Article
Clinical Neurology
Davina Biel, Matthias Brendel, Anna Rubinski, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Nicolai Franzmeier
Summary: This study found that global tau-PET SUVRs explained more variance in future cognitive decline than Centiloid across all cognitive tests, and the association between tau-PET and cognitive decline remained consistent when controlling for Centiloid. More advanced Braak-stage was associated with gradually worsening future cognitive decline, independent of Centiloid or diagnostic group. Overall, tau-PET and Braak-staging are highly predictive markers of future cognitive decline and conversion risk to MCI/dementia.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Michael Rullmann, Matthias Brendel, Matthias L. Schroeter, Dorothee Saur, Johannes Levin, Robert G. Perneczky, Solveig Tiepolt, Marianne Patt, Andre Mueller, Victor L. Villemagne, Joseph Classen, Andrew W. Stephens, Osama Sabri, Henryk Barthel
Summary: This study utilized the F-18-PI-2620 tracer and PET imaging to perform Tau Braak staging in patients with AD, and found that PET positivity closely followed the Braak staging scheme, allowing for the categorization of most cases into the six-stage hierarchical Braak model.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ganna Blazhenets, Lars Frings, Arnd Soerensen, Philipp T. Meyer
Summary: This study conducted voxel-based principal component analysis to identify patterns related to the conversion from MCI to AD, and validated them against neuropathologic findings. The results showed significant associations between the expression scores and Braak stage, as well as between the expression scores and Thal phase, with strong correlation observed between amyloid pathology and Thal phase.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Clinical Neurology
Chiara Cappelletti, Sandra Pilar Henriksen, Hanneke Geut, Annemieke J. M. Rozemuller, Wilma D. J. van de Berg, Lasse Pihlstrom, Mathias Toft
Summary: This study identified disease stage-specific transcriptomic changes in Parkinson's disease, with early stage showing specific gene expression changes in brain-specific pathways and immune mechanisms. The study also found that mitochondrial mechanisms are enriched throughout the disease course. Furthermore, several poorly characterized long non-coding RNAs were implicated in disease development and progression, and two candidate genes for future functional studies were highlighted.
ACTA NEUROPATHOLOGICA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arthur C. Macedo, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez-Arias, Nesrine Rahmouni, Firoza Z. Lussier, Marie Vermeiren, Gleb Bezgin, Paolo Vitali, Kok Pin Ng, Eduardo R. Zimmer, Marie-Christine Guiot, Tharick A. Pascoal, Serge Gauthier, Pedro Rosa-Neto
Summary: Amyloid-13 plaques and neurofibrillary tangles (NFTs) are the two histopathologic hallmarks of Alzheimer disease (AD). Braak and Braak proposed a histopathologic staging system for AD based on the pattern of NFT distribution in the brain. The PET-based Braak staging shows promise in staging AD and correlating with AD biomarkers, but further refinement and standardization are needed.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Yanjun Guo, Qinqiu Wang, Shenghui Chen, Chengfu Xu
Summary: This article summarizes the regulatory effects of APP and its cleavage peptides on metabolism in the central nervous system and peripheral tissues, indicating that peptides generated by non-amyloidogenic processing can have positive effects on metabolism, while those produced by amyloidogenic processing may have negative impacts. Abnormal expression of APP is associated with metabolic diseases (such as diabetes, obesity, etc.) and cancer.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Clinical Neurology
Kyoungwon Baik, Hye Ryun Kim, Mincheol Park, Younggun Lee, Han Kyu Na, Young H. H. Sohn, Joon-Kyung Seong, Phil Hyu Lee
Summary: This study investigated the effect of amyloid accumulation on cognitive dysfunction in patients with Parkinson's disease and dementia with Lewy bodies. The results showed that while the burden of amyloid was higher in the dementia with Lewy bodies group, amyloid accumulation was negatively associated with memory and language functions only in the Parkinson's disease group.
MOVEMENT DISORDERS
(2023)
Article
Geriatrics & Gerontology
Xin Wang, Lei Zhang, Hui Lu, Juanli Wu, Huazheng Liang, Bing Sun, Keqing Zhu
Summary: This study analyzed the distribution pattern of p62 in the brains of PART and AD patients, found a positive correlation between Braak NFT stage and p62 expression distribution, and proposed 6 stages of p62 expression.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Food Science & Technology
Ana Caroline de Oliveira, Vanete Thomaz-Soccol, Michelle Zibetti Tadra-Sfeir, Emanuel Maltempi de Souza, Maria Elena Crespo-Lopez, Herve Rogez
Summary: A new mRNA-based RT-qPCR technique was developed for rapid detection and quantification of viable Trypanosoma cruzi in acai fruits and juice, with a maximum recovery rate of 82.50% and a detection and quantification limit of 10 parasites/mL. The RT-qPCR efficiency was estimated at 97.27%, showing high accuracy in discriminating between viable and nonviable cells.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Neurosciences
Aslina Pahrudin Arrozi, Siti Nur Syazwani Shukri, Nuraqila Mohd Murshid, Ahmad Baihaqi Ahmad Shahzalli, Wan Zurinah Wan Ngah, Hanafi Ahmad Damanhuri, Suzana Makpol
Summary: This study investigated the modulatory effects of different tocopherol isomers on the APP processing pathway in Alzheimer's disease. Results showed that alpha-tocopherol and gamma-tocopherol significantly decreased APP mRNA level and A beta-42 in SH-SY5Y APP Swedish cells, potentially offering a therapeutic approach for reducing amyloid load in AD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Kseniia S. Orobets, Andrey L. Karamyshev
Summary: Alzheimer's disease is a common neurodegenerative disorder associated with age or inherited mutations. It is characterized by severe dementia that affects memory, cognitive functions, and daily life. The disease is linked to the accumulation of cytotoxic amyloid beta and hyperphosphorylated tau protein, as well as other pathological features. Various treatment options, such as antibody-based therapy and stem cell transplantation, are being investigated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Jiang Chen, Jun-Sheng Chen, Song Li, Fengning Zhang, Jie Deng, Ling-Hui Zeng, Jun Tan
Summary: Decades of research have shown that amyloid-beta (Aβ) plays an undeniable role in the development of Alzheimer's disease (AD). However, the focus on the pathological effects of Aβ may overshadow the significance of its metabolic precursor, amyloid precursor protein (APP), in the occurrence and progression of AD. This review explores the various roles of APP in AD, including its structure, functions, enzymatic processing, and potential therapeutic approaches to targeting APP to ameliorate AD pathologies and halt disease progression.
Article
Neurosciences
Sara Hall, Christina D. Orru, Geidy E. Serrano, Douglas Galasko, Andrew G. Hughson, Bradley R. Groveman, Charles H. Adler, Thomas G. Beach, Byron Caughey, Oskar Hansson
Summary: This study used α Syn RT-QuIC to analyze CSF samples from patients with Lewy body disorders (LBD), and found that it has high sensitivity and specificity for identifying LBD cases with clinicopathological confirmation. However, it has lower sensitivity for non-standard LBD or asymptomatic LBD cases.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Neurosciences
Yang Hyun Lee, Seun Jeon, Han Soo Yoo, Seok Jong Chung, Jin Ho Jung, Kyoungwon Baik, Young H. Sohn, Phil Hyu Lee, Mijin Yun, Alan C. Evans, Byoung Seok Ye
Summary: The study investigated the relationship among amyloid-beta deposition, cortical metabolism, and clinical diagnosis in AD and LBD patients. Results showed that AD and LBD patients commonly exhibited hypometabolism in specific brain regions. Combining clinical and metabolic evaluations may enhance the diagnostic accuracy of AD, LBD, and mixed disease cases.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Takashi Nihashi, Keita Sakurai, Takashi Kato, Kaori Iwata, Yasuyuki Kimura, Hiroshi Ikenuma, Akiko Yamaoka, Akinori Takeda, Yutaka Arahata, Yukihiko Washimi, Keisuke Suzuki, Masahiko Bundo, Takashi Sakurai, Nobuyuki Okamura, Kazuhiko Yanai, Kengo Ito, Akinori Nakamura
Summary: Using the F-18-THK5351 tracer, the study investigated the changes in accumulation patterns in individuals along the Alzheimer's disease continuum. The results showed an increase in F-18-THK5351 accumulation with disease progression, suggesting its potential as a tool for visualizing the severity of Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)