期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 22, 期 -, 页码 S35-S41出版社
IOS PRESS
DOI: 10.3233/JAD-2010-101317
关键词
Alzheimer's disease; amyloid-beta peptide; anesthesia; anesthetics; central cholinergic system; cholinergic receptors; liaison; neurodegenerative disorders; oligomerization
资金
- Italian Ministry for University and Research [2007H84XNH]
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation and aggregation of amyloid-beta peptide and loss of forebrain cholinergic neurons, resulting in progressive loss of memory and irreversible impairment of higher cognitive functions. Several studies have accounted for the close relationship between AD and the central cholinergic system, suggesting that a dysfunction of acetylcholine containing neurons in the brain contributes significantly to the cognitive deficit of individuals with AD. The aim of the present review is to survey current literature on this topic in order to provide a clear understanding of the role of the cholinergic system in the development and neurodegenerative process of AD. The implications for anesthesia are also discussed. This knowledge could be valuable to improve anesthesia performance and patient safety.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据