Article
Geriatrics & Gerontology
Flora Cozzolino, Luisa Cane, Luigi Sacchettino, Maria Claudia Gatto, Ilaria Iacobucci, Claudia Gatta, Davide De Biase, Evaristo Di Napoli, Orlando Paciello, Luigi Avallone, Maria Monti, Danila d'Angelo, Francesco Napolitano
Summary: Brain aging is a physiological process associated with physical and cognitive decline. The hippocampus, a brain region involved in memory and learning, is particularly susceptible to the effects of aging. Using proteomics, this study identified proteins in the hippocampus of aged grazing milk cows that are involved in myelination, synaptic vesicle, metabolism, and calcium-related pathways.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Flora Cozzolino, Luisa Cane, Maria Claudia Gatto, Ilaria Iacobucci, Luigi Sacchettino, Davide De Biase, Evaristo Di Napoli, Orlando Paciello, Luigi Avallone, Maria Monti, Danila d'Angelo, Francesco Napolitano
Summary: Aging is a physiological process that leads to functional decline and increases the risk of diseases. This study investigated the effects of aging on the brain cortex of Podolica cattle using proteomics and bioinformatic analysis. The results showed down-regulation of proteins involved in cellular respiration, dendric spine development, synaptic vesicle transport, and myelination, as well as up-regulation of GFAP and vimentin. This study provides insights into the molecular mechanisms of brain aging in grazing cattle and may contribute to improving animal welfare and husbandry practices.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Cell Biology
Adam Krzystyniak, Malgorzata Wesierska, Gregory Petrazzo, Agnieszka Gadecka, Magdalena Dudkowska, Anna Bielak-Zmijewska, Grazyna Mosieniak, Izabela Figiel, Jakub Wlodarczyk, Ewa Sikora
Summary: By conducting experiments on aged rats, it was found that the use of senolytic agents D+Q can improve the learning and memory abilities of aged rats, reduce peripheral inflammation, and regulate the structure of hippocampal neurons and histone modifications. Moreover, the benefits of this treatment are long-lasting, even after the cessation of drug administration.
Article
Immunology
Sarah R. Ocanas, Kevin D. Pham, Jillian E. J. Cox, Alex W. Keck, Sunghwan Ko, Felix A. Ampadu, Hunter L. Porter, Victor A. Ansere, Adam Kulpa, Collyn M. Kellogg, Adeline H. Machalinski, Manu A. Thomas, Zsabre Wright, Ana J. Chucair-Elliott, Willard M. Freeman
Summary: This study compared the transcriptome and translatome of hippocampal microglia between young and old mice and found sex differences in microglial gene expression. In old age, these differences were primarily female-biased and enriched in markers of senescence and disease. These findings may explain the differences in susceptibility and disease progression in Alzheimer's disease between males and females. Further studies are needed to explore the role of sex differences in microglial heterogeneity and the involvement of sex-specific regulators in response to Alzheimer's pathology.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Cell Biology
Shuai Zhang, Juanjuan Duan, Yu Du, Jinlu Xie, Haijing Zhang, Changyu Li, Wensheng Zhang
Summary: This study explored the profiles of long non-coding RNAs (lncRNAs) in the liver genomes of SAMP8 and SAMR1 mouse models, revealing that certain lncRNAs play a role in liver aging and could serve as potential targets for molecular-based diagnosis and therapy of age-related liver diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Geriatrics & Gerontology
Yuko Yamaguchi, Marta Zampino, Toshiko Tanaka, Stefania Bandinelli, Yusuke Osawa, Luigi Ferrucci, Richard D. Semba
Summary: The study found that circulating GDF-15 is associated with the development of anemia in older adults, and higher levels of GDF-15 are linked to an increased risk of anemia.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Li-Ya Lee, Wayne Chou, Wan-Ping Chen, Ming-Fu Wang, Ying-Ju Chen, Chin-Chu Chen, Kwong-Chung Tung
Summary: The study demonstrated that Hericium erinaceus mycelium enriched with erinacine A improved learning and memory in mice, reduced levels of aging-related biomarkers, such as iNOS, TBARS, and 8-OHdG, in a dose-dependent manner. This suggests that Hericium erinaceus mycelium may have potential neuroprotective effects in delaying brain aging.
Review
Cell Biology
Nanshuo Cai, Yifan Wu, Yan Huang
Summary: With the global increase in the elderly population, understanding the mechanisms of aging and aging-related disorders has become crucial. Mice have emerged as prevalent animal models for aging studies due to their genetic similarity, physiological structure, short lifespan, and ease of reproduction. This review discusses common and emerging mouse models used in the study of accelerated aging and chronic diseases, aiming to provide a reference for future research in fundamental and translational studies.
Article
Cell Biology
Chetan Ahire, Adam Nyul-Toth, Jordan DelFavero, Rafal Gulej, Janet A. Faakye, Stefano Tarantini, Tamas Kiss, Anna Kuan-Celarier, Priya Balasubramanian, Anna Ungvari, Amber Tarantini, Raghavendra Nagaraja, Feng Yan, Qinggong Tang, Peter Mukli, Tamas Csipo, Andriy Yabluchanskiy, Judith Campisi, Zoltan Ungvari, Anna Csiszar
Summary: Chemotherapy-induced cognitive impairment (chemobrain) is a common side effect in cancer survivors treated with paclitaxel. This study investigates the hypothesis that paclitaxel induces endothelial senescence, which impairs microvascular function and contributes to cognitive decline.
Article
Medicine, Research & Experimental
Tao Wang, Yusheng Zhang, Weiwu Chen, Jin Tao, Qiao Xue, Wei Ge, Wanchen Dou, Chao Ma
Summary: This study utilized a high throughput quantitative proteomic approach to evaluate proteomic changes in the hippocampus and motor cortex in a rat model of cerebral palsy (CP) induced by lipopolysaccharide (LPS) combined with hypoxia/ischemia (H/I). The research revealed that neuroinflammatory responses in the brain induced by the CP model could be reversed by the topical application of Baimai ointment. Furthermore, the application of Baimai ointment not only alleviated motor deficits in CP model rats, but also restored the proteomes in the brain cortex.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Lars Nyberg, Fredrik Magnussen, Anders Lundquist, William Baare, David Bartres-Faz, Lars Bertram, C. J. Boraxbekk, Andreas M. Brandmaier, Christian A. Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N. Henson, Carme Junque, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Brenda W. J. H. Penninx, Sara Pudas, Oystein Sorensen, Lidia Vaque-Alcazar, Kristine B. Walhovd, Anders M. Fjell
Summary: Despite the modest association between education and cortical volume, higher education does not influence the rates of brain aging. The findings challenge the assumption that education slows down brain aging.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Diego Quintana-Torres, Alejandra Valle-Cao, Pablo Bousquets-Munoz, Sandra Freitas-Rodriguez, Francisco Rodriguez, Alejandro Lucia, Carlos Lopez-Otin, Alejandro Lopez-Soto, Alicia R. Folgueras
Summary: This study conducted a global plasma proteomic analysis in progeroid mouse models and found several upregulated proteins related to cardiovascular disease, the main cause of death in HGPS patients. The plasma proteome of progeroid mice exhibited an old signature, indicating accelerated aging. Furthermore, specific differences were observed in the circulating proteins between physiological and premature aging, highlighting potential biomarkers and therapeutic targets.
Article
Pharmacology & Pharmacy
Jaione Auzmendi-Iriarte, Leire Moreno-Cugnon, Ander Saenz-Antonanzas, Daniela Grassi, Marian M. de Pancorbo, Maria-Angeles Arevalo, Ian C. Wood, Ander Matheu
Summary: The study found that levels of HDACs increase in microglial cells upon induction of senescence in vitro and in mouse and human hippocampal biopsies in vivo. Publicly available datasets showed changes in HDAC expression in different brain areas during physiological aging.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Review
Oncology
Jorge Morales-Valencia, Gregory David
Summary: Senescent cells play a crucial role in cancer progression by altering cancer cell properties and promoting tumor growth through the generation of a supportive microenvironment. Recent studies indicate that senescent cells have the capacity to resume proliferation and drive cancer relapse, highlighting the potential use of senolytics and SASP modulators to prevent tumor resurgence. Understanding the mechanisms of senescence and the impact of SASP may lead to the development of targeted therapeutic strategies to exploit vulnerabilities associated with this cellular state.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yuli Hou, Qiao Song, Yaqi Wang, Jing Liu, Yuting Cui, Xiaomin Zhang, Jingjing Zhang, Jingxuan Fu, Min Cao, Chi Zhang, Congcong Liu, Xiaoling Wang, Huanli Duan, Peichang Wang
Summary: The study found that KLF14 plays a suppressive role in cellular senescence during aging. Lack of KLF14 leads to cellular senescence and aging-related pathologies, while overexpression of KLF14 can attenuate cellular senescence. Additionally, activating KLF14 to upregulate POLD1 expression can delay cellular senescence and aging-related pathologies.