Review
Biochemistry & Molecular Biology
Marta Waliszewska-Prosol, Marta Nowakowska-Kotas, Justyna Chojdak-Lukasiewicz, Slawomir Budrewicz
Summary: Migraine and sleep disorders are common chronic diseases with significant negative impacts on society and economy. The association between them is observed but not fully understood, with recent progress in understanding common anatomical structures and pathogenetic mechanisms. Better understanding of these mechanisms in the future will expand treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Raquel B. Ariede, Milena Freitas, Lieschen V. G. Lira, John F. G. Agudelo, Carolina H. S. Borges, Vito A. Mastrochirico-Filho, Pablo Caceres, Jose M. Yanez, Diogo T. Hashimoto
Summary: This study represents the first application of a 30 K SNP array to build a dense linkage map anchoring 27 megascaffolds (chromosomes) of the Tambaqui genome, and to identify genetic variants associated with A. hydrophila resistance. Genomic analysis revealed low to moderate heritability values for the resistance traits. GWAS analysis identified several putative QTLs associated with A. hydrophila resistance.
Article
Clinical Neurology
Alexander M. Kulminski, Ian Philipp, Yury Loika, Liang He, Irina Culminskaya
Summary: The protective role of the apolipoprotein E (APOE) epsilon 2 allele in Alzheimer's disease (AD) may be influenced by different immunomodulation functions of TOMM40 and APOE variants in a sex-specific manner, defining a more homogeneous AD-protective epsilon 2/epsilon 3-bearing profile in men.
ALZHEIMERS & DEMENTIA
(2021)
Article
Biology
Jianqiao Wang, Hongzhe Li
Summary: The study developed a method of moments estimator of genetic correlation between two traits in the framework of high-dimensional linear models, showing its robustness and interpretability compared to existing methods under different genetic architectures.
Article
Environmental Sciences
Zhengkang Su, Kaiyu Guan, Yunbin Liu, Hai Zhang, Zhengwei Huang, Miaomiao Zheng, Ya Zhu, He Zhang, Weihong Song, Xi Li
Summary: The use of clinical psychoactive drugs can pose unpredictable threats to fetal development. Opicapone, a newly effective peripheral COMT inhibitor, is used for the treatment of Parkinson's disease and other dopamine-related disorders. However, the impact of opicapone on embryonic development is still unknown.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Chao Xue, Lin Jiang, Miao Zhou, Qihan Long, Ying Chen, Xiangyi Li, Wenjie Peng, Qi Yang, Miaoxin Li
Summary: PCGA is a comprehensive web server that can estimate the associated tissues/cell types and susceptibility genes for complex phenotypes using GWAS summary statistics. It integrates extensive RNA sequencing data to provide expression profiles of diverse tissues and cell types for accurate estimation of associated tissues/cell types and genes for complex phenotypes.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Brittany L. Mitchell, Jake R. Saklatvala, Nick Dand, Fiona A. Hagenbeek, Xin Li, Josine L. Min, Laurent Thomas, Meike Bartels, Jouke Jan Hottenga, Michelle K. Lupton, Dorret Boomsma, Xianjun Dong, Kristian Hveem, Mari Loset, Nicholas G. Martin, Jonathan N. Barker, Jiali Han, Catherine H. Smith, Miguel E. Renteria, Michael A. Simpson
Summary: This study conducted a meta-analysis of genome-wide association studies in over 20,000 cases of acne and identified 29 new susceptibility loci for acne, revealing genetic links to Mendelian hair and skin disorders and other complex traits.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Maria Arnoriaga-Rodriguez, Jordi Mayneris-Perxachs, Oren Contreras-Rodriguez, Aurelijus Burokas, Juan-Antonio Ortega-Sanchez, Gerard Blasco, Claudia Coll, Carles Biarnes, Anna Castells-Nobau, Josep Puig, Josep Garre-Olmo, Rafel Ramos, Salvador Pedraza, Ramon Brugada, Joan C. Vilanova, Joaquin Serena, Jordi Barretina, Jordi Gich, Vicente Perez-Brocal, Andres Moya, Xavier Fernandez-Real, Lluis Ramio-Torrenta, Reinald Pamplona, Joaquim Sol, Mariona Jove, Wifredo Ricart, Manuel Portero-Otin, Rafael Maldonado, Jose Manuel Fernandez-Real
Summary: The study revealed the relationship between inhibitory control and obesity, as well as the interactions between gut microbiota, metabolomics, and brain structure. Metabolic pathway alterations associated with obesity were found to be linked to inhibitory control, and results were validated in mice through fecal microbiota transplantation.
Article
Neurosciences
Jingsong Ma, Mingzhe Zhao, Wei Zhou, Mo Li, Cong Huai, Lu Shen, Ting Wang, Hao Wu, Na Zhang, Zhiruo Zhang, Lin He, Shengying Qin
Summary: The study used meta-analysis to demonstrate a significant association between COMT Val158Met polymorphism and antipsychotic response, which was consistent in both Caucasian and Asian patient populations. Genotyping of patients for predicting antipsychotic response may be relevant for future randomized clinical trials.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ju-Yu Yen, Pai-Cheng Lin, Huang-Chi Lin, Pei-Yun Lin, Wei-Po Chou, Chih-Hung Ko
Summary: This study examined the association of the COMT val158met polymorphism with Internet gaming disorder (IGD) and found that impulsivity and fun-seeking behaviors mediate this relationship among individuals with the Val/Val genotype. The Val/Val genotype, indicative of low frontal functioning, is a predictive factor for IGD, with its effect being influenced by impulsivity and fun-seeking behaviors. Targeting interventions towards impulsivity and fun-seeking could help mitigate the risk of IGD, especially in individuals with the Val/Val genotype. Additional research is needed to further understand the role of dopamine functioning in IGD.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Subhamita Maitra, Mahasweta Chatterjee, Anirban Roychowdhury, Chinmay Kumar Panda, Swagata Sinha, Kanchan Mukhopadhyay
Summary: This study investigates the association between functional gene variants of the dopamine transporter and catechol-O-methyltransferase with ADHD-related impulsive behavior, executive deficits, and disease persistence. The findings suggest that these genetic variants may serve as predictors for the success of individual therapeutic sessions during cognitive training.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Psychiatry
Teri W. Hoenemeyer, Navneet Kaur Baidwan, Kathryn Hall, Ted J. Kaptchuk, Kevin R. Fontaine, Tapan S. Mehta
Summary: Research suggests that genetic variations in COMT may influence cancer survivors' response to open-label placebo, with rs4680 and rs4818 genotypes being associated with changes in fatigue severity and quality of life improvements.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Zhifeng Zhong, Simin Zhou, Bin Xiang, Yu Wu, Jiaxin Xie, Peng Li
Summary: Living at high altitude can impair cognitive function, with significant associations found between peripheral plasma neurotransmitters and cognitive performance. Exposure to chronic hypobaric hypoxia can alter brain neurotransmitter levels, emphasizing a possible causal effect on cognitive performance.
Article
Multidisciplinary Sciences
Manju Mamtani, Manisha T. Jaisinghani, Sujeet G. Jaiswal, Kanchan V. Pipal, Ashwini A. Patel, Hemant Kulkarni
Summary: This study in Sindhi families in India revealed a genetic and environmental concordance between anthropometric traits and type 2 diabetes. Waist circumference, arm circumference, and abdominal skinfold thickness were significantly associated with type 2 diabetes. The heritability range for anthropometric traits and type 2 diabetes related traits was 0.27-0.73 and 0.00-0.39, respectively.
Article
Multidisciplinary Sciences
Aki Takahashi, Romain Durand-de Cuttoli, Meghan E. Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D. Blitzer, Michael Lazarus, Kenji F. Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J. Russo
Summary: The glutamatergic projections from the lateral habenula (LHb) to the dorsal raphe nucleus (DRN) modulate male mice's aggressive behavior. Inhibition of LHb-DRN projection blocks the increase in aggression after social instigation. The activity of this pathway is not necessary for the expression of species-typical aggressive behavior but essential for the increase in aggression resulting from social instigation.
NATURE COMMUNICATIONS
(2022)
