agent for the better part of 20 years, tau protein was shown to play a crucial role in sAD genesis. With the discovery of possible prion-like phenomena in this disease supposedly driven by cell-autonomous processes, an evaluation of the similarities and differences between tau-driven neurodegeneration and prion disease becomes necessary. In this article, we provide a comparison of the template agent genesis, filament assembly, as well as intra-and inter-individual spread of prions and tauons.
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