Article
Geriatrics & Gerontology
Takeshi Kuroda, Kenjiro Ono, Motoyasu Honma, Miki Asano, Yukiko Mori, Akinori Futamura, Satoshi Yano, Mizuki Kanemoto, Sotaro Hieda, Yasuhiko Baba, Masahiko Izumizaki, Hidetomo Murakami
Summary: This study investigated the association between white matter lesions (WML), regional cerebral blood flow (rCBF), and cognitive impairment in early-stage cognitive impairment (ESCI). The results showed significant correlations between lateral ventricular (LV-V), periventricular white matter lesions (PvWML-V), and rCBF in the anterior cingulate gyrus (ACG), which directly affected the MMSE score in ESCI. Further research is needed to understand the mechanisms behind these interactions and the impact of PvWML-V on cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jooyeon J. Im, Hyeonseok Jeong, Young Do Kim, Kyung-Sool Jang, In-Uk Song, Yong-An Chung
Summary: This study investigated brain perfusion abnormalities in patients with neurosyphilis, showing cognitive impairments and multifocal hypoperfusion predominantly in the frontal, insular, and posterior cingulate regions. Further studies with larger samples are needed to confirm these findings.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Tetsuo Kashibayashi, Ryuichi Takahashi, Jun Fujita, Ryoko Fujito, Naoto Kamimura, Fumino Okutani, Hiroaki Kazui
Summary: Olfactory dysfunction in patients with MCI and AD is associated with reduced CBF in the left temporal pole, entorhinal area, and bilateral frontal pole.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhe Lei, Jingjing Lou, Han Wu, Xiaohan Chen, Yinghui Ou, Xin Shi, Qian Xu, Keqing Shi, Yujing Zhou, Lingling Zheng, You Yin, Xingdang Liu
Summary: This study aimed to investigate the impact of CSVD on regional cerebral perfusion in MCI patients using NeuroGam (TM) software and brain perfusion SPECT imaging, and evaluate the ability of SPECT in distinguishing MCI with and without CSVD. The results indicate that CSVD may exacerbate hypoperfusion in certain brain areas in MCI patients, while also compensating for cerebral blood perfusion disorder in other areas. Brain perfusion SPECT may be helpful in differentiating MCI patients with and without CSVD.
ANNALS OF NUCLEAR MEDICINE
(2022)
Article
Clinical Neurology
Yoshikazu Nakano, Shigeki Hirano, Kazuho Kojima, Honglinag Li, Toru Sakurai, Masahide Suzuki, Hong Tai, Shogo Furukawa, Atsuhiko Sugiyama, Yoshitaka Yamanaka, Tatsuya Yamamoto, Takashi Iimori, Hajime Yokota, Hiroki Mukai, Takuro Horikoshi, Takashi Uno, Satoshi Kuwabara
Summary: This study found a correlation between cerebral blood flow (CBF) and dopamine transporter (DAT) in patients with Parkinson's disease (PD) and atypical parkinsonian syndromes (APS). Using machine learning, the combination of CBF and DAT was found to be better for distinguishing PD from APS than either modality alone.
MOVEMENT DISORDERS
(2022)
Review
Clinical Neurology
Quentin Devignes, Renaud Lopes, Kathy Dujardin
Summary: Recent studies have found that there is cognitive heterogeneity within mild cognitive impairment in Parkinson's disease, and further research is needed to explore the corresponding neuroimaging, especially in terms of brain modifications associated with specific subtypes.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Neurosciences
Fang Liu, Yudi Shi, Qiuyan Wu, Huifeng Chen, Ying Wang, Li Cai, Nan Zhang
Summary: The study aimed to analyze the value of F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with amyloid PET in cognitive impairment diagnosis. The results showed that hypometabolism in the temporoparietal and posterior cingulate/precuneus cortex on FDG PET suggested amyloid pathology in patients with cognitive impairment. This combined approach is helpful in diagnostic decision-making and predicting the conversion from MCI to AD dementia.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Ana Carolina do A. H. de Souza, Hendrik J. Harms, Laurel Martell, Courtney Bibbo, Meagan Harrington, Kyle Sullivan, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Viviany R. Taqueti, Marie Foley Kijewski, Mi-Ae Park, Alejandro Meretta, Christopher Breault, Nathaniel Roth, Alexis Poitrasson-Riviere, Prem Soman, Grant T. Gullberg, Marcelo F. Di Carli
Summary: This study aimed to validate the accuracy of Tc-99m-sestamibi SPECT in quantifying MBF and MFR, as well as evaluate its reproducibility. The results showed that using splines in SPECT imaging improved the correlation with N-13-ammonia positron emission tomography and demonstrated good test/retest reproducibility.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhe Wen, Hongming Zhuang, Jigang Yang
Summary: The purpose of this study was to determine if the image acquisition time for the salivagram can be shortened without significantly reducing the sensitivity in detecting aspiration. It was found that evidence of aspiration could be detected within the first 40 minutes of dynamic imaging, therefore the originally described 60-minute protocol can be safely shortened to 40 or even 30 minutes.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Medicine, General & Internal
Hyeonseok Jeong, Ilhyang Kang, Jong-Sik Park, Seung-Hee Na, Seunghee Kim, Sujung Yoon, In-Uk Song, Yong-An Chung
Summary: This study investigated the relationship between regional cerebral blood flow (rCBF) and neuropsychiatric symptom domains in early Alzheimer's disease (AD) patients. The results showed differential correlations between symptom domains and brain perfusion, with altered rCBF in the prefrontal cortex found in all domains. Further studies with larger samples and control participants are needed to confirm these preliminary findings.
Review
Clinical Neurology
Antonio Martin-Bastida, Manuel Delgado-Alvarado, Irene Navalpotro-Gomez, Maria Cruz Rodriguez-Oroz
Summary: Dementia, mild cognitive impairment, and neuropsychiatric symptoms are common non-motor symptoms of Parkinson's disease. Neuroimaging studies play a critical role in early diagnosis, monitoring, and understanding the pathophysiology of cognitive and neuropsychiatric symptoms associated with PD. This literature review provides an update on the latest neuroimaging findings for assessing cognitive dysfunction and impulse control disorders in PD.
FRONTIERS IN NEUROLOGY
(2021)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Article
Clinical Neurology
Maud M. van Dinther, Astrid E. Hooghiemstra, Esther Bron, Adriaan E. Versteeg, Anna Leeuwis, Tugba E. Kalay, Justine Moonen, Sanne H. Kuipers, Walter Backes, Jacobus F. A. Jansen, Mathias J. P. van Osch, Geert-Jan Biessels, Julie J. Staals, Robert van Oostenbrugge, Heart-Brain Connection consortium
Summary: Impaired cerebral blood flow (CBF) at baseline is associated with faster cognitive decline in VCI and normal aging. Our results suggest that low CBF precedes and contributes to the development of vascular cognitive impairment. CBF determined by ASL might be used as a biomarker to monitor disease progression or treatment responses in VCI.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Medicine, General & Internal
Marco Mauri, Clara Luigia Gobbo, Lucia Princiotta Cariddi, Ilaria Schiorlin, Maurizio Versino
Summary: Metabolic abnormalities suggestive of depression and/or evolution to dementia can be detected in patients with mild cognitive impairment (MCI) using FDG-PET/CT.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Krystyna Pyrzynska, Krzysztof Kilian, Mateusz Pegier
Summary: This paper provides a brief overview of the application of porphyrin ligands in tumor diagnostics, including the chelation of metallic radioisotopes to form radiopharmaceuticals and the evaluation of metabolic changes in the human body through SPECT and PET. The chelation reactions are discussed in terms of the conditions, kinetics, and complex stability.
Article
Oncology
Anthony J. Bazzan, George Zabrecky, Nancy Wintering, Andrew B. Newberg, Daniel A. Monti
INTEGRATIVE CANCER THERAPIES
(2018)
Article
Integrative & Complementary Medicine
Andrew B. Newberg, Mijail Serruya, Nancy Wintering, Aleeze Sattar Moss, Diane Reibel, Daniel A. Monti
ADVANCES IN MEDITATION RESEARCH: NEUROSCIENCE AND CLINICAL APPLICATIONS
(2014)
Article
Medicine, Research & Experimental
Debbie L. Cohen, Anne Bowler, Stephen A. Fisher, Angela Norris, Andrew Newberg, Hengyi Rao, Rupal Bhavsar, John A. Detre, Thomas Tenhave, Raymond R. Townsend
CONTEMPORARY CLINICAL TRIALS
(2013)
Review
Cardiac & Cardiovascular Systems
Stephen Olex, Andrew Newberg, Vincent M. Figueredo
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Article
Medicine, Research & Experimental
Anthony J. Bazzan, George P. Zabrecky, Andrew B. Newberg
JOURNAL OF TRANSLATIONAL MEDICINE
(2013)
Article
Oncology
Daniel A. Monti, Kathryn M. Kash, Elisabeth J. Kunkel, Aleeze Moss, Michael Mathews, George Brainard, Ranni Anne, Benjamin E. Leiby, Edward Pequinot, Andrew B. Newberg
Article
Neurosciences
Evangelia G. Chrysikou, Christopher Wertz, David B. Yaden, Scott Barry Kaufman, Donna Bacon, Nancy A. Wintering, Rex E. Jung, Andrew B. Newberg
Article
Neurosciences
Evangelia G. Chrysikou, Constanza Jacial, David B. Yaden, Wessel van Dam, Scott Barry Kaufman, Christopher J. Conklin, Nancy A. Wintering, Rebecca E. Abraham, Rex E. Jung, Andrew B. Newberg
Review
Psychology, Multidisciplinary
Brandon Joa, Andrew B. Newberg
Summary: This review examines the role of guilt in the development of prolonged grief disorder (PGD) in bereaved individuals, using an integrative approach combining developmental psychology and neurophysiology. While the literature extensively mentions guilt and grief, there is limited understanding of the mechanisms linking guilt and PGD. This study suggests that targeting guilt may be a promising approach for the treatment of PGD, including considering the positive and prosocial aspects of guilt.
OMEGA-JOURNAL OF DEATH AND DYING
(2023)
Review
Integrative & Complementary Medicine
Pooja Selvan, Chloe Hriso, Julita Mitchell, Andrew Newberg
Summary: The work performed on this article did not receive any funding.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2022)
Article
Health Care Sciences & Services
Sameh Gomaa, Carly West, Ana Maria Lopez, Tingting Zhan, Max Schnoll, Maysa Abu-Khalaf, Andrew Newberg, Kuang-Yi Wen
Summary: The study evaluated the safety, feasibility, acceptability, and potential efficacy of a telehealth-based tai chi intervention for reducing arthralgia induced by aromatase inhibitors in breast cancer patients. The intervention showed promising results in reducing pain and stiffness, and improving sleep quality and depressive symptoms.
JMIR FORMATIVE RESEARCH
(2022)
Correction
Health Care Sciences & Services
Sameh Gomaa, Carly West, Ana Maria Lopez, Tingting Zhan, Max Schnoll, Maysa Abu-Khalaf, Andrew Newberg, Kuang-Yi Wen
JMIR FORMATIVE RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Aleeze Sattar Moss, Diane K. Reibel, Nancy Wintering, Faezeh Vedaei, Hannah Porter, Mohsen Khosravi, Justin Heholt, Mahdi Alizadeh, Feroze B. Mohamed, Andrew B. Newberg
Summary: After participating in a Mindfulness-Based Stress Reduction program, elderly adults showed altered cerebral blood flow and functional connectivity, similar to findings in younger populations in other meditation-related studies. These changes were associated with significant improvements in depression symptoms.
BEHAVIORAL SCIENCES
(2022)
Article
Religion
Nancy A. Wintering, David B. Yaden, Christopher Conklin, Mahdi Alizadeh, Feroze B. Mohamed, Li Zhong, Brendan Bowens, Daniel A. Monti, Andrew B. Newberg
Summary: The study found significant changes in brain functional connectivity in individuals following a spiritual retreat, affecting multiple brain regions; in addition, psychological and spiritual measures also showed important changes related to retreat participation.
Article
Integrative & Complementary Medicine
Jay D. Amsterdam, Justine Shults, Irene Soeller, Jun James Mao, Kenneth Rockwell, Andrew B. Newberg
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2012)