期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 21, 期 1, 页码 75-79出版社
IOS PRESS
DOI: 10.3233/JAD-2010-091603
关键词
Amyloid; metabolism; neurodegeneration; noncoding; RTqPCR; tau
资金
- National Institutes of Health, Bethesda, MD [R01 NS061933, K08 NS050110]
- Alzheimer's Association
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K08NS050110, R01NS061933] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P30AG028383] Funding Source: NIH RePORTER
MiR-107 is a microRNA (miRNA) that we reported previously to have decreased expression in the temporal cortical gray matter early in the progression of Alzheimer's disease (AD). Here we study a new group of well-characterized human temporal cortex samples (N = 19). MiR-107 expression was assessed, normalized to miR-124 and let-7a. Correlation was observed between decreased miR-107 expression and increased neuritic plaque counts (P < 0.05) and neurofibrillary tangle counts (P < 0.02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P < 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses.
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