Article
Psychiatry
Dawei Miao, Xiaoguang Zhou, Xiaoyuan Wu, Chengdong Chen, Le Tian
Summary: This study investigated the differences in functional connectivity density (FCD) between AD and MCI, and found significant differences in global FCD values between AD, MCI, and healthy controls. These findings provide new insights into the progressive brain changes from MCI to AD.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Sendy Caffarra, Sung Jun Joo, David Bloom, John Kruper, Ariel Rokem, Jason D. Yeatman
Summary: The latency of neural responses in the visual cortex varies across the lifespan, with faster M100 responses for high contrast stimuli observed with age, where optic radiation FA values mediate this effect.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Hatice Eraslan Boz, Koray Kocoglu, Muege Akkoyun, Isil Yagmur Tufekci, Merve Ekin, Guelden Akdal
Summary: The study found that visual search impairment exists in early stages of both AD and aMCI, highlighting the importance of addressing visual processes in the Alzheimer's continuum.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Yuping Cao, Huan Yang, Zhenhe Zhou, Zaohuo Cheng, Xingfu Zhao
Summary: The study demonstrates abnormal DMN network homogeneity in MCI patients, with significant differences in specific brain regions. These results emphasize the importance of the DMN in the pathophysiology of cognitive problems in MCI.
FRONTIERS IN NEUROLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Sunghong Park, Chang Hyung Hong, Dong-gi Lee, Kanghee Park, Hyunjung Shin
Summary: With the rapid aging of the population, Alzheimer's disease (AD) is becoming a serious problem, and early detection of the disease is crucial. By learning brain atrophy patterns, machine learning algorithms can predict the conversion from mild cognitive impairment (MCI) to AD. However, it is challenging to distinguish between the conversion group and the non-conversion group due to small differences and large within-group variability in brain images. To address this issue, a method called prospective classification, which projects brain images into the future for classification, is proposed.
Article
Geriatrics & Gerontology
Zhenrong Fu, Mingyan Zhao, Yirong He, Xuetong Wang, Jiadong Lu, Shaoxian Li, Xin Li, Guixia Kang, Ying Han, Shuyu Li
Summary: The study revealed that structural covariance and connectivity strength are decreased in individuals with subjective cognitive decline (SCD) compared to normal controls (NC), and structural covariance patterns in specific large-scale brain networks show divergent changes at the early Alzheimer's disease (aMCI) stage and dementia (AD) stage.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Sian Wilson, Maximilian Pietsch, Lucilio Cordero-Grande, Anthony N. Price, Jana Hutter, Jiaxin Xiao, Laura McCabe, Mary A. Rutherford, Emer J. Hughes, Serena J. Counsell, Jacques-Donald Tournier, Tomoki Arichi, Joseph V. Hajnal, A. David Edwards, Daan Christiaens, Jonathan O'Muircheartaigh
Summary: A study characterizing the in utero maturation of white matter microstructure in human fetal brains using high-resolution MRI data identified unique maturational trends in different white matter bundles and regions, suggesting potential insights into connectivity abnormalities associated with preterm birth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Antonio Carotenuto, Paola Valsasina, Menno M. Schoonheim, Jeroen J. G. Geurts, Frederik Barkhof, Antonio Gallo, Gioacchino Tedeschi, Silvia Tommasin, Patrizia Pantano, Massimo Filippi, Maria A. Rocca, MAGNIMS Study Grp
Summary: Patients with multiple sclerosis (MS) showed abnormalities in the centrality of functional networks, with reduced centrality in the salience and sensorimotor networks and increased centrality in the default-mode network. These centrality abnormalities were specific to different disease phenotypes and were associated with clinical and cognitive disability. The voxel-wise centrality analysis may reflect the pathologic substrates underlying disability accrual in MS.
Article
Neurosciences
Xiaomei Zhong, Ben Chen, Le Hou, Qiang Wang, Meiling Liu, Mingfeng Yang, Min Zhang, Huarong Zhou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Ning
Summary: This study aimed to compare temporal variability in the spontaneous fluctuations of activity and connectivity between amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The results showed that both aMCI and naMCI patients exhibited abnormal brain activity and connectivity. The variability in dALFF, dReHo, and hippocampal dFC was different between aMCI and naMCI patients and was associated with cognitive scores. The dReHo of the superior parietal lobule and dFC of the hippocampus-cerebellum contributed to the memory heterogeneity of MCI subtypes.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Geriatrics & Gerontology
Shuntai Chen, Dian Zhang, Honggang Zheng, Tianyu Cao, Kun Xia, Mingwan Su, Qinggang Meng
Summary: The thickness of the retina is found to degenerate in the pathological process of Alzheimer's disease (AD), while hippocampal atrophy is a typical feature of AD. The association between retinal thickness and hippocampal atrophy in AD is unclear. This study aims to quantify the correlation between these two parameters and explore the potential of using retinal thickness as a biomarker for early AD detection.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Neurosciences
Buhari Ibrahim, Subapriya Suppiah, Normala Ibrahim, Mazlyfarina Mohamad, Hasyma Abu Hassan, Nisha Syed Nasser, M. Iqbal Saripan
Summary: Resting-state fMRI can detect functional connectivity abnormalities in the brains of AD and MCI patients, while multimodal features combined with machine learning methods can enhance diagnostic power. Nodes of the DMN show promising potential to distinguish between AD and MCI patients.
HUMAN BRAIN MAPPING
(2021)
Article
Geriatrics & Gerontology
Maurizio Bergamino, Simona Schiavi, Alessandro Daducci, Ryan R. Walsh, Ashley M. Stokes
Summary: This study utilized advanced diffusion MRI technology to investigate white matter integrity and structural connectivity in healthy controls and individuals with mild cognitive impairment (MCI). The results showed lower intracellular compartment and higher isotropic values in the MCI group compared to the healthy control group. Significant correlations were also found between intracellular compartment values and Montreal Cognitive Assessment scores in the MCI group. Network analysis revealed differences in structural connectivity between the two groups, as well as significant differences in global network efficiency.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Yongqiang Shu, Liting Chen, Kunyao Li, Haijun Li, Linghong Kong, Xiang Liu, Panmei Li, Wei Xie, Yaping Zeng, Dechang Peng
Summary: This study aimed to investigate the temporal variability of spontaneous brain activity in patients with obstructive sleep apnea (OSA). The results showed that OSA patients with and without mild cognitive impairment (MCI) have different dynamic brain functions, suggesting the presence of variable intermediate states in OSA patients without MCI. The study also found that the functional abnormalities of the cerebellar-prefrontal cortex pathway in OSA patients may cause cognitive impairment.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Yu-Qian Wu, Yi-Ning Wang, Li-Juan Zhang, Li-Qi Liu, Yi-Cong Pan, Ting Su, Xu-Lin Liao, Hui-Ye Shu, Min Kang, Ping Ying, San-Hua Xu, Yi Shao
Summary: The study aimed to analyze potential changes in brain neural networks in patients with mild cognitive impairment (MCI) using the regional homogeneity (ReHo) method in resting state functional magnetic resonance imaging (rs-fMRI) scans. The results showed significant differences in signal intensity in specific brain regions between MCI patients and healthy controls, and these differences were correlated with clinical features. These findings may have implications for clinical diagnosis.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Lars Nyberg, Micael Andersson, Anders Lundquist, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Naiara Demnitz, Christian A. Drevon, Sandra Duezel, Klaus P. Ebmeier, Paolo Ghisletta, Richard Henson, Daria E. A. Jensen, Rogier A. Kievit, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Anna Plachti, Sara Pudas, James M. Roe, Kathrine Skak Madsen, Cristina Sole-Padulles, Yasmine Sommerer, Sana Suri, Eniko Zsoldos, Anders M. Fjell, Kristine B. Walhovd
Summary: We found heterogeneity in regional-atrophy patterns through latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. Our findings suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
Article
Neurosciences
Maria Cabello-Toscano, Lidia Vaque-Alcazar, Gabriele Cattaneo, Javier Solana-Sanchez, Ivet Bayes-Marin, Kilian Abellaneda-Perez, Didac Macia-Bros, Lidia Mulet-Pons, Cristina Portellano-Ortiz, Miquel Angel Fullana, Laura Oleaga, Sofia Gonzalez, Nuria Bargallo, Jose M. Tormos, Alvaro Pascual-Leone, David Bartres-Faz
Summary: This study investigates the resilience to the mental health impact of the COVID-19 pandemic and identifies the demographic, psychological, and neurobiological factors associated with interindividual differences. The findings suggest that age, sex, coping strategies, and brain network status are all related to mental health. Therefore, preventive strategies should consider these factors to promote mental health during similar adverse events.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychiatry
Elena Iurina, Eva Bailles, Mar Carreno, Antonio Donaire, Jordi Rumia, Teresa Boget, Nuria Bargallo, Xavier Setoain, Pedro Roldan, Estefania Conde-Blanco, Maria Centeno, Luis Pintor
Summary: The study aims to investigate the influence of personality profile in drug-resistant epilepsy patients on quality of life after surgical treatment. The results showed significant improvement in quality of life in the surgical group, which was not associated with baseline or postoperative seizure frequency at one year. The personality profile at baseline was found to be related to postoperative quality of life.
PERSONALITY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Gonzalo Forno, Jose Contador, Agnes Perez-Millan, Nuria Guillen, Neus Falgas, Jordi Sarto, Adria Tort-Merino, Magdalena Castellvi, Beatriz Bosch, Guadalupe Fernandez-Villullas, Mircea Balasa, Anna Antonell, Roser Sala-Llonch, Raquel Sanchez-Valle, Michael Hornberger, Albert Llado
Summary: This study assessed how the APOE genotype differentially affects cortical and subcortical memory structures in biomarker-confirmed early-onset (EOAD) and late-onset (LOAD) Alzheimer's disease patients. The results showed that the APOE genotype has a significant effect on grey matter volume, with LOAD APOE4 genotype mostly associated with cortical and temporal atrophy, while EOAD APOE4 genotype might have a more specific effect on subcortical structures (mammillary body). Therefore, the APOE genotype needs to be taken into account when classifying patients by age at onset.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Agnes Perez-Millan, Jose Contador, Jordi Junca-Parella, Beatriz Bosch, Laia Borrell, Adria Tort-Merino, Neus Falgas, Sergi Borrego-Ecija, Nuria Bargallo, Lorena Rami, Mircea Balasa, Albert Llado, Raquel Sanchez-Valle, Roser Sala-Llonch
Summary: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are common causes of dementia with overlapping symptoms and brain signatures. This study used brain magnetic resonance imaging (MRI) and machine learning to accurately diagnose and classify AD and FTD. The algorithm achieved good accuracy in cross-sectional and longitudinal data.
HUMAN BRAIN MAPPING
(2023)
Article
Psychology, Developmental
Sara Bertolin, Pino Alonso, Ignacio Martinez-Zalacain, Jose M. Menchon, Susana Jimenez-Murcia, Justin T. Baker, Nuria Bargallo, Marcelo Camargo Batistuzzo, Premika S. W. Boedhoe, Brian P. Brennan, Jamie D. Feusner, Kate D. Fitzgerald, Martine Fontaine, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Neda Jahanshad, Fern Jaspers-Fayer, Masaru Kuno, Gerd Kvale, Luisa Lazaro, Mafalda Machado-Sousa, Rachel Marsh, Pedro Morgado, Akiko Nakagawa, Luke Norman, Erika L. Nurmi, Joseph O'Neill, Ana E. Ortiz, Chris Perriello, John Piacentini, Maria Pico-Perez, Roseli G. Shavitt, Eiji Shimizu, Helen Blair Simpson, S. Evelyn Stewart, Sophia I. Thomopoulos, Anders Lillevik Thorsen, Susanne Walitza, Lidewij H. Wolters, Paul M. Thompson, Odile A. van den Heuvel, Dan J. Stein, Carles Soriano-Mas
Summary: The results of the study suggest that higher cortical thickness in specific right prefrontal cortex regions may play an important role in the response to cognitive-behavioral therapy in children with OCD.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Clinical Neurology
Anna Campabadal, Javier Oltra, Carme Junque, Nuria Guillen, Maria Angeles Boti, Roser Sala-Llonch, Gemma C. Monte-Rubio, Gema Lledo, Nuria Bargallo, Lorena Rami, Raquel Sanchez-Valle, Barbara Segura
Summary: This study investigates structural brain changes in patients with persistent olfactory dysfunctions after COVID-19. It found differences in gray matter volume and diffusion in the olfactory system among COVID-19 patients, which can explain the prolonged olfactory deficits in these patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Isabelle Budin-Ljosne, Barbara B. Friedman, William F. C. Baare, David Bartres-Faz, Rebecca B. Carver, Christian A. Drevon, Klaus P. Ebmeier, Anders M. Fjell, Paolo Ghisletta, Richard N. Henson, Rogier Kievit, Kathrine S. Madsen, Laura Nawijn, Sana Suri, Cristina Sole-Padulles, Kristine B. Walhovd, Eniko Zsoldos
Summary: The involvement of stakeholders in the "Lifebrain" project was seen as meaningful and relevant, benefiting both researchers and stakeholders. However, there were barriers such as lack of time, difficulties in identifying relevant stakeholders, and challenges in communicating scientific issues. Stakeholder engagement in basic brain research requires dedicated resources, clear communication, and defined roles and responsibilities.
HEALTH EXPECTATIONS
(2023)
Article
Psychology, Biological
Anders M. Fjell, Oystein Sorensen, Yunpeng Wang, Inge K. Amlien, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Ilja Demuth, Christian A. Drevon, Klaus P. Ebmeier, Paolo Ghisletta, Rogier Kievit, Simone Kuehn, Kathrine Skak Madsen, Athanasia M. Mowinckel, Lars Nyberg, Claire E. Sexton, Cristina Sole-Padulles, Didac Vidal-Pineiro, Gerd Wagner, Leiv Otto Watne, Kristine B. Walhovd
Summary: Short sleep duration is not directly associated with brain health, and normal brains promote adequate sleep.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Multidisciplinary Sciences
E. Monteagudo-Gimeno, R. Sanchez-Gonzalez, J. Radua-Castano, L. Fortea-Gonzalez, T. Boget-Llucia, M. Carreno-Martinez, A. Donaire-Pedraza, N. Bargallo-Alabart, X. Setoain-Perego, J. Rumia-Arboix, A. Bulbena-Vilarrasaa, L. Pintor-Perez
Article
Psychiatry
I. Bayes-Marin, M. Cabello-Toscano, G. Cattaneo, J. Solana-Sanchez, D. Fernandez, C. Portellano-Ortiz, J. M. Tormos, A. Pascual-Leone, D. Bartres-Faz
Summary: The study aimed to identify trajectories of mental health during a two-year follow-up of the COVID-19 pandemic and investigate the associations between these trajectories and various factors. They found that most participants belonged to the "resilient" trajectory, while a smaller proportion belonged to the "chronic-worsening" trajectory. Protective factors and risk factors played different roles in different mental health outcomes.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2023)
Meeting Abstract
Clinical Neurology
J. Oltra, A. Campabadal, C. Uribe, J. Pardo, M. J. Marti, Y. Compta, F. Valldeoriola, N. Bargallo, A. Iranzo, C. Junque, B. Segura
MOVEMENT DISORDERS
(2022)